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<!--Generated by DFIN XBRL Instance Document - http://www.dfinsolutions.com/ - Version R3.0 - on 22-March-2023 [08:05:16] {AM}-->
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<roleRef xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd#netLabel" roleURI="http://www.xbrl.org/2009/role/netLabel" />
<labelLink xlink:type="extended" xlink:role="http://www.xbrl.org/2003/role/link">
<loc xlink:type="locator" xlink:href="wynn-20221231.xsd#wynn_BaseSalaryForNeo" xlink:label="loc_wynn_BaseSalaryForNeo" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_wynn_BaseSalaryForNeo" xml:lang="en-US">Base Salary for NEO</label>
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<loc xlink:type="locator" xlink:href="wynn-20221231.xsd#wynn_ChangeInFairValueOfEquityAwardsAtTheVestingMember" xlink:label="loc_wynn_ChangeInFairValueOfEquityAwardsAtTheVestingMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_wynn_ChangeInFairValueOfEquityAwardsAtTheVestingMember" xml:lang="en-US">Change in Fair Value of Equity Awards at the Vesting [Member]</label>
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<loc xlink:type="locator" xlink:href="wynn-20221231.xsd#wynn_ForfeitureOfPreviouslyGrantedEquityAwardsMember" xlink:label="loc_wynn_ForfeitureOfPreviouslyGrantedEquityAwardsMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_wynn_ForfeitureOfPreviouslyGrantedEquityAwardsMember" xml:lang="en-US">Forfeiture of Previously Granted Equity Awards [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_wynn_ForfeitureOfPreviouslyGrantedEquityAwardsMember" xlink:to="lab_wynn_ForfeitureOfPreviouslyGrantedEquityAwardsMember" />
<loc xlink:type="locator" xlink:href="wynn-20221231.xsd#wynn_ChangeInFairValueOfEquityAwardsAtEitherTheVestingMember" xlink:label="loc_wynn_ChangeInFairValueOfEquityAwardsAtEitherTheVestingMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_wynn_ChangeInFairValueOfEquityAwardsAtEitherTheVestingMember" xml:lang="en-US">Change in Fair Value of Equity Awards at Either the Vesting [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_wynn_ChangeInFairValueOfEquityAwardsAtEitherTheVestingMember" xlink:to="lab_wynn_ChangeInFairValueOfEquityAwardsAtEitherTheVestingMember" />
<loc xlink:type="locator" xlink:href="wynn-20221231.xsd#wynn_ReversalOfCompensationActuallyPaidRelatedToTheForfeitureMember" xlink:label="loc_wynn_ReversalOfCompensationActuallyPaidRelatedToTheForfeitureMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_wynn_ReversalOfCompensationActuallyPaidRelatedToTheForfeitureMember" xml:lang="en-US">Reversal of Compensation Actually Paid Related to the Forfeiture [Member]</label>
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<loc xlink:type="locator" xlink:href="wynn-20221231.xsd#wynn_CraigS.BillingsMember" xlink:label="loc_wynn_CraigS.BillingsMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_wynn_CraigS.BillingsMember" xml:lang="en-US">Craig S. Billings [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_wynn_CraigS.BillingsMember" xlink:to="lab_wynn_CraigS.BillingsMember" />
<loc xlink:type="locator" xlink:href="wynn-20221231.xsd#wynn_MattMaddoxMember" xlink:label="loc_wynn_MattMaddoxMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_wynn_MattMaddoxMember" xml:lang="en-US">Matt Maddox [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_wynn_MattMaddoxMember" xlink:to="lab_wynn_MattMaddoxMember" />
<loc xlink:type="locator" xlink:href="wynn-20221231.xsd#wynn_JulieM.CameronDoeMember" xlink:label="loc_wynn_JulieM.CameronDoeMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_wynn_JulieM.CameronDoeMember" xml:lang="en-US">Julie M. Cameron Doe [Member]</label>
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<loc xlink:type="locator" xlink:href="wynn-20221231.xsd#wynn_EllenF.WhittemoreMember" xlink:label="loc_wynn_EllenF.WhittemoreMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_wynn_EllenF.WhittemoreMember" xml:lang="en-US">Ellen F. Whittemore [Member]</label>
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