<?xml version="1.0" encoding="US-ASCII"?>
<!--XBRL Document Created with Wdesk from Workiva-->
<!-- -->
<linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns="http://www.xbrl.org/2003/linkbase" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <roleRef roleURI="http://www.wynnresorts.com/role/AccumulatedOtherComprehensiveIncomeLoss" xlink:href="wynn-20170630.xsd#AccumulatedOtherComprehensiveIncomeLoss" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/AccumulatedOtherComprehensiveIncomeLossChangesByComponentInAccumulatedOtherComprehensiveIncomeLossDetail" xlink:href="wynn-20170630.xsd#AccumulatedOtherComprehensiveIncomeLossChangesByComponentInAccumulatedOtherComprehensiveIncomeLossDetail" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/AccumulatedOtherComprehensiveIncomeLossTables" xlink:href="wynn-20170630.xsd#AccumulatedOtherComprehensiveIncomeLossTables" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/CommitmentsAndContingencies" xlink:href="wynn-20170630.xsd#CommitmentsAndContingencies" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/CommitmentsAndContingenciesAdditionalInformationDetail" xlink:href="wynn-20170630.xsd#CommitmentsAndContingenciesAdditionalInformationDetail" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedBalanceSheets" xlink:href="wynn-20170630.xsd#CondensedConsolidatedBalanceSheets" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:href="wynn-20170630.xsd#CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementOfStockholdersEquityDeficitUnaudited" xlink:href="wynn-20170630.xsd#CondensedConsolidatedStatementOfStockholdersEquityDeficitUnaudited" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsOfCashFlowsUnaudited" xlink:href="wynn-20170630.xsd#CondensedConsolidatedStatementsOfCashFlowsUnaudited" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsOfComprehensiveIncomeLossUnaudited" xlink:href="wynn-20170630.xsd#CondensedConsolidatedStatementsOfComprehensiveIncomeLossUnaudited" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsOfIncomeUnaudited" xlink:href="wynn-20170630.xsd#CondensedConsolidatedStatementsOfIncomeUnaudited" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/DocumentAndEntityInformation" xlink:href="wynn-20170630.xsd#DocumentAndEntityInformation" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/EarningsPerShare" xlink:href="wynn-20170630.xsd#EarningsPerShare" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/EarningsPerShareScheduleOfSharesUsedInCalculationOfEarningsPerShareDetail" xlink:href="wynn-20170630.xsd#EarningsPerShareScheduleOfSharesUsedInCalculationOfEarningsPerShareDetail" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/EarningsPerShareTables" xlink:href="wynn-20170630.xsd#EarningsPerShareTables" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/IncomeTaxes" xlink:href="wynn-20170630.xsd#IncomeTaxes" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/IncomeTaxesAdditionalInformationDetail" xlink:href="wynn-20170630.xsd#IncomeTaxesAdditionalInformationDetail" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/InvestmentSecurities" xlink:href="wynn-20170630.xsd#InvestmentSecurities" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/InvestmentSecuritiesInvestmentsByContractualMaturityDetails" xlink:href="wynn-20170630.xsd#InvestmentSecuritiesInvestmentsByContractualMaturityDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/InvestmentSecuritiesScheduleOfInvestmentSecuritiesDetail" xlink:href="wynn-20170630.xsd#InvestmentSecuritiesScheduleOfInvestmentSecuritiesDetail" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/InvestmentSecuritiesTables" xlink:href="wynn-20170630.xsd#InvestmentSecuritiesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebt" xlink:href="wynn-20170630.xsd#LongTermDebt" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebtAdditionalInformationDetail" xlink:href="wynn-20170630.xsd#LongTermDebtAdditionalInformationDetail" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebtSummaryOfLongTermDebtAdditionalInformationDetail" xlink:href="wynn-20170630.xsd#LongTermDebtSummaryOfLongTermDebtAdditionalInformationDetail" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebtSummaryOfLongTermDebtDetail" xlink:href="wynn-20170630.xsd#LongTermDebtSummaryOfLongTermDebtDetail" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebtTables" xlink:href="wynn-20170630.xsd#LongTermDebtTables" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/NoncontrollingInterestDetails" xlink:href="wynn-20170630.xsd#NoncontrollingInterestDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/NoncontrollingInterestNotes" xlink:href="wynn-20170630.xsd#NoncontrollingInterestNotes" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/OrganizationAndBasisOfPresentation" xlink:href="wynn-20170630.xsd#OrganizationAndBasisOfPresentation" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/OrganizationAndBasisOfPresentationAdditionalInformationDetail" xlink:href="wynn-20170630.xsd#OrganizationAndBasisOfPresentationAdditionalInformationDetail" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/PropertyAndEquipmentNet" xlink:href="wynn-20170630.xsd#PropertyAndEquipmentNet" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/PropertyAndEquipmentNetScheduleOfPropertyAndEquipmentNetDetail" xlink:href="wynn-20170630.xsd#PropertyAndEquipmentNetScheduleOfPropertyAndEquipmentNetDetail" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/PropertyAndEquipmentNetTables" xlink:href="wynn-20170630.xsd#PropertyAndEquipmentNetTables" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/ReceivablesNet" xlink:href="wynn-20170630.xsd#ReceivablesNet" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/ReceivablesNetSummaryOfReceivablesNetDetail" xlink:href="wynn-20170630.xsd#ReceivablesNetSummaryOfReceivablesNetDetail" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/ReceivablesNetTables" xlink:href="wynn-20170630.xsd#ReceivablesNetTables" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/RelatedPartyTransactions" xlink:href="wynn-20170630.xsd#RelatedPartyTransactions" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/RelatedPartyTransactionsAdditionalInformationDetail" xlink:href="wynn-20170630.xsd#RelatedPartyTransactionsAdditionalInformationDetail" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/RetailJointVenture" xlink:href="wynn-20170630.xsd#RetailJointVenture" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/RetailJointVentureAdditionalInformationDetails" xlink:href="wynn-20170630.xsd#RetailJointVentureAdditionalInformationDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/SegmentInformation" xlink:href="wynn-20170630.xsd#SegmentInformation" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/SegmentInformationAdditionalInformationDetails" xlink:href="wynn-20170630.xsd#SegmentInformationAdditionalInformationDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/SegmentInformationSummaryOfAssetsBySegmentDetail" xlink:href="wynn-20170630.xsd#SegmentInformationSummaryOfAssetsBySegmentDetail" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/SegmentInformationSummaryOfResultsOfOperationsBySegmentDetail" xlink:href="wynn-20170630.xsd#SegmentInformationSummaryOfResultsOfOperationsBySegmentDetail" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/SegmentInformationTables" xlink:href="wynn-20170630.xsd#SegmentInformationTables" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/StockBasedCompensation" xlink:href="wynn-20170630.xsd#StockBasedCompensation" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/StockBasedCompensationAdditionalInformationDetails" xlink:href="wynn-20170630.xsd#StockBasedCompensationAdditionalInformationDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/StockBasedCompensationSummaryOfTotalStockBasedCompensationCostDetail" xlink:href="wynn-20170630.xsd#StockBasedCompensationSummaryOfTotalStockBasedCompensationCostDetail" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/StockBasedCompensationTables" xlink:href="wynn-20170630.xsd#StockBasedCompensationTables" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/SubsequentEvent" xlink:href="wynn-20170630.xsd#SubsequentEvent" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/SubsequentEventAdditionalInformationDetail" xlink:href="wynn-20170630.xsd#SubsequentEventAdditionalInformationDetail" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/SummaryOfSignificantAccountingPolicies" xlink:href="wynn-20170630.xsd#SummaryOfSignificantAccountingPolicies" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/SummaryOfSignificantAccountingPoliciesAdditionalInformationDetail" xlink:href="wynn-20170630.xsd#SummaryOfSignificantAccountingPoliciesAdditionalInformationDetail" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/SummaryOfSignificantAccountingPoliciesEstimatedCostOfPromotionalAllowancesDetail" xlink:href="wynn-20170630.xsd#SummaryOfSignificantAccountingPoliciesEstimatedCostOfPromotionalAllowancesDetail" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/SummaryOfSignificantAccountingPoliciesEstimatedRetailValueOfPromotionalAllowancesDetail" xlink:href="wynn-20170630.xsd#SummaryOfSignificantAccountingPoliciesEstimatedRetailValueOfPromotionalAllowancesDetail" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:href="wynn-20170630.xsd#SummaryOfSignificantAccountingPoliciesPolicies" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/SummaryOfSignificantAccountingPoliciesScheduleOfAssetsAndLiabilitiesCarriedAtFairValueDetail" xlink:href="wynn-20170630.xsd#SummaryOfSignificantAccountingPoliciesScheduleOfAssetsAndLiabilitiesCarriedAtFairValueDetail" xlink:type="simple" />
  <roleRef roleURI="http://www.wynnresorts.com/role/SummaryOfSignificantAccountingPoliciesTables" xlink:href="wynn-20170630.xsd#SummaryOfSignificantAccountingPoliciesTables" xlink:type="simple" />
  <arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" xlink:type="simple" />
  <arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" xlink:type="simple" />
  <arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" xlink:type="simple" />
  <arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" xlink:type="simple" />
  <arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" xlink:type="simple" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/AccumulatedOtherComprehensiveIncomeLoss" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/AccumulatedOtherComprehensiveIncomeLossChangesByComponentInAccumulatedOtherComprehensiveIncomeLossDetail" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_5C31F87F50BB02317D83A38E1F7AB385" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_9E00144A0804D380A4ACA38E1F7635B7" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_5C31F87F50BB02317D83A38E1F7AB385" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_9E00144A0804D380A4ACA38E1F7635B7" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_50B4EBE2B7A25954964DA38E1F77B2D3" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_9E00144A0804D380A4ACA38E1F7635B7" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_50B4EBE2B7A25954964DA38E1F77B2D3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_D600B26FEA37EAE2EB9FA38E1F771D2C_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_50B4EBE2B7A25954964DA38E1F77B2D3" xlink:to="loc_us-gaap_EquityComponentDomain_D600B26FEA37EAE2EB9FA38E1F771D2C_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_D600B26FEA37EAE2EB9FA38E1F771D2C" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_50B4EBE2B7A25954964DA38E1F77B2D3" xlink:to="loc_us-gaap_EquityComponentDomain_D600B26FEA37EAE2EB9FA38E1F771D2C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedTranslationAdjustmentMember" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_BBCBF3BADD74D7604B66A38E1F77498A" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_D600B26FEA37EAE2EB9FA38E1F771D2C" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_BBCBF3BADD74D7604B66A38E1F77498A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember" xlink:label="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_1F347CD4DFAD790A552BA38E1F7AF807" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_D600B26FEA37EAE2EB9FA38E1F771D2C" xlink:to="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_1F347CD4DFAD790A552BA38E1F7AF807" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_ChangesinAccumulatedOtherComprehensiveIncomeRollForward" xlink:label="loc_wynn_ChangesinAccumulatedOtherComprehensiveIncomeRollForward_8FA72CE04AE9CF3169A7A38E1F7A544E" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_5C31F87F50BB02317D83A38E1F7AB385" xlink:to="loc_wynn_ChangesinAccumulatedOtherComprehensiveIncomeRollForward_8FA72CE04AE9CF3169A7A38E1F7A544E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_FBB97BDCBC3A9FF58585A38E1F7A1217" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_ChangesinAccumulatedOtherComprehensiveIncomeRollForward_8FA72CE04AE9CF3169A7A38E1F7A544E" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_FBB97BDCBC3A9FF58585A38E1F7A1217" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_59F019C7792C73857401A38E1F7A0E46" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_ChangesinAccumulatedOtherComprehensiveIncomeRollForward_8FA72CE04AE9CF3169A7A38E1F7A544E" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_59F019C7792C73857401A38E1F7A0E46" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.wynnresorts.com/role/AccumulatedOtherComprehensiveIncomeLossTables" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/CommitmentsAndContingencies" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/CommitmentsAndContingenciesAdditionalInformationDetail" xlink:type="extended">
    <loc xlink:href="wynn-20170630.xsd#wynn_CommitmentsAndContingenciesLineItems" xlink:label="loc_wynn_CommitmentsAndContingenciesLineItems_8AD9E1FF8A8D5D63AE59303716F98E27" xlink:type="locator" />
    <loc xlink:href="wynn-20170630.xsd#wynn_CommitmentsAndContingenciesTable" xlink:label="loc_wynn_CommitmentsAndContingenciesTable_51761563B42A52D9A5F9FFDF58FB759C" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_wynn_CommitmentsAndContingenciesLineItems_8AD9E1FF8A8D5D63AE59303716F98E27" xlink:to="loc_wynn_CommitmentsAndContingenciesTable_51761563B42A52D9A5F9FFDF58FB759C" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_F4A7D70F9E3B5ADBB61F19198C611C57" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_CommitmentsAndContingenciesTable_51761563B42A52D9A5F9FFDF58FB759C" xlink:to="loc_us-gaap_DebtInstrumentAxis_F4A7D70F9E3B5ADBB61F19198C611C57" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_A4CB9359E07B585B2064CA69E5ADCDF2_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_F4A7D70F9E3B5ADBB61F19198C611C57" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_A4CB9359E07B585B2064CA69E5ADCDF2_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_FC25DF3DA84157B4A49FF3F581F43048" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_F4A7D70F9E3B5ADBB61F19198C611C57" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_FC25DF3DA84157B4A49FF3F581F43048" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_ConstructionPerformanceBondMember" xlink:label="loc_wynn_ConstructionPerformanceBondMember_EF6E0B9199575E0DBAB53EF6B4E9689B" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_FC25DF3DA84157B4A49FF3F581F43048" xlink:to="loc_wynn_ConstructionPerformanceBondMember_EF6E0B9199575E0DBAB53EF6B4E9689B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_3F9BCF05D0705440A84F6A6EA6AE083A" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_CommitmentsAndContingenciesTable_51761563B42A52D9A5F9FFDF58FB759C" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_3F9BCF05D0705440A84F6A6EA6AE083A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_BBD7B1F82328D90BCA79CA69E5AE12A2_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_3F9BCF05D0705440A84F6A6EA6AE083A" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_BBD7B1F82328D90BCA79CA69E5AE12A2_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_130D3B9175F35C26BE1567B79329F910" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_3F9BCF05D0705440A84F6A6EA6AE083A" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_130D3B9175F35C26BE1567B79329F910" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_1A883E87E7395248BD2C7E7D85F95EDB" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_130D3B9175F35C26BE1567B79329F910" xlink:to="loc_us-gaap_SubsequentEventMember_1A883E87E7395248BD2C7E7D85F95EDB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LitigationStatusAxis" xlink:label="loc_us-gaap_LitigationStatusAxis_76F2D032627251A6B182B2D9227086A7" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_CommitmentsAndContingenciesTable_51761563B42A52D9A5F9FFDF58FB759C" xlink:to="loc_us-gaap_LitigationStatusAxis_76F2D032627251A6B182B2D9227086A7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LitigationStatusDomain" xlink:label="loc_us-gaap_LitigationStatusDomain_8458B82D0A05BA70991ECA69E5B31574_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LitigationStatusAxis_76F2D032627251A6B182B2D9227086A7" xlink:to="loc_us-gaap_LitigationStatusDomain_8458B82D0A05BA70991ECA69E5B31574_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LitigationStatusDomain" xlink:label="loc_us-gaap_LitigationStatusDomain_CFE27A75CC0B5222874260DD35516901" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LitigationStatusAxis_76F2D032627251A6B182B2D9227086A7" xlink:to="loc_us-gaap_LitigationStatusDomain_CFE27A75CC0B5222874260DD35516901" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PendingLitigationMember" xlink:label="loc_us-gaap_PendingLitigationMember_8C1B1993939356A4BB6A1FD5528C83B1" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LitigationStatusDomain_CFE27A75CC0B5222874260DD35516901" xlink:to="loc_us-gaap_PendingLitigationMember_8C1B1993939356A4BB6A1FD5528C83B1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LitigationCaseAxis" xlink:label="loc_us-gaap_LitigationCaseAxis_D868E4B9C2BE58F6AB7FAC579A871DC5" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_CommitmentsAndContingenciesTable_51761563B42A52D9A5F9FFDF58FB759C" xlink:to="loc_us-gaap_LitigationCaseAxis_D868E4B9C2BE58F6AB7FAC579A871DC5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LitigationCaseTypeDomain" xlink:label="loc_us-gaap_LitigationCaseTypeDomain_FF78622E1965196B2637CA69E5B4AC8E_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LitigationCaseAxis_D868E4B9C2BE58F6AB7FAC579A871DC5" xlink:to="loc_us-gaap_LitigationCaseTypeDomain_FF78622E1965196B2637CA69E5B4AC8E_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LitigationCaseTypeDomain" xlink:label="loc_us-gaap_LitigationCaseTypeDomain_51C56E5249985B848D76FDF92566B550" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LitigationCaseAxis_D868E4B9C2BE58F6AB7FAC579A871DC5" xlink:to="loc_us-gaap_LitigationCaseTypeDomain_51C56E5249985B848D76FDF92566B550" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_DerivativeClaimsMember" xlink:label="loc_wynn_DerivativeClaimsMember_9A65130E04B95DA58FA6F74AA785F78B" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LitigationCaseTypeDomain_51C56E5249985B848D76FDF92566B550" xlink:to="loc_wynn_DerivativeClaimsMember_9A65130E04B95DA58FA6F74AA785F78B" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_ContractTerminationAxis" xlink:label="loc_wynn_ContractTerminationAxis_0C4521EF019C5EBD80E3546400062E8F" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_CommitmentsAndContingenciesTable_51761563B42A52D9A5F9FFDF58FB759C" xlink:to="loc_wynn_ContractTerminationAxis_0C4521EF019C5EBD80E3546400062E8F" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_ContractTerminationDomain" xlink:label="loc_wynn_ContractTerminationDomain_98DA7D25F926C837BC1BCA69E5B42ACB_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_wynn_ContractTerminationAxis_0C4521EF019C5EBD80E3546400062E8F" xlink:to="loc_wynn_ContractTerminationDomain_98DA7D25F926C837BC1BCA69E5B42ACB_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_ContractTerminationDomain" xlink:label="loc_wynn_ContractTerminationDomain_B10D93AC5EF05906A495569428EE475C" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_wynn_ContractTerminationAxis_0C4521EF019C5EBD80E3546400062E8F" xlink:to="loc_wynn_ContractTerminationDomain_B10D93AC5EF05906A495569428EE475C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DirectorMember" xlink:label="loc_us-gaap_DirectorMember_85305DC6E1855D54876ABD8AE106C601" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_ContractTerminationDomain_B10D93AC5EF05906A495569428EE475C" xlink:to="loc_us-gaap_DirectorMember_85305DC6E1855D54876ABD8AE106C601" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_ECFAE841C4C5528696A18BE94E960753" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_CommitmentsAndContingenciesTable_51761563B42A52D9A5F9FFDF58FB759C" xlink:to="loc_dei_LegalEntityAxis_ECFAE841C4C5528696A18BE94E960753" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_48F00A0C4185946BCB28CA69E5B455CA_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_ECFAE841C4C5528696A18BE94E960753" xlink:to="loc_dei_EntityDomain_48F00A0C4185946BCB28CA69E5B455CA_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_CE100BADBA2E5CBEBF46FBF5FED27874" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_ECFAE841C4C5528696A18BE94E960753" xlink:to="loc_dei_EntityDomain_CE100BADBA2E5CBEBF46FBF5FED27874" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnMALLCMember" xlink:label="loc_wynn_WynnMALLCMember_7215F555CA69582EA08F232EB5257406" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_CE100BADBA2E5CBEBF46FBF5FED27874" xlink:to="loc_wynn_WynnMALLCMember_7215F555CA69582EA08F232EB5257406" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_AruzeUnitedStatesOfAmericaIncMember" xlink:label="loc_wynn_AruzeUnitedStatesOfAmericaIncMember_0ABEA714C53B5F1DA83D054DC7D3D97F" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_CE100BADBA2E5CBEBF46FBF5FED27874" xlink:to="loc_wynn_AruzeUnitedStatesOfAmericaIncMember_0ABEA714C53B5F1DA83D054DC7D3D97F" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnPalaceMember" xlink:label="loc_wynn_WynnPalaceMember_1BE8043F10C256BD8D13BCB03E30E454" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_CE100BADBA2E5CBEBF46FBF5FED27874" xlink:to="loc_wynn_WynnPalaceMember_1BE8043F10C256BD8D13BCB03E30E454" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_BEECF583EDC05E25A3BACE8BD4E0A408" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_CommitmentsAndContingenciesTable_51761563B42A52D9A5F9FFDF58FB759C" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_BEECF583EDC05E25A3BACE8BD4E0A408" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_740EE7D6FEE639F88B2ECA69E5B56382_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_BEECF583EDC05E25A3BACE8BD4E0A408" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_740EE7D6FEE639F88B2ECA69E5B56382_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_9130E4EBF3FD5E0DBE32F85733451E68" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_BEECF583EDC05E25A3BACE8BD4E0A408" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_9130E4EBF3FD5E0DBE32F85733451E68" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FourAndOneOverFourPercentageWynnLasVegasSeniorNotesDueMayThirtyTwoThousandTwentyThreeMember" xlink:label="loc_wynn_FourAndOneOverFourPercentageWynnLasVegasSeniorNotesDueMayThirtyTwoThousandTwentyThreeMember_031AA382F5DE504C909A06DDFF7CA14A" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_9130E4EBF3FD5E0DBE32F85733451E68" xlink:to="loc_wynn_FourAndOneOverFourPercentageWynnLasVegasSeniorNotesDueMayThirtyTwoThousandTwentyThreeMember_031AA382F5DE504C909A06DDFF7CA14A" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_RedemptionPricePromissoryNoteWithFormerStockholderAndRelatedPartyDueFebruaryEighteenTwoThousandTwentyTwoMember" xlink:label="loc_wynn_RedemptionPricePromissoryNoteWithFormerStockholderAndRelatedPartyDueFebruaryEighteenTwoThousandTwentyTwoMember_317F45E702FD53F683FC636E2842A343" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_9130E4EBF3FD5E0DBE32F85733451E68" xlink:to="loc_wynn_RedemptionPricePromissoryNoteWithFormerStockholderAndRelatedPartyDueFebruaryEighteenTwoThousandTwentyTwoMember_317F45E702FD53F683FC636E2842A343" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_TwothousandtwentythreeindentureMember" xlink:label="loc_wynn_TwothousandtwentythreeindentureMember_A361798833255A85A4112937CD94B4D4" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_9130E4EBF3FD5E0DBE32F85733451E68" xlink:to="loc_wynn_TwothousandtwentythreeindentureMember_A361798833255A85A4112937CD94B4D4" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_GuaranteedMaximumConstructionPrice" xlink:label="loc_wynn_GuaranteedMaximumConstructionPrice_AC397423BB7D543AB4B8C461A6A06899" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_CommitmentsAndContingenciesLineItems_8AD9E1FF8A8D5D63AE59303716F98E27" xlink:to="loc_wynn_GuaranteedMaximumConstructionPrice_AC397423BB7D543AB4B8C461A6A06899" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_PerformanceBond" xlink:label="loc_wynn_PerformanceBond_3609E2AB4E605C8F912C0D33CFB45B1C" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_CommitmentsAndContingenciesLineItems_8AD9E1FF8A8D5D63AE59303716F98E27" xlink:to="loc_wynn_PerformanceBond_3609E2AB4E605C8F912C0D33CFB45B1C" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_PercentageOfVotingInFavorOfRemoval" xlink:label="loc_wynn_PercentageOfVotingInFavorOfRemoval_9CE49E21CBCC5EACBECFF4F64C2551A5" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_CommitmentsAndContingenciesLineItems_8AD9E1FF8A8D5D63AE59303716F98E27" xlink:to="loc_wynn_PercentageOfVotingInFavorOfRemoval_9CE49E21CBCC5EACBECFF4F64C2551A5" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_CommonStockNumberOfVotes" xlink:label="loc_wynn_CommonStockNumberOfVotes_A2F406FD3210591CB2AFBBA0FBA3DCCE" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_CommitmentsAndContingenciesLineItems_8AD9E1FF8A8D5D63AE59303716F98E27" xlink:to="loc_wynn_CommonStockNumberOfVotes_A2F406FD3210591CB2AFBBA0FBA3DCCE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockRedeemedOrCalledDuringPeriodShares" xlink:label="loc_us-gaap_StockRedeemedOrCalledDuringPeriodShares_70F04CBA4DC1575FBA249833AC3AF0EA" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_CommitmentsAndContingenciesLineItems_8AD9E1FF8A8D5D63AE59303716F98E27" xlink:to="loc_us-gaap_StockRedeemedOrCalledDuringPeriodShares_70F04CBA4DC1575FBA249833AC3AF0EA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_CAA46F3F7409516591D223C3CF055BD6" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_CommitmentsAndContingenciesLineItems_8AD9E1FF8A8D5D63AE59303716F98E27" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_CAA46F3F7409516591D223C3CF055BD6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentMaturityDate" xlink:label="loc_us-gaap_DebtInstrumentMaturityDate_75ED8B40D7225D40A20CB7164228B096" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_CommitmentsAndContingenciesLineItems_8AD9E1FF8A8D5D63AE59303716F98E27" xlink:to="loc_us-gaap_DebtInstrumentMaturityDate_75ED8B40D7225D40A20CB7164228B096" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_CEE0F9B107D2570BB33D58665E4231CB" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_CommitmentsAndContingenciesLineItems_8AD9E1FF8A8D5D63AE59303716F98E27" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_CEE0F9B107D2570BB33D58665E4231CB" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_DebtPurchasePricePercentOfPrincipalAmount" xlink:label="loc_wynn_DebtPurchasePricePercentOfPrincipalAmount_D218776B44FB524A9F6132926C7CFF21" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_CommitmentsAndContingenciesLineItems_8AD9E1FF8A8D5D63AE59303716F98E27" xlink:to="loc_wynn_DebtPurchasePricePercentOfPrincipalAmount_D218776B44FB524A9F6132926C7CFF21" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InterestExpenseLongTermDebt" xlink:label="loc_us-gaap_InterestExpenseLongTermDebt_9DCC20F4E219523F86290FBA99DF0252" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_CommitmentsAndContingenciesLineItems_8AD9E1FF8A8D5D63AE59303716F98E27" xlink:to="loc_us-gaap_InterestExpenseLongTermDebt_9DCC20F4E219523F86290FBA99DF0252" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LossContingencyNewClaimsFiledNumber" xlink:label="loc_us-gaap_LossContingencyNewClaimsFiledNumber_8FCB96E5B03E5403B2A507B555914E7F" xlink:type="locator" />
    <definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_CommitmentsAndContingenciesLineItems_8AD9E1FF8A8D5D63AE59303716F98E27" xlink:to="loc_us-gaap_LossContingencyNewClaimsFiledNumber_8FCB96E5B03E5403B2A507B555914E7F" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedStatementOfStockholdersEquityDeficitUnaudited" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_647F94F8A81A411AF4B8A54DEFB8F245" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_CE3CD5D17989845AF6F0A54DEFB8723D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_647F94F8A81A411AF4B8A54DEFB8F245" xlink:to="loc_us-gaap_StatementTable_CE3CD5D17989845AF6F0A54DEFB8723D" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_85FEFDD993CD8493FC2AA54DEFB85D37" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_CE3CD5D17989845AF6F0A54DEFB8723D" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_85FEFDD993CD8493FC2AA54DEFB85D37" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_D66182207B8C5AAB8865A54DEFB8110F_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_85FEFDD993CD8493FC2AA54DEFB85D37" xlink:to="loc_us-gaap_EquityComponentDomain_D66182207B8C5AAB8865A54DEFB8110F_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_D66182207B8C5AAB8865A54DEFB8110F" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_85FEFDD993CD8493FC2AA54DEFB85D37" xlink:to="loc_us-gaap_EquityComponentDomain_D66182207B8C5AAB8865A54DEFB8110F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ParentMember" xlink:label="loc_us-gaap_ParentMember_E38F4BE34A98048C08DFA54DEFB8F5DE" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_D66182207B8C5AAB8865A54DEFB8110F" xlink:to="loc_us-gaap_ParentMember_E38F4BE34A98048C08DFA54DEFB8F5DE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_2A1F32D5C1BC7E78CC01A54DEFB88B00" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_E38F4BE34A98048C08DFA54DEFB8F5DE" xlink:to="loc_us-gaap_CommonStockMember_2A1F32D5C1BC7E78CC01A54DEFB88B00" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TreasuryStockMember" xlink:label="loc_us-gaap_TreasuryStockMember_35E260AA78B04DA0D7C7A54DEFB8912A" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_E38F4BE34A98048C08DFA54DEFB8F5DE" xlink:to="loc_us-gaap_TreasuryStockMember_35E260AA78B04DA0D7C7A54DEFB8912A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_327A5CB25CCD58267801A54DEFB87F90" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_E38F4BE34A98048C08DFA54DEFB8F5DE" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_327A5CB25CCD58267801A54DEFB87F90" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_2EFF1FE5FBBC90BA88BAA54DEFB82FB4" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_E38F4BE34A98048C08DFA54DEFB8F5DE" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_2EFF1FE5FBBC90BA88BAA54DEFB82FB4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:label="loc_us-gaap_RetainedEarningsMember_8552DEE2D2AB7765A0CFA54DEFB8D331" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_E38F4BE34A98048C08DFA54DEFB8F5DE" xlink:to="loc_us-gaap_RetainedEarningsMember_8552DEE2D2AB7765A0CFA54DEFB8D331" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NoncontrollingInterestMember" xlink:label="loc_us-gaap_NoncontrollingInterestMember_EFE9B32D8807A62DB607A54DEFB8549A" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_D66182207B8C5AAB8865A54DEFB8110F" xlink:to="loc_us-gaap_NoncontrollingInterestMember_EFE9B32D8807A62DB607A54DEFB8549A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_B5980E13AC3E41B1C634A54DEFB807EB" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_647F94F8A81A411AF4B8A54DEFB8F245" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_B5980E13AC3E41B1C634A54DEFB807EB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_DE67E683A93F40384057A54DEFB85236" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_B5980E13AC3E41B1C634A54DEFB807EB" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_DE67E683A93F40384057A54DEFB85236" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_D1AD75B2D001C4E03C0AA54DEFB8D1C5" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_B5980E13AC3E41B1C634A54DEFB807EB" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_D1AD75B2D001C4E03C0AA54DEFB8D1C5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" xlink:label="loc_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption_DCA4B4C05ADBEB02E907A54DEFB89493" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_B5980E13AC3E41B1C634A54DEFB807EB" xlink:to="loc_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption_DCA4B4C05ADBEB02E907A54DEFB89493" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAdjustedBalance1" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAdjustedBalance1_74D482DC41F93DA6868CA54DEFB8D012" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_B5980E13AC3E41B1C634A54DEFB807EB" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAdjustedBalance1_74D482DC41F93DA6868CA54DEFB8D012" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaap_ProfitLoss_BE8444552115C24C5728A54DEFB8E4D7" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_B5980E13AC3E41B1C634A54DEFB807EB" xlink:to="loc_us-gaap_ProfitLoss_BE8444552115C24C5728A54DEFB8E4D7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_BF6247E04C2D9260BB8DA54DEFB8F6AB" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_B5980E13AC3E41B1C634A54DEFB807EB" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_BF6247E04C2D9260BB8DA54DEFB8F6AB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_36094B4F9B35901BB409A54DEFB8166D" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_B5980E13AC3E41B1C634A54DEFB807EB" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_36094B4F9B35901BB409A54DEFB8166D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures_A63B278D0B907CF8DB94A54DEFB81957" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_B5980E13AC3E41B1C634A54DEFB807EB" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures_A63B278D0B907CF8DB94A54DEFB81957" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_77698090DD8C91EE5966A54DEFB838F8" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_B5980E13AC3E41B1C634A54DEFB807EB" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_77698090DD8C91EE5966A54DEFB838F8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited_389B5A77DB9008148AB7A54DEFB871F3" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_B5980E13AC3E41B1C634A54DEFB807EB" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited_389B5A77DB9008148AB7A54DEFB871F3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_14EC893854E8760D88BAA54DEFB8967F" xlink:type="locator" />
    <definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_B5980E13AC3E41B1C634A54DEFB807EB" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_14EC893854E8760D88BAA54DEFB8967F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_8B091DC53D2DCBCE7530A54DEFB8E369" xlink:type="locator" />
    <definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_B5980E13AC3E41B1C634A54DEFB807EB" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_8B091DC53D2DCBCE7530A54DEFB8E369" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_F9C7372E996C3B4F4EF6A54DEFB8813B" xlink:type="locator" />
    <definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_B5980E13AC3E41B1C634A54DEFB807EB" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_F9C7372E996C3B4F4EF6A54DEFB8813B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TreasuryStockSharesAcquired" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_5D906227791BFD818DACA54DEFB8E184" xlink:type="locator" />
    <definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_B5980E13AC3E41B1C634A54DEFB807EB" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_5D906227791BFD818DACA54DEFB8E184" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DividendsCash" xlink:label="loc_us-gaap_DividendsCash_E8C10D91C493F1789AE6A54DEFB879A8" xlink:type="locator" />
    <definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_B5980E13AC3E41B1C634A54DEFB807EB" xlink:to="loc_us-gaap_DividendsCash_E8C10D91C493F1789AE6A54DEFB879A8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders" xlink:label="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_D88D591A52B2D5D4D4CEA54DEFB8A239" xlink:type="locator" />
    <definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_B5980E13AC3E41B1C634A54DEFB807EB" xlink:to="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_D88D591A52B2D5D4D4CEA54DEFB8A239" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_79C5968D330C9E37E963A54DEFB85BE4" xlink:type="locator" />
    <definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_B5980E13AC3E41B1C634A54DEFB807EB" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_79C5968D330C9E37E963A54DEFB85BE4" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsOfCashFlowsUnaudited" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsOfComprehensiveIncomeLossUnaudited" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsOfIncomeUnaudited" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/DocumentAndEntityInformation" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/EarningsPerShare" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/EarningsPerShareScheduleOfSharesUsedInCalculationOfEarningsPerShareDetail" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/EarningsPerShareTables" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/IncomeTaxes" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/IncomeTaxesAdditionalInformationDetail" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/InvestmentSecurities" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/InvestmentSecuritiesInvestmentsByContractualMaturityDetails" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/InvestmentSecuritiesScheduleOfInvestmentSecuritiesDetail" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_CE8C8750B2EB569D8EE3978A648C445B" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesTable" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_A93D9950D8AE5C3D8B02CFBDA990AB22" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_CE8C8750B2EB569D8EE3978A648C445B" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_A93D9950D8AE5C3D8B02CFBDA990AB22" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_E0DC98337CA551FD85BF56E375D0DDD5" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_A93D9950D8AE5C3D8B02CFBDA990AB22" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_E0DC98337CA551FD85BF56E375D0DDD5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_CD6A4B0FC7331DDDAAB9BF3E23794D70_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_E0DC98337CA551FD85BF56E375D0DDD5" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_CD6A4B0FC7331DDDAAB9BF3E23794D70_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_DFB0AC0332D657D79B8F3E16CF7F70D2" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_E0DC98337CA551FD85BF56E375D0DDD5" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_DFB0AC0332D657D79B8F3E16CF7F70D2" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_DomesticAndForeignCorporateBondsMember" xlink:label="loc_wynn_DomesticAndForeignCorporateBondsMember_202BA1404B55511AA16F9F8950EC1EF7" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_DFB0AC0332D657D79B8F3E16CF7F70D2" xlink:to="loc_wynn_DomesticAndForeignCorporateBondsMember_202BA1404B55511AA16F9F8950EC1EF7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember" xlink:label="loc_us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember_BC8ABD4B250C563689F7CFA1C917E5C6" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_DFB0AC0332D657D79B8F3E16CF7F70D2" xlink:to="loc_us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember_BC8ABD4B250C563689F7CFA1C917E5C6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAmortizedCost" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_537D5CFC86F85DE7B2B0B2EEF583C0C7" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_CE8C8750B2EB569D8EE3978A648C445B" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_537D5CFC86F85DE7B2B0B2EEF583C0C7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3BC3062F305A563B958C6839EB23AB36" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_CE8C8750B2EB569D8EE3978A648C445B" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3BC3062F305A563B958C6839EB23AB36" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleEquitySecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleEquitySecuritiesAccumulatedGrossUnrealizedLossBeforeTax_D1406425625A5DA9A6413925DB577B72" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_CE8C8750B2EB569D8EE3978A648C445B" xlink:to="loc_us-gaap_AvailableForSaleEquitySecuritiesAccumulatedGrossUnrealizedLossBeforeTax_D1406425625A5DA9A6413925DB577B72" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecurities_38703F77DA045ABB84A4312BF77F932C" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_CE8C8750B2EB569D8EE3978A648C445B" xlink:to="loc_us-gaap_AvailableForSaleSecurities_38703F77DA045ABB84A4312BF77F932C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ImpairmentOfInvestments" xlink:label="loc_us-gaap_ImpairmentOfInvestments_9909B87793A657B1BCAF7C1B36DDECE9" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_CE8C8750B2EB569D8EE3978A648C445B" xlink:to="loc_us-gaap_ImpairmentOfInvestments_9909B87793A657B1BCAF7C1B36DDECE9" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.wynnresorts.com/role/InvestmentSecuritiesTables" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/LongTermDebt" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/LongTermDebtAdditionalInformationDetail" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_6B97C20A8B0CCDAECB93A40AA7799D1E" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_FF2B596ABE4A406AEA81A40AA7790E60" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6B97C20A8B0CCDAECB93A40AA7799D1E" xlink:to="loc_us-gaap_DebtInstrumentTable_FF2B596ABE4A406AEA81A40AA7790E60" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_71CEE65C39FA8F8DE8AAA40AA779AF0D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_FF2B596ABE4A406AEA81A40AA7790E60" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_71CEE65C39FA8F8DE8AAA40AA779AF0D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_F4E585018A63BA50CAFEA40AA779FA45_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_71CEE65C39FA8F8DE8AAA40AA779AF0D" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_F4E585018A63BA50CAFEA40AA779FA45_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_F4E585018A63BA50CAFEA40AA779FA45" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_71CEE65C39FA8F8DE8AAA40AA779AF0D" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_F4E585018A63BA50CAFEA40AA779FA45" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodOneMember" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_045D5B0E26C99140C621A40AA7797C4D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_F4E585018A63BA50CAFEA40AA779FA45" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_045D5B0E26C99140C621A40AA7797C4D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodTwoMember" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_78AF6430F156D030CDEAA40AA7792442" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_F4E585018A63BA50CAFEA40AA779FA45" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_78AF6430F156D030CDEAA40AA7792442" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodThreeMember" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodThreeMember_9DD9C6C65A9A2EBF85A1A40AA779CB4C" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_F4E585018A63BA50CAFEA40AA779FA45" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodThreeMember_9DD9C6C65A9A2EBF85A1A40AA779CB4C" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_ConsolidatedEntitiesAxis" xlink:label="loc_wynn_ConsolidatedEntitiesAxis_2CB415E7420FDB2B9E3CA40AA7793318" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_FF2B596ABE4A406AEA81A40AA7790E60" xlink:to="loc_wynn_ConsolidatedEntitiesAxis_2CB415E7420FDB2B9E3CA40AA7793318" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_ConsolidatedEntitiesDomain" xlink:label="loc_wynn_ConsolidatedEntitiesDomain_89F59629723791313BB3A40AA779BD8A_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_wynn_ConsolidatedEntitiesAxis_2CB415E7420FDB2B9E3CA40AA7793318" xlink:to="loc_wynn_ConsolidatedEntitiesDomain_89F59629723791313BB3A40AA779BD8A_default" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_ConsolidatedEntitiesDomain" xlink:label="loc_wynn_ConsolidatedEntitiesDomain_89F59629723791313BB3A40AA779BD8A" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_wynn_ConsolidatedEntitiesAxis_2CB415E7420FDB2B9E3CA40AA7793318" xlink:to="loc_wynn_ConsolidatedEntitiesDomain_89F59629723791313BB3A40AA779BD8A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsidiariesMember" xlink:label="loc_us-gaap_SubsidiariesMember_F1347DEC0A54A48CC422A40AA7790678" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_ConsolidatedEntitiesDomain_89F59629723791313BB3A40AA779BD8A" xlink:to="loc_us-gaap_SubsidiariesMember_F1347DEC0A54A48CC422A40AA7790678" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsidiaryIssuerMember" xlink:label="loc_us-gaap_SubsidiaryIssuerMember_328897C789EB499A8179A40AA779407F" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_ConsolidatedEntitiesDomain_89F59629723791313BB3A40AA779BD8A" xlink:to="loc_us-gaap_SubsidiaryIssuerMember_328897C789EB499A8179A40AA779407F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ExtinguishmentOfDebtAxis" xlink:label="loc_us-gaap_ExtinguishmentOfDebtAxis_5DADFCEC059840EE22E5A40AA7797FD1" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_FF2B596ABE4A406AEA81A40AA7790E60" xlink:to="loc_us-gaap_ExtinguishmentOfDebtAxis_5DADFCEC059840EE22E5A40AA7797FD1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ExtinguishmentOfDebtTypeDomain" xlink:label="loc_us-gaap_ExtinguishmentOfDebtTypeDomain_BF2351D213659FEF3173A40AA77904BE_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ExtinguishmentOfDebtAxis_5DADFCEC059840EE22E5A40AA7797FD1" xlink:to="loc_us-gaap_ExtinguishmentOfDebtTypeDomain_BF2351D213659FEF3173A40AA77904BE_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ExtinguishmentOfDebtTypeDomain" xlink:label="loc_us-gaap_ExtinguishmentOfDebtTypeDomain_BF2351D213659FEF3173A40AA77904BE" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ExtinguishmentOfDebtAxis_5DADFCEC059840EE22E5A40AA7797FD1" xlink:to="loc_us-gaap_ExtinguishmentOfDebtTypeDomain_BF2351D213659FEF3173A40AA77904BE" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FiveAndThreeOverEightPercentageWynnLasVegasFirstMortgageNotesDueMarchFifteenTwoThousandTwentyTwoMember" xlink:label="loc_wynn_FiveAndThreeOverEightPercentageWynnLasVegasFirstMortgageNotesDueMarchFifteenTwoThousandTwentyTwoMember_42C7CBD6DAC7A1A858BEA40AA77970D2" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ExtinguishmentOfDebtTypeDomain_BF2351D213659FEF3173A40AA77904BE" xlink:to="loc_wynn_FiveAndThreeOverEightPercentageWynnLasVegasFirstMortgageNotesDueMarchFifteenTwoThousandTwentyTwoMember_42C7CBD6DAC7A1A858BEA40AA77970D2" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WASeniorTermLoanFacilityIDueDecember2021Member" xlink:label="loc_wynn_WASeniorTermLoanFacilityIDueDecember2021Member_5FD2F0B3E860A3E9E299A40AA7796EA6" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ExtinguishmentOfDebtTypeDomain_BF2351D213659FEF3173A40AA77904BE" xlink:to="loc_wynn_WASeniorTermLoanFacilityIDueDecember2021Member_5FD2F0B3E860A3E9E299A40AA7796EA6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_D799A38584450008340AA40AA779048C" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_FF2B596ABE4A406AEA81A40AA7790E60" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_D799A38584450008340AA40AA779048C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_C828ABC442B352A696D3A40AA77949D0_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_D799A38584450008340AA40AA779048C" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_C828ABC442B352A696D3A40AA77949D0_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_C828ABC442B352A696D3A40AA77949D0" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_D799A38584450008340AA40AA779048C" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_C828ABC442B352A696D3A40AA77949D0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_B30ED822E4C283E0AF8FA40AA779A251" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_C828ABC442B352A696D3A40AA77949D0" xlink:to="loc_us-gaap_SubsequentEventMember_B30ED822E4C283E0AF8FA40AA779A251" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CreditFacilityAxis" xlink:label="loc_us-gaap_CreditFacilityAxis_32E893C651C8CD1A56E0A40AA779544A" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_FF2B596ABE4A406AEA81A40AA7790E60" xlink:to="loc_us-gaap_CreditFacilityAxis_32E893C651C8CD1A56E0A40AA779544A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CreditFacilityDomain" xlink:label="loc_us-gaap_CreditFacilityDomain_DB06A21E52B391522C9EA40AA77980D3_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_32E893C651C8CD1A56E0A40AA779544A" xlink:to="loc_us-gaap_CreditFacilityDomain_DB06A21E52B391522C9EA40AA77980D3_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CreditFacilityDomain" xlink:label="loc_us-gaap_CreditFacilityDomain_DB06A21E52B391522C9EA40AA77980D3" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_32E893C651C8CD1A56E0A40AA779544A" xlink:to="loc_us-gaap_CreditFacilityDomain_DB06A21E52B391522C9EA40AA77980D3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LineOfCreditMember" xlink:label="loc_us-gaap_LineOfCreditMember_C5301A88E886B0A1517EA40AA779D25D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_DB06A21E52B391522C9EA40AA77980D3" xlink:to="loc_us-gaap_LineOfCreditMember_C5301A88E886B0A1517EA40AA779D25D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SecuredDebtMember" xlink:label="loc_us-gaap_SecuredDebtMember_D25197504B6FD00F0590A40AA779B066" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_DB06A21E52B391522C9EA40AA77980D3" xlink:to="loc_us-gaap_SecuredDebtMember_D25197504B6FD00F0590A40AA779B066" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RevolvingCreditFacilityMember" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_F6E7F94F65EEAC0D9647A40AA779F717" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_DB06A21E52B391522C9EA40AA77980D3" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_F6E7F94F65EEAC0D9647A40AA779F717" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_VariableRateAxis" xlink:label="loc_us-gaap_VariableRateAxis_9A717B8477864AE48E46A40AA7796CCC" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_FF2B596ABE4A406AEA81A40AA7790E60" xlink:to="loc_us-gaap_VariableRateAxis_9A717B8477864AE48E46A40AA7796CCC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_VariableRateDomain" xlink:label="loc_us-gaap_VariableRateDomain_D9370C550DA38B8B8A10A40AA7790DF5_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableRateAxis_9A717B8477864AE48E46A40AA7796CCC" xlink:to="loc_us-gaap_VariableRateDomain_D9370C550DA38B8B8A10A40AA7790DF5_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_VariableRateDomain" xlink:label="loc_us-gaap_VariableRateDomain_D9370C550DA38B8B8A10A40AA7790DF5" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableRateAxis_9A717B8477864AE48E46A40AA7796CCC" xlink:to="loc_us-gaap_VariableRateDomain_D9370C550DA38B8B8A10A40AA7790DF5" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_LIBORorHIBORMember" xlink:label="loc_wynn_LIBORorHIBORMember_DA1E2A0A9A03B2864810A40AA7797BB9" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_D9370C550DA38B8B8A10A40AA7790DF5" xlink:to="loc_wynn_LIBORorHIBORMember_DA1E2A0A9A03B2864810A40AA7797BB9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_832D0EB162936086CBA8A40AA7794A03" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_FF2B596ABE4A406AEA81A40AA7790E60" xlink:to="loc_dei_LegalEntityAxis_832D0EB162936086CBA8A40AA7794A03" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_3E8BA22E62E4DACD25D1A40AA7791526_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_832D0EB162936086CBA8A40AA7794A03" xlink:to="loc_dei_EntityDomain_3E8BA22E62E4DACD25D1A40AA7791526_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_3E8BA22E62E4DACD25D1A40AA7791526" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_832D0EB162936086CBA8A40AA7794A03" xlink:to="loc_dei_EntityDomain_3E8BA22E62E4DACD25D1A40AA7791526" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnMacauMember" xlink:label="loc_wynn_WynnMacauMember_F296715953E065727E29A40AA7795AF6" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_3E8BA22E62E4DACD25D1A40AA7791526" xlink:to="loc_wynn_WynnMacauMember_F296715953E065727E29A40AA7795AF6" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnAmericaMember" xlink:label="loc_wynn_WynnAmericaMember_238643FE622488163158A40AA779B1E0" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_3E8BA22E62E4DACD25D1A40AA7791526" xlink:to="loc_wynn_WynnAmericaMember_238643FE622488163158A40AA779B1E0" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnMacauLimitedMember" xlink:label="loc_wynn_WynnMacauLimitedMember_15FD7F91FE8606C9FA39A40AA7792BE7" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_3E8BA22E62E4DACD25D1A40AA7791526" xlink:to="loc_wynn_WynnMacauLimitedMember_15FD7F91FE8606C9FA39A40AA7792BE7" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember" xlink:label="loc_wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember_9A8876A950D2E58B3F93A40AA779B061" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_3E8BA22E62E4DACD25D1A40AA7791526" xlink:to="loc_wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember_9A8876A950D2E58B3F93A40AA779B061" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_F8E9B6661DD62F2EF531A40AA779E756" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_FF2B596ABE4A406AEA81A40AA7790E60" xlink:to="loc_us-gaap_DebtInstrumentAxis_F8E9B6661DD62F2EF531A40AA779E756" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_7E8A954AE2D68FF25F42A40AA7798475_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_F8E9B6661DD62F2EF531A40AA779E756" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_7E8A954AE2D68FF25F42A40AA7798475_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_7E8A954AE2D68FF25F42A40AA7798475" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_F8E9B6661DD62F2EF531A40AA779E756" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_7E8A954AE2D68FF25F42A40AA7798475" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_SeniorTermLoanFacilityDueSeptember2021Member" xlink:label="loc_wynn_SeniorTermLoanFacilityDueSeptember2021Member_CF1A48C5BD2423AC9099A40AA7793C7C" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7E8A954AE2D68FF25F42A40AA7798475" xlink:to="loc_wynn_SeniorTermLoanFacilityDueSeptember2021Member_CF1A48C5BD2423AC9099A40AA7793C7C" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnAmericaCreditFacilitiesMember" xlink:label="loc_wynn_WynnAmericaCreditFacilitiesMember_3EEE583433F5DE93945AA40AA779BEC5" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7E8A954AE2D68FF25F42A40AA7798475" xlink:to="loc_wynn_WynnAmericaCreditFacilitiesMember_3EEE583433F5DE93945AA40AA779BEC5" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WASeniorTermLoanFacilityIIMember" xlink:label="loc_wynn_WASeniorTermLoanFacilityIIMember_390BD91CB9307494FA1EA40AA77934C7" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7E8A954AE2D68FF25F42A40AA7798475" xlink:to="loc_wynn_WASeniorTermLoanFacilityIIMember_390BD91CB9307494FA1EA40AA77934C7" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WMLFinanceCreditFacilityDomain" xlink:label="loc_wynn_WMLFinanceCreditFacilityDomain_7C81FDEABA8C1FF30476A40AA7793FC2" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7E8A954AE2D68FF25F42A40AA7798475" xlink:to="loc_wynn_WMLFinanceCreditFacilityDomain_7C81FDEABA8C1FF30476A40AA7793FC2" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WASeniorTermLoanFacilityIDueDecember2021Member" xlink:label="loc_wynn_WASeniorTermLoanFacilityIDueDecember2021Member_3A7029E025D581A8EBF3A40AA77975CF" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7E8A954AE2D68FF25F42A40AA7798475" xlink:to="loc_wynn_WASeniorTermLoanFacilityIDueDecember2021Member_3A7029E025D581A8EBF3A40AA77975CF" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WASeniorTermLoanFacilityIIDueDecember2021Member" xlink:label="loc_wynn_WASeniorTermLoanFacilityIIDueDecember2021Member_F4B0410D2E3C54115F10A40AA779D180" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7E8A954AE2D68FF25F42A40AA7798475" xlink:to="loc_wynn_WASeniorTermLoanFacilityIIDueDecember2021Member_F4B0410D2E3C54115F10A40AA779D180" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WASeniorRevolvingCreditFacilityDueDecember2021Member" xlink:label="loc_wynn_WASeniorRevolvingCreditFacilityDueDecember2021Member_C31759059F811D3C3148A40AA7798874" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7E8A954AE2D68FF25F42A40AA7798475" xlink:to="loc_wynn_WASeniorRevolvingCreditFacilityDueDecember2021Member_C31759059F811D3C3148A40AA7798874" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_A5.14SeniorNotesDueMay152027Member" xlink:label="loc_wynn_A5.14SeniorNotesDueMay152027Member_923E2B9B040E15EA90CEA40AA7796FA2" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7E8A954AE2D68FF25F42A40AA7798475" xlink:to="loc_wynn_A5.14SeniorNotesDueMay152027Member_923E2B9B040E15EA90CEA40AA7796FA2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_93AB2A06C049DB5BED15A40AA7790B22" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_FF2B596ABE4A406AEA81A40AA7790E60" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_93AB2A06C049DB5BED15A40AA7790B22" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_1DCBBBEF745B591A4AD7A40AA7791D48_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_93AB2A06C049DB5BED15A40AA7790B22" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_1DCBBBEF745B591A4AD7A40AA7791D48_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_1DCBBBEF745B591A4AD7A40AA7791D48" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_93AB2A06C049DB5BED15A40AA7790B22" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_1DCBBBEF745B591A4AD7A40AA7791D48" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SeniorNotesMember" xlink:label="loc_us-gaap_SeniorNotesMember_37A69D1F79A718F647A4A40AA779A1DC" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1DCBBBEF745B591A4AD7A40AA7791D48" xlink:to="loc_us-gaap_SeniorNotesMember_37A69D1F79A718F647A4A40AA779A1DC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SecuredDebtMember" xlink:label="loc_us-gaap_SecuredDebtMember_D0FBC986A3902B27771DA40AA779D1C1" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1DCBBBEF745B591A4AD7A40AA7791D48" xlink:to="loc_us-gaap_SecuredDebtMember_D0FBC986A3902B27771DA40AA779D1C1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RevolvingCreditFacilityMember" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_F026A80A815D8496CE84A40AA779F90E" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1DCBBBEF745B591A4AD7A40AA7791D48" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_F026A80A815D8496CE84A40AA779F90E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MortgagesMember" xlink:label="loc_us-gaap_MortgagesMember_BAED94900E267A1699CDA40AA779865F" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1DCBBBEF745B591A4AD7A40AA7791D48" xlink:to="loc_us-gaap_MortgagesMember_BAED94900E267A1699CDA40AA779865F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommonStockDividendsPerShareDeclared" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared_ADE7ADF127CB4D8E98D6A40AA7794910" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6B97C20A8B0CCDAECB93A40AA7799D1E" xlink:to="loc_us-gaap_CommonStockDividendsPerShareDeclared_ADE7ADF127CB4D8E98D6A40AA7794910" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_B02371A21CCDDA7401ECA40AA77918ED" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6B97C20A8B0CCDAECB93A40AA7799D1E" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_B02371A21CCDDA7401ECA40AA77918ED" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_E5C9778DDE04FCEA67C6A40AA77928D6" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6B97C20A8B0CCDAECB93A40AA7799D1E" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_E5C9778DDE04FCEA67C6A40AA77928D6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_A6AB2448BE17BD925379A40AA779B3C8" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6B97C20A8B0CCDAECB93A40AA7799D1E" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_A6AB2448BE17BD925379A40AA779B3C8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentRedemptionPricePercentage" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_A3FE7D2EC77C9485C09BA40AA7791830" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6B97C20A8B0CCDAECB93A40AA7799D1E" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_A3FE7D2EC77C9485C09BA40AA7791830" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_DebtInstrumentCovenantPercentageofTotalAssets" xlink:label="loc_wynn_DebtInstrumentCovenantPercentageofTotalAssets_D73EB18D803A80DA5C7BA40AA7799A8D" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6B97C20A8B0CCDAECB93A40AA7799D1E" xlink:to="loc_wynn_DebtInstrumentCovenantPercentageofTotalAssets_D73EB18D803A80DA5C7BA40AA7799A8D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ExtinguishmentOfDebtAmount" xlink:label="loc_us-gaap_ExtinguishmentOfDebtAmount_C6BE85D5C4990EE65D52A40AA779E55B" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6B97C20A8B0CCDAECB93A40AA7799D1E" xlink:to="loc_us-gaap_ExtinguishmentOfDebtAmount_C6BE85D5C4990EE65D52A40AA779E55B" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_ExtinguishmentOfDebtAmountPremium" xlink:label="loc_wynn_ExtinguishmentOfDebtAmountPremium_EA9168F59DC73BE51182A40AA7792BD8" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6B97C20A8B0CCDAECB93A40AA7799D1E" xlink:to="loc_wynn_ExtinguishmentOfDebtAmountPremium_EA9168F59DC73BE51182A40AA7792BD8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentPeriodicPayment" xlink:label="loc_us-gaap_DebtInstrumentPeriodicPayment_CC28D19FA66A67F65F90A40AA779C485" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6B97C20A8B0CCDAECB93A40AA7799D1E" xlink:to="loc_us-gaap_DebtInstrumentPeriodicPayment_CC28D19FA66A67F65F90A40AA779C485" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentAnnualPrincipalPayment" xlink:label="loc_us-gaap_DebtInstrumentAnnualPrincipalPayment_5F7C5633DCE0EF5AB353A40AA779E9C7" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6B97C20A8B0CCDAECB93A40AA7799D1E" xlink:to="loc_us-gaap_DebtInstrumentAnnualPrincipalPayment_5F7C5633DCE0EF5AB353A40AA779E9C7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity" xlink:label="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_9C26BEADC163E1784EFEA40AA77986EE" xlink:type="locator" />
    <definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6B97C20A8B0CCDAECB93A40AA7799D1E" xlink:to="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_9C26BEADC163E1784EFEA40AA77986EE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_1BB9C3827431B741CDF4A40AA779F487" xlink:type="locator" />
    <definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6B97C20A8B0CCDAECB93A40AA7799D1E" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_1BB9C3827431B741CDF4A40AA779F487" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_Marginowedforcashcollateral" xlink:label="loc_wynn_Marginowedforcashcollateral_34B8E8251CE7DAF665E5A40AA7791863" xlink:type="locator" />
    <definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6B97C20A8B0CCDAECB93A40AA7799D1E" xlink:to="loc_wynn_Marginowedforcashcollateral_34B8E8251CE7DAF665E5A40AA7791863" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LettersOfCreditOutstandingAmount" xlink:label="loc_us-gaap_LettersOfCreditOutstandingAmount_65D183CD37687228935BA40AA779A19F" xlink:type="locator" />
    <definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6B97C20A8B0CCDAECB93A40AA7799D1E" xlink:to="loc_us-gaap_LettersOfCreditOutstandingAmount_65D183CD37687228935BA40AA779A19F" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_DebtInstrumentFairValueExcludingTheRedemptionNote" xlink:label="loc_wynn_DebtInstrumentFairValueExcludingTheRedemptionNote_864D643E1904FE1E1653A40AA7791FBA" xlink:type="locator" />
    <definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6B97C20A8B0CCDAECB93A40AA7799D1E" xlink:to="loc_wynn_DebtInstrumentFairValueExcludingTheRedemptionNote_864D643E1904FE1E1653A40AA7791FBA" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_LongTermDebtExcludingRedemptionNotedebtissuancecostoriginalissuediscountandpremium" xlink:label="loc_wynn_LongTermDebtExcludingRedemptionNotedebtissuancecostoriginalissuediscountandpremium_4A650F7871FFCDD676A8A40AA77993F8" xlink:type="locator" />
    <definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6B97C20A8B0CCDAECB93A40AA7799D1E" xlink:to="loc_wynn_LongTermDebtExcludingRedemptionNotedebtissuancecostoriginalissuediscountandpremium_4A650F7871FFCDD676A8A40AA77993F8" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.wynnresorts.com/role/LongTermDebtSummaryOfLongTermDebtAdditionalInformationDetail" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_B3B9A381E66FA75B48FDA3AD899C14EB" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_3C135BF885C3CDD631B2A3AD899C7463" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_B3B9A381E66FA75B48FDA3AD899C14EB" xlink:to="loc_us-gaap_DebtInstrumentTable_3C135BF885C3CDD631B2A3AD899C7463" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_VariableRateAxis" xlink:label="loc_us-gaap_VariableRateAxis_66EA60E77C6F0194299DA3AD899CBA54" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_3C135BF885C3CDD631B2A3AD899C7463" xlink:to="loc_us-gaap_VariableRateAxis_66EA60E77C6F0194299DA3AD899CBA54" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_VariableRateDomain" xlink:label="loc_us-gaap_VariableRateDomain_04E2422C418CEEE4A1A0A3AD899C264F_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableRateAxis_66EA60E77C6F0194299DA3AD899CBA54" xlink:to="loc_us-gaap_VariableRateDomain_04E2422C418CEEE4A1A0A3AD899C264F_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_VariableRateDomain" xlink:label="loc_us-gaap_VariableRateDomain_04E2422C418CEEE4A1A0A3AD899C264F" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableRateAxis_66EA60E77C6F0194299DA3AD899CBA54" xlink:to="loc_us-gaap_VariableRateDomain_04E2422C418CEEE4A1A0A3AD899C264F" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_LIBORorHIBORMember" xlink:label="loc_wynn_LIBORorHIBORMember_74B9DDA86E483D0D3410A3AD899CB73D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_04E2422C418CEEE4A1A0A3AD899C264F" xlink:to="loc_wynn_LIBORorHIBORMember_74B9DDA86E483D0D3410A3AD899CB73D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LondonInterbankOfferedRateLIBORMember" xlink:label="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_5AB9C371AD26704FD432A3AD899CBB8B" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_04E2422C418CEEE4A1A0A3AD899C264F" xlink:to="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_5AB9C371AD26704FD432A3AD899CBB8B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_5121BC7C598A0E96B67DA3AD899C1098" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_3C135BF885C3CDD631B2A3AD899C7463" xlink:to="loc_dei_LegalEntityAxis_5121BC7C598A0E96B67DA3AD899C1098" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_5D78E59356A997DE8F10A3AD899C5645_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_5121BC7C598A0E96B67DA3AD899C1098" xlink:to="loc_dei_EntityDomain_5D78E59356A997DE8F10A3AD899C5645_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_5D78E59356A997DE8F10A3AD899C5645" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_5121BC7C598A0E96B67DA3AD899C1098" xlink:to="loc_dei_EntityDomain_5D78E59356A997DE8F10A3AD899C5645" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnMacauMember" xlink:label="loc_wynn_WynnMacauMember_ABE3DC1007F8BBE3D6CEA3AD899CEC13" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_5D78E59356A997DE8F10A3AD899C5645" xlink:to="loc_wynn_WynnMacauMember_ABE3DC1007F8BBE3D6CEA3AD899CEC13" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnAmericaMember" xlink:label="loc_wynn_WynnAmericaMember_9A3BD6391E58E6D27911A3AD899C8E80" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_5D78E59356A997DE8F10A3AD899C5645" xlink:to="loc_wynn_WynnAmericaMember_9A3BD6391E58E6D27911A3AD899C8E80" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_AruzeUnitedStatesOfAmericaIncMember" xlink:label="loc_wynn_AruzeUnitedStatesOfAmericaIncMember_FE4E03C45B73659E2D28A3AD899CEB27" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_5D78E59356A997DE8F10A3AD899C5645" xlink:to="loc_wynn_AruzeUnitedStatesOfAmericaIncMember_FE4E03C45B73659E2D28A3AD899CEB27" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_BD7C111366FF1E6AE258A3AD899C7131" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_3C135BF885C3CDD631B2A3AD899C7463" xlink:to="loc_us-gaap_DebtInstrumentAxis_BD7C111366FF1E6AE258A3AD899C7131" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_59CDB523931E224762A5A3AD899C6767_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_BD7C111366FF1E6AE258A3AD899C7131" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_59CDB523931E224762A5A3AD899C6767_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_59CDB523931E224762A5A3AD899C6767" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_BD7C111366FF1E6AE258A3AD899C7131" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_59CDB523931E224762A5A3AD899C6767" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_SeniorTermLoanFacilityDueSeptember2021Member" xlink:label="loc_wynn_SeniorTermLoanFacilityDueSeptember2021Member_AB27A6C0ABD5548718CCA3AD899C15F8" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_59CDB523931E224762A5A3AD899C6767" xlink:to="loc_wynn_SeniorTermLoanFacilityDueSeptember2021Member_AB27A6C0ABD5548718CCA3AD899C15F8" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_SeniorRevolvingCreditFacilityDueSeptember2020Domain" xlink:label="loc_wynn_SeniorRevolvingCreditFacilityDueSeptember2020Domain_B5A15A98983BD2626113A3AD899CB670" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_59CDB523931E224762A5A3AD899C6767" xlink:to="loc_wynn_SeniorRevolvingCreditFacilityDueSeptember2020Domain_B5A15A98983BD2626113A3AD899CB670" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_RedemptionPricePromissoryNoteWithFormerStockholderAndRelatedPartyDueFebruaryEighteenTwoThousandTwentyTwoMember" xlink:label="loc_wynn_RedemptionPricePromissoryNoteWithFormerStockholderAndRelatedPartyDueFebruaryEighteenTwoThousandTwentyTwoMember_990993DE23F35F6CAF41A3AD899C91C9" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_59CDB523931E224762A5A3AD899C6767" xlink:to="loc_wynn_RedemptionPricePromissoryNoteWithFormerStockholderAndRelatedPartyDueFebruaryEighteenTwoThousandTwentyTwoMember_990993DE23F35F6CAF41A3AD899C91C9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_E6F1788A36083D0B55FBA3AD899C0407" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_3C135BF885C3CDD631B2A3AD899C7463" xlink:to="loc_us-gaap_RangeAxis_E6F1788A36083D0B55FBA3AD899C0407" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_6C7990B694D03EEA416FA3AD899CD599_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RangeAxis_E6F1788A36083D0B55FBA3AD899C0407" xlink:to="loc_us-gaap_RangeMember_6C7990B694D03EEA416FA3AD899CD599_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_6C7990B694D03EEA416FA3AD899CD599" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RangeAxis_E6F1788A36083D0B55FBA3AD899C0407" xlink:to="loc_us-gaap_RangeMember_6C7990B694D03EEA416FA3AD899CD599" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_4C64153E2262CB5D0E1AA3AD899C4269" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_6C7990B694D03EEA416FA3AD899CD599" xlink:to="loc_us-gaap_MinimumMember_4C64153E2262CB5D0E1AA3AD899C4269" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_017AEE9F618A188447C3A3AD899CD4E5" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_6C7990B694D03EEA416FA3AD899CD599" xlink:to="loc_us-gaap_MaximumMember_017AEE9F618A188447C3A3AD899CD4E5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_C72DE27B453F4226D6B7A3AD899C83ED" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_3C135BF885C3CDD631B2A3AD899C7463" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_C72DE27B453F4226D6B7A3AD899C83ED" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_5B9BF8E466ABA0E4E891A3AD899C6F61_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_C72DE27B453F4226D6B7A3AD899C83ED" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_5B9BF8E466ABA0E4E891A3AD899C6F61_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_5B9BF8E466ABA0E4E891A3AD899C6F61" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_C72DE27B453F4226D6B7A3AD899C83ED" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_5B9BF8E466ABA0E4E891A3AD899C6F61" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NotesPayableOtherPayablesMember" xlink:label="loc_us-gaap_NotesPayableOtherPayablesMember_993F6C5DBC7082AF979DA3AD899CC346" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_5B9BF8E466ABA0E4E891A3AD899C6F61" xlink:to="loc_us-gaap_NotesPayableOtherPayablesMember_993F6C5DBC7082AF979DA3AD899CC346" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SecuredDebtMember" xlink:label="loc_us-gaap_SecuredDebtMember_D0E79D4D5425841AC568A3AD899CBE0D" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_5B9BF8E466ABA0E4E891A3AD899C6F61" xlink:to="loc_us-gaap_SecuredDebtMember_D0E79D4D5425841AC568A3AD899CBE0D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RevolvingCreditFacilityMember" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_F1BCAD8478C4526A4120A3AD899CC40E" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_5B9BF8E466ABA0E4E891A3AD899C6F61" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_F1BCAD8478C4526A4120A3AD899CC40E" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FiveAndTwoPointFivePercentageWynnMacauSeniorNotesDueOctoberFifteenTwentyTwentyOneMember" xlink:label="loc_wynn_FiveAndTwoPointFivePercentageWynnMacauSeniorNotesDueOctoberFifteenTwentyTwentyOneMember_D9A63CA057C504871B8FA3AD899CAB8E" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_5B9BF8E466ABA0E4E891A3AD899C6F61" xlink:to="loc_wynn_FiveAndTwoPointFivePercentageWynnMacauSeniorNotesDueOctoberFifteenTwentyTwentyOneMember_D9A63CA057C504871B8FA3AD899CAB8E" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WMLFinanceCreditFacilityDomain" xlink:label="loc_wynn_WMLFinanceCreditFacilityDomain_AA596AF697810725CD24A3AD899C0D85" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_5B9BF8E466ABA0E4E891A3AD899C6F61" xlink:to="loc_wynn_WMLFinanceCreditFacilityDomain_AA596AF697810725CD24A3AD899C0D85" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnAmericaCreditFacilitiesAmendedMember" xlink:label="loc_wynn_WynnAmericaCreditFacilitiesAmendedMember_6FBF230575870DADDF3BA3AD899C8658" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_5B9BF8E466ABA0E4E891A3AD899C6F61" xlink:to="loc_wynn_WynnAmericaCreditFacilitiesAmendedMember_6FBF230575870DADDF3BA3AD899C8658" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FiveAndThreeOverEightPercentageWynnLasVegasFirstMortgageNotesDueMarchFifteenTwoThousandTwentyTwoMember" xlink:label="loc_wynn_FiveAndThreeOverEightPercentageWynnLasVegasFirstMortgageNotesDueMarchFifteenTwoThousandTwentyTwoMember_03709779859610491034A3AD899CC49B" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_5B9BF8E466ABA0E4E891A3AD899C6F61" xlink:to="loc_wynn_FiveAndThreeOverEightPercentageWynnLasVegasFirstMortgageNotesDueMarchFifteenTwoThousandTwentyTwoMember_03709779859610491034A3AD899CC49B" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FourAndOneOverFourPercentageWynnLasSeniorNotesDueMayThirtyTwentyTwentyThreeMember" xlink:label="loc_wynn_FourAndOneOverFourPercentageWynnLasSeniorNotesDueMayThirtyTwentyTwentyThreeMember_69CADBE54B27577C3AD0A3AD899C4101" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_5B9BF8E466ABA0E4E891A3AD899C6F61" xlink:to="loc_wynn_FourAndOneOverFourPercentageWynnLasSeniorNotesDueMayThirtyTwentyTwentyThreeMember_69CADBE54B27577C3AD0A3AD899C4101" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember" xlink:label="loc_wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember_0942B5131A73523088C3A3AD899C8C3F" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_5B9BF8E466ABA0E4E891A3AD899C6F61" xlink:to="loc_wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember_0942B5131A73523088C3A3AD899C8C3F" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_RedemptionPricePromissoryNoteWithFormerStockholderAndRelatedPartyDueFebruaryEighteenTwoThousandTwentyTwoMember" xlink:label="loc_wynn_RedemptionPricePromissoryNoteWithFormerStockholderAndRelatedPartyDueFebruaryEighteenTwoThousandTwentyTwoMember_FC9050BA3705973E261BA3AD899CDC11" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_5B9BF8E466ABA0E4E891A3AD899C6F61" xlink:to="loc_wynn_RedemptionPricePromissoryNoteWithFormerStockholderAndRelatedPartyDueFebruaryEighteenTwoThousandTwentyTwoMember_FC9050BA3705973E261BA3AD899CDC11" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FiveAndOneFourthPercentSeniorNotesDueMayFifteenTwoThousandTwentySevenDomain" xlink:label="loc_wynn_FiveAndOneFourthPercentSeniorNotesDueMayFifteenTwoThousandTwentySevenDomain_E2F03E6588B43A6FBCEEA3B3D38315B2" xlink:type="locator" />
    <definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_5B9BF8E466ABA0E4E891A3AD899C6F61" xlink:to="loc_wynn_FiveAndOneFourthPercentSeniorNotesDueMayFifteenTwoThousandTwentySevenDomain_E2F03E6588B43A6FBCEEA3B3D38315B2" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_Unamortizeddebtissuanceandoriginalissuancediscountpremium" xlink:label="loc_wynn_Unamortizeddebtissuanceandoriginalissuancediscountpremium_7C05872E4E46CD7EF4FEA3AD899C52E6" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_B3B9A381E66FA75B48FDA3AD899C14EB" xlink:to="loc_wynn_Unamortizeddebtissuanceandoriginalissuancediscountpremium_7C05872E4E46CD7EF4FEA3AD899C52E6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_E561F69BD5BF21570453A3AD899C556F" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_B3B9A381E66FA75B48FDA3AD899C14EB" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_E561F69BD5BF21570453A3AD899C556F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_6C98FF303E219A70F30DA3AD899C5408" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_B3B9A381E66FA75B48FDA3AD899C14EB" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_6C98FF303E219A70F30DA3AD899C5408" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentMaturityDate" xlink:label="loc_us-gaap_DebtInstrumentMaturityDate_A68AB9460D110299A4A7A3AD899C0247" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_B3B9A381E66FA75B48FDA3AD899C14EB" xlink:to="loc_us-gaap_DebtInstrumentMaturityDate_A68AB9460D110299A4A7A3AD899C0247" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentInterestRateDuringPeriod" xlink:label="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_0C440C887B7EA7CC6648A3AD899C0E60" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_B3B9A381E66FA75B48FDA3AD899C14EB" xlink:to="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_0C440C887B7EA7CC6648A3AD899C0E60" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FairValueAdjustmentofDebt" xlink:label="loc_wynn_FairValueAdjustmentofDebt_F097E0DE77643AD6CB18A3AD899C2066" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_B3B9A381E66FA75B48FDA3AD899C14EB" xlink:to="loc_wynn_FairValueAdjustmentofDebt_F097E0DE77643AD6CB18A3AD899C2066" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.wynnresorts.com/role/LongTermDebtSummaryOfLongTermDebtDetail" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_0D3F2DAE56466B532C73A40BFC86A669" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_75B5BBF2A44E17110865A40BFC863E0C" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0D3F2DAE56466B532C73A40BFC86A669" xlink:to="loc_us-gaap_DebtInstrumentTable_75B5BBF2A44E17110865A40BFC863E0C" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_219A284F78D63EA4ADACA40BFC86C961" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_75B5BBF2A44E17110865A40BFC863E0C" xlink:to="loc_dei_LegalEntityAxis_219A284F78D63EA4ADACA40BFC86C961" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_10111249DD0A2F99ED2BA40BFC8646B1_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_219A284F78D63EA4ADACA40BFC86C961" xlink:to="loc_dei_EntityDomain_10111249DD0A2F99ED2BA40BFC8646B1_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_10111249DD0A2F99ED2BA40BFC8646B1" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_219A284F78D63EA4ADACA40BFC86C961" xlink:to="loc_dei_EntityDomain_10111249DD0A2F99ED2BA40BFC8646B1" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnMacauMember" xlink:label="loc_wynn_WynnMacauMember_2400CA15289EE5366546A40BFC863DF9" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_10111249DD0A2F99ED2BA40BFC8646B1" xlink:to="loc_wynn_WynnMacauMember_2400CA15289EE5366546A40BFC863DF9" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnMacauLimitedMember" xlink:label="loc_wynn_WynnMacauLimitedMember_C0A9AE8D67899A60B2F8A40BFC86E888" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_10111249DD0A2F99ED2BA40BFC8646B1" xlink:to="loc_wynn_WynnMacauLimitedMember_C0A9AE8D67899A60B2F8A40BFC86E888" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember" xlink:label="loc_wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember_E1A72EAB0489E4B18508A40BFC869395" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_10111249DD0A2F99ED2BA40BFC8646B1" xlink:to="loc_wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember_E1A72EAB0489E4B18508A40BFC869395" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnAmericaMember" xlink:label="loc_wynn_WynnAmericaMember_90DB8ED2E98E79312D76A40BFC86422B" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_10111249DD0A2F99ED2BA40BFC8646B1" xlink:to="loc_wynn_WynnAmericaMember_90DB8ED2E98E79312D76A40BFC86422B" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_AruzeUnitedStatesOfAmericaIncMember" xlink:label="loc_wynn_AruzeUnitedStatesOfAmericaIncMember_E734AED6C2FB322EF8D3A40BFC8649E5" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_10111249DD0A2F99ED2BA40BFC8646B1" xlink:to="loc_wynn_AruzeUnitedStatesOfAmericaIncMember_E734AED6C2FB322EF8D3A40BFC8649E5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_134518E206D8F80E0299A40BFC869648" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_75B5BBF2A44E17110865A40BFC863E0C" xlink:to="loc_us-gaap_DebtInstrumentAxis_134518E206D8F80E0299A40BFC869648" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_29B24F7D8A8E33F24470A40BFC86FF67_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_134518E206D8F80E0299A40BFC869648" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_29B24F7D8A8E33F24470A40BFC86FF67_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_29B24F7D8A8E33F24470A40BFC86FF67" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_134518E206D8F80E0299A40BFC869648" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_29B24F7D8A8E33F24470A40BFC86FF67" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_SeniorTermLoanFacilityDueSeptember2021Member" xlink:label="loc_wynn_SeniorTermLoanFacilityDueSeptember2021Member_2274ACF82274984C1AC6A40BFC866CCA" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_29B24F7D8A8E33F24470A40BFC86FF67" xlink:to="loc_wynn_SeniorTermLoanFacilityDueSeptember2021Member_2274ACF82274984C1AC6A40BFC866CCA" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_SeniorRevolvingCreditFacilityDueSeptember2020Domain" xlink:label="loc_wynn_SeniorRevolvingCreditFacilityDueSeptember2020Domain_2EF78EE019D39A1F29A4A40BFC866D2C" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_29B24F7D8A8E33F24470A40BFC86FF67" xlink:to="loc_wynn_SeniorRevolvingCreditFacilityDueSeptember2020Domain_2EF78EE019D39A1F29A4A40BFC866D2C" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FiveAndOneOverFourPercentageWynnMacauSeniorNotesDueOctoberFifteenTwoThousandTwentyOneMember" xlink:label="loc_wynn_FiveAndOneOverFourPercentageWynnMacauSeniorNotesDueOctoberFifteenTwoThousandTwentyOneMember_094ADAF6008180DA3824A40BFC868B09" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_29B24F7D8A8E33F24470A40BFC86FF67" xlink:to="loc_wynn_FiveAndOneOverFourPercentageWynnMacauSeniorNotesDueOctoberFifteenTwoThousandTwentyOneMember_094ADAF6008180DA3824A40BFC868B09" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WMLFinanceCreditFacilityDomain" xlink:label="loc_wynn_WMLFinanceCreditFacilityDomain_E600003512F20B4F7301A40BFC8613DC" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_29B24F7D8A8E33F24470A40BFC86FF67" xlink:to="loc_wynn_WMLFinanceCreditFacilityDomain_E600003512F20B4F7301A40BFC8613DC" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_SeniorTermLoanFacilityVariableRateDueNovemberTwentyTwentyMember" xlink:label="loc_wynn_SeniorTermLoanFacilityVariableRateDueNovemberTwentyTwentyMember_76F1B735AADC4733BC87A40BFC860442" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_29B24F7D8A8E33F24470A40BFC86FF67" xlink:to="loc_wynn_SeniorTermLoanFacilityVariableRateDueNovemberTwentyTwentyMember_76F1B735AADC4733BC87A40BFC860442" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FiveAndThreeOverEightPercentageWynnLasVegasFirstMortgageNotesDueMarchFifteenTwoThousandTwentyTwoMember" xlink:label="loc_wynn_FiveAndThreeOverEightPercentageWynnLasVegasFirstMortgageNotesDueMarchFifteenTwoThousandTwentyTwoMember_8942D1FB2A0A483BD939A40BFC86310D" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_29B24F7D8A8E33F24470A40BFC86FF67" xlink:to="loc_wynn_FiveAndThreeOverEightPercentageWynnLasVegasFirstMortgageNotesDueMarchFifteenTwoThousandTwentyTwoMember_8942D1FB2A0A483BD939A40BFC86310D" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FourAndOneOverFourPercentageWynnLasVegasSeniorNotesDueMayThirtyTwoThousandTwentyThreeMember" xlink:label="loc_wynn_FourAndOneOverFourPercentageWynnLasVegasSeniorNotesDueMayThirtyTwoThousandTwentyThreeMember_2A1985F10D6B8E4F618EA40BFC862DEA" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_29B24F7D8A8E33F24470A40BFC86FF67" xlink:to="loc_wynn_FourAndOneOverFourPercentageWynnLasVegasSeniorNotesDueMayThirtyTwoThousandTwentyThreeMember_2A1985F10D6B8E4F618EA40BFC862DEA" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember" xlink:label="loc_wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember_47429CA60457C6A3488FA40BFC860B02" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_29B24F7D8A8E33F24470A40BFC86FF67" xlink:to="loc_wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember_47429CA60457C6A3488FA40BFC860B02" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_A5.14SeniorNotesDueMay152027Member" xlink:label="loc_wynn_A5.14SeniorNotesDueMay152027Member_A8BEBC9F3ED9FFF33E9DA40BFC864BF1" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_29B24F7D8A8E33F24470A40BFC86FF67" xlink:to="loc_wynn_A5.14SeniorNotesDueMay152027Member_A8BEBC9F3ED9FFF33E9DA40BFC864BF1" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_RedemptionPricePromissoryNoteWithFormerStockholderAndRelatedPartyDueFebruaryEighteenTwoThousandTwentyTwoMember" xlink:label="loc_wynn_RedemptionPricePromissoryNoteWithFormerStockholderAndRelatedPartyDueFebruaryEighteenTwoThousandTwentyTwoMember_73B3B4399C8991989A44A40BFC86D211" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_29B24F7D8A8E33F24470A40BFC86FF67" xlink:to="loc_wynn_RedemptionPricePromissoryNoteWithFormerStockholderAndRelatedPartyDueFebruaryEighteenTwoThousandTwentyTwoMember_73B3B4399C8991989A44A40BFC86D211" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_6A111476FE8D56A0C856A40BFC86C496" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_75B5BBF2A44E17110865A40BFC863E0C" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_6A111476FE8D56A0C856A40BFC86C496" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_12EF9E4D86E4FFE3BA27A40BFC86C38E_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_6A111476FE8D56A0C856A40BFC86C496" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_12EF9E4D86E4FFE3BA27A40BFC86C38E_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_12EF9E4D86E4FFE3BA27A40BFC86C38E" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_6A111476FE8D56A0C856A40BFC86C496" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_12EF9E4D86E4FFE3BA27A40BFC86C38E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SecuredDebtMember" xlink:label="loc_us-gaap_SecuredDebtMember_287530FA72EE4D72A9C4A40BFC8625CC" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_12EF9E4D86E4FFE3BA27A40BFC86C38E" xlink:to="loc_us-gaap_SecuredDebtMember_287530FA72EE4D72A9C4A40BFC8625CC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RevolvingCreditFacilityMember" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_6CB8C4025C1C26CC22CAA40BFC862C89" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_12EF9E4D86E4FFE3BA27A40BFC86C38E" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_6CB8C4025C1C26CC22CAA40BFC862C89" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SeniorNotesMember" xlink:label="loc_us-gaap_SeniorNotesMember_9F4844FC07533712F29DA40BFC860300" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_12EF9E4D86E4FFE3BA27A40BFC86C38E" xlink:to="loc_us-gaap_SeniorNotesMember_9F4844FC07533712F29DA40BFC860300" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MortgagesMember" xlink:label="loc_us-gaap_MortgagesMember_1A0A901680D5304C3577A40BFC866CAE" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_12EF9E4D86E4FFE3BA27A40BFC86C38E" xlink:to="loc_us-gaap_MortgagesMember_1A0A901680D5304C3577A40BFC866CAE" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnAmericaCreditFacilitiesAmendedMember" xlink:label="loc_wynn_WynnAmericaCreditFacilitiesAmendedMember_1D0EB629A81DDC9D696EA40BFC867A9F" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_12EF9E4D86E4FFE3BA27A40BFC86C38E" xlink:to="loc_wynn_WynnAmericaCreditFacilitiesAmendedMember_1D0EB629A81DDC9D696EA40BFC867A9F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NotesPayableOtherPayablesMember" xlink:label="loc_us-gaap_NotesPayableOtherPayablesMember_9A3AE26F2B0059941DB9A40BFC86218C" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_12EF9E4D86E4FFE3BA27A40BFC86C38E" xlink:to="loc_us-gaap_NotesPayableOtherPayablesMember_9A3AE26F2B0059941DB9A40BFC86218C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_AE81B15293BCBBBBDE03A40BFC86F804" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_75B5BBF2A44E17110865A40BFC863E0C" xlink:to="loc_us-gaap_RangeAxis_AE81B15293BCBBBBDE03A40BFC86F804" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_F88D1138FFE0408E5DFBA40BFC86250D_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RangeAxis_AE81B15293BCBBBBDE03A40BFC86F804" xlink:to="loc_us-gaap_RangeMember_F88D1138FFE0408E5DFBA40BFC86250D_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_F88D1138FFE0408E5DFBA40BFC86250D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RangeAxis_AE81B15293BCBBBBDE03A40BFC86F804" xlink:to="loc_us-gaap_RangeMember_F88D1138FFE0408E5DFBA40BFC86250D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_556FD0D5AB1BE9286FFCA40BFC8648DF" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_F88D1138FFE0408E5DFBA40BFC86250D" xlink:to="loc_us-gaap_MaximumMember_556FD0D5AB1BE9286FFCA40BFC8648DF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_3D97A2313EE0F7E43300A40BFC86CDFE" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0D3F2DAE56466B532C73A40BFC86A669" xlink:to="loc_us-gaap_LongTermDebt_3D97A2313EE0F7E43300A40BFC86CDFE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebtCurrent" xlink:label="loc_us-gaap_LongTermDebtCurrent_34B0DCC172B40B6002BBA40BFC86385C" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0D3F2DAE56466B532C73A40BFC86A669" xlink:to="loc_us-gaap_LongTermDebtCurrent_34B0DCC172B40B6002BBA40BFC86385C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_A2B08CB0F4174244D36FA40BFC86A662" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0D3F2DAE56466B532C73A40BFC86A669" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_A2B08CB0F4174244D36FA40BFC86A662" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.wynnresorts.com/role/LongTermDebtTables" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/NoncontrollingInterestDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MinorityInterestLineItems" xlink:label="loc_us-gaap_MinorityInterestLineItems_3605E3BCF81328AF2BB4A54E61A2A8BF" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MinorityInterestTable" xlink:label="loc_us-gaap_MinorityInterestTable_0C60A4B00EB37050A4ADA54E61A1A92C" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_MinorityInterestLineItems_3605E3BCF81328AF2BB4A54E61A2A8BF" xlink:to="loc_us-gaap_MinorityInterestTable_0C60A4B00EB37050A4ADA54E61A1A92C" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CounterpartyNameAxis" xlink:label="loc_us-gaap_CounterpartyNameAxis_066F778E800C513F696CA54E61A18315" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_MinorityInterestTable_0C60A4B00EB37050A4ADA54E61A1A92C" xlink:to="loc_us-gaap_CounterpartyNameAxis_066F778E800C513F696CA54E61A18315" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_A8E9432C110FBA2C26CCA54E61A12F5D_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CounterpartyNameAxis_066F778E800C513F696CA54E61A18315" xlink:to="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_A8E9432C110FBA2C26CCA54E61A12F5D_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_A8E9432C110FBA2C26CCA54E61A12F5D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CounterpartyNameAxis_066F778E800C513F696CA54E61A18315" xlink:to="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_A8E9432C110FBA2C26CCA54E61A12F5D" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnMacauLimitedMember" xlink:label="loc_wynn_WynnMacauLimitedMember_D02D50E790401FAC906BA54E61A161BD" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_A8E9432C110FBA2C26CCA54E61A12F5D" xlink:to="loc_wynn_WynnMacauLimitedMember_D02D50E790401FAC906BA54E61A161BD" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_ConsolidatedEntitiesAxis" xlink:label="loc_wynn_ConsolidatedEntitiesAxis_3DC6D14FB81555701D4DA54E61A105BD" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_MinorityInterestTable_0C60A4B00EB37050A4ADA54E61A1A92C" xlink:to="loc_wynn_ConsolidatedEntitiesAxis_3DC6D14FB81555701D4DA54E61A105BD" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_ConsolidatedEntitiesDomain" xlink:label="loc_wynn_ConsolidatedEntitiesDomain_24FDFD64E57D1CF47BB8A54E61A106E8_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_wynn_ConsolidatedEntitiesAxis_3DC6D14FB81555701D4DA54E61A105BD" xlink:to="loc_wynn_ConsolidatedEntitiesDomain_24FDFD64E57D1CF47BB8A54E61A106E8_default" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_ConsolidatedEntitiesDomain" xlink:label="loc_wynn_ConsolidatedEntitiesDomain_24FDFD64E57D1CF47BB8A54E61A106E8" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_wynn_ConsolidatedEntitiesAxis_3DC6D14FB81555701D4DA54E61A105BD" xlink:to="loc_wynn_ConsolidatedEntitiesDomain_24FDFD64E57D1CF47BB8A54E61A106E8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsidiariesMember" xlink:label="loc_us-gaap_SubsidiariesMember_936F12AD9CE7C8A7E9A2A54E61A12F2B" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_ConsolidatedEntitiesDomain_24FDFD64E57D1CF47BB8A54E61A106E8" xlink:to="loc_us-gaap_SubsidiariesMember_936F12AD9CE7C8A7E9A2A54E61A12F2B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_5BFD76EC7095E7C71038A54E61A21687" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_MinorityInterestTable_0C60A4B00EB37050A4ADA54E61A1A92C" xlink:to="loc_dei_LegalEntityAxis_5BFD76EC7095E7C71038A54E61A21687" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_499113DF742658CA9849A54E61A20BF8_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_5BFD76EC7095E7C71038A54E61A21687" xlink:to="loc_dei_EntityDomain_499113DF742658CA9849A54E61A20BF8_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_499113DF742658CA9849A54E61A20BF8" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_5BFD76EC7095E7C71038A54E61A21687" xlink:to="loc_dei_EntityDomain_499113DF742658CA9849A54E61A20BF8" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnMacauLimitedMember" xlink:label="loc_wynn_WynnMacauLimitedMember_38051F3749F88BF4DBAEA54E61A2D3A3" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_499113DF742658CA9849A54E61A20BF8" xlink:to="loc_wynn_WynnMacauLimitedMember_38051F3749F88BF4DBAEA54E61A2D3A3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Dividends" xlink:label="loc_us-gaap_Dividends_D255D27EE41D96670D04A54E61A2F8C1" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MinorityInterestLineItems_3605E3BCF81328AF2BB4A54E61A2A8BF" xlink:to="loc_us-gaap_Dividends_D255D27EE41D96670D04A54E61A2F8C1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromDividendsReceived" xlink:label="loc_us-gaap_ProceedsFromDividendsReceived_864460D4CBDA9EB44AFDA54E61A2F16D" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MinorityInterestLineItems_3605E3BCF81328AF2BB4A54E61A2A8BF" xlink:to="loc_us-gaap_ProceedsFromDividendsReceived_864460D4CBDA9EB44AFDA54E61A2F16D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders" xlink:label="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_FE09FD2041AB7DC1717DA54E61A280F6" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MinorityInterestLineItems_3605E3BCF81328AF2BB4A54E61A2A8BF" xlink:to="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_FE09FD2041AB7DC1717DA54E61A280F6" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.wynnresorts.com/role/NoncontrollingInterestNotes" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/OrganizationAndBasisOfPresentation" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/OrganizationAndBasisOfPresentationAdditionalInformationDetail" xlink:type="extended">
    <loc xlink:href="wynn-20170630.xsd#wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems" xlink:label="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_97251ACEE9BD8DA13802A07744727665" xlink:type="locator" />
    <loc xlink:href="wynn-20170630.xsd#wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable" xlink:label="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_0D3D1A455D7F2BFEA3ECA077446F2DC9" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_97251ACEE9BD8DA13802A07744727665" xlink:to="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_0D3D1A455D7F2BFEA3ECA077446F2DC9" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_F221F5CA9B12455FE9D4A077447050DC" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_0D3D1A455D7F2BFEA3ECA077446F2DC9" xlink:to="loc_dei_LegalEntityAxis_F221F5CA9B12455FE9D4A077447050DC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_3B9435885425363D028EA0774470F5B9_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_F221F5CA9B12455FE9D4A077447050DC" xlink:to="loc_dei_EntityDomain_3B9435885425363D028EA0774470F5B9_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_3B9435885425363D028EA0774470F5B9" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_F221F5CA9B12455FE9D4A077447050DC" xlink:to="loc_dei_EntityDomain_3B9435885425363D028EA0774470F5B9" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnMacauMember" xlink:label="loc_wynn_WynnMacauMember_B5C8D5947048E065E1D8A0774470FA0A" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_3B9435885425363D028EA0774470F5B9" xlink:to="loc_wynn_WynnMacauMember_B5C8D5947048E065E1D8A0774470FA0A" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnPalaceMember" xlink:label="loc_wynn_WynnPalaceMember_D1A76F2EBAF04722D4F5A0774471A055" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_3B9435885425363D028EA0774470F5B9" xlink:to="loc_wynn_WynnPalaceMember_D1A76F2EBAF04722D4F5A0774471A055" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnLasVegasMember" xlink:label="loc_wynn_WynnLasVegasMember_0968788340728C0D0700A0774471B411" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_3B9435885425363D028EA0774470F5B9" xlink:to="loc_wynn_WynnLasVegasMember_0968788340728C0D0700A0774471B411" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnRetailMember" xlink:label="loc_wynn_WynnRetailMember_6F7AC4147A2CF7B199DDA07744710333" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_3B9435885425363D028EA0774470F5B9" xlink:to="loc_wynn_WynnRetailMember_6F7AC4147A2CF7B199DDA07744710333" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_B3EC8308E1634E586468A077447186CB" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_0D3D1A455D7F2BFEA3ECA077446F2DC9" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_B3EC8308E1634E586468A077447186CB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_3D9CD2614BBDB57D03CDA077447161D5_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_B3EC8308E1634E586468A077447186CB" xlink:to="loc_us-gaap_SegmentDomain_3D9CD2614BBDB57D03CDA077447161D5_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_3D9CD2614BBDB57D03CDA077447161D5" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_B3EC8308E1634E586468A077447186CB" xlink:to="loc_us-gaap_SegmentDomain_3D9CD2614BBDB57D03CDA077447161D5" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_CasinoMember" xlink:label="loc_wynn_CasinoMember_DA020E932A922E50C78FA0774471C398" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_3D9CD2614BBDB57D03CDA077447161D5" xlink:to="loc_wynn_CasinoMember_DA020E932A922E50C78FA0774471C398" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_InpersonCommitteeMeetingMember" xlink:label="loc_wynn_InpersonCommitteeMeetingMember_736D7376E092E44E60FCA0774471097B" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_3D9CD2614BBDB57D03CDA077447161D5" xlink:to="loc_wynn_InpersonCommitteeMeetingMember_736D7376E092E44E60FCA0774471097B" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_RetailMember" xlink:label="loc_wynn_RetailMember_A4100CAD21D7A5E83420A0774471D858" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_3D9CD2614BBDB57D03CDA077447161D5" xlink:to="loc_wynn_RetailMember_A4100CAD21D7A5E83420A0774471D858" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FoodAndBeverageMember" xlink:label="loc_wynn_FoodAndBeverageMember_AF86D04B97A75D48FFD8A07744723DF8" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_3D9CD2614BBDB57D03CDA077447161D5" xlink:to="loc_wynn_FoodAndBeverageMember_AF86D04B97A75D48FFD8A07744723DF8" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_ShowroomsMember" xlink:label="loc_wynn_ShowroomsMember_7949C65504F464B1A27EA07744723512" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_3D9CD2614BBDB57D03CDA077447161D5" xlink:to="loc_wynn_ShowroomsMember_7949C65504F464B1A27EA07744723512" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_NightclubsMember" xlink:label="loc_wynn_NightclubsMember_5D656237CAB81301EEFBA07744724DD7" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_3D9CD2614BBDB57D03CDA077447161D5" xlink:to="loc_wynn_NightclubsMember_5D656237CAB81301EEFBA07744724DD7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_4469923945A60CED5B0BA0774472CA97" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_97251ACEE9BD8DA13802A07744727665" xlink:to="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_4469923945A60CED5B0BA0774472CA97" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MinorityInterestOwnershipPercentageByParent" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_9BA71D56B0E5A5370616A0774472A0CE" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_4469923945A60CED5B0BA0774472CA97" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_9BA71D56B0E5A5370616A0774472A0CE" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_NumberOfHotelTowers" xlink:label="loc_wynn_NumberOfHotelTowers_F198D4F43323104DF1DEA07744722EB5" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_4469923945A60CED5B0BA0774472CA97" xlink:to="loc_wynn_NumberOfHotelTowers_F198D4F43323104DF1DEA07744722EB5" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_NumberOfRoomsInHotel" xlink:label="loc_wynn_NumberOfRoomsInHotel_89EC034758FE4BA10648A077447217C8" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_4469923945A60CED5B0BA0774472CA97" xlink:to="loc_wynn_NumberOfRoomsInHotel_89EC034758FE4BA10648A077447217C8" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FunctionalAreaSquareFootage" xlink:label="loc_wynn_FunctionalAreaSquareFootage_EDD137DA8CE41927517CA07744726F08" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_4469923945A60CED5B0BA0774472CA97" xlink:to="loc_wynn_FunctionalAreaSquareFootage_EDD137DA8CE41927517CA07744726F08" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NumberOfRestaurants" xlink:label="loc_us-gaap_NumberOfRestaurants_08395B44C8D61694ECE6A07744722868" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_4469923945A60CED5B0BA0774472CA97" xlink:to="loc_us-gaap_NumberOfRestaurants_08395B44C8D61694ECE6A07744722868" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_NumberOfFacilities" xlink:label="loc_wynn_NumberOfFacilities_EA8B1A9DEF10A901A254A0774472E87B" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_4469923945A60CED5B0BA0774472CA97" xlink:to="loc_wynn_NumberOfFacilities_EA8B1A9DEF10A901A254A0774472E87B" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_NumberOfFoodAndBeverageOutlets" xlink:label="loc_wynn_NumberOfFoodAndBeverageOutlets_A902A0A8290B03B00190A07744732E8D" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_4469923945A60CED5B0BA0774472CA97" xlink:to="loc_wynn_NumberOfFoodAndBeverageOutlets_A902A0A8290B03B00190A07744732E8D" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_NumberOfShowrooms" xlink:label="loc_wynn_NumberOfShowrooms_D3A035FF0E6A5FF13182A077447343BD" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_4469923945A60CED5B0BA0774472CA97" xlink:to="loc_wynn_NumberOfShowrooms_D3A035FF0E6A5FF13182A077447343BD" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FunctionalAreaSquareFootageUnderConstruction" xlink:label="loc_wynn_FunctionalAreaSquareFootageUnderConstruction_C2AA68393C0483638767A07744736849" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_4469923945A60CED5B0BA0774472CA97" xlink:to="loc_wynn_FunctionalAreaSquareFootageUnderConstruction_C2AA68393C0483638767A07744736849" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.wynnresorts.com/role/PropertyAndEquipmentNet" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/PropertyAndEquipmentNetScheduleOfPropertyAndEquipmentNetDetail" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/PropertyAndEquipmentNetTables" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/ReceivablesNet" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/ReceivablesNetSummaryOfReceivablesNetDetail" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_7E5F3841715A5DD1A1CF7D906A25FC02" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable" xlink:label="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_B5B4A03FFE4E5BDFAD638FE32502FCE5" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_7E5F3841715A5DD1A1CF7D906A25FC02" xlink:to="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_B5B4A03FFE4E5BDFAD638FE32502FCE5" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis" xlink:label="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_F9F7018594FB549586A4D72149BEC6ED" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_B5B4A03FFE4E5BDFAD638FE32502FCE5" xlink:to="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_F9F7018594FB549586A4D72149BEC6ED" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LegalEntityTypeOfCounterpartyDomain" xlink:label="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_DCC7D27BA33724663E416432970D3EDA_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_F9F7018594FB549586A4D72149BEC6ED" xlink:to="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_DCC7D27BA33724663E416432970D3EDA_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LegalEntityTypeOfCounterpartyDomain" xlink:label="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_D54172692D905218B3DE38A3F8C71527" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_F9F7018594FB549586A4D72149BEC6ED" xlink:to="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_D54172692D905218B3DE38A3F8C71527" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_CasinoMember" xlink:label="loc_wynn_CasinoMember_61A7B60DFA465B2BB03A4922EEA36585" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_D54172692D905218B3DE38A3F8C71527" xlink:to="loc_wynn_CasinoMember_61A7B60DFA465B2BB03A4922EEA36585" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HotelMember" xlink:label="loc_us-gaap_HotelMember_B03CF6941EC651CCB254E5DB9DA72014" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_D54172692D905218B3DE38A3F8C71527" xlink:to="loc_us-gaap_HotelMember_B03CF6941EC651CCB254E5DB9DA72014" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_RetailLeasesAndOtherMember" xlink:label="loc_wynn_RetailLeasesAndOtherMember_1D4285CA0D8D5B5BA5B109B8DC807BA9" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_D54172692D905218B3DE38A3F8C71527" xlink:to="loc_wynn_RetailLeasesAndOtherMember_1D4285CA0D8D5B5BA5B109B8DC807BA9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccountsReceivableGrossCurrent" xlink:label="loc_us-gaap_AccountsReceivableGrossCurrent_6954080CAD6851598A7A26EF45C0BB64" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_7E5F3841715A5DD1A1CF7D906A25FC02" xlink:to="loc_us-gaap_AccountsReceivableGrossCurrent_6954080CAD6851598A7A26EF45C0BB64" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_FD886361E39A5CADA641499579F27455" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_7E5F3841715A5DD1A1CF7D906A25FC02" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_FD886361E39A5CADA641499579F27455" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ReceivablesNetCurrent" xlink:label="loc_us-gaap_ReceivablesNetCurrent_1B1872E2C8B550AC889DD1C953EA9A70" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_7E5F3841715A5DD1A1CF7D906A25FC02" xlink:to="loc_us-gaap_ReceivablesNetCurrent_1B1872E2C8B550AC889DD1C953EA9A70" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.wynnresorts.com/role/ReceivablesNetTables" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/RelatedPartyTransactions" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/RelatedPartyTransactionsAdditionalInformationDetail" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/RetailJointVenture" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/RetailJointVentureAdditionalInformationDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsLineItems" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_C458A5C22A995389801DDE987FCEAD11" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsTable" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_F0867CBF40EF51CFACD71190232CBA1E" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_C458A5C22A995389801DDE987FCEAD11" xlink:to="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_F0867CBF40EF51CFACD71190232CBA1E" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_CE8D15FC862A5A68B522D52DDC12C82B" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_F0867CBF40EF51CFACD71190232CBA1E" xlink:to="loc_us-gaap_StatementScenarioAxis_CE8D15FC862A5A68B522D52DDC12C82B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_1222A7C8F9615D542F85CF540802557E_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementScenarioAxis_CE8D15FC862A5A68B522D52DDC12C82B" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_1222A7C8F9615D542F85CF540802557E_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_BB35F02D558054AB9BBD2DC11975BC74" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementScenarioAxis_CE8D15FC862A5A68B522D52DDC12C82B" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_BB35F02D558054AB9BBD2DC11975BC74" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioForecastMember" xlink:label="loc_us-gaap_ScenarioForecastMember_375A4D959D405F7B885A6BC4ED4A4684" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScenarioUnspecifiedDomain_BB35F02D558054AB9BBD2DC11975BC74" xlink:to="loc_us-gaap_ScenarioForecastMember_375A4D959D405F7B885A6BC4ED4A4684" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_E513FDD90AD4555488727F21A6A484A3" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_F0867CBF40EF51CFACD71190232CBA1E" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_E513FDD90AD4555488727F21A6A484A3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_DBB365295251046C89B0CF540802EAA4_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_E513FDD90AD4555488727F21A6A484A3" xlink:to="loc_us-gaap_SegmentDomain_DBB365295251046C89B0CF540802EAA4_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_B9071E55C236597E858284872635267F" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_E513FDD90AD4555488727F21A6A484A3" xlink:to="loc_us-gaap_SegmentDomain_B9071E55C236597E858284872635267F" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_RetailMember" xlink:label="loc_wynn_RetailMember_A2BA5CE414CE5D89A8A6ACDEAD02A394" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_B9071E55C236597E858284872635267F" xlink:to="loc_wynn_RetailMember_A2BA5CE414CE5D89A8A6ACDEAD02A394" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_BAFC064BD87F522B87AADA065A5CEE38" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_F0867CBF40EF51CFACD71190232CBA1E" xlink:to="loc_dei_LegalEntityAxis_BAFC064BD87F522B87AADA065A5CEE38" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_CCB396B59C7B4BE76728CF540802355C_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_BAFC064BD87F522B87AADA065A5CEE38" xlink:to="loc_dei_EntityDomain_CCB396B59C7B4BE76728CF540802355C_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_6DFB8DF4E8485AF4B4FB74E5FE80F3F7" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_BAFC064BD87F522B87AADA065A5CEE38" xlink:to="loc_dei_EntityDomain_6DFB8DF4E8485AF4B4FB74E5FE80F3F7" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_RetailJointVentureMember" xlink:label="loc_wynn_RetailJointVentureMember_269FAC99D9095062B46CF1DC3B846583" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_6DFB8DF4E8485AF4B4FB74E5FE80F3F7" xlink:to="loc_wynn_RetailJointVentureMember_269FAC99D9095062B46CF1DC3B846583" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CorporateJointVentureMember" xlink:label="loc_us-gaap_CorporateJointVentureMember_52AA62DECA8E56CB87644E0E990EF1FD" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_6DFB8DF4E8485AF4B4FB74E5FE80F3F7" xlink:to="loc_us-gaap_CorporateJointVentureMember_52AA62DECA8E56CB87644E0E990EF1FD" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FunctionalAreaSquareFootage" xlink:label="loc_wynn_FunctionalAreaSquareFootage_60C6A2ECFED351E2B6BC1968EBD4E881" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_C458A5C22A995389801DDE987FCEAD11" xlink:to="loc_wynn_FunctionalAreaSquareFootage_60C6A2ECFED351E2B6BC1968EBD4E881" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_NetBookValueOfAssetsAndLiabilitiesTransferredForJointVenture" xlink:label="loc_wynn_NetBookValueOfAssetsAndLiabilitiesTransferredForJointVenture_C564A02DBCD65E7BAAA0152B1A0FF022" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_C458A5C22A995389801DDE987FCEAD11" xlink:to="loc_wynn_NetBookValueOfAssetsAndLiabilitiesTransferredForJointVenture_C564A02DBCD65E7BAAA0152B1A0FF022" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MinorityInterestOwnershipPercentageByNoncontrollingOwners" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByNoncontrollingOwners_3B4F397C195E56B8864F65414E9C09CD" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_C458A5C22A995389801DDE987FCEAD11" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByNoncontrollingOwners_3B4F397C195E56B8864F65414E9C09CD" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_JointVentureCashConsiderationReceived" xlink:label="loc_wynn_JointVentureCashConsiderationReceived_275A1662474C5D91AC1AEC62C4BA70CC" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_C458A5C22A995389801DDE987FCEAD11" xlink:to="loc_wynn_JointVentureCashConsiderationReceived_275A1662474C5D91AC1AEC62C4BA70CC" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_JointVentureNoteReceivable" xlink:label="loc_wynn_JointVentureNoteReceivable_59A8D77A300A5340872E98296785CB4C" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_C458A5C22A995389801DDE987FCEAD11" xlink:to="loc_wynn_JointVentureNoteReceivable_59A8D77A300A5340872E98296785CB4C" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_Presentvalueofnote" xlink:label="loc_wynn_Presentvalueofnote_82A10303344958609061BAAAC9E9C75E" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_C458A5C22A995389801DDE987FCEAD11" xlink:to="loc_wynn_Presentvalueofnote_82A10303344958609061BAAAC9E9C75E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MinorityInterestOwnershipPercentageByParent" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_B615C22A231251FC843F7C9662C5637C" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_C458A5C22A995389801DDE987FCEAD11" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_B615C22A231251FC843F7C9662C5637C" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FunctionalAreaSquareFootageUnderConstruction" xlink:label="loc_wynn_FunctionalAreaSquareFootageUnderConstruction_3520CFD9E2475127832527366C93BB88" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_C458A5C22A995389801DDE987FCEAD11" xlink:to="loc_wynn_FunctionalAreaSquareFootageUnderConstruction_3520CFD9E2475127832527366C93BB88" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromDivestitureOfInterestInJointVenture" xlink:label="loc_us-gaap_ProceedsFromDivestitureOfInterestInJointVenture_CD15590CFC32586FBC629DE972317F85" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_C458A5C22A995389801DDE987FCEAD11" xlink:to="loc_us-gaap_ProceedsFromDivestitureOfInterestInJointVenture_CD15590CFC32586FBC629DE972317F85" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_VariableInterestEntityNonconsolidatedCarryingAmountAssets" xlink:label="loc_us-gaap_VariableInterestEntityNonconsolidatedCarryingAmountAssets_1B6A9807D32655A48737A38850AD5A1C" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_C458A5C22A995389801DDE987FCEAD11" xlink:to="loc_us-gaap_VariableInterestEntityNonconsolidatedCarryingAmountAssets_1B6A9807D32655A48737A38850AD5A1C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_VariableInterestEntityConsolidatedCarryingAmountLiabilities" xlink:label="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountLiabilities_A8DFF81DB07B59C580D7B74770D95DFC" xlink:type="locator" />
    <definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_C458A5C22A995389801DDE987FCEAD11" xlink:to="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountLiabilities_A8DFF81DB07B59C580D7B74770D95DFC" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.wynnresorts.com/role/SegmentInformation" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/SegmentInformationAdditionalInformationDetails" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/SegmentInformationSummaryOfAssetsBySegmentDetail" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentReportingInformationLineItems" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_6AC9DFDFDFFF54F18224CD6AEACFAF91" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_364A1C3150A85D3FA1E21C952229E043" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_6AC9DFDFDFFF54F18224CD6AEACFAF91" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_364A1C3150A85D3FA1E21C952229E043" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConsolidationItemsAxis" xlink:label="loc_us-gaap_ConsolidationItemsAxis_9B25C7FC4A0D5FDFA2210180F1B077A9" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_364A1C3150A85D3FA1E21C952229E043" xlink:to="loc_us-gaap_ConsolidationItemsAxis_9B25C7FC4A0D5FDFA2210180F1B077A9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConsolidationItemsDomain" xlink:label="loc_us-gaap_ConsolidationItemsDomain_249B1D77FBF003FA39FEBF3E22ED1996_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConsolidationItemsAxis_9B25C7FC4A0D5FDFA2210180F1B077A9" xlink:to="loc_us-gaap_ConsolidationItemsDomain_249B1D77FBF003FA39FEBF3E22ED1996_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConsolidationItemsDomain" xlink:label="loc_us-gaap_ConsolidationItemsDomain_FAB7ED84480C565BB554D9009C52F0A5" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConsolidationItemsAxis_9B25C7FC4A0D5FDFA2210180F1B077A9" xlink:to="loc_us-gaap_ConsolidationItemsDomain_FAB7ED84480C565BB554D9009C52F0A5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OperatingSegmentsMember" xlink:label="loc_us-gaap_OperatingSegmentsMember_FF31917085A758949F2FA599308B5894" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConsolidationItemsDomain_FAB7ED84480C565BB554D9009C52F0A5" xlink:to="loc_us-gaap_OperatingSegmentsMember_FF31917085A758949F2FA599308B5894" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="loc_us-gaap_StatementGeographicalAxis_FA691FC597805542989CF4C3D3630CD8" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_364A1C3150A85D3FA1E21C952229E043" xlink:to="loc_us-gaap_StatementGeographicalAxis_FA691FC597805542989CF4C3D3630CD8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_E6B7E072F4E1F3C50582BF3E22EDC987_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementGeographicalAxis_FA691FC597805542989CF4C3D3630CD8" xlink:to="loc_us-gaap_SegmentGeographicalDomain_E6B7E072F4E1F3C50582BF3E22EDC987_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_5895F45CF4C758A7B4801AA84A5CA156" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementGeographicalAxis_FA691FC597805542989CF4C3D3630CD8" xlink:to="loc_us-gaap_SegmentGeographicalDomain_5895F45CF4C758A7B4801AA84A5CA156" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/country/2016/country-2016-01-31.xsd#country_MO" xlink:label="loc_country_MO_18212634D43C5F97AEFF94DB6328D1F5" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentGeographicalDomain_5895F45CF4C758A7B4801AA84A5CA156" xlink:to="loc_country_MO_18212634D43C5F97AEFF94DB6328D1F5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_3723232D809F59F4A8957E06E7CE6BD7" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_364A1C3150A85D3FA1E21C952229E043" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_3723232D809F59F4A8957E06E7CE6BD7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_E8EACE4C5719A184326EBF3E22ED9749_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_3723232D809F59F4A8957E06E7CE6BD7" xlink:to="loc_us-gaap_SegmentDomain_E8EACE4C5719A184326EBF3E22ED9749_DFDFCA6C426F5B4DA84EF353A51E57DA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_2A8EDD3CB7F55660906E8F97E4C7D22A" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_3723232D809F59F4A8957E06E7CE6BD7" xlink:to="loc_us-gaap_SegmentDomain_2A8EDD3CB7F55660906E8F97E4C7D22A" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnMacauMember" xlink:label="loc_wynn_WynnMacauMember_46C912C656875B88A95B486FCD5F7A31" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_2A8EDD3CB7F55660906E8F97E4C7D22A" xlink:to="loc_wynn_WynnMacauMember_46C912C656875B88A95B486FCD5F7A31" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnPalaceMember" xlink:label="loc_wynn_WynnPalaceMember_1FD345A936625F52B9215FC5373294DD" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_2A8EDD3CB7F55660906E8F97E4C7D22A" xlink:to="loc_wynn_WynnPalaceMember_1FD345A936625F52B9215FC5373294DD" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_OtherMacauMember" xlink:label="loc_wynn_OtherMacauMember_7AB168801C6F5EEC9FF95CCAFF3DA63E" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_2A8EDD3CB7F55660906E8F97E4C7D22A" xlink:to="loc_wynn_OtherMacauMember_7AB168801C6F5EEC9FF95CCAFF3DA63E" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnLasVegasMember" xlink:label="loc_wynn_WynnLasVegasMember_EEC3681A573D536C84BE7A164018ADD4" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_2A8EDD3CB7F55660906E8F97E4C7D22A" xlink:to="loc_wynn_WynnLasVegasMember_EEC3681A573D536C84BE7A164018ADD4" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnBostonHarborMember" xlink:label="loc_wynn_WynnBostonHarborMember_F1F9CE5E470D5C3BB899FBD51607FB1E" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_2A8EDD3CB7F55660906E8F97E4C7D22A" xlink:to="loc_wynn_WynnBostonHarborMember_F1F9CE5E470D5C3BB899FBD51607FB1E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CorporateAndOtherMember" xlink:label="loc_us-gaap_CorporateAndOtherMember_1E1DFCF3220950E0B29E5F057315BE56" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_2A8EDD3CB7F55660906E8F97E4C7D22A" xlink:to="loc_us-gaap_CorporateAndOtherMember_1E1DFCF3220950E0B29E5F057315BE56" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_BB8C0AFF80035EC7957C78DC4B20D66F" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_6AC9DFDFDFFF54F18224CD6AEACFAF91" xlink:to="loc_us-gaap_Assets_BB8C0AFF80035EC7957C78DC4B20D66F" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.wynnresorts.com/role/SegmentInformationSummaryOfResultsOfOperationsBySegmentDetail" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentReportingInformationLineItems" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_EB18312D325845BABDDBA40C5ABED0B0" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_6C40399A5E24BA5DD05DA40C5AB9853D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_EB18312D325845BABDDBA40C5ABED0B0" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_6C40399A5E24BA5DD05DA40C5AB9853D" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_E0DCCBB1C739DDEAC3C0A40C5AB937BB" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_6C40399A5E24BA5DD05DA40C5AB9853D" xlink:to="loc_dei_LegalEntityAxis_E0DCCBB1C739DDEAC3C0A40C5AB937BB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_FFA745833CE3BFD95737A40C5AB9111D_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_E0DCCBB1C739DDEAC3C0A40C5AB937BB" xlink:to="loc_dei_EntityDomain_FFA745833CE3BFD95737A40C5AB9111D_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_FFA745833CE3BFD95737A40C5AB9111D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_E0DCCBB1C739DDEAC3C0A40C5AB937BB" xlink:to="loc_dei_EntityDomain_FFA745833CE3BFD95737A40C5AB9111D" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnMacauMember" xlink:label="loc_wynn_WynnMacauMember_34A212030798ABBD7F7EA40C5AB9A36D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_FFA745833CE3BFD95737A40C5AB9111D" xlink:to="loc_wynn_WynnMacauMember_34A212030798ABBD7F7EA40C5AB9A36D" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnPalaceMember" xlink:label="loc_wynn_WynnPalaceMember_A44AFFE7F7E236F1BC8EA40C5ABE6421" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_FFA745833CE3BFD95737A40C5AB9111D" xlink:to="loc_wynn_WynnPalaceMember_A44AFFE7F7E236F1BC8EA40C5ABE6421" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_MacauOperationsDomain" xlink:label="loc_wynn_MacauOperationsDomain_2F11CEABF115B927D6F5A40C5ABEAC2C" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_FFA745833CE3BFD95737A40C5AB9111D" xlink:to="loc_wynn_MacauOperationsDomain_2F11CEABF115B927D6F5A40C5ABEAC2C" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_WynnLasVegasMember" xlink:label="loc_wynn_WynnLasVegasMember_C80454AEBB39BBEE86C7A40C5ABE6676" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_FFA745833CE3BFD95737A40C5AB9111D" xlink:to="loc_wynn_WynnLasVegasMember_C80454AEBB39BBEE86C7A40C5ABE6676" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SalesRevenueNet" xlink:label="loc_us-gaap_SalesRevenueNet_10898959BDD315538347A40C5ABF217C" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_EB18312D325845BABDDBA40C5ABED0B0" xlink:to="loc_us-gaap_SalesRevenueNet_10898959BDD315538347A40C5ABF217C" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_AdjustedPropertyEbitda" xlink:label="loc_wynn_AdjustedPropertyEbitda_FBB9BF9098897373EE79A40C5ABFF4C1" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_EB18312D325845BABDDBA40C5ABED0B0" xlink:to="loc_wynn_AdjustedPropertyEbitda_FBB9BF9098897373EE79A40C5ABFF4C1" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_OtherOperatingCostsAndExpensesAbstract" xlink:label="loc_wynn_OtherOperatingCostsAndExpensesAbstract_5309F44DB6B675CD07D8A40C5ABFB3A9" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_EB18312D325845BABDDBA40C5ABED0B0" xlink:to="loc_wynn_OtherOperatingCostsAndExpensesAbstract_5309F44DB6B675CD07D8A40C5ABFB3A9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PreOpeningCosts" xlink:label="loc_us-gaap_PreOpeningCosts_167091B4DDBE34D01660A40C5ABF10FE" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_5309F44DB6B675CD07D8A40C5ABFB3A9" xlink:to="loc_us-gaap_PreOpeningCosts_167091B4DDBE34D01660A40C5ABF10FE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DepreciationAndAmortization" xlink:label="loc_us-gaap_DepreciationAndAmortization_FDDECBF383E2D4AF6403A40C5ABF051C" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_5309F44DB6B675CD07D8A40C5ABFB3A9" xlink:to="loc_us-gaap_DepreciationAndAmortization_FDDECBF383E2D4AF6403A40C5ABF051C" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_ProjectAbandonmentCosts" xlink:label="loc_wynn_ProjectAbandonmentCosts_01C6B880E720FF2B16A8A40C5ABFEB77" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_5309F44DB6B675CD07D8A40C5ABFB3A9" xlink:to="loc_wynn_ProjectAbandonmentCosts_01C6B880E720FF2B16A8A40C5ABFEB77" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_CorporateExpensesAndOther" xlink:label="loc_wynn_CorporateExpensesAndOther_E29AFAFCBE24D35D8D80A40C5ABFF69E" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_5309F44DB6B675CD07D8A40C5ABFB3A9" xlink:to="loc_wynn_CorporateExpensesAndOther_E29AFAFCBE24D35D8D80A40C5ABFF69E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_5C135F421F09871CF0A8A40C5ABFEEA2" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_5309F44DB6B675CD07D8A40C5ABFB3A9" xlink:to="loc_us-gaap_ShareBasedCompensation_5C135F421F09871CF0A8A40C5ABFEEA2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_65EAA719418B0EC3E5F5A40C5AC08DF9" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_5309F44DB6B675CD07D8A40C5ABFB3A9" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_65EAA719418B0EC3E5F5A40C5AC08DF9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherCostAndExpenseOperating" xlink:label="loc_us-gaap_OtherCostAndExpenseOperating_3FDF7412676F45F12E0EA40C5AC0BE5F" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_5309F44DB6B675CD07D8A40C5ABFB3A9" xlink:to="loc_us-gaap_OtherCostAndExpenseOperating_3FDF7412676F45F12E0EA40C5AC0BE5F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_A38267FF20812649CA9EA40C5AC0C771" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_EB18312D325845BABDDBA40C5ABED0B0" xlink:to="loc_us-gaap_OperatingIncomeLoss_A38267FF20812649CA9EA40C5AC0C771" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NonoperatingIncomeExpenseAbstract" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_34E88999D0ECD49D227AA40C5AC02C6E" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_EB18312D325845BABDDBA40C5ABED0B0" xlink:to="loc_us-gaap_NonoperatingIncomeExpenseAbstract_34E88999D0ECD49D227AA40C5AC02C6E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InvestmentIncomeInterest" xlink:label="loc_us-gaap_InvestmentIncomeInterest_60E5DA95557FA65F4DEFA40C5AC095B3" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_34E88999D0ECD49D227AA40C5AC02C6E" xlink:to="loc_us-gaap_InvestmentIncomeInterest_60E5DA95557FA65F4DEFA40C5AC095B3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_95F5268E161605785955A40C5AC04F1B" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_34E88999D0ECD49D227AA40C5AC02C6E" xlink:to="loc_us-gaap_InterestExpense_95F5268E161605785955A40C5AC04F1B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_6B10B48EBD4560928958A40C5AC01528" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_34E88999D0ECD49D227AA40C5AC02C6E" xlink:to="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_6B10B48EBD4560928958A40C5AC01528" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FairValueAdjustmentofDebt" xlink:label="loc_wynn_FairValueAdjustmentofDebt_9F1D59DB98B4EFA092B4A40C5AC5CF30" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_34E88999D0ECD49D227AA40C5AC02C6E" xlink:to="loc_wynn_FairValueAdjustmentofDebt_9F1D59DB98B4EFA092B4A40C5AC5CF30" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_3FA1B5B435F355A192E0A40C5AC60518" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_34E88999D0ECD49D227AA40C5AC02C6E" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_3FA1B5B435F355A192E0A40C5AC60518" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_341BC34EB41846676714A40C5AC6ADE5" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_34E88999D0ECD49D227AA40C5AC02C6E" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_341BC34EB41846676714A40C5AC6ADE5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_C2507DA0436D06D8099FA40C5AC653DB" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_34E88999D0ECD49D227AA40C5AC02C6E" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_C2507DA0436D06D8099FA40C5AC653DB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_52FAD8E3161AD60CE80EA40C5AC6BA3C" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_EB18312D325845BABDDBA40C5ABED0B0" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_52FAD8E3161AD60CE80EA40C5AC6BA3C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_4A047791D7BB27BB016CA40C5AC6CCBE" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_EB18312D325845BABDDBA40C5ABED0B0" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_4A047791D7BB27BB016CA40C5AC6CCBE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaap_ProfitLoss_338DF7926DF44351C1D0A40C5AC6776B" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_EB18312D325845BABDDBA40C5ABED0B0" xlink:to="loc_us-gaap_ProfitLoss_338DF7926DF44351C1D0A40C5AC6776B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_1A033770BBC151A57639A40C5AC6F191" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_EB18312D325845BABDDBA40C5ABED0B0" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_1A033770BBC151A57639A40C5AC6F191" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_011C057FF213A247E932A40C5AC630BA" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_EB18312D325845BABDDBA40C5ABED0B0" xlink:to="loc_us-gaap_NetIncomeLoss_011C057FF213A247E932A40C5AC630BA" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.wynnresorts.com/role/SegmentInformationTables" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/StockBasedCompensation" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/StockBasedCompensationAdditionalInformationDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_A1C925C0F49A5A8183978B77E5D311E4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_F4672F0DB485A32B37728B77E5D3F745" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_A1C925C0F49A5A8183978B77E5D311E4" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_F4672F0DB485A32B37728B77E5D3F745" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_ABE26A0836EA1D0150BE8B77E5D3A0A2" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_F4672F0DB485A32B37728B77E5D3F745" xlink:to="loc_us-gaap_AwardTypeAxis_ABE26A0836EA1D0150BE8B77E5D3A0A2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_81128CEDB460F9FF70B98B77E5D3FFD6_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_ABE26A0836EA1D0150BE8B77E5D3A0A2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_81128CEDB460F9FF70B98B77E5D3FFD6_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_81128CEDB460F9FF70B98B77E5D3FFD6" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_ABE26A0836EA1D0150BE8B77E5D3A0A2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_81128CEDB460F9FF70B98B77E5D3FFD6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PerformanceSharesMember" xlink:label="loc_us-gaap_PerformanceSharesMember_79D758CB616C4953B5448B77E5D38C8C" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_81128CEDB460F9FF70B98B77E5D3FFD6" xlink:to="loc_us-gaap_PerformanceSharesMember_79D758CB616C4953B5448B77E5D38C8C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_BA13100D1AC41002B9B58B77E5D36216" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_A1C925C0F49A5A8183978B77E5D311E4" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_BA13100D1AC41002B9B58B77E5D36216" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.wynnresorts.com/role/StockBasedCompensationSummaryOfTotalStockBasedCompensationCostDetail" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_21FD013E9F0B08CD599989C2FB4FA04B" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_1BDB340CC016E29F3A5389C2FB4EF6E8" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_21FD013E9F0B08CD599989C2FB4FA04B" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_1BDB340CC016E29F3A5389C2FB4EF6E8" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_EC921825B6E187FFB43B89C2FB4E983C" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_1BDB340CC016E29F3A5389C2FB4EF6E8" xlink:to="loc_us-gaap_AwardTypeAxis_EC921825B6E187FFB43B89C2FB4E983C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_13B044361CC0A74679A689C2FB4EC239_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_EC921825B6E187FFB43B89C2FB4E983C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_13B044361CC0A74679A689C2FB4EC239_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_13B044361CC0A74679A689C2FB4EC239" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_EC921825B6E187FFB43B89C2FB4E983C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_13B044361CC0A74679A689C2FB4EC239" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PerformanceSharesMember" xlink:label="loc_us-gaap_PerformanceSharesMember_E372C2A96CE7D922115489C2FB4E7E09" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_13B044361CC0A74679A689C2FB4EC239" xlink:to="loc_us-gaap_PerformanceSharesMember_E372C2A96CE7D922115489C2FB4E7E09" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_6515571620A4F3A5D7FC89C2FB4FC255" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_1BDB340CC016E29F3A5389C2FB4EF6E8" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_6515571620A4F3A5D7FC89C2FB4FC255" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_F59D5FB2235FFA74CE7B89C2FB4F2E0C_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_6515571620A4F3A5D7FC89C2FB4FC255" xlink:to="loc_us-gaap_SegmentDomain_F59D5FB2235FFA74CE7B89C2FB4F2E0C_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_F59D5FB2235FFA74CE7B89C2FB4F2E0C" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_6515571620A4F3A5D7FC89C2FB4FC255" xlink:to="loc_us-gaap_SegmentDomain_F59D5FB2235FFA74CE7B89C2FB4F2E0C" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_CasinoMember" xlink:label="loc_wynn_CasinoMember_6905AD65E801D5B00AEF89C2FB4F9316" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_F59D5FB2235FFA74CE7B89C2FB4F2E0C" xlink:to="loc_wynn_CasinoMember_6905AD65E801D5B00AEF89C2FB4F9316" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_RoomsMember" xlink:label="loc_wynn_RoomsMember_13586E0A265440E5E52B89C2FB4F8594" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_F59D5FB2235FFA74CE7B89C2FB4F2E0C" xlink:to="loc_wynn_RoomsMember_13586E0A265440E5E52B89C2FB4F8594" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FoodAndBeverageMember" xlink:label="loc_wynn_FoodAndBeverageMember_4C27D12E047686BF7D4E89C2FB4F0E59" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_F59D5FB2235FFA74CE7B89C2FB4F2E0C" xlink:to="loc_wynn_FoodAndBeverageMember_4C27D12E047686BF7D4E89C2FB4F0E59" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_EntertainmentRetailAndOtherMember" xlink:label="loc_wynn_EntertainmentRetailAndOtherMember_F11B712CB841636D82B789C2FB4F6113" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_F59D5FB2235FFA74CE7B89C2FB4F2E0C" xlink:to="loc_wynn_EntertainmentRetailAndOtherMember_F11B712CB841636D82B789C2FB4F6113" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_GeneralAndAdministrativeMember" xlink:label="loc_wynn_GeneralAndAdministrativeMember_089802AC2CD1C60A002E89C2FB4F93FC" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_F59D5FB2235FFA74CE7B89C2FB4F2E0C" xlink:to="loc_wynn_GeneralAndAdministrativeMember_089802AC2CD1C60A002E89C2FB4F93FC" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_PreOpenCostsMember" xlink:label="loc_wynn_PreOpenCostsMember_FF0A7BB145800E24ED6289C2FB4FA368" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_F59D5FB2235FFA74CE7B89C2FB4F2E0C" xlink:to="loc_wynn_PreOpenCostsMember_FF0A7BB145800E24ED6289C2FB4FA368" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_4741F26022B407ECFA3E89C2FB4FC5FC" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_21FD013E9F0B08CD599989C2FB4FA04B" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_4741F26022B407ECFA3E89C2FB4FC5FC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount_7AD672B45012C49588A489C2FB54F7E2" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_21FD013E9F0B08CD599989C2FB4FA04B" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount_7AD672B45012C49588A489C2FB54F7E2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_21CF46177102435F1AB289C2FB54820F" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_21FD013E9F0B08CD599989C2FB4FA04B" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_21CF46177102435F1AB289C2FB54820F" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.wynnresorts.com/role/StockBasedCompensationTables" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/SubsequentEvent" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/SubsequentEventAdditionalInformationDetail" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventLineItems" xlink:label="loc_us-gaap_SubsequentEventLineItems_93EBC50445665AFFA0227E5C7DFD9E13" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTable" xlink:label="loc_us-gaap_SubsequentEventTable_6A95C2473B9359A4A3F2EBD6DD4FCF40" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SubsequentEventLineItems_93EBC50445665AFFA0227E5C7DFD9E13" xlink:to="loc_us-gaap_SubsequentEventTable_6A95C2473B9359A4A3F2EBD6DD4FCF40" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_433D4F074270525891AA3A6F72B68514" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_6A95C2473B9359A4A3F2EBD6DD4FCF40" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_433D4F074270525891AA3A6F72B68514" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_064D7027885EAB157BAD2C07B6E4F947_D1CA0DD772635FA9A0AE336AA5EC572E" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_433D4F074270525891AA3A6F72B68514" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_064D7027885EAB157BAD2C07B6E4F947_D1CA0DD772635FA9A0AE336AA5EC572E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_76AB8E3F246F5E60849A1D9353027779" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_433D4F074270525891AA3A6F72B68514" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_76AB8E3F246F5E60849A1D9353027779" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_29BE2401ECE6582EB5047EBA84ACE3F7" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_76AB8E3F246F5E60849A1D9353027779" xlink:to="loc_us-gaap_SubsequentEventMember_29BE2401ECE6582EB5047EBA84ACE3F7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DividendsPayableAmountPerShare" xlink:label="loc_us-gaap_DividendsPayableAmountPerShare_F09C0AB446B859FAB9672AB77927862A" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_93EBC50445665AFFA0227E5C7DFD9E13" xlink:to="loc_us-gaap_DividendsPayableAmountPerShare_F09C0AB446B859FAB9672AB77927862A" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.wynnresorts.com/role/SummaryOfSignificantAccountingPolicies" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/SummaryOfSignificantAccountingPoliciesAdditionalInformationDetail" xlink:type="extended">
    <loc xlink:href="wynn-20170630.xsd#wynn_SummaryOfSignificantAccountingPoliciesLineItems" xlink:label="loc_wynn_SummaryOfSignificantAccountingPoliciesLineItems_F3D94677FCEF442FF2CE8B77E668756D" xlink:type="locator" />
    <loc xlink:href="wynn-20170630.xsd#wynn_SummaryOfSignificantAccountingPoliciesTable" xlink:label="loc_wynn_SummaryOfSignificantAccountingPoliciesTable_69A3740BACA4536A5D138B77E6664502" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_wynn_SummaryOfSignificantAccountingPoliciesLineItems_F3D94677FCEF442FF2CE8B77E668756D" xlink:to="loc_wynn_SummaryOfSignificantAccountingPoliciesTable_69A3740BACA4536A5D138B77E6664502" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_QuantifyingMisstatementInCurrentYearFinancialStatementsByNatureOfErrorAxis" xlink:label="loc_us-gaap_QuantifyingMisstatementInCurrentYearFinancialStatementsByNatureOfErrorAxis_0B853B274E274950DC438B77E666C4E4" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_SummaryOfSignificantAccountingPoliciesTable_69A3740BACA4536A5D138B77E6664502" xlink:to="loc_us-gaap_QuantifyingMisstatementInCurrentYearFinancialStatementsByNatureOfErrorAxis_0B853B274E274950DC438B77E666C4E4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NatureOfErrorDomain" xlink:label="loc_us-gaap_NatureOfErrorDomain_CED9352705B6844558638B77E666340D_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_QuantifyingMisstatementInCurrentYearFinancialStatementsByNatureOfErrorAxis_0B853B274E274950DC438B77E666C4E4" xlink:to="loc_us-gaap_NatureOfErrorDomain_CED9352705B6844558638B77E666340D_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NatureOfErrorDomain" xlink:label="loc_us-gaap_NatureOfErrorDomain_CED9352705B6844558638B77E666340D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_QuantifyingMisstatementInCurrentYearFinancialStatementsByNatureOfErrorAxis_0B853B274E274950DC438B77E666C4E4" xlink:to="loc_us-gaap_NatureOfErrorDomain_CED9352705B6844558638B77E666340D" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_CapitalizedInterestAdjustment2015Member" xlink:label="loc_wynn_CapitalizedInterestAdjustment2015Member_A7EEF8D214E24306CC718B77E666BE17" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NatureOfErrorDomain_CED9352705B6844558638B77E666340D" xlink:to="loc_wynn_CapitalizedInterestAdjustment2015Member_A7EEF8D214E24306CC718B77E666BE17" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_239871C98816DC37745B8B77E6662057" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_SummaryOfSignificantAccountingPoliciesTable_69A3740BACA4536A5D138B77E6664502" xlink:to="loc_us-gaap_StatementScenarioAxis_239871C98816DC37745B8B77E6662057" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_53C01C281D89E5AD61FA8B77E666DDE1_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementScenarioAxis_239871C98816DC37745B8B77E6662057" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_53C01C281D89E5AD61FA8B77E666DDE1_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_53C01C281D89E5AD61FA8B77E666DDE1" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementScenarioAxis_239871C98816DC37745B8B77E6662057" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_53C01C281D89E5AD61FA8B77E666DDE1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RestatementAdjustmentMember" xlink:label="loc_us-gaap_RestatementAdjustmentMember_61440EEFA50ECD3F3FFF8B77E6677277" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScenarioUnspecifiedDomain_53C01C281D89E5AD61FA8B77E666DDE1" xlink:to="loc_us-gaap_RestatementAdjustmentMember_61440EEFA50ECD3F3FFF8B77E6677277" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_86EC189B09BEBF4325388B77E6672560" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_SummaryOfSignificantAccountingPoliciesTable_69A3740BACA4536A5D138B77E6664502" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_86EC189B09BEBF4325388B77E6672560" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_7F22823E4A2AE593411F8B77E66761AC_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_86EC189B09BEBF4325388B77E6672560" xlink:to="loc_us-gaap_EquityComponentDomain_7F22823E4A2AE593411F8B77E66761AC_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_7F22823E4A2AE593411F8B77E66761AC" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_86EC189B09BEBF4325388B77E6672560" xlink:to="loc_us-gaap_EquityComponentDomain_7F22823E4A2AE593411F8B77E66761AC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:label="loc_us-gaap_RetainedEarningsMember_74020583DAFF35E30EA08B77E6673915" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_7F22823E4A2AE593411F8B77E66761AC" xlink:to="loc_us-gaap_RetainedEarningsMember_74020583DAFF35E30EA08B77E6673915" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_61726902E87BFB7B57DA8B77E667B5DB" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_SummaryOfSignificantAccountingPoliciesTable_69A3740BACA4536A5D138B77E6664502" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_61726902E87BFB7B57DA8B77E667B5DB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_E3B60A7DA2B63F64EE5E8B77E667BFD1_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_61726902E87BFB7B57DA8B77E667B5DB" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_E3B60A7DA2B63F64EE5E8B77E667BFD1_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_E3B60A7DA2B63F64EE5E8B77E667BFD1" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_61726902E87BFB7B57DA8B77E667B5DB" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_E3B60A7DA2B63F64EE5E8B77E667BFD1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NotesPayableOtherPayablesMember" xlink:label="loc_us-gaap_NotesPayableOtherPayablesMember_7F0152EB51B7BBCFB2D18B77E6671731" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_E3B60A7DA2B63F64EE5E8B77E667BFD1" xlink:to="loc_us-gaap_NotesPayableOtherPayablesMember_7F0152EB51B7BBCFB2D18B77E6671731" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_3685F9F5DFAB035363908B77E667F776" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_SummaryOfSignificantAccountingPoliciesTable_69A3740BACA4536A5D138B77E6664502" xlink:to="loc_dei_LegalEntityAxis_3685F9F5DFAB035363908B77E667F776" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_B5B598AEBE513BB4D8998B77E6673B82_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_3685F9F5DFAB035363908B77E667F776" xlink:to="loc_dei_EntityDomain_B5B598AEBE513BB4D8998B77E6673B82_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_B5B598AEBE513BB4D8998B77E6673B82" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_3685F9F5DFAB035363908B77E667F776" xlink:to="loc_dei_EntityDomain_B5B598AEBE513BB4D8998B77E6673B82" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_AruzeUnitedStatesOfAmericaIncMember" xlink:label="loc_wynn_AruzeUnitedStatesOfAmericaIncMember_AE094AFD7E2D4D6D220D8B77E6678A54" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_B5B598AEBE513BB4D8998B77E6673B82" xlink:to="loc_wynn_AruzeUnitedStatesOfAmericaIncMember_AE094AFD7E2D4D6D220D8B77E6678A54" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_2DC9D6F5BB5C0ED2E5A68B77E6671E2B" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_SummaryOfSignificantAccountingPoliciesTable_69A3740BACA4536A5D138B77E6664502" xlink:to="loc_us-gaap_DebtInstrumentAxis_2DC9D6F5BB5C0ED2E5A68B77E6671E2B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_F5CDBAB086B697D07E8D8B77E667DC44_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_2DC9D6F5BB5C0ED2E5A68B77E6671E2B" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_F5CDBAB086B697D07E8D8B77E667DC44_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_F5CDBAB086B697D07E8D8B77E667DC44" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_2DC9D6F5BB5C0ED2E5A68B77E6671E2B" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_F5CDBAB086B697D07E8D8B77E667DC44" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_RedemptionPricePromissoryNoteWithFormerStockholderAndRelatedPartyDueFebruaryEighteenTwoThousandTwentyTwoMember" xlink:label="loc_wynn_RedemptionPricePromissoryNoteWithFormerStockholderAndRelatedPartyDueFebruaryEighteenTwoThousandTwentyTwoMember_13A9D8E5DA8FFA71015C8B77E667400D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_F5CDBAB086B697D07E8D8B77E667DC44" xlink:to="loc_wynn_RedemptionPricePromissoryNoteWithFormerStockholderAndRelatedPartyDueFebruaryEighteenTwoThousandTwentyTwoMember_13A9D8E5DA8FFA71015C8B77E667400D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_1C76737F1AD35C2718F08B77E6670B91" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_SummaryOfSignificantAccountingPoliciesTable_69A3740BACA4536A5D138B77E6664502" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_1C76737F1AD35C2718F08B77E6670B91" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_6BEFFA9F9CD2F49A0E568B77E6674B1F_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_1C76737F1AD35C2718F08B77E6670B91" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_6BEFFA9F9CD2F49A0E568B77E6674B1F_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_6BEFFA9F9CD2F49A0E568B77E6674B1F" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_1C76737F1AD35C2718F08B77E6670B91" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_6BEFFA9F9CD2F49A0E568B77E6674B1F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_284651CDBA4AD90D7AD68B77E668500F" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_6BEFFA9F9CD2F49A0E568B77E6674B1F" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_284651CDBA4AD90D7AD68B77E668500F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_144AF5D8EC4F29099C268B77E668C1E7" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_SummaryOfSignificantAccountingPoliciesLineItems_F3D94677FCEF442FF2CE8B77E668756D" xlink:to="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_144AF5D8EC4F29099C268B77E668C1E7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValue_EB895D5F3B15CA0FECD28B77E66835A9" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_SummaryOfSignificantAccountingPoliciesLineItems_F3D94677FCEF442FF2CE8B77E668756D" xlink:to="loc_us-gaap_CashEquivalentsAtCarryingValue_EB895D5F3B15CA0FECD28B77E66835A9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Cash" xlink:label="loc_us-gaap_Cash_1C6698273A43B2F71BE48B77E668B5A0" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_SummaryOfSignificantAccountingPoliciesLineItems_F3D94677FCEF442FF2CE8B77E668756D" xlink:to="loc_us-gaap_Cash_1C6698273A43B2F71BE48B77E668B5A0" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_PercentageOfCreditMarkersDueFromCustomersResidingOutsideOfUnitedStates" xlink:label="loc_wynn_PercentageOfCreditMarkersDueFromCustomersResidingOutsideOfUnitedStates_1D12E87198C2D510ED778B77E66813D6" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_SummaryOfSignificantAccountingPoliciesLineItems_F3D94677FCEF442FF2CE8B77E668756D" xlink:to="loc_wynn_PercentageOfCreditMarkersDueFromCustomersResidingOutsideOfUnitedStates_1D12E87198C2D510ED778B77E66813D6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_279B579D731CA3A558E48B77E66DAE05" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_SummaryOfSignificantAccountingPoliciesLineItems_F3D94677FCEF442FF2CE8B77E668756D" xlink:to="loc_us-gaap_LongTermDebt_279B579D731CA3A558E48B77E66DAE05" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_GamingTaxExpenses" xlink:label="loc_wynn_GamingTaxExpenses_4FF34FC2244C18A658388B77E66DA849" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_SummaryOfSignificantAccountingPoliciesLineItems_F3D94677FCEF442FF2CE8B77E668756D" xlink:to="loc_wynn_GamingTaxExpenses_4FF34FC2244C18A658388B77E66DA849" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NewAccountingPronouncementOrChangeInAccountingPrincipleCumulativeEffectOfChangeOnEquityOrNetAssets1" xlink:label="loc_us-gaap_NewAccountingPronouncementOrChangeInAccountingPrincipleCumulativeEffectOfChangeOnEquityOrNetAssets1_9D9D685DF249B0CFC38C8B77E66D9CD4" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_SummaryOfSignificantAccountingPoliciesLineItems_F3D94677FCEF442FF2CE8B77E668756D" xlink:to="loc_us-gaap_NewAccountingPronouncementOrChangeInAccountingPrincipleCumulativeEffectOfChangeOnEquityOrNetAssets1_9D9D685DF249B0CFC38C8B77E66D9CD4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InterestCostsCapitalizedAdjustment" xlink:label="loc_us-gaap_InterestCostsCapitalizedAdjustment_83AEC6482D93819DE6CD8B77E66D2360" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_SummaryOfSignificantAccountingPoliciesLineItems_F3D94677FCEF442FF2CE8B77E668756D" xlink:to="loc_us-gaap_InterestCostsCapitalizedAdjustment_83AEC6482D93819DE6CD8B77E66D2360" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_0518A9E668765EB06D598B77E66D0D92" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_SummaryOfSignificantAccountingPoliciesLineItems_F3D94677FCEF442FF2CE8B77E668756D" xlink:to="loc_us-gaap_InterestExpense_0518A9E668765EB06D598B77E66D0D92" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_79D1B6A97BFC0D45267E8B77E66DFDEE" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_SummaryOfSignificantAccountingPoliciesLineItems_F3D94677FCEF442FF2CE8B77E668756D" xlink:to="loc_us-gaap_NetIncomeLoss_79D1B6A97BFC0D45267E8B77E66DFDEE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_764240D560D05E2FB1E48B77E66D24F9" xlink:type="locator" />
    <definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_SummaryOfSignificantAccountingPoliciesLineItems_F3D94677FCEF442FF2CE8B77E668756D" xlink:to="loc_us-gaap_EarningsPerShareBasic_764240D560D05E2FB1E48B77E66D24F9" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.wynnresorts.com/role/SummaryOfSignificantAccountingPoliciesEstimatedCostOfPromotionalAllowancesDetail" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductInformationLineItems" xlink:label="loc_us-gaap_ProductInformationLineItems_208945C4D51EF1FF14978A5E95E6B7DF" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfProductInformationTable" xlink:label="loc_us-gaap_ScheduleOfProductInformationTable_2108F2E4D5C61A1CFB7C8A5E95E6704D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ProductInformationLineItems_208945C4D51EF1FF14978A5E95E6B7DF" xlink:to="loc_us-gaap_ScheduleOfProductInformationTable_2108F2E4D5C61A1CFB7C8A5E95E6704D" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="loc_us-gaap_ProductOrServiceAxis_828A084CCE3C331FF5998A5E95E6E959" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfProductInformationTable_2108F2E4D5C61A1CFB7C8A5E95E6704D" xlink:to="loc_us-gaap_ProductOrServiceAxis_828A084CCE3C331FF5998A5E95E6E959" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_A5021E963DE645397B808A5E95E621AD_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ProductOrServiceAxis_828A084CCE3C331FF5998A5E95E6E959" xlink:to="loc_us-gaap_ProductsAndServicesDomain_A5021E963DE645397B808A5E95E621AD_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_A5021E963DE645397B808A5E95E621AD" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ProductOrServiceAxis_828A084CCE3C331FF5998A5E95E6E959" xlink:to="loc_us-gaap_ProductsAndServicesDomain_A5021E963DE645397B808A5E95E621AD" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_RoomsMember" xlink:label="loc_wynn_RoomsMember_357642D7A3E8930D6CB88A5E95E6B78B" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_A5021E963DE645397B808A5E95E621AD" xlink:to="loc_wynn_RoomsMember_357642D7A3E8930D6CB88A5E95E6B78B" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FoodAndBeverageMember" xlink:label="loc_wynn_FoodAndBeverageMember_2EF7D93B3F35AABCC08B8A5E95E6E393" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_A5021E963DE645397B808A5E95E621AD" xlink:to="loc_wynn_FoodAndBeverageMember_2EF7D93B3F35AABCC08B8A5E95E6E393" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_EntertainmentRetailAndOtherMember" xlink:label="loc_wynn_EntertainmentRetailAndOtherMember_55DBCB94AAB183A382628A5E95E67CCF" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_A5021E963DE645397B808A5E95E621AD" xlink:to="loc_wynn_EntertainmentRetailAndOtherMember_55DBCB94AAB183A382628A5E95E67CCF" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_CostsofPromotionalAllowances" xlink:label="loc_wynn_CostsofPromotionalAllowances_A2BB8A70DDA6E9C7F9418A5E95E613D2" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductInformationLineItems_208945C4D51EF1FF14978A5E95E6B7DF" xlink:to="loc_wynn_CostsofPromotionalAllowances_A2BB8A70DDA6E9C7F9418A5E95E613D2" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.wynnresorts.com/role/SummaryOfSignificantAccountingPoliciesEstimatedRetailValueOfPromotionalAllowancesDetail" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductInformationLineItems" xlink:label="loc_us-gaap_ProductInformationLineItems_1D8992099BCE2EF6C3928A5E04C144B6" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfProductInformationTable" xlink:label="loc_us-gaap_ScheduleOfProductInformationTable_2E4B823CD6D4F590D0378A5E04BF9F10" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ProductInformationLineItems_1D8992099BCE2EF6C3928A5E04C144B6" xlink:to="loc_us-gaap_ScheduleOfProductInformationTable_2E4B823CD6D4F590D0378A5E04BF9F10" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="loc_us-gaap_ProductOrServiceAxis_32E08ED859062079907B8A5E04C0EC60" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfProductInformationTable_2E4B823CD6D4F590D0378A5E04BF9F10" xlink:to="loc_us-gaap_ProductOrServiceAxis_32E08ED859062079907B8A5E04C0EC60" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_C3CFF05D5F62DEDC50698A5E04C129D2_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ProductOrServiceAxis_32E08ED859062079907B8A5E04C0EC60" xlink:to="loc_us-gaap_ProductsAndServicesDomain_C3CFF05D5F62DEDC50698A5E04C129D2_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_C3CFF05D5F62DEDC50698A5E04C129D2" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ProductOrServiceAxis_32E08ED859062079907B8A5E04C0EC60" xlink:to="loc_us-gaap_ProductsAndServicesDomain_C3CFF05D5F62DEDC50698A5E04C129D2" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_RoomsMember" xlink:label="loc_wynn_RoomsMember_1AA0075422BF0FD0772F8A5E04C1F797" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_C3CFF05D5F62DEDC50698A5E04C129D2" xlink:to="loc_wynn_RoomsMember_1AA0075422BF0FD0772F8A5E04C1F797" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_FoodAndBeverageMember" xlink:label="loc_wynn_FoodAndBeverageMember_61B64411064DFC166F568A5E04C146A8" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_C3CFF05D5F62DEDC50698A5E04C129D2" xlink:to="loc_wynn_FoodAndBeverageMember_61B64411064DFC166F568A5E04C146A8" xlink:type="arc" />
    <loc xlink:href="wynn-20170630.xsd#wynn_EntertainmentRetailAndOtherMember" xlink:label="loc_wynn_EntertainmentRetailAndOtherMember_A38CDED9C438059423FB8A5E04C18835" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_C3CFF05D5F62DEDC50698A5E04C129D2" xlink:to="loc_wynn_EntertainmentRetailAndOtherMember_A38CDED9C438059423FB8A5E04C18835" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PromotionalAllowances" xlink:label="loc_us-gaap_PromotionalAllowances_E3024F37E4B11654E0CA8A5E04C1367A" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductInformationLineItems_1D8992099BCE2EF6C3928A5E04C144B6" xlink:to="loc_us-gaap_PromotionalAllowances_E3024F37E4B11654E0CA8A5E04C1367A" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.wynnresorts.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:type="extended" />
  <definitionLink xlink:role="http://www.wynnresorts.com/role/SummaryOfSignificantAccountingPoliciesScheduleOfAssetsAndLiabilitiesCarriedAtFairValueDetail" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_680E97883D7404B76DC68B77E6319A35" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_18AB70613861184982578B77E630C58C" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_680E97883D7404B76DC68B77E6319A35" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_18AB70613861184982578B77E630C58C" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_D8296FA1471BF6E8286D8B77E630B615" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_18AB70613861184982578B77E630C58C" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_D8296FA1471BF6E8286D8B77E630B615" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_3BA3BDED8F97030F2EE28B77E630542F_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_D8296FA1471BF6E8286D8B77E630B615" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_3BA3BDED8F97030F2EE28B77E630542F_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_3BA3BDED8F97030F2EE28B77E630542F" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_D8296FA1471BF6E8286D8B77E630B615" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_3BA3BDED8F97030F2EE28B77E630542F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_3591CC7B70F36B7694FF8B77E631893D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_3BA3BDED8F97030F2EE28B77E630542F" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_3591CC7B70F36B7694FF8B77E631893D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_803A937D2220BA10F0BB8B77E6319A65" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_18AB70613861184982578B77E630C58C" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_803A937D2220BA10F0BB8B77E6319A65" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2E1BBA83DBC19A559F7B8B77E6314F32_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_803A937D2220BA10F0BB8B77E6319A65" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2E1BBA83DBC19A559F7B8B77E6314F32_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2E1BBA83DBC19A559F7B8B77E6314F32" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_803A937D2220BA10F0BB8B77E6319A65" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2E1BBA83DBC19A559F7B8B77E6314F32" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_438B7148C8611DDAB1FE8B77E6315299" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2E1BBA83DBC19A559F7B8B77E6314F32" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_438B7148C8611DDAB1FE8B77E6315299" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_F4A80A3A02812FFECF7D8B77E631818B" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2E1BBA83DBC19A559F7B8B77E6314F32" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_F4A80A3A02812FFECF7D8B77E631818B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_6FD8B85204051A31198F8B77E63182AF" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2E1BBA83DBC19A559F7B8B77E6314F32" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_6FD8B85204051A31198F8B77E63182AF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AssetsFairValueDisclosureAbstract" xlink:label="loc_us-gaap_AssetsFairValueDisclosureAbstract_421D388C94328026D8D08B77E6318701" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_680E97883D7404B76DC68B77E6319A35" xlink:to="loc_us-gaap_AssetsFairValueDisclosureAbstract_421D388C94328026D8D08B77E6318701" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValue_61DA7E9CB86B8F18B9698B77E63196D0" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_421D388C94328026D8D08B77E6318701" xlink:to="loc_us-gaap_CashEquivalentsAtCarryingValue_61DA7E9CB86B8F18B9698B77E63196D0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecurities_2A0867FC520BCCB452E08B77E6316D31" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_421D388C94328026D8D08B77E6318701" xlink:to="loc_us-gaap_AvailableForSaleSecurities_2A0867FC520BCCB452E08B77E6316D31" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_97D59059BBAB28C62CFF8B77E6315128" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_421D388C94328026D8D08B77E6318701" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_97D59059BBAB28C62CFF8B77E6315128" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InterestRateDerivativeAssetsAtFairValue" xlink:label="loc_us-gaap_InterestRateDerivativeAssetsAtFairValue_D3FDAB5A5651D0B548628B77E6316647" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_421D388C94328026D8D08B77E6318701" xlink:to="loc_us-gaap_InterestRateDerivativeAssetsAtFairValue_D3FDAB5A5651D0B548628B77E6316647" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosureAbstract" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_987ADF0DB39238CF6D598B77E63181FA" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_680E97883D7404B76DC68B77E6319A35" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_987ADF0DB39238CF6D598B77E63181FA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentFairValue" xlink:label="loc_us-gaap_DebtInstrumentFairValue_97DD150D2538D440D19F8B77E63195C6" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_987ADF0DB39238CF6D598B77E63181FA" xlink:to="loc_us-gaap_DebtInstrumentFairValue_97DD150D2538D440D19F8B77E63195C6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InterestRateDerivativeLiabilitiesAtFairValue" xlink:label="loc_us-gaap_InterestRateDerivativeLiabilitiesAtFairValue_BF6863FB5BF74F1647AD8B77E631772D" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_987ADF0DB39238CF6D598B77E63181FA" xlink:to="loc_us-gaap_InterestRateDerivativeLiabilitiesAtFairValue_BF6863FB5BF74F1647AD8B77E631772D" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.wynnresorts.com/role/SummaryOfSignificantAccountingPoliciesTables" xlink:type="extended" />
</linkbase>
