<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:98e26e5a-99c2-4f98-8b8a-334fdc8e0ed7,g:2ba2c89e-c68f-4e2e-ad84-ce3ae39f1a3d-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsofOperationsunaudited" xlink:type="simple" xlink:href="wynn-20220930.xsd#CondensedConsolidatedStatementsofOperationsunaudited"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsofOperationsunaudited" xlink:type="extended" id="i50b3a7f167504fb79f39ef412389e2f3_CondensedConsolidatedStatementsofOperationsunaudited">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_07cb718d-4cf8-42ec-838a-78dcb1d44bca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_f162d880-3bdf-4483-9c53-591e70b6b8b6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_07cb718d-4cf8-42ec-838a-78dcb1d44bca" xlink:to="loc_us-gaap_RevenuesAbstract_f162d880-3bdf-4483-9c53-591e70b6b8b6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_ea2c4751-b117-46c0-be16-74ee505e673e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_f162d880-3bdf-4483-9c53-591e70b6b8b6" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_ea2c4751-b117-46c0-be16-74ee505e673e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpensesAbstract_f1c12a1f-b1bc-45cf-a6f1-2af82145246f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostsAndExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_07cb718d-4cf8-42ec-838a-78dcb1d44bca" xlink:to="loc_us-gaap_CostsAndExpensesAbstract_f1c12a1f-b1bc-45cf-a6f1-2af82145246f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_d15af0ce-1e63-4eb8-bbd7-1a29f70333a2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_f1c12a1f-b1bc-45cf-a6f1-2af82145246f" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_d15af0ce-1e63-4eb8-bbd7-1a29f70333a2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_085dc33d-03f2-4604-b43c-ac68a352f31e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_f1c12a1f-b1bc-45cf-a6f1-2af82145246f" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_085dc33d-03f2-4604-b43c-ac68a352f31e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_593646b1-8363-42ce-97ff-2ad4d2838e3d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProvisionForDoubtfulAccounts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_f1c12a1f-b1bc-45cf-a6f1-2af82145246f" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_593646b1-8363-42ce-97ff-2ad4d2838e3d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreOpeningCosts_dc951cef-22c9-4dbb-a392-7da95e405baa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreOpeningCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_f1c12a1f-b1bc-45cf-a6f1-2af82145246f" xlink:to="loc_us-gaap_PreOpeningCosts_dc951cef-22c9-4dbb-a392-7da95e405baa" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAndAmortization_8bfd0593-c35e-486c-b8f5-a2f2468afa08" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_f1c12a1f-b1bc-45cf-a6f1-2af82145246f" xlink:to="loc_us-gaap_DepreciationAndAmortization_8bfd0593-c35e-486c-b8f5-a2f2468afa08" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_ProjectAbandonmentCosts_cdd392b6-83f7-4451-afa7-0868c482942c" xlink:href="wynn-20220930.xsd#wynn_ProjectAbandonmentCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_f1c12a1f-b1bc-45cf-a6f1-2af82145246f" xlink:to="loc_wynn_ProjectAbandonmentCosts_cdd392b6-83f7-4451-afa7-0868c482942c" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_f2a6b6c9-7e62-4238-affa-a29d5d8a1b5b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostsAndExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_f1c12a1f-b1bc-45cf-a6f1-2af82145246f" xlink:to="loc_us-gaap_CostsAndExpenses_f2a6b6c9-7e62-4238-affa-a29d5d8a1b5b" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_975505b0-cc5b-4496-b538-3d3201136151" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_07cb718d-4cf8-42ec-838a-78dcb1d44bca" xlink:to="loc_us-gaap_OperatingIncomeLoss_975505b0-cc5b-4496-b538-3d3201136151" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_00564139-5f2d-43f0-b4ff-9693b32bfbb1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonoperatingIncomeExpenseAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_07cb718d-4cf8-42ec-838a-78dcb1d44bca" xlink:to="loc_us-gaap_NonoperatingIncomeExpenseAbstract_00564139-5f2d-43f0-b4ff-9693b32bfbb1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_97ce35e0-4d48-433d-a700-fd7a2d396b27" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_00564139-5f2d-43f0-b4ff-9693b32bfbb1" xlink:to="loc_us-gaap_InvestmentIncomeInterest_97ce35e0-4d48-433d-a700-fd7a2d396b27" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_f0db0d72-079c-4653-8a7d-1f44c8ce1f16" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_00564139-5f2d-43f0-b4ff-9693b32bfbb1" xlink:to="loc_us-gaap_InterestExpense_f0db0d72-079c-4653-8a7d-1f44c8ce1f16" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_92776472-b660-43e5-8504-3b255fc79e19" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_00564139-5f2d-43f0-b4ff-9693b32bfbb1" xlink:to="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_92776472-b660-43e5-8504-3b255fc79e19" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_25ad246e-28eb-4323-a44f-e15bcd350a65" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_00564139-5f2d-43f0-b4ff-9693b32bfbb1" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_25ad246e-28eb-4323-a44f-e15bcd350a65" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_c2da02e4-5bba-4f24-9925-65c0c8a2cbd5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_00564139-5f2d-43f0-b4ff-9693b32bfbb1" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_c2da02e4-5bba-4f24-9925-65c0c8a2cbd5" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_f5f369a8-3e7e-499a-bd37-3962182aaaa3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_00564139-5f2d-43f0-b4ff-9693b32bfbb1" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_f5f369a8-3e7e-499a-bd37-3962182aaaa3" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_ac97e7d8-4d82-47dc-9f08-5e6ec0354c1f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_07cb718d-4cf8-42ec-838a-78dcb1d44bca" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_ac97e7d8-4d82-47dc-9f08-5e6ec0354c1f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_b947106d-9541-4934-843f-788c36d47ae4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_07cb718d-4cf8-42ec-838a-78dcb1d44bca" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_b947106d-9541-4934-843f-788c36d47ae4" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_096ec136-0b70-437d-b3a8-4e8619183dca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_07cb718d-4cf8-42ec-838a-78dcb1d44bca" xlink:to="loc_us-gaap_ProfitLoss_096ec136-0b70-437d-b3a8-4e8619183dca" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_a73ea6c8-ae7a-4c96-99ca-7ebe57d08328" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_07cb718d-4cf8-42ec-838a-78dcb1d44bca" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_a73ea6c8-ae7a-4c96-99ca-7ebe57d08328" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_6f02d84e-a84c-4f65-857a-896c376f7bc6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_07cb718d-4cf8-42ec-838a-78dcb1d44bca" xlink:to="loc_us-gaap_NetIncomeLoss_6f02d84e-a84c-4f65-857a-896c376f7bc6" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_4ef390c6-a241-4b27-930a-b058bd6bb55e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareBasicAndDilutedAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_07cb718d-4cf8-42ec-838a-78dcb1d44bca" xlink:to="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_4ef390c6-a241-4b27-930a-b058bd6bb55e" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_cd198073-b443-46fb-8592-a1812ac902f2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_4ef390c6-a241-4b27-930a-b058bd6bb55e" xlink:to="loc_us-gaap_EarningsPerShareAbstract_cd198073-b443-46fb-8592-a1812ac902f2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_dd54e5fa-dbc2-41ac-9b3e-a4c3c2b9cec7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_cd198073-b443-46fb-8592-a1812ac902f2" xlink:to="loc_us-gaap_EarningsPerShareBasic_dd54e5fa-dbc2-41ac-9b3e-a4c3c2b9cec7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_584d0513-a581-4979-802c-52ba5d40f2a3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_cd198073-b443-46fb-8592-a1812ac902f2" xlink:to="loc_us-gaap_EarningsPerShareDiluted_584d0513-a581-4979-802c-52ba5d40f2a3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_268d2b97-248b-48ae-b051-1da94401a950" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_07cb718d-4cf8-42ec-838a-78dcb1d44bca" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_268d2b97-248b-48ae-b051-1da94401a950" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_6c74609e-e495-4542-8dce-77a9a86adf78" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_268d2b97-248b-48ae-b051-1da94401a950" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_6c74609e-e495-4542-8dce-77a9a86adf78" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_b2d66037-bd29-4424-a3b5-cda46c16f357" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_268d2b97-248b-48ae-b051-1da94401a950" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_b2d66037-bd29-4424-a3b5-cda46c16f357" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_e3835162-17a3-4bb3-8cb0-8d81224b4b0e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_07cb718d-4cf8-42ec-838a-78dcb1d44bca" xlink:to="loc_us-gaap_StatementTable_e3835162-17a3-4bb3-8cb0-8d81224b4b0e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_45138e58-0329-492c-b2a0-dbaf8613e057" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_e3835162-17a3-4bb3-8cb0-8d81224b4b0e" xlink:to="loc_srt_ProductOrServiceAxis_45138e58-0329-492c-b2a0-dbaf8613e057" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_45138e58-0329-492c-b2a0-dbaf8613e057_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_45138e58-0329-492c-b2a0-dbaf8613e057" xlink:to="loc_srt_ProductsAndServicesDomain_45138e58-0329-492c-b2a0-dbaf8613e057_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_00540334-09dc-4535-af0d-320a82aabdf5" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_45138e58-0329-492c-b2a0-dbaf8613e057" xlink:to="loc_srt_ProductsAndServicesDomain_00540334-09dc-4535-af0d-320a82aabdf5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CasinoMember_dc8c06d6-f6a3-44a3-8d13-6436561698bc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CasinoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_00540334-09dc-4535-af0d-320a82aabdf5" xlink:to="loc_us-gaap_CasinoMember_dc8c06d6-f6a3-44a3-8d13-6436561698bc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OccupancyMember_79ae5bd0-5f93-4e73-adf2-9edaf667c008" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OccupancyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_00540334-09dc-4535-af0d-320a82aabdf5" xlink:to="loc_us-gaap_OccupancyMember_79ae5bd0-5f93-4e73-adf2-9edaf667c008" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FoodAndBeverageMember_8e51e71e-bd3b-4f94-89ec-5333e225bada" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FoodAndBeverageMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_00540334-09dc-4535-af0d-320a82aabdf5" xlink:to="loc_us-gaap_FoodAndBeverageMember_8e51e71e-bd3b-4f94-89ec-5333e225bada" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EntertainmentRetailAndOtherMember_8f589158-8af1-4d84-978d-4764950568db" xlink:href="wynn-20220930.xsd#wynn_EntertainmentRetailAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_00540334-09dc-4535-af0d-320a82aabdf5" xlink:to="loc_wynn_EntertainmentRetailAndOtherMember_8f589158-8af1-4d84-978d-4764950568db" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementofStockholdersDeficitunaudited" xlink:type="simple" xlink:href="wynn-20220930.xsd#CondensedConsolidatedStatementofStockholdersDeficitunaudited"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedStatementofStockholdersDeficitunaudited" xlink:type="extended" id="i79c465822aec4a478195bc0a641b6d27_CondensedConsolidatedStatementofStockholdersDeficitunaudited">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_b1aab8d5-3ac5-4140-8d2a-2bd54d801757" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1ad68573-e9fc-4dbc-b8a2-d4ae1b835c5d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b1aab8d5-3ac5-4140-8d2a-2bd54d801757" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1ad68573-e9fc-4dbc-b8a2-d4ae1b835c5d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_35ad431a-8ae1-497d-b9d8-8eb434eab430" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1ad68573-e9fc-4dbc-b8a2-d4ae1b835c5d" xlink:to="loc_us-gaap_SharesOutstanding_35ad431a-8ae1-497d-b9d8-8eb434eab430" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_fc0f94ce-003e-4e6a-854a-dd501451bfb4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1ad68573-e9fc-4dbc-b8a2-d4ae1b835c5d" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_fc0f94ce-003e-4e6a-854a-dd501451bfb4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_809808f2-47a5-4588-be70-7f7864bd0d45" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1ad68573-e9fc-4dbc-b8a2-d4ae1b835c5d" xlink:to="loc_us-gaap_ProfitLoss_809808f2-47a5-4588-be70-7f7864bd0d45" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_5285c1fb-6f48-456b-a5ce-475870e65efa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1ad68573-e9fc-4dbc-b8a2-d4ae1b835c5d" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_5285c1fb-6f48-456b-a5ce-475870e65efa" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_70a239f4-85bb-45a8-917a-740fae22a70c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1ad68573-e9fc-4dbc-b8a2-d4ae1b835c5d" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_70a239f4-85bb-45a8-917a-740fae22a70c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_ed9198ce-1f1f-4415-9831-1fb7e9ffbaea" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1ad68573-e9fc-4dbc-b8a2-d4ae1b835c5d" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_ed9198ce-1f1f-4415-9831-1fb7e9ffbaea" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_6dbc779c-da62-4a8a-b3e3-d66ba53a8b0a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1ad68573-e9fc-4dbc-b8a2-d4ae1b835c5d" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_6dbc779c-da62-4a8a-b3e3-d66ba53a8b0a" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures_db21ddf8-9091-4912-9b6f-6a0812720d3c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1ad68573-e9fc-4dbc-b8a2-d4ae1b835c5d" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures_db21ddf8-9091-4912-9b6f-6a0812720d3c" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited_dcc06360-b79e-4b40-91a4-e1d05f603395" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1ad68573-e9fc-4dbc-b8a2-d4ae1b835c5d" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited_dcc06360-b79e-4b40-91a4-e1d05f603395" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardForfeitures_1588bb7f-5b8b-4642-863c-ee3795906f58" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardForfeitures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1ad68573-e9fc-4dbc-b8a2-d4ae1b835c5d" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardForfeitures_1588bb7f-5b8b-4642-863c-ee3795906f58" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_554604c9-e338-43d3-8841-93ee1e334ced" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockSharesAcquired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1ad68573-e9fc-4dbc-b8a2-d4ae1b835c5d" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_554604c9-e338-43d3-8841-93ee1e334ced" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_30941fb2-9c6f-4d5d-9ad9-9ff03a7be4a9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1ad68573-e9fc-4dbc-b8a2-d4ae1b835c5d" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_30941fb2-9c6f-4d5d-9ad9-9ff03a7be4a9" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_7e50f5cd-ca9f-4e88-b48d-b39052566c10" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1ad68573-e9fc-4dbc-b8a2-d4ae1b835c5d" xlink:to="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_7e50f5cd-ca9f-4e88-b48d-b39052566c10" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestIncreaseFromSubsidiaryEquityIssuance_5710f59c-433b-4097-b942-dbf1045a6458" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoncontrollingInterestIncreaseFromSubsidiaryEquityIssuance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1ad68573-e9fc-4dbc-b8a2-d4ae1b835c5d" xlink:to="loc_us-gaap_NoncontrollingInterestIncreaseFromSubsidiaryEquityIssuance_5710f59c-433b-4097-b942-dbf1045a6458" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_AdditionalPaidInCapitalSubsidiaryStockIssuedDuringPeriodValueNewIssues_85cc14c0-2570-4bf7-a789-a3cf9d4ca5bf" xlink:href="wynn-20220930.xsd#wynn_AdditionalPaidInCapitalSubsidiaryStockIssuedDuringPeriodValueNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1ad68573-e9fc-4dbc-b8a2-d4ae1b835c5d" xlink:to="loc_wynn_AdditionalPaidInCapitalSubsidiaryStockIssuedDuringPeriodValueNewIssues_85cc14c0-2570-4bf7-a789-a3cf9d4ca5bf" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_43b49440-8a3c-49a5-8f9c-a3104f103dbd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1ad68573-e9fc-4dbc-b8a2-d4ae1b835c5d" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_43b49440-8a3c-49a5-8f9c-a3104f103dbd" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_133e5482-ffaa-4b56-adc5-c2288fef2397" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_0b104e44-bdbe-4865-a4a8-2dc4e7ae26f4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_c08a4406-e172-4a82-a784-b0e43fe43277" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_b1aab8d5-3ac5-4140-8d2a-2bd54d801757" xlink:to="loc_us-gaap_StatementTable_c08a4406-e172-4a82-a784-b0e43fe43277" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_c54b5718-cd80-4d1c-b664-ef73ce2b3fc1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_c08a4406-e172-4a82-a784-b0e43fe43277" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_c54b5718-cd80-4d1c-b664-ef73ce2b3fc1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_c54b5718-cd80-4d1c-b664-ef73ce2b3fc1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_c54b5718-cd80-4d1c-b664-ef73ce2b3fc1" xlink:to="loc_us-gaap_EquityComponentDomain_c54b5718-cd80-4d1c-b664-ef73ce2b3fc1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_feb6aa1f-ee16-4761-b873-274fbd85c678" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_c54b5718-cd80-4d1c-b664-ef73ce2b3fc1" xlink:to="loc_us-gaap_EquityComponentDomain_feb6aa1f-ee16-4761-b873-274fbd85c678" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ParentMember_a68822c4-c115-4c9f-955c-46ace5a814a2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_feb6aa1f-ee16-4761-b873-274fbd85c678" xlink:to="loc_us-gaap_ParentMember_a68822c4-c115-4c9f-955c-46ace5a814a2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_97eb19ce-4fef-4a1d-8680-09ddae9e33bc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_a68822c4-c115-4c9f-955c-46ace5a814a2" xlink:to="loc_us-gaap_CommonStockMember_97eb19ce-4fef-4a1d-8680-09ddae9e33bc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockMember_0ec89ec2-7b17-4bee-9ca7-bbfba4f38326" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_a68822c4-c115-4c9f-955c-46ace5a814a2" xlink:to="loc_us-gaap_TreasuryStockMember_0ec89ec2-7b17-4bee-9ca7-bbfba4f38326" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_b4c77bcf-639e-4d16-ba7a-9955008dc165" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_a68822c4-c115-4c9f-955c-46ace5a814a2" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_b4c77bcf-639e-4d16-ba7a-9955008dc165" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_8be7154d-0b0a-4c6c-a66e-78b86a61c8c8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_a68822c4-c115-4c9f-955c-46ace5a814a2" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_8be7154d-0b0a-4c6c-a66e-78b86a61c8c8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_be722cbb-fe4e-4065-854c-9e7191db0409" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_a68822c4-c115-4c9f-955c-46ace5a814a2" xlink:to="loc_us-gaap_RetainedEarningsMember_be722cbb-fe4e-4065-854c-9e7191db0409" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestMember_e6546d0f-df56-46fe-bcff-8fd65c8f2f40" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_feb6aa1f-ee16-4761-b873-274fbd85c678" xlink:to="loc_us-gaap_NoncontrollingInterestMember_e6546d0f-df56-46fe-bcff-8fd65c8f2f40" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/OrganizationDetails" xlink:type="simple" xlink:href="wynn-20220930.xsd#OrganizationDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/OrganizationDetails" xlink:type="extended" id="icfd5d1bccefe46c18c0f153544db6d2a_OrganizationDetails">
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_e0d5d996-2111-4e7f-9dc3-2ebd17485ab6" xlink:href="wynn-20220930.xsd#wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_ff05814d-cddd-4ea2-84b3-72525789983f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MinorityInterestOwnershipPercentageByParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_e0d5d996-2111-4e7f-9dc3-2ebd17485ab6" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_ff05814d-cddd-4ea2-84b3-72525789983f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_b7f3ff82-19ba-4f07-8250-c12548d94399" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_e0d5d996-2111-4e7f-9dc3-2ebd17485ab6" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_b7f3ff82-19ba-4f07-8250-c12548d94399" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_10445c45-9645-40ba-b7d7-f64ff1a77c58" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_e0d5d996-2111-4e7f-9dc3-2ebd17485ab6" xlink:to="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_10445c45-9645-40ba-b7d7-f64ff1a77c58" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_PaymentsForUseOfIntangibleAssets_dd49efc1-acf6-456c-b302-8b6a18dce386" xlink:href="wynn-20220930.xsd#wynn_PaymentsForUseOfIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_e0d5d996-2111-4e7f-9dc3-2ebd17485ab6" xlink:to="loc_wynn_PaymentsForUseOfIntangibleAssets_dd49efc1-acf6-456c-b302-8b6a18dce386" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_GamingConcessionExtensionDemandBankGuarantee_6b715392-9e21-401d-acac-055dce466e3f" xlink:href="wynn-20220930.xsd#wynn_GamingConcessionExtensionDemandBankGuarantee"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_e0d5d996-2111-4e7f-9dc3-2ebd17485ab6" xlink:to="loc_wynn_GamingConcessionExtensionDemandBankGuarantee_6b715392-9e21-401d-acac-055dce466e3f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_f5e3043d-8daf-4929-bfb6-ba909ac3ada5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_e0d5d996-2111-4e7f-9dc3-2ebd17485ab6" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_f5e3043d-8daf-4929-bfb6-ba909ac3ada5" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_DebtInstrumentCovenantCompliancePeriod_46fd8288-27f1-439c-b580-39225e02d124" xlink:href="wynn-20220930.xsd#wynn_DebtInstrumentCovenantCompliancePeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_e0d5d996-2111-4e7f-9dc3-2ebd17485ab6" xlink:to="loc_wynn_DebtInstrumentCovenantCompliancePeriod_46fd8288-27f1-439c-b580-39225e02d124" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_NumberOfGamingConcessions_c5305422-dcfa-46b3-a0a9-a2b36ffe9c12" xlink:href="wynn-20220930.xsd#wynn_NumberOfGamingConcessions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_e0d5d996-2111-4e7f-9dc3-2ebd17485ab6" xlink:to="loc_wynn_NumberOfGamingConcessions_c5305422-dcfa-46b3-a0a9-a2b36ffe9c12" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_GamingConcessionsTerm_a42856ac-5404-4aab-9ef4-d437542b4344" xlink:href="wynn-20220930.xsd#wynn_GamingConcessionsTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_e0d5d996-2111-4e7f-9dc3-2ebd17485ab6" xlink:to="loc_wynn_GamingConcessionsTerm_a42856ac-5404-4aab-9ef4-d437542b4344" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_GamingConcessionsExtensionTerm_a0c2dab1-b011-46bb-9d63-3f4bf52f3a5c" xlink:href="wynn-20220930.xsd#wynn_GamingConcessionsExtensionTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_e0d5d996-2111-4e7f-9dc3-2ebd17485ab6" xlink:to="loc_wynn_GamingConcessionsExtensionTerm_a0c2dab1-b011-46bb-9d63-3f4bf52f3a5c" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_GamingConcessionMinimumCapitalRequirement_193363a0-fe83-40e7-a395-f259fe7be1ae" xlink:href="wynn-20220930.xsd#wynn_GamingConcessionMinimumCapitalRequirement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_e0d5d996-2111-4e7f-9dc3-2ebd17485ab6" xlink:to="loc_wynn_GamingConcessionMinimumCapitalRequirement_193363a0-fe83-40e7-a395-f259fe7be1ae" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_ShareCapitalHeldByManagingDirectorPercentage_dfcff8b5-ecb7-4dd6-bb78-965882e64d70" xlink:href="wynn-20220930.xsd#wynn_ShareCapitalHeldByManagingDirectorPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_e0d5d996-2111-4e7f-9dc3-2ebd17485ab6" xlink:to="loc_wynn_ShareCapitalHeldByManagingDirectorPercentage_dfcff8b5-ecb7-4dd6-bb78-965882e64d70" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_98f6c5fc-eb04-46d7-ae60-3f89cf1190ef" xlink:href="wynn-20220930.xsd#wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_e0d5d996-2111-4e7f-9dc3-2ebd17485ab6" xlink:to="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_98f6c5fc-eb04-46d7-ae60-3f89cf1190ef" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipAxis_099d59ca-be60-49f1-90f6-a03348a5d40e" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_OwnershipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_98f6c5fc-eb04-46d7-ae60-3f89cf1190ef" xlink:to="loc_srt_OwnershipAxis_099d59ca-be60-49f1-90f6-a03348a5d40e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_099d59ca-be60-49f1-90f6-a03348a5d40e_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_OwnershipAxis_099d59ca-be60-49f1-90f6-a03348a5d40e" xlink:to="loc_srt_OwnershipDomain_099d59ca-be60-49f1-90f6-a03348a5d40e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_768806e2-943d-4514-912b-3401f16cf989" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_OwnershipAxis_099d59ca-be60-49f1-90f6-a03348a5d40e" xlink:to="loc_srt_OwnershipDomain_768806e2-943d-4514-912b-3401f16cf989" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnPalaceandWynnMacauMember_963baab3-a467-4a9c-9461-0916b1cc0b80" xlink:href="wynn-20220930.xsd#wynn_WynnPalaceandWynnMacauMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_768806e2-943d-4514-912b-3401f16cf989" xlink:to="loc_wynn_WynnPalaceandWynnMacauMember_963baab3-a467-4a9c-9461-0916b1cc0b80" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnLasVegasMember_4a08339f-4f01-4ddf-bbc8-50b29e14a6a7" xlink:href="wynn-20220930.xsd#wynn_WynnLasVegasMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_768806e2-943d-4514-912b-3401f16cf989" xlink:to="loc_wynn_WynnLasVegasMember_4a08339f-4f01-4ddf-bbc8-50b29e14a6a7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailJointVentureMember_47101e73-98f2-4eb7-8e0c-348f281c6edc" xlink:href="wynn-20220930.xsd#wynn_RetailJointVentureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_768806e2-943d-4514-912b-3401f16cf989" xlink:to="loc_wynn_RetailJointVentureMember_47101e73-98f2-4eb7-8e0c-348f281c6edc" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EncoreBostonHarborMember_5b7cf250-ef5e-470d-8162-b1423492ea37" xlink:href="wynn-20220930.xsd#wynn_EncoreBostonHarborMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_768806e2-943d-4514-912b-3401f16cf989" xlink:to="loc_wynn_EncoreBostonHarborMember_5b7cf250-ef5e-470d-8162-b1423492ea37" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnInteractiveLtdMember_d5b74c20-e3f1-452d-9c25-5f255cef5a2a" xlink:href="wynn-20220930.xsd#wynn_WynnInteractiveLtdMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_768806e2-943d-4514-912b-3401f16cf989" xlink:to="loc_wynn_WynnInteractiveLtdMember_d5b74c20-e3f1-452d-9c25-5f255cef5a2a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_55ba4816-6b37-47c1-bd19-a336ae3deb68" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_98f6c5fc-eb04-46d7-ae60-3f89cf1190ef" xlink:to="loc_us-gaap_DebtInstrumentAxis_55ba4816-6b37-47c1-bd19-a336ae3deb68" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_55ba4816-6b37-47c1-bd19-a336ae3deb68_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_55ba4816-6b37-47c1-bd19-a336ae3deb68" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_55ba4816-6b37-47c1-bd19-a336ae3deb68_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_20d27f73-fb1f-49eb-9a2e-00a0804471bb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_55ba4816-6b37-47c1-bd19-a336ae3deb68" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_20d27f73-fb1f-49eb-9a2e-00a0804471bb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_696ed865-c0f1-4062-9493-dde17ef94894" xlink:href="wynn-20220930.xsd#wynn_SeniorRevolvingCreditFacilityDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_20d27f73-fb1f-49eb-9a2e-00a0804471bb" xlink:to="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_696ed865-c0f1-4062-9493-dde17ef94894" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMCaymanIIRevolverDue2025Member_13d8a772-0539-4298-afde-ee89bf163c79" xlink:href="wynn-20220930.xsd#wynn_WMCaymanIIRevolverDue2025Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_20d27f73-fb1f-49eb-9a2e-00a0804471bb" xlink:to="loc_wynn_WMCaymanIIRevolverDue2025Member_13d8a772-0539-4298-afde-ee89bf163c79" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauLimitedSeniorNotesMember_23d15de5-e305-4134-96d1-dc2100221dad" xlink:href="wynn-20220930.xsd#wynn_WynnMacauLimitedSeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_20d27f73-fb1f-49eb-9a2e-00a0804471bb" xlink:to="loc_wynn_WynnMacauLimitedSeniorNotesMember_23d15de5-e305-4134-96d1-dc2100221dad" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_1060c7f1-a27f-49fa-9035-28fa7506f2c4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_98f6c5fc-eb04-46d7-ae60-3f89cf1190ef" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_1060c7f1-a27f-49fa-9035-28fa7506f2c4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_1060c7f1-a27f-49fa-9035-28fa7506f2c4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_1060c7f1-a27f-49fa-9035-28fa7506f2c4" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_1060c7f1-a27f-49fa-9035-28fa7506f2c4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_cf05957b-7b0c-4865-9a88-c94afd680937" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_1060c7f1-a27f-49fa-9035-28fa7506f2c4" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_cf05957b-7b0c-4865-9a88-c94afd680937" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_70fb6eae-4b3d-4724-b86b-ca13b457b077" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_cf05957b-7b0c-4865-9a88-c94afd680937" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_70fb6eae-4b3d-4724-b86b-ca13b457b077" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_589c3b95-cfce-480a-a62a-57888a8dd6c9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_cf05957b-7b0c-4865-9a88-c94afd680937" xlink:to="loc_us-gaap_SeniorNotesMember_589c3b95-cfce-480a-a62a-57888a8dd6c9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_bd91f7a1-8449-4e1f-a062-9e35d8dd9236" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_98f6c5fc-eb04-46d7-ae60-3f89cf1190ef" xlink:to="loc_dei_LegalEntityAxis_bd91f7a1-8449-4e1f-a062-9e35d8dd9236" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_bd91f7a1-8449-4e1f-a062-9e35d8dd9236_default" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_bd91f7a1-8449-4e1f-a062-9e35d8dd9236" xlink:to="loc_dei_EntityDomain_bd91f7a1-8449-4e1f-a062-9e35d8dd9236_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_fbf43644-3469-4d63-a8c7-a4879cc2e012" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_bd91f7a1-8449-4e1f-a062-9e35d8dd9236" xlink:to="loc_dei_EntityDomain_fbf43644-3469-4d63-a8c7-a4879cc2e012" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnResortsFinanceLLCMember_0cabeaa4-32d6-4d09-a07f-029cc4711d9b" xlink:href="wynn-20220930.xsd#wynn_WynnResortsFinanceLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_fbf43644-3469-4d63-a8c7-a4879cc2e012" xlink:to="loc_wynn_WynnResortsFinanceLLCMember_0cabeaa4-32d6-4d09-a07f-029cc4711d9b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMCaymanHoldingsLimitedIIMember_34b899f7-4f14-456f-810d-360b1377e1b5" xlink:href="wynn-20220930.xsd#wynn_WMCaymanHoldingsLimitedIIMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_fbf43644-3469-4d63-a8c7-a4879cc2e012" xlink:to="loc_wynn_WMCaymanHoldingsLimitedIIMember_34b899f7-4f14-456f-810d-360b1377e1b5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauMember_49120b9f-fdd3-494a-b96c-2f7d1780ac83" xlink:href="wynn-20220930.xsd#wynn_WynnMacauMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_fbf43644-3469-4d63-a8c7-a4879cc2e012" xlink:to="loc_wynn_WynnMacauMember_49120b9f-fdd3-494a-b96c-2f7d1780ac83" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_fbc3908d-330e-4c94-ab3a-00fe0fc5c2c6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_98f6c5fc-eb04-46d7-ae60-3f89cf1190ef" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_fbc3908d-330e-4c94-ab3a-00fe0fc5c2c6" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_fbc3908d-330e-4c94-ab3a-00fe0fc5c2c6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_fbc3908d-330e-4c94-ab3a-00fe0fc5c2c6" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_fbc3908d-330e-4c94-ab3a-00fe0fc5c2c6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ff2d2fa0-af8b-49be-9446-d50644d3a6b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_fbc3908d-330e-4c94-ab3a-00fe0fc5c2c6" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ff2d2fa0-af8b-49be-9446-d50644d3a6b4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_MacauGamingConcessionMember_0e283567-95cb-431f-8fc0-d5e9bf73b149" xlink:href="wynn-20220930.xsd#wynn_MacauGamingConcessionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ff2d2fa0-af8b-49be-9446-d50644d3a6b4" xlink:to="loc_wynn_MacauGamingConcessionMember_0e283567-95cb-431f-8fc0-d5e9bf73b149" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/ReceivablesnetDetails" xlink:type="simple" xlink:href="wynn-20220930.xsd#ReceivablesnetDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/ReceivablesnetDetails" xlink:type="extended" id="icdadc63228c04db69c78f087d731da7e_ReceivablesnetDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_915b7247-6cd8-4d1a-a13d-eac107fd2a79" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableGrossCurrent_3ce60c17-b293-4846-b4b3-696516bb4647" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsReceivableGrossCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_915b7247-6cd8-4d1a-a13d-eac107fd2a79" xlink:to="loc_us-gaap_AccountsReceivableGrossCurrent_3ce60c17-b293-4846-b4b3-696516bb4647" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_13b4fd77-0fa4-4650-862f-fc688bb48627" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_915b7247-6cd8-4d1a-a13d-eac107fd2a79" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_13b4fd77-0fa4-4650-862f-fc688bb48627" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_4d60dc96-1704-4b06-b8db-21518bc74364" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_915b7247-6cd8-4d1a-a13d-eac107fd2a79" xlink:to="loc_us-gaap_ReceivablesNetCurrent_4d60dc96-1704-4b06-b8db-21518bc74364" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_744647df-d1cd-4a86-998e-43954d9e2033" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_915b7247-6cd8-4d1a-a13d-eac107fd2a79" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_744647df-d1cd-4a86-998e-43954d9e2033" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_AccountsReceivableAllowanceForCreditLossPercentOfGrossCasinoReceivables_9d3facb1-ff11-4d05-b3eb-c8f75991a7b1" xlink:href="wynn-20220930.xsd#wynn_AccountsReceivableAllowanceForCreditLossPercentOfGrossCasinoReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_915b7247-6cd8-4d1a-a13d-eac107fd2a79" xlink:to="loc_wynn_AccountsReceivableAllowanceForCreditLossPercentOfGrossCasinoReceivables_9d3facb1-ff11-4d05-b3eb-c8f75991a7b1" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_9979a435-2e00-41ae-9440-17d531c931b8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_915b7247-6cd8-4d1a-a13d-eac107fd2a79" xlink:to="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_9979a435-2e00-41ae-9440-17d531c931b8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_eac6d805-91c7-46d7-bde6-1da980286115" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_9979a435-2e00-41ae-9440-17d531c931b8" xlink:to="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_eac6d805-91c7-46d7-bde6-1da980286115" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_eac6d805-91c7-46d7-bde6-1da980286115_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LegalEntityTypeOfCounterpartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_eac6d805-91c7-46d7-bde6-1da980286115" xlink:to="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_eac6d805-91c7-46d7-bde6-1da980286115_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_4c23d745-63e0-4a25-a02c-0db11fee4298" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LegalEntityTypeOfCounterpartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_eac6d805-91c7-46d7-bde6-1da980286115" xlink:to="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_4c23d745-63e0-4a25-a02c-0db11fee4298" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CasinoMember_4e42054a-b3ba-4f25-8a5c-56756609b59b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CasinoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_4c23d745-63e0-4a25-a02c-0db11fee4298" xlink:to="loc_us-gaap_CasinoMember_4e42054a-b3ba-4f25-8a5c-56756609b59b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_HotelMember_5e34c9f0-59c9-4f50-bc1c-16b0d2666017" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_HotelMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_4c23d745-63e0-4a25-a02c-0db11fee4298" xlink:to="loc_srt_HotelMember_5e34c9f0-59c9-4f50-bc1c-16b0d2666017" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailLeasesAndOtherMember_706a737f-4879-4d6d-8d02-19e54848566d" xlink:href="wynn-20220930.xsd#wynn_RetailLeasesAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_4c23d745-63e0-4a25-a02c-0db11fee4298" xlink:to="loc_wynn_RetailLeasesAndOtherMember_706a737f-4879-4d6d-8d02-19e54848566d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_2b5bffed-600e-4d50-9c3a-7bbd67a33b7d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_9979a435-2e00-41ae-9440-17d531c931b8" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_2b5bffed-600e-4d50-9c3a-7bbd67a33b7d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_2b5bffed-600e-4d50-9c3a-7bbd67a33b7d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_2b5bffed-600e-4d50-9c3a-7bbd67a33b7d" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_2b5bffed-600e-4d50-9c3a-7bbd67a33b7d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_a42051f7-501c-437f-982e-f41fe4d6f63e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_2b5bffed-600e-4d50-9c3a-7bbd67a33b7d" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_a42051f7-501c-437f-982e-f41fe4d6f63e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeographicConcentrationRiskMember_8892b371-88c3-463a-b89a-42e53663ee83" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GeographicConcentrationRiskMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_a42051f7-501c-437f-982e-f41fe4d6f63e" xlink:to="loc_us-gaap_GeographicConcentrationRiskMember_8892b371-88c3-463a-b89a-42e53663ee83" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_b7803f8a-1428-4009-ace0-78750457bf4d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_9979a435-2e00-41ae-9440-17d531c931b8" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_b7803f8a-1428-4009-ace0-78750457bf4d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_b7803f8a-1428-4009-ace0-78750457bf4d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_b7803f8a-1428-4009-ace0-78750457bf4d" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_b7803f8a-1428-4009-ace0-78750457bf4d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_3c276617-9972-4e11-833b-8ebadeb7b9ef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_b7803f8a-1428-4009-ace0-78750457bf4d" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_3c276617-9972-4e11-833b-8ebadeb7b9ef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableMember_e04013d0-02ab-44f7-a1c7-c2484dddd820" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsReceivableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_3c276617-9972-4e11-833b-8ebadeb7b9ef" xlink:to="loc_us-gaap_AccountsReceivableMember_e04013d0-02ab-44f7-a1c7-c2484dddd820" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_95bef9a2-9fbd-4df0-96a1-5f8c2d44e84a" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_9979a435-2e00-41ae-9440-17d531c931b8" xlink:to="loc_srt_StatementGeographicalAxis_95bef9a2-9fbd-4df0-96a1-5f8c2d44e84a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_95bef9a2-9fbd-4df0-96a1-5f8c2d44e84a_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_95bef9a2-9fbd-4df0-96a1-5f8c2d44e84a" xlink:to="loc_srt_SegmentGeographicalDomain_95bef9a2-9fbd-4df0-96a1-5f8c2d44e84a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_e8df3bd0-9ecb-4cca-8ac6-fa6ab820d27d" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_95bef9a2-9fbd-4df0-96a1-5f8c2d44e84a" xlink:to="loc_srt_SegmentGeographicalDomain_e8df3bd0-9ecb-4cca-8ac6-fa6ab820d27d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_AsiaMember_5b88b5bc-1cea-44d0-81a3-ba08a047179b" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_AsiaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_e8df3bd0-9ecb-4cca-8ac6-fa6ab820d27d" xlink:to="loc_srt_AsiaMember_5b88b5bc-1cea-44d0-81a3-ba08a047179b" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/PropertyandEquipmentnetNarrativeDetails" xlink:type="simple" xlink:href="wynn-20220930.xsd#PropertyandEquipmentnetNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/PropertyandEquipmentnetNarrativeDetails" xlink:type="extended" id="i21be96ba3df84d7c884ca5389575a2c6_PropertyandEquipmentnetNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_99931f34-297e-4e06-a5ea-1134380fae66" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_6aa1483c-ddf5-4ca8-ba23-1aac121f1498" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Depreciation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_99931f34-297e-4e06-a5ea-1134380fae66" xlink:to="loc_us-gaap_Depreciation_6aa1483c-ddf5-4ca8-ba23-1aac121f1498" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SaleLeasebackTransactionGrossProceeds_cc47da27-fb51-49cb-b991-5f8b1c8f093e" xlink:href="wynn-20220930.xsd#wynn_SaleLeasebackTransactionGrossProceeds"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_99931f34-297e-4e06-a5ea-1134380fae66" xlink:to="loc_wynn_SaleLeasebackTransactionGrossProceeds_cc47da27-fb51-49cb-b991-5f8b1c8f093e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SaleLeasebackTransactionMinimumAnnualRentalPayments_2ef84bbb-8cc9-443b-b6c8-934bb25de0b8" xlink:href="wynn-20220930.xsd#wynn_SaleLeasebackTransactionMinimumAnnualRentalPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_99931f34-297e-4e06-a5ea-1134380fae66" xlink:to="loc_wynn_SaleLeasebackTransactionMinimumAnnualRentalPayments_2ef84bbb-8cc9-443b-b6c8-934bb25de0b8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SaleLeasebackTransactionTerm_5928c51c-073d-473a-892a-26d3fe9b831f" xlink:href="wynn-20220930.xsd#wynn_SaleLeasebackTransactionTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_99931f34-297e-4e06-a5ea-1134380fae66" xlink:to="loc_wynn_SaleLeasebackTransactionTerm_5928c51c-073d-473a-892a-26d3fe9b831f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_9868c879-dba1-4d6f-8f64-dac688bb5a80" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_99931f34-297e-4e06-a5ea-1134380fae66" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_9868c879-dba1-4d6f-8f64-dac688bb5a80" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_5c2c5f8a-0b07-4ee4-a195-f3e20aae7b97" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_StatementScenarioAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_9868c879-dba1-4d6f-8f64-dac688bb5a80" xlink:to="loc_srt_StatementScenarioAxis_5c2c5f8a-0b07-4ee4-a195-f3e20aae7b97" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_5c2c5f8a-0b07-4ee4-a195-f3e20aae7b97_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementScenarioAxis_5c2c5f8a-0b07-4ee4-a195-f3e20aae7b97" xlink:to="loc_srt_ScenarioUnspecifiedDomain_5c2c5f8a-0b07-4ee4-a195-f3e20aae7b97_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_bab3f059-c2ec-46f5-b3e7-99c8bfa61125" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementScenarioAxis_5c2c5f8a-0b07-4ee4-a195-f3e20aae7b97" xlink:to="loc_srt_ScenarioUnspecifiedDomain_bab3f059-c2ec-46f5-b3e7-99c8bfa61125" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioForecastMember_6ce80d36-25db-43bc-b78f-3b1699bd36ba" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScenarioForecastMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ScenarioUnspecifiedDomain_bab3f059-c2ec-46f5-b3e7-99c8bfa61125" xlink:to="loc_srt_ScenarioForecastMember_6ce80d36-25db-43bc-b78f-3b1699bd36ba" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_cafece14-6eca-4133-bb9f-b8f6a6a5be7e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_9868c879-dba1-4d6f-8f64-dac688bb5a80" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_cafece14-6eca-4133-bb9f-b8f6a6a5be7e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_cafece14-6eca-4133-bb9f-b8f6a6a5be7e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_cafece14-6eca-4133-bb9f-b8f6a6a5be7e" xlink:to="loc_us-gaap_SegmentDomain_cafece14-6eca-4133-bb9f-b8f6a6a5be7e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_33d148eb-e6d1-4a82-b7ad-b7f941e6a248" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_cafece14-6eca-4133-bb9f-b8f6a6a5be7e" xlink:to="loc_us-gaap_SegmentDomain_33d148eb-e6d1-4a82-b7ad-b7f941e6a248" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EncoreBostonHarborMember_269759af-c88c-459c-b90c-f4611a7f0b36" xlink:href="wynn-20220930.xsd#wynn_EncoreBostonHarborMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_33d148eb-e6d1-4a82-b7ad-b7f941e6a248" xlink:to="loc_wynn_EncoreBostonHarborMember_269759af-c88c-459c-b90c-f4611a7f0b36" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/GoodwillandIntangibleAssetsnetScheduleofIntangibleAssetsNetDetails" xlink:type="simple" xlink:href="wynn-20220930.xsd#GoodwillandIntangibleAssetsnetScheduleofIntangibleAssetsNetDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/GoodwillandIntangibleAssetsnetScheduleofIntangibleAssetsNetDetails" xlink:type="extended" id="ifb19c0441622483ba272bb108e742347_GoodwillandIntangibleAssetsnetScheduleofIntangibleAssetsNetDetails">
    <link:loc xlink:type="locator" xlink:label="loc_wynn_ScheduleOfIntangibleAssetsLineItems_91c3323f-2531-4868-9fac-2d2e19ef084a" xlink:href="wynn-20220930.xsd#wynn_ScheduleOfIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_8c7aa494-c63c-4a21-abdd-8ce603ed2aea" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_91c3323f-2531-4868-9fac-2d2e19ef084a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_8c7aa494-c63c-4a21-abdd-8ce603ed2aea" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_ac78c98d-b07f-4c12-ad39-043b6ce6e841" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_91c3323f-2531-4868-9fac-2d2e19ef084a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_ac78c98d-b07f-4c12-ad39-043b6ce6e841" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_a7673b72-4aaa-4e7f-b56f-0a8fd4c9443a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_91c3323f-2531-4868-9fac-2d2e19ef084a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_a7673b72-4aaa-4e7f-b56f-0a8fd4c9443a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_a4ead7eb-f856-48a2-b12f-aaa89338bf3c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_91c3323f-2531-4868-9fac-2d2e19ef084a" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_a4ead7eb-f856-48a2-b12f-aaa89338bf3c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillRollForward_a16b6ccb-d99d-49c3-9401-6c341510cbe4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_91c3323f-2531-4868-9fac-2d2e19ef084a" xlink:to="loc_us-gaap_GoodwillRollForward_a16b6ccb-d99d-49c3-9401-6c341510cbe4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_1c8a6cfc-b403-4249-b474-cec3e802dde2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_a16b6ccb-d99d-49c3-9401-6c341510cbe4" xlink:to="loc_us-gaap_Goodwill_1c8a6cfc-b403-4249-b474-cec3e802dde2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_ade6cecd-1596-49d0-9b6a-45fa2f00ddf7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillForeignCurrencyTranslationGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_a16b6ccb-d99d-49c3-9401-6c341510cbe4" xlink:to="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_ade6cecd-1596-49d0-9b6a-45fa2f00ddf7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_40603bba-c6ed-4c5d-9073-1f0995d8dab1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_a16b6ccb-d99d-49c3-9401-6c341510cbe4" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_40603bba-c6ed-4c5d-9073-1f0995d8dab1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_4dca99ba-ea87-4917-88ce-949e004bcbeb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_d93e8a77-77a0-417f-9f7b-b1c2b804e066" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_91c3323f-2531-4868-9fac-2d2e19ef084a" xlink:to="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_d93e8a77-77a0-417f-9f7b-b1c2b804e066" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_ScheduleOfIntangibleAssetsTable_93a4b03d-5993-4c7f-9bc0-9f4ddd3f2780" xlink:href="wynn-20220930.xsd#wynn_ScheduleOfIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_91c3323f-2531-4868-9fac-2d2e19ef084a" xlink:to="loc_wynn_ScheduleOfIntangibleAssetsTable_93a4b03d-5993-4c7f-9bc0-9f4ddd3f2780" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_624305aa-3cdd-4262-bf72-074e2c181b49" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsTable_93a4b03d-5993-4c7f-9bc0-9f4ddd3f2780" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_624305aa-3cdd-4262-bf72-074e2c181b49" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_624305aa-3cdd-4262-bf72-074e2c181b49_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_624305aa-3cdd-4262-bf72-074e2c181b49" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_624305aa-3cdd-4262-bf72-074e2c181b49_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_c9cc034f-253b-4f4b-80f3-03be052c4477" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_624305aa-3cdd-4262-bf72-074e2c181b49" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_c9cc034f-253b-4f4b-80f3-03be052c4477" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_MacauGamingConcessionMember_8f856922-e93a-41b2-a69c-8f54c20b75ef" xlink:href="wynn-20220930.xsd#wynn_MacauGamingConcessionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_c9cc034f-253b-4f4b-80f3-03be052c4477" xlink:to="loc_wynn_MacauGamingConcessionMember_8f856922-e93a-41b2-a69c-8f54c20b75ef" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_MassachusettsGamingLicenseMember_8b96c8fc-dafe-459c-9371-e0a503f05a16" xlink:href="wynn-20220930.xsd#wynn_MassachusettsGamingLicenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_c9cc034f-253b-4f4b-80f3-03be052c4477" xlink:to="loc_wynn_MassachusettsGamingLicenseMember_8b96c8fc-dafe-459c-9371-e0a503f05a16" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIntangibleAssetsMember_87d8adcc-0b95-4925-892a-95cc2ec6b06e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherIntangibleAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_c9cc034f-253b-4f4b-80f3-03be052c4477" xlink:to="loc_us-gaap_OtherIntangibleAssetsMember_87d8adcc-0b95-4925-892a-95cc2ec6b06e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_be5def60-ccb0-461f-a703-86fa50c303c3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsTable_93a4b03d-5993-4c7f-9bc0-9f4ddd3f2780" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_be5def60-ccb0-461f-a703-86fa50c303c3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_be5def60-ccb0-461f-a703-86fa50c303c3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_be5def60-ccb0-461f-a703-86fa50c303c3" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_be5def60-ccb0-461f-a703-86fa50c303c3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_f24473c1-8c8e-4f7f-8a64-36ae94d2401c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_be5def60-ccb0-461f-a703-86fa50c303c3" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_f24473c1-8c8e-4f7f-8a64-36ae94d2401c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WaterRightsAndOtherMember_5d8c19d9-17f2-42e5-9d8d-00729cde2aa6" xlink:href="wynn-20220930.xsd#wynn_WaterRightsAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_f24473c1-8c8e-4f7f-8a64-36ae94d2401c" xlink:to="loc_wynn_WaterRightsAndOtherMember_5d8c19d9-17f2-42e5-9d8d-00729cde2aa6" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/GoodwillandIntangibleAssetsnetNarrativeDetails" xlink:type="simple" xlink:href="wynn-20220930.xsd#GoodwillandIntangibleAssetsnetNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/GoodwillandIntangibleAssetsnetNarrativeDetails" xlink:type="extended" id="ic3c1a198427b41d1806c3aeb157e2fd0_GoodwillandIntangibleAssetsnetNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_wynn_ScheduleOfIntangibleAssetsLineItems_632af100-726a-407d-bf49-8c18188298e1" xlink:href="wynn-20220930.xsd#wynn_ScheduleOfIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_c89e2f5e-292e-4b00-bdb3-b8fa1a7044e0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_632af100-726a-407d-bf49-8c18188298e1" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_c89e2f5e-292e-4b00-bdb3-b8fa1a7044e0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_PaymentsForUseOfIntangibleAssets_ba25c40f-cd56-4b77-844f-b8d3d5312388" xlink:href="wynn-20220930.xsd#wynn_PaymentsForUseOfIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_632af100-726a-407d-bf49-8c18188298e1" xlink:to="loc_wynn_PaymentsForUseOfIntangibleAssets_ba25c40f-cd56-4b77-844f-b8d3d5312388" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_a485b1a9-73b2-476b-958d-d3b5b50f2826" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_632af100-726a-407d-bf49-8c18188298e1" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_a485b1a9-73b2-476b-958d-d3b5b50f2826" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiniteLivedIntangibleAssetExpectedAmortizationYearsOneThroughEleven_04154906-dc8a-43a2-bd1d-6d68ad93f2f5" xlink:href="wynn-20220930.xsd#wynn_FiniteLivedIntangibleAssetExpectedAmortizationYearsOneThroughEleven"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_632af100-726a-407d-bf49-8c18188298e1" xlink:to="loc_wynn_FiniteLivedIntangibleAssetExpectedAmortizationYearsOneThroughEleven_04154906-dc8a-43a2-bd1d-6d68ad93f2f5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiniteLivedIntangibleAssetExpectedAmortizationYearTwelve_9939857e-bbbb-464c-9780-87fce449142f" xlink:href="wynn-20220930.xsd#wynn_FiniteLivedIntangibleAssetExpectedAmortizationYearTwelve"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_632af100-726a-407d-bf49-8c18188298e1" xlink:to="loc_wynn_FiniteLivedIntangibleAssetExpectedAmortizationYearTwelve_9939857e-bbbb-464c-9780-87fce449142f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_06835bed-7ccf-4101-a5f6-3646b3180b91" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsFinitelived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_632af100-726a-407d-bf49-8c18188298e1" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_06835bed-7ccf-4101-a5f6-3646b3180b91" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_8a01d81e-3101-47d9-894d-1c6f747ea017" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_632af100-726a-407d-bf49-8c18188298e1" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_8a01d81e-3101-47d9-894d-1c6f747ea017" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_ScheduleOfIntangibleAssetsTable_a6277ccc-0228-4f08-b709-c6e8833e7367" xlink:href="wynn-20220930.xsd#wynn_ScheduleOfIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_632af100-726a-407d-bf49-8c18188298e1" xlink:to="loc_wynn_ScheduleOfIntangibleAssetsTable_a6277ccc-0228-4f08-b709-c6e8833e7367" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_d9b70911-ec43-48c3-bbf2-de3d0014867c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsTable_a6277ccc-0228-4f08-b709-c6e8833e7367" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_d9b70911-ec43-48c3-bbf2-de3d0014867c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_d9b70911-ec43-48c3-bbf2-de3d0014867c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_d9b70911-ec43-48c3-bbf2-de3d0014867c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_d9b70911-ec43-48c3-bbf2-de3d0014867c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_4ec421fe-b134-43ae-bb1f-a4f7be3b92a6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_d9b70911-ec43-48c3-bbf2-de3d0014867c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_4ec421fe-b134-43ae-bb1f-a4f7be3b92a6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_MacauGamingConcessionMember_5cdca668-7468-473c-a658-d6bd0696f4c3" xlink:href="wynn-20220930.xsd#wynn_MacauGamingConcessionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_4ec421fe-b134-43ae-bb1f-a4f7be3b92a6" xlink:to="loc_wynn_MacauGamingConcessionMember_5cdca668-7468-473c-a658-d6bd0696f4c3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_MassachusettsGamingLicenseMember_c0d48aaa-c972-4f9b-88a7-082181edbeae" xlink:href="wynn-20220930.xsd#wynn_MassachusettsGamingLicenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_4ec421fe-b134-43ae-bb1f-a4f7be3b92a6" xlink:to="loc_wynn_MassachusettsGamingLicenseMember_c0d48aaa-c972-4f9b-88a7-082181edbeae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_1a928375-39b6-4e94-871f-f23c5b86a7d1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsTable_a6277ccc-0228-4f08-b709-c6e8833e7367" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_1a928375-39b6-4e94-871f-f23c5b86a7d1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_1a928375-39b6-4e94-871f-f23c5b86a7d1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_1a928375-39b6-4e94-871f-f23c5b86a7d1" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_1a928375-39b6-4e94-871f-f23c5b86a7d1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ea1e6ed3-4941-40d8-abac-77b25e3fdec6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_1a928375-39b6-4e94-871f-f23c5b86a7d1" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ea1e6ed3-4941-40d8-abac-77b25e3fdec6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_BetbullTransactionMember_e3d64df0-5fd2-410d-8d70-d2fd511d3cb9" xlink:href="wynn-20220930.xsd#wynn_BetbullTransactionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ea1e6ed3-4941-40d8-abac-77b25e3fdec6" xlink:to="loc_wynn_BetbullTransactionMember_e3d64df0-5fd2-410d-8d70-d2fd511d3cb9" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebtSummaryofLongTermDebtDetail" xlink:type="simple" xlink:href="wynn-20220930.xsd#LongTermDebtSummaryofLongTermDebtDetail"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/LongTermDebtSummaryofLongTermDebtDetail" xlink:type="extended" id="ib07f07d919f149b090bd088d5b0af559_LongTermDebtSummaryofLongTermDebtDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_82095ddc-47e1-4a3b-b92c-7a80a4c5061f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_1dade768-7636-4e64-a304-bd49f728060f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_82095ddc-47e1-4a3b-b92c-7a80a4c5061f" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_1dade768-7636-4e64-a304-bd49f728060f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_0378102a-28c2-42e4-95bd-8f6e07ff63ce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_82095ddc-47e1-4a3b-b92c-7a80a4c5061f" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_0378102a-28c2-42e4-95bd-8f6e07ff63ce" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_1e50bc25-4a52-424d-bf59-daa12dfbeed0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_82095ddc-47e1-4a3b-b92c-7a80a4c5061f" xlink:to="loc_us-gaap_LongTermDebt_1e50bc25-4a52-424d-bf59-daa12dfbeed0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_9ab14d99-7543-4a2e-b00d-e07fc6ea9dfa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_82095ddc-47e1-4a3b-b92c-7a80a4c5061f" xlink:to="loc_us-gaap_LongTermDebtCurrent_9ab14d99-7543-4a2e-b00d-e07fc6ea9dfa" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_3cfdb3aa-6c88-46df-b3f5-f9cf0dfac9fd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_82095ddc-47e1-4a3b-b92c-7a80a4c5061f" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_3cfdb3aa-6c88-46df-b3f5-f9cf0dfac9fd" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_8bf22be2-de7b-4272-9daf-c2a094693341" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_82095ddc-47e1-4a3b-b92c-7a80a4c5061f" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_8bf22be2-de7b-4272-9daf-c2a094693341" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_e281224f-2a4d-47c1-b8cb-0d4bc0a0c431" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_82095ddc-47e1-4a3b-b92c-7a80a4c5061f" xlink:to="loc_us-gaap_DebtInstrumentTable_e281224f-2a4d-47c1-b8cb-0d4bc0a0c431" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_e0fe2a20-9fe3-47bd-92fe-1e9874b48b3d" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_e281224f-2a4d-47c1-b8cb-0d4bc0a0c431" xlink:to="loc_dei_LegalEntityAxis_e0fe2a20-9fe3-47bd-92fe-1e9874b48b3d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_e0fe2a20-9fe3-47bd-92fe-1e9874b48b3d_default" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_e0fe2a20-9fe3-47bd-92fe-1e9874b48b3d" xlink:to="loc_dei_EntityDomain_e0fe2a20-9fe3-47bd-92fe-1e9874b48b3d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_a2d7eea6-3561-4b1f-b1db-c4debd28eecb" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_e0fe2a20-9fe3-47bd-92fe-1e9874b48b3d" xlink:to="loc_dei_EntityDomain_a2d7eea6-3561-4b1f-b1db-c4debd28eecb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMCaymanHoldingsLimitedIIMember_d9803619-10d9-4891-b5de-08344b581aa5" xlink:href="wynn-20220930.xsd#wynn_WMCaymanHoldingsLimitedIIMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_a2d7eea6-3561-4b1f-b1db-c4debd28eecb" xlink:to="loc_wynn_WMCaymanHoldingsLimitedIIMember_d9803619-10d9-4891-b5de-08344b581aa5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauLimitedMember_9e67e37e-b322-40fa-9035-d583d8d0ef8a" xlink:href="wynn-20220930.xsd#wynn_WynnMacauLimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_a2d7eea6-3561-4b1f-b1db-c4debd28eecb" xlink:to="loc_wynn_WynnMacauLimitedMember_9e67e37e-b322-40fa-9035-d583d8d0ef8a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnResortsFinanceLLCMember_98632258-3f96-420a-a9bf-81d6f82d1eb1" xlink:href="wynn-20220930.xsd#wynn_WynnResortsFinanceLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_a2d7eea6-3561-4b1f-b1db-c4debd28eecb" xlink:to="loc_wynn_WynnResortsFinanceLLCMember_98632258-3f96-420a-a9bf-81d6f82d1eb1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember_4769066f-20c4-4327-8b1b-fbbdca179231" xlink:href="wynn-20220930.xsd#wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_a2d7eea6-3561-4b1f-b1db-c4debd28eecb" xlink:to="loc_wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember_4769066f-20c4-4327-8b1b-fbbdca179231" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember_c7ca1a02-2e3c-4768-910e-8db8d38d357b" xlink:href="wynn-20220930.xsd#wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_a2d7eea6-3561-4b1f-b1db-c4debd28eecb" xlink:to="loc_wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember_c7ca1a02-2e3c-4768-910e-8db8d38d357b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_c704b479-4f41-4969-b097-a023912473a4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_e281224f-2a4d-47c1-b8cb-0d4bc0a0c431" xlink:to="loc_us-gaap_DebtInstrumentAxis_c704b479-4f41-4969-b097-a023912473a4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_c704b479-4f41-4969-b097-a023912473a4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_c704b479-4f41-4969-b097-a023912473a4" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_c704b479-4f41-4969-b097-a023912473a4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_794aba48-7414-4bf8-940f-11c9fa4bcd96" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_c704b479-4f41-4969-b097-a023912473a4" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_794aba48-7414-4bf8-940f-11c9fa4bcd96" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMCaymanIIRevolverDue2025Member_35a7e456-b835-418e-b7d8-bee0949ca20f" xlink:href="wynn-20220930.xsd#wynn_WMCaymanIIRevolverDue2025Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_794aba48-7414-4bf8-940f-11c9fa4bcd96" xlink:to="loc_wynn_WMCaymanIIRevolverDue2025Member_35a7e456-b835-418e-b7d8-bee0949ca20f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FourandSevenOverEightPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentyFourMember_fb7a18bc-19b8-481e-b53c-13a8f67d470c" xlink:href="wynn-20220930.xsd#wynn_FourandSevenOverEightPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentyFourMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_794aba48-7414-4bf8-940f-11c9fa4bcd96" xlink:to="loc_wynn_FourandSevenOverEightPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentyFourMember_fb7a18bc-19b8-481e-b53c-13a8f67d470c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentySixMember_b0881bc0-cec7-4e0d-a455-d526f36026b1" xlink:href="wynn-20220930.xsd#wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentySixMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_794aba48-7414-4bf8-940f-11c9fa4bcd96" xlink:to="loc_wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentySixMember_b0881bc0-cec7-4e0d-a455-d526f36026b1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentySevenMember_66c583ab-ddee-4c7d-92e1-80cb9c0a9f04" xlink:href="wynn-20220930.xsd#wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentySevenMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_794aba48-7414-4bf8-940f-11c9fa4bcd96" xlink:to="loc_wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentySevenMember_66c583ab-ddee-4c7d-92e1-80cb9c0a9f04" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyNineMember_5a2b4fb9-6565-4b2a-a19f-8da02d9ee7f0" xlink:href="wynn-20220930.xsd#wynn_FiveAndOneOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyNineMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_794aba48-7414-4bf8-940f-11c9fa4bcd96" xlink:to="loc_wynn_FiveAndOneOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyNineMember_5a2b4fb9-6565-4b2a-a19f-8da02d9ee7f0" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndFiveOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyEightMember_be0dfdb9-7c6a-4fda-bb54-26e64976e7cd" xlink:href="wynn-20220930.xsd#wynn_FiveAndFiveOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyEightMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_794aba48-7414-4bf8-940f-11c9fa4bcd96" xlink:to="loc_wynn_FiveAndFiveOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyEightMember_be0dfdb9-7c6a-4fda-bb54-26e64976e7cd" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_08752c1a-dfda-4b82-b667-fc207275787f" xlink:href="wynn-20220930.xsd#wynn_WRFSeniorSecuredCreditFacilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_794aba48-7414-4bf8-940f-11c9fa4bcd96" xlink:to="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_08752c1a-dfda-4b82-b667-fc207275787f" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorTermLoanFacilityDue2024Member_29448559-e579-4741-9d4f-adc1d32c1642" xlink:href="wynn-20220930.xsd#wynn_SeniorTermLoanFacilityDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_08752c1a-dfda-4b82-b667-fc207275787f" xlink:to="loc_wynn_SeniorTermLoanFacilityDue2024Member_29448559-e579-4741-9d4f-adc1d32c1642" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_6e0bdd1f-655a-4b5b-a13d-f420172a84b0" xlink:href="wynn-20220930.xsd#wynn_SeniorRevolvingCreditFacilityDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_08752c1a-dfda-4b82-b667-fc207275787f" xlink:to="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_6e0bdd1f-655a-4b5b-a13d-f420172a84b0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FourAndOneOverFourPercentageWynnLasVegasSeniorNotesDueMayThirtyTwoThousandTwentyThreeMember_de37687b-1a5b-4e2a-9a92-979aa2e0431e" xlink:href="wynn-20220930.xsd#wynn_FourAndOneOverFourPercentageWynnLasVegasSeniorNotesDueMayThirtyTwoThousandTwentyThreeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_794aba48-7414-4bf8-940f-11c9fa4bcd96" xlink:to="loc_wynn_FourAndOneOverFourPercentageWynnLasVegasSeniorNotesDueMayThirtyTwoThousandTwentyThreeMember_de37687b-1a5b-4e2a-9a92-979aa2e0431e" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember_cc115274-1829-4768-8419-dc31abb3dd05" xlink:href="wynn-20220930.xsd#wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_794aba48-7414-4bf8-940f-11c9fa4bcd96" xlink:to="loc_wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember_cc115274-1829-4768-8419-dc31abb3dd05" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverFourPercentageSeniorNotesDueMay152027Member_a2c9f7b3-904f-48ca-9636-b4dbc27be004" xlink:href="wynn-20220930.xsd#wynn_FiveAndOneOverFourPercentageSeniorNotesDueMay152027Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_794aba48-7414-4bf8-940f-11c9fa4bcd96" xlink:to="loc_wynn_FiveAndOneOverFourPercentageSeniorNotesDueMay152027Member_a2c9f7b3-904f-48ca-9636-b4dbc27be004" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverEightPercentageSeniorNotesDue2029Member_e227976b-40ba-4a3e-abbd-363c63df34b9" xlink:href="wynn-20220930.xsd#wynn_FiveAndOneOverEightPercentageSeniorNotesDue2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_794aba48-7414-4bf8-940f-11c9fa4bcd96" xlink:to="loc_wynn_FiveAndOneOverEightPercentageSeniorNotesDue2029Member_e227976b-40ba-4a3e-abbd-363c63df34b9" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SevenAndThreeOverFourPercentageWRFSeniorNotesDue2025Member_dcc06a6b-6441-4cda-a7c8-3f358b3a52bf" xlink:href="wynn-20220930.xsd#wynn_SevenAndThreeOverFourPercentageWRFSeniorNotesDue2025Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_794aba48-7414-4bf8-940f-11c9fa4bcd96" xlink:to="loc_wynn_SevenAndThreeOverFourPercentageWRFSeniorNotesDue2025Member_dcc06a6b-6441-4cda-a7c8-3f358b3a52bf" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailTermLoanAgreementMember_7be51036-97cd-424c-9a9e-d1de91180997" xlink:href="wynn-20220930.xsd#wynn_RetailTermLoanAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_794aba48-7414-4bf8-940f-11c9fa4bcd96" xlink:to="loc_wynn_RetailTermLoanAgreementMember_7be51036-97cd-424c-9a9e-d1de91180997" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_1af74c4d-85ee-46e9-8940-9002644688d9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_e281224f-2a4d-47c1-b8cb-0d4bc0a0c431" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_1af74c4d-85ee-46e9-8940-9002644688d9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_1af74c4d-85ee-46e9-8940-9002644688d9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_1af74c4d-85ee-46e9-8940-9002644688d9" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_1af74c4d-85ee-46e9-8940-9002644688d9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_1d8b5eee-299b-4624-8c35-6cd49ef86c6a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_1af74c4d-85ee-46e9-8940-9002644688d9" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_1d8b5eee-299b-4624-8c35-6cd49ef86c6a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredDebtMember_bb78535f-bb9b-4459-b15c-dbc1259c07fd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuredDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1d8b5eee-299b-4624-8c35-6cd49ef86c6a" xlink:to="loc_us-gaap_SecuredDebtMember_bb78535f-bb9b-4459-b15c-dbc1259c07fd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_57ac63f9-933b-4064-bcc4-07ba83e2d215" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1d8b5eee-299b-4624-8c35-6cd49ef86c6a" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_57ac63f9-933b-4064-bcc4-07ba83e2d215" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_4256658f-cc12-4633-8cb6-f1cf7a04e35a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1d8b5eee-299b-4624-8c35-6cd49ef86c6a" xlink:to="loc_us-gaap_SeniorNotesMember_4256658f-cc12-4633-8cb6-f1cf7a04e35a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MediumTermNotesMember_5c4779a2-9763-4907-a484-08c6384d6a2d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MediumTermNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1d8b5eee-299b-4624-8c35-6cd49ef86c6a" xlink:to="loc_us-gaap_MediumTermNotesMember_5c4779a2-9763-4907-a484-08c6384d6a2d" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebtSummaryofLongTermDebtAdditionalInformationDetail" xlink:type="simple" xlink:href="wynn-20220930.xsd#LongTermDebtSummaryofLongTermDebtAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/LongTermDebtSummaryofLongTermDebtAdditionalInformationDetail" xlink:type="extended" id="i7514fa5d5332476693637daf0d8b8b48_LongTermDebtSummaryofLongTermDebtAdditionalInformationDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_99b2acd1-85af-401d-983f-10881e5c4e93" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_c2353142-8429-475f-950c-5054bd34a01d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_99b2acd1-85af-401d-983f-10881e5c4e93" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_c2353142-8429-475f-950c-5054bd34a01d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_4e8650fe-db35-4493-ba13-08152d389f3e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_99b2acd1-85af-401d-983f-10881e5c4e93" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_4e8650fe-db35-4493-ba13-08152d389f3e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtWeightedAverageInterestRate_f9daeba2-201f-4762-9776-bf72631977c3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtWeightedAverageInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_99b2acd1-85af-401d-983f-10881e5c4e93" xlink:to="loc_us-gaap_DebtWeightedAverageInterestRate_f9daeba2-201f-4762-9776-bf72631977c3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_04db0639-71ac-4436-a690-41480dfb99d1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_99b2acd1-85af-401d-983f-10881e5c4e93" xlink:to="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_04db0639-71ac-4436-a690-41480dfb99d1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LettersOfCreditOutstandingAmount_88cdaf3e-e259-49a4-a3e7-8f55cb8c81b3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LettersOfCreditOutstandingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_99b2acd1-85af-401d-983f-10881e5c4e93" xlink:to="loc_us-gaap_LettersOfCreditOutstandingAmount_88cdaf3e-e259-49a4-a3e7-8f55cb8c81b3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_5d62f27d-088a-4e9c-bdc7-73796dc5e012" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentInterestRateDuringPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_99b2acd1-85af-401d-983f-10881e5c4e93" xlink:to="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_5d62f27d-088a-4e9c-bdc7-73796dc5e012" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_5ed91d23-c409-43a2-8ec2-a0aca7bea78d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_99b2acd1-85af-401d-983f-10881e5c4e93" xlink:to="loc_us-gaap_DebtInstrumentTable_5ed91d23-c409-43a2-8ec2-a0aca7bea78d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_283f8eb4-55c4-41a6-89bd-ff051103ba36" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_VariableRateAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_5ed91d23-c409-43a2-8ec2-a0aca7bea78d" xlink:to="loc_us-gaap_VariableRateAxis_283f8eb4-55c4-41a6-89bd-ff051103ba36" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_283f8eb4-55c4-41a6-89bd-ff051103ba36_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableRateAxis_283f8eb4-55c4-41a6-89bd-ff051103ba36" xlink:to="loc_us-gaap_VariableRateDomain_283f8eb4-55c4-41a6-89bd-ff051103ba36_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_7177b098-ac6f-4d08-8be6-c2c4780bc263" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableRateAxis_283f8eb4-55c4-41a6-89bd-ff051103ba36" xlink:to="loc_us-gaap_VariableRateDomain_7177b098-ac6f-4d08-8be6-c2c4780bc263" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_HIBOROrLIBORMember_b5c4c921-4272-49cc-91f9-837dedca99c3" xlink:href="wynn-20220930.xsd#wynn_HIBOROrLIBORMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_7177b098-ac6f-4d08-8be6-c2c4780bc263" xlink:to="loc_wynn_HIBOROrLIBORMember_b5c4c921-4272-49cc-91f9-837dedca99c3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BaseRateMember_4e6a8bed-3fa6-45fb-b1d5-ca7e5b0b047d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BaseRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_7177b098-ac6f-4d08-8be6-c2c4780bc263" xlink:to="loc_us-gaap_BaseRateMember_4e6a8bed-3fa6-45fb-b1d5-ca7e5b0b047d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_337cba79-05b8-4ac8-8f2e-aec7e6d535c2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LondonInterbankOfferedRateLIBORMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_7177b098-ac6f-4d08-8be6-c2c4780bc263" xlink:to="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_337cba79-05b8-4ac8-8f2e-aec7e6d535c2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_HIBORMember_a81b2cd2-984e-4868-bede-225f6967b5ec" xlink:href="wynn-20220930.xsd#wynn_HIBORMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_7177b098-ac6f-4d08-8be6-c2c4780bc263" xlink:to="loc_wynn_HIBORMember_a81b2cd2-984e-4868-bede-225f6967b5ec" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_60139640-413b-4336-9a9c-c1d391272819" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_5ed91d23-c409-43a2-8ec2-a0aca7bea78d" xlink:to="loc_dei_LegalEntityAxis_60139640-413b-4336-9a9c-c1d391272819" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_60139640-413b-4336-9a9c-c1d391272819_default" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_60139640-413b-4336-9a9c-c1d391272819" xlink:to="loc_dei_EntityDomain_60139640-413b-4336-9a9c-c1d391272819_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_c0230af9-aaa7-405c-9de9-2c2006242d46" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_60139640-413b-4336-9a9c-c1d391272819" xlink:to="loc_dei_EntityDomain_c0230af9-aaa7-405c-9de9-2c2006242d46" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnResortsFinanceLLCMember_81b7d7b0-8b33-4423-9efe-21cf51dd6256" xlink:href="wynn-20220930.xsd#wynn_WynnResortsFinanceLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_c0230af9-aaa7-405c-9de9-2c2006242d46" xlink:to="loc_wynn_WynnResortsFinanceLLCMember_81b7d7b0-8b33-4423-9efe-21cf51dd6256" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember_4b10d125-c79e-4667-b3dc-5ff12bf1f156" xlink:href="wynn-20220930.xsd#wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_c0230af9-aaa7-405c-9de9-2c2006242d46" xlink:to="loc_wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember_4b10d125-c79e-4667-b3dc-5ff12bf1f156" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMCaymanHoldingsLimitedIIMember_b0ec8759-98d6-4918-bccb-427eb6fc7633" xlink:href="wynn-20220930.xsd#wynn_WMCaymanHoldingsLimitedIIMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_c0230af9-aaa7-405c-9de9-2c2006242d46" xlink:to="loc_wynn_WMCaymanHoldingsLimitedIIMember_b0ec8759-98d6-4918-bccb-427eb6fc7633" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_3861e0b7-450d-48cd-8353-c94026227e61" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_5ed91d23-c409-43a2-8ec2-a0aca7bea78d" xlink:to="loc_us-gaap_DebtInstrumentAxis_3861e0b7-450d-48cd-8353-c94026227e61" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_3861e0b7-450d-48cd-8353-c94026227e61_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_3861e0b7-450d-48cd-8353-c94026227e61" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_3861e0b7-450d-48cd-8353-c94026227e61_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_ca7dc7e7-052f-47d6-b971-faa609086930" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_3861e0b7-450d-48cd-8353-c94026227e61" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_ca7dc7e7-052f-47d6-b971-faa609086930" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMCaymanIIRevolverDue2025Member_5a4919c6-4ef3-403b-81b5-c9cdea161bea" xlink:href="wynn-20220930.xsd#wynn_WMCaymanIIRevolverDue2025Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_ca7dc7e7-052f-47d6-b971-faa609086930" xlink:to="loc_wynn_WMCaymanIIRevolverDue2025Member_5a4919c6-4ef3-403b-81b5-c9cdea161bea" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_b8b87c5e-efa7-4711-b0e1-eed187bbed39" xlink:href="wynn-20220930.xsd#wynn_WRFSeniorSecuredCreditFacilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_ca7dc7e7-052f-47d6-b971-faa609086930" xlink:to="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_b8b87c5e-efa7-4711-b0e1-eed187bbed39" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_add5f5a4-611d-4d6e-9e0b-9dc823b54896" xlink:href="wynn-20220930.xsd#wynn_SeniorRevolvingCreditFacilityDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_b8b87c5e-efa7-4711-b0e1-eed187bbed39" xlink:to="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_add5f5a4-611d-4d6e-9e0b-9dc823b54896" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailTermLoanAgreementMember_94cd3b2e-028c-4cfd-a17d-d0e5f97135de" xlink:href="wynn-20220930.xsd#wynn_RetailTermLoanAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_ca7dc7e7-052f-47d6-b971-faa609086930" xlink:to="loc_wynn_RetailTermLoanAgreementMember_94cd3b2e-028c-4cfd-a17d-d0e5f97135de" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_6637b8c3-e470-4087-b2b8-eaf1b5fff88f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_5ed91d23-c409-43a2-8ec2-a0aca7bea78d" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_6637b8c3-e470-4087-b2b8-eaf1b5fff88f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_6637b8c3-e470-4087-b2b8-eaf1b5fff88f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_6637b8c3-e470-4087-b2b8-eaf1b5fff88f" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_6637b8c3-e470-4087-b2b8-eaf1b5fff88f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_3aa96f73-d16f-4ada-ac0b-2a8777f60e67" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_6637b8c3-e470-4087-b2b8-eaf1b5fff88f" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_3aa96f73-d16f-4ada-ac0b-2a8777f60e67" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_b7b61113-ca58-4c98-a593-1178cbd98da7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_3aa96f73-d16f-4ada-ac0b-2a8777f60e67" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_b7b61113-ca58-4c98-a593-1178cbd98da7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MediumTermNotesMember_74cfcb2c-669b-4029-945e-6bad9c20dc6c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MediumTermNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_3aa96f73-d16f-4ada-ac0b-2a8777f60e67" xlink:to="loc_us-gaap_MediumTermNotesMember_74cfcb2c-669b-4029-945e-6bad9c20dc6c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_143c0c83-2b93-4941-bea3-7dba37c31d2a" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_5ed91d23-c409-43a2-8ec2-a0aca7bea78d" xlink:to="loc_srt_RangeAxis_143c0c83-2b93-4941-bea3-7dba37c31d2a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_143c0c83-2b93-4941-bea3-7dba37c31d2a_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_143c0c83-2b93-4941-bea3-7dba37c31d2a" xlink:to="loc_srt_RangeMember_143c0c83-2b93-4941-bea3-7dba37c31d2a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_f65402c1-a65f-4a91-8c17-0f38de129505" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_143c0c83-2b93-4941-bea3-7dba37c31d2a" xlink:to="loc_srt_RangeMember_f65402c1-a65f-4a91-8c17-0f38de129505" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_bf706d02-852b-4c82-b5c8-ce5e19b8c00c" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_f65402c1-a65f-4a91-8c17-0f38de129505" xlink:to="loc_srt_MinimumMember_bf706d02-852b-4c82-b5c8-ce5e19b8c00c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_35c301f9-9dbd-4c3a-b596-1e8e11aeecda" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_f65402c1-a65f-4a91-8c17-0f38de129505" xlink:to="loc_srt_MaximumMember_35c301f9-9dbd-4c3a-b596-1e8e11aeecda" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebtAdditionalInformationDetail" xlink:type="simple" xlink:href="wynn-20220930.xsd#LongTermDebtAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/LongTermDebtAdditionalInformationDetail" xlink:type="extended" id="iacb17fdda9cb40029763d5d1c6a3d807_LongTermDebtAdditionalInformationDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_374d2912-f460-49a5-9ca8-d9d68817ee73" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_DebtInstrumentBasisSpreadOnVariableRateFloor_33507c33-1f6d-4fb8-b050-8b7bd8f6ae18" xlink:href="wynn-20220930.xsd#wynn_DebtInstrumentBasisSpreadOnVariableRateFloor"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_374d2912-f460-49a5-9ca8-d9d68817ee73" xlink:to="loc_wynn_DebtInstrumentBasisSpreadOnVariableRateFloor_33507c33-1f6d-4fb8-b050-8b7bd8f6ae18" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFairValue_84132e61-72e2-4b53-a7b7-8e5993f0192a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_374d2912-f460-49a5-9ca8-d9d68817ee73" xlink:to="loc_us-gaap_DebtInstrumentFairValue_84132e61-72e2-4b53-a7b7-8e5993f0192a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_f2d69c58-0bb8-4958-a420-e7e7307e7260" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_374d2912-f460-49a5-9ca8-d9d68817ee73" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_f2d69c58-0bb8-4958-a420-e7e7307e7260" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_03f73894-0757-4a13-8bb4-6f92f72452c6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_374d2912-f460-49a5-9ca8-d9d68817ee73" xlink:to="loc_us-gaap_DebtInstrumentTable_03f73894-0757-4a13-8bb4-6f92f72452c6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_033a127f-7166-4aa5-ad9d-ce902f08a095" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_03f73894-0757-4a13-8bb4-6f92f72452c6" xlink:to="loc_dei_LegalEntityAxis_033a127f-7166-4aa5-ad9d-ce902f08a095" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_033a127f-7166-4aa5-ad9d-ce902f08a095_default" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_033a127f-7166-4aa5-ad9d-ce902f08a095" xlink:to="loc_dei_EntityDomain_033a127f-7166-4aa5-ad9d-ce902f08a095_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_54f2e0e4-855d-491d-b398-03435fca838d" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_033a127f-7166-4aa5-ad9d-ce902f08a095" xlink:to="loc_dei_EntityDomain_54f2e0e4-855d-491d-b398-03435fca838d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMCaymanHoldingsLimitedIIMember_c17325c1-cddc-404c-9976-b1fda0f5b493" xlink:href="wynn-20220930.xsd#wynn_WMCaymanHoldingsLimitedIIMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_54f2e0e4-855d-491d-b398-03435fca838d" xlink:to="loc_wynn_WMCaymanHoldingsLimitedIIMember_c17325c1-cddc-404c-9976-b1fda0f5b493" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_25ea4256-55ad-44f1-b27a-7419afe5e643" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_03f73894-0757-4a13-8bb4-6f92f72452c6" xlink:to="loc_us-gaap_DebtInstrumentAxis_25ea4256-55ad-44f1-b27a-7419afe5e643" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_25ea4256-55ad-44f1-b27a-7419afe5e643_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_25ea4256-55ad-44f1-b27a-7419afe5e643" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_25ea4256-55ad-44f1-b27a-7419afe5e643_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_0db61c04-1898-4890-a82b-00f969b83b65" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_25ea4256-55ad-44f1-b27a-7419afe5e643" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_0db61c04-1898-4890-a82b-00f969b83b65" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMCaymanIIRevolverDue2025Member_5b6936bc-50d5-4c7f-b80b-816fdb17f140" xlink:href="wynn-20220930.xsd#wynn_WMCaymanIIRevolverDue2025Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_0db61c04-1898-4890-a82b-00f969b83b65" xlink:to="loc_wynn_WMCaymanIIRevolverDue2025Member_5b6936bc-50d5-4c7f-b80b-816fdb17f140" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_fc281a13-6fea-496d-b0ed-5e4783cf124f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_03f73894-0757-4a13-8bb4-6f92f72452c6" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_fc281a13-6fea-496d-b0ed-5e4783cf124f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_fc281a13-6fea-496d-b0ed-5e4783cf124f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_fc281a13-6fea-496d-b0ed-5e4783cf124f" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_fc281a13-6fea-496d-b0ed-5e4783cf124f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_dcc57b4e-4834-4394-85cf-9bb68b6d38ee" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_fc281a13-6fea-496d-b0ed-5e4783cf124f" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_dcc57b4e-4834-4394-85cf-9bb68b6d38ee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_bd5a9727-5e2a-40df-afbd-15ed0e5a1fc6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_dcc57b4e-4834-4394-85cf-9bb68b6d38ee" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_bd5a9727-5e2a-40df-afbd-15ed0e5a1fc6" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/StockholdersEquityDeficitDetails" xlink:type="simple" xlink:href="wynn-20220930.xsd#StockholdersEquityDeficitDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/StockholdersEquityDeficitDetails" xlink:type="extended" id="i9f16d923bc7c438b96955997a02511d0_StockholdersEquityDeficitDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockLineItems_d41d9d07-562d-45a0-a717-8b267678a2b6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsidiarySaleOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_ca1b6b1e-729e-4141-ba25-ac775e85271e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_d41d9d07-562d-45a0-a717-8b267678a2b6" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_ca1b6b1e-729e-4141-ba25-ac775e85271e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_48933299-2f51-48b8-b1b0-1159ca090937" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockSharesAcquired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_d41d9d07-562d-45a0-a717-8b267678a2b6" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_48933299-2f51-48b8-b1b0-1159ca090937" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockAcquiredAverageCostPerShare_e632c9ef-6f39-491a-9837-23e4b6b06c77" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockAcquiredAverageCostPerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_d41d9d07-562d-45a0-a717-8b267678a2b6" xlink:to="loc_us-gaap_TreasuryStockAcquiredAverageCostPerShare_e632c9ef-6f39-491a-9837-23e4b6b06c77" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_725e9cd8-bc39-4ac4-8f2f-09f38e798203" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_d41d9d07-562d-45a0-a717-8b267678a2b6" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_725e9cd8-bc39-4ac4-8f2f-09f38e798203" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_ab7ad6fb-a9b6-4147-8fe8-8ce794406e55" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_d41d9d07-562d-45a0-a717-8b267678a2b6" xlink:to="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_ab7ad6fb-a9b6-4147-8fe8-8ce794406e55" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_3355a853-6809-49d9-a199-64e5cc2d33e1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_d41d9d07-562d-45a0-a717-8b267678a2b6" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_3355a853-6809-49d9-a199-64e5cc2d33e1" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_9db56c8e-bbe5-49dd-bcdf-214f7095745a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_d41d9d07-562d-45a0-a717-8b267678a2b6" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_9db56c8e-bbe5-49dd-bcdf-214f7095745a" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_25a13e3c-8b90-492c-8679-e12c8337dd46" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_d41d9d07-562d-45a0-a717-8b267678a2b6" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_25a13e3c-8b90-492c-8679-e12c8337dd46" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_1f6bd526-f6ae-4cb6-97b0-93364b6555bd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_d41d9d07-562d-45a0-a717-8b267678a2b6" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_1f6bd526-f6ae-4cb6-97b0-93364b6555bd" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SaleOfStockConsiderationReceivedOnTransactionNetAmortizationOfDiscountAndPremium_8e26b6af-e684-41c7-8a31-2a545af0ed69" xlink:href="wynn-20220930.xsd#wynn_SaleOfStockConsiderationReceivedOnTransactionNetAmortizationOfDiscountAndPremium"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_d41d9d07-562d-45a0-a717-8b267678a2b6" xlink:to="loc_wynn_SaleOfStockConsiderationReceivedOnTransactionNetAmortizationOfDiscountAndPremium_8e26b6af-e684-41c7-8a31-2a545af0ed69" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDistributionsToAffiliates_9d3ba2e3-0e08-4816-bff7-ea83a3e76c9d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDistributionsToAffiliates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_d41d9d07-562d-45a0-a717-8b267678a2b6" xlink:to="loc_us-gaap_PaymentsOfDistributionsToAffiliates_9d3ba2e3-0e08-4816-bff7-ea83a3e76c9d" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRealEstateAndRealEstateJointVentures_3f6bdb77-1d0c-45a5-a969-e5b7c9a821cf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromRealEstateAndRealEstateJointVentures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_d41d9d07-562d-45a0-a717-8b267678a2b6" xlink:to="loc_us-gaap_ProceedsFromRealEstateAndRealEstateJointVentures_3f6bdb77-1d0c-45a5-a969-e5b7c9a821cf" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_34ea5d88-f6a9-43ac-85c9-89d98f7578e9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MinorityInterestOwnershipPercentageByParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_d41d9d07-562d-45a0-a717-8b267678a2b6" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_34ea5d88-f6a9-43ac-85c9-89d98f7578e9" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_64ed0842-97df-41ac-a08c-09e0af9b3ae5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_d41d9d07-562d-45a0-a717-8b267678a2b6" xlink:to="loc_us-gaap_AdditionalPaidInCapital_64ed0842-97df-41ac-a08c-09e0af9b3ae5" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestIncreaseFromSubsidiaryEquityIssuance_4de885e0-8a98-4d06-a67d-929cf934809d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoncontrollingInterestIncreaseFromSubsidiaryEquityIssuance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_d41d9d07-562d-45a0-a717-8b267678a2b6" xlink:to="loc_us-gaap_NoncontrollingInterestIncreaseFromSubsidiaryEquityIssuance_4de885e0-8a98-4d06-a67d-929cf934809d" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_020e7576-9a8b-415a-92e1-5a633f994875" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_d41d9d07-562d-45a0-a717-8b267678a2b6" xlink:to="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_020e7576-9a8b-415a-92e1-5a633f994875" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_06b07da7-ae79-43de-a063-4f7bd402f3bc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_020e7576-9a8b-415a-92e1-5a633f994875" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_06b07da7-ae79-43de-a063-4f7bd402f3bc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_06b07da7-ae79-43de-a063-4f7bd402f3bc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_06b07da7-ae79-43de-a063-4f7bd402f3bc" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_06b07da7-ae79-43de-a063-4f7bd402f3bc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_da775d1d-20c3-4cb2-b8eb-9a2731a4fca5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_06b07da7-ae79-43de-a063-4f7bd402f3bc" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_da775d1d-20c3-4cb2-b8eb-9a2731a4fca5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_PublicStockOfferingMember_5ed458d2-a343-4be0-a39a-291c46fc429f" xlink:href="wynn-20220930.xsd#wynn_PublicStockOfferingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_da775d1d-20c3-4cb2-b8eb-9a2731a4fca5" xlink:to="loc_wynn_PublicStockOfferingMember_5ed458d2-a343-4be0-a39a-291c46fc429f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionAxis_517211d8-6a60-4828-8ea4-54dae55af3dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyTransactionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_020e7576-9a8b-415a-92e1-5a633f994875" xlink:to="loc_us-gaap_RelatedPartyTransactionAxis_517211d8-6a60-4828-8ea4-54dae55af3dd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_517211d8-6a60-4828-8ea4-54dae55af3dd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_517211d8-6a60-4828-8ea4-54dae55af3dd" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_517211d8-6a60-4828-8ea4-54dae55af3dd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_8d4b8bfc-4ff0-4b7b-8f8b-65823f9b6431" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_517211d8-6a60-4828-8ea4-54dae55af3dd" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_8d4b8bfc-4ff0-4b7b-8f8b-65823f9b6431" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailJointVentureMember_af4dd7ca-102f-48aa-9e69-553e0f1ea84e" xlink:href="wynn-20220930.xsd#wynn_RetailJointVentureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_8d4b8bfc-4ff0-4b7b-8f8b-65823f9b6431" xlink:to="loc_wynn_RetailJointVentureMember_af4dd7ca-102f-48aa-9e69-553e0f1ea84e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_5d780f20-3118-4101-ade1-a23876d782fe" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_020e7576-9a8b-415a-92e1-5a633f994875" xlink:to="loc_dei_LegalEntityAxis_5d780f20-3118-4101-ade1-a23876d782fe" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_5d780f20-3118-4101-ade1-a23876d782fe_default" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_5d780f20-3118-4101-ade1-a23876d782fe" xlink:to="loc_dei_EntityDomain_5d780f20-3118-4101-ade1-a23876d782fe_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_8f4e2ca9-13bb-4bc9-8e22-8a2b04a5961f" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_5d780f20-3118-4101-ade1-a23876d782fe" xlink:to="loc_dei_EntityDomain_8f4e2ca9-13bb-4bc9-8e22-8a2b04a5961f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_CrownAcquisitionsIncMember_423e6ba4-9ca2-45bb-af35-135b24156e16" xlink:href="wynn-20220930.xsd#wynn_CrownAcquisitionsIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_8f4e2ca9-13bb-4bc9-8e22-8a2b04a5961f" xlink:to="loc_wynn_CrownAcquisitionsIncMember_423e6ba4-9ca2-45bb-af35-135b24156e16" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipAxis_9c91ad55-605b-4aba-9bda-b211e66cc391" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_OwnershipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_020e7576-9a8b-415a-92e1-5a633f994875" xlink:to="loc_srt_OwnershipAxis_9c91ad55-605b-4aba-9bda-b211e66cc391" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_9c91ad55-605b-4aba-9bda-b211e66cc391_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_OwnershipAxis_9c91ad55-605b-4aba-9bda-b211e66cc391" xlink:to="loc_srt_OwnershipDomain_9c91ad55-605b-4aba-9bda-b211e66cc391_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_b1a9d70f-fb61-4317-9db2-7ce9981bbe99" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_OwnershipAxis_9c91ad55-605b-4aba-9bda-b211e66cc391" xlink:to="loc_srt_OwnershipDomain_b1a9d70f-fb61-4317-9db2-7ce9981bbe99" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnResortsLtdMember_fe6c4354-8890-4836-bea0-8a9ba12ce49a" xlink:href="wynn-20220930.xsd#wynn_WynnResortsLtdMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_b1a9d70f-fb61-4317-9db2-7ce9981bbe99" xlink:to="loc_wynn_WynnResortsLtdMember_fe6c4354-8890-4836-bea0-8a9ba12ce49a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramAxis_edf52f7e-1f51-41bd-949c-2d9c9de06aab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareRepurchaseProgramAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_020e7576-9a8b-415a-92e1-5a633f994875" xlink:to="loc_us-gaap_ShareRepurchaseProgramAxis_edf52f7e-1f51-41bd-949c-2d9c9de06aab" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_edf52f7e-1f51-41bd-949c-2d9c9de06aab_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareRepurchaseProgramDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_edf52f7e-1f51-41bd-949c-2d9c9de06aab" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_edf52f7e-1f51-41bd-949c-2d9c9de06aab_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_b9a63b63-125a-4000-8aca-5e2fc3819d3a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareRepurchaseProgramDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_edf52f7e-1f51-41bd-949c-2d9c9de06aab" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_b9a63b63-125a-4000-8aca-5e2fc3819d3a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_April2016RepurchaseProgramMember_84b90136-76f4-486b-a158-d5f9a0df7e84" xlink:href="wynn-20220930.xsd#wynn_April2016RepurchaseProgramMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareRepurchaseProgramDomain_b9a63b63-125a-4000-8aca-5e2fc3819d3a" xlink:to="loc_wynn_April2016RepurchaseProgramMember_84b90136-76f4-486b-a158-d5f9a0df7e84" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/FairValueMeasurementsDetails" xlink:type="simple" xlink:href="wynn-20220930.xsd#FairValueMeasurementsDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/FairValueMeasurementsDetails" xlink:type="extended" id="idf8d3e27b2e249dd960a23fbc0978b53_FairValueMeasurementsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_e8db25fc-243d-451f-bd05-9cc36e1e0de3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosureAbstract_755b7981-bd94-4376-a17b-3ed0e172deae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsFairValueDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_e8db25fc-243d-451f-bd05-9cc36e1e0de3" xlink:to="loc_us-gaap_AssetsFairValueDisclosureAbstract_755b7981-bd94-4376-a17b-3ed0e172deae" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValue_e9024ec9-d665-48d5-851d-05588c24ef5c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_755b7981-bd94-4376-a17b-3ed0e172deae" xlink:to="loc_us-gaap_CashEquivalentsAtCarryingValue_e9024ec9-d665-48d5-851d-05588c24ef5c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_e75ad493-e44a-496f-bc44-aeb1e4db6849" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_755b7981-bd94-4376-a17b-3ed0e172deae" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_e75ad493-e44a-496f-bc44-aeb1e4db6849" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_2b7ee706-e931-4cbd-be07-6bf817e0b6c6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_755b7981-bd94-4376-a17b-3ed0e172deae" xlink:to="loc_us-gaap_DerivativeAssets_2b7ee706-e931-4cbd-be07-6bf817e0b6c6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_63ec5595-2755-41f8-b4c4-17891fc3c705" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_e8db25fc-243d-451f-bd05-9cc36e1e0de3" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_63ec5595-2755-41f8-b4c4-17891fc3c705" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_397d8bad-9410-4ae9-a64d-540b31e12592" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_63ec5595-2755-41f8-b4c4-17891fc3c705" xlink:to="loc_us-gaap_DerivativeLiabilities_397d8bad-9410-4ae9-a64d-540b31e12592" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_f8a208fe-fe1d-431a-b3fb-9dd337d19e0a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_e8db25fc-243d-451f-bd05-9cc36e1e0de3" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_f8a208fe-fe1d-431a-b3fb-9dd337d19e0a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_617f2e31-1182-42c1-9713-12ef2011bef2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_f8a208fe-fe1d-431a-b3fb-9dd337d19e0a" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_617f2e31-1182-42c1-9713-12ef2011bef2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_617f2e31-1182-42c1-9713-12ef2011bef2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_617f2e31-1182-42c1-9713-12ef2011bef2" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_617f2e31-1182-42c1-9713-12ef2011bef2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_dfb12656-180e-4df8-aebf-6670a4842724" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_617f2e31-1182-42c1-9713-12ef2011bef2" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_dfb12656-180e-4df8-aebf-6670a4842724" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_6d985d2c-b7ee-46e3-9731-cc7010b8906f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_dfb12656-180e-4df8-aebf-6670a4842724" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_6d985d2c-b7ee-46e3-9731-cc7010b8906f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_a9aba07e-253b-4ebe-8c8e-e5d182cc8321" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_f8a208fe-fe1d-431a-b3fb-9dd337d19e0a" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_a9aba07e-253b-4ebe-8c8e-e5d182cc8321" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_a9aba07e-253b-4ebe-8c8e-e5d182cc8321_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_a9aba07e-253b-4ebe-8c8e-e5d182cc8321" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_a9aba07e-253b-4ebe-8c8e-e5d182cc8321_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_0aaa9987-c982-417c-ba29-4376fdfe3ba6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_a9aba07e-253b-4ebe-8c8e-e5d182cc8321" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_0aaa9987-c982-417c-ba29-4376fdfe3ba6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_75e9a3aa-9b1b-422b-852d-058b10fa8a9b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_0aaa9987-c982-417c-ba29-4376fdfe3ba6" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_75e9a3aa-9b1b-422b-852d-058b10fa8a9b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_c4282ba2-99a4-4856-ad81-289c26283639" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_0aaa9987-c982-417c-ba29-4376fdfe3ba6" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_c4282ba2-99a4-4856-ad81-289c26283639" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_2f108a03-5af1-45e2-8716-7c49d3e3590f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_0aaa9987-c982-417c-ba29-4376fdfe3ba6" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_2f108a03-5af1-45e2-8716-7c49d3e3590f" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/StockBasedCompensationShareBasedCompensationAllocatedCostsDetail" xlink:type="simple" xlink:href="wynn-20220930.xsd#StockBasedCompensationShareBasedCompensationAllocatedCostsDetail"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/StockBasedCompensationShareBasedCompensationAllocatedCostsDetail" xlink:type="extended" id="i3a261d01dbef43fa84df5b2b1f571129_StockBasedCompensationShareBasedCompensationAllocatedCostsDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_cb90863d-1caf-40af-b400-4cf8f7239272" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_12ff4d45-abcc-494d-b860-07c311cba912" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_cb90863d-1caf-40af-b400-4cf8f7239272" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_12ff4d45-abcc-494d-b860-07c311cba912" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount_4318f605-e9c3-4d23-b9f6-c555a7d54129" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_cb90863d-1caf-40af-b400-4cf8f7239272" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount_4318f605-e9c3-4d23-b9f6-c555a7d54129" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_e3bfc3bc-a680-4104-b99e-a5623cd2f52f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_cb90863d-1caf-40af-b400-4cf8f7239272" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_e3bfc3bc-a680-4104-b99e-a5623cd2f52f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_a9bab2bd-24b1-4bf5-a24e-3bfa3adc6da4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_cb90863d-1caf-40af-b400-4cf8f7239272" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_a9bab2bd-24b1-4bf5-a24e-3bfa3adc6da4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_60553eb9-8e2a-4867-b0c7-664a8ec59990" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_a9bab2bd-24b1-4bf5-a24e-3bfa3adc6da4" xlink:to="loc_srt_ProductOrServiceAxis_60553eb9-8e2a-4867-b0c7-664a8ec59990" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_60553eb9-8e2a-4867-b0c7-664a8ec59990_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_60553eb9-8e2a-4867-b0c7-664a8ec59990" xlink:to="loc_srt_ProductsAndServicesDomain_60553eb9-8e2a-4867-b0c7-664a8ec59990_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_30d3fdea-79a5-492a-a116-c9b793b1279a" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_60553eb9-8e2a-4867-b0c7-664a8ec59990" xlink:to="loc_srt_ProductsAndServicesDomain_30d3fdea-79a5-492a-a116-c9b793b1279a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CasinoMember_1935e247-6e8e-4b7a-b023-65b17bcbea93" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CasinoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_30d3fdea-79a5-492a-a116-c9b793b1279a" xlink:to="loc_us-gaap_CasinoMember_1935e247-6e8e-4b7a-b023-65b17bcbea93" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RoomsMember_1e98225d-40e1-4080-a7a5-1549e2f88f73" xlink:href="wynn-20220930.xsd#wynn_RoomsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_30d3fdea-79a5-492a-a116-c9b793b1279a" xlink:to="loc_wynn_RoomsMember_1e98225d-40e1-4080-a7a5-1549e2f88f73" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FoodAndBeverageMember_621d4fbd-3442-4fbf-b619-54793260976b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FoodAndBeverageMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_30d3fdea-79a5-492a-a116-c9b793b1279a" xlink:to="loc_us-gaap_FoodAndBeverageMember_621d4fbd-3442-4fbf-b619-54793260976b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EntertainmentRetailAndOtherMember_eb5aa7fd-5e63-4ba3-9ef8-f1339445384d" xlink:href="wynn-20220930.xsd#wynn_EntertainmentRetailAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_30d3fdea-79a5-492a-a116-c9b793b1279a" xlink:to="loc_wynn_EntertainmentRetailAndOtherMember_eb5aa7fd-5e63-4ba3-9ef8-f1339445384d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_GeneralAndAdministrativeMember_0bcb6dd6-a9be-4da3-8ced-929b42d069ed" xlink:href="wynn-20220930.xsd#wynn_GeneralAndAdministrativeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_30d3fdea-79a5-492a-a116-c9b793b1279a" xlink:to="loc_wynn_GeneralAndAdministrativeMember_0bcb6dd6-a9be-4da3-8ced-929b42d069ed" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/RelatedPartyTransactionsDetails" xlink:type="simple" xlink:href="wynn-20220930.xsd#RelatedPartyTransactionsDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/RelatedPartyTransactionsDetails" xlink:type="extended" id="id91bc900497344bd838c775323eb01d2_RelatedPartyTransactionsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_abc202c7-0fa4-4b89-9ece-467703918e32" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyTransactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionAmountsOfTransaction_187720ba-36f2-415d-9680-ebc5f7bb0129" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyTransactionAmountsOfTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_abc202c7-0fa4-4b89-9ece-467703918e32" xlink:to="loc_us-gaap_RelatedPartyTransactionAmountsOfTransaction_187720ba-36f2-415d-9680-ebc5f7bb0129" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_4d5f7347-5764-43bc-85f8-6415abb24742" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_abc202c7-0fa4-4b89-9ece-467703918e32" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_4d5f7347-5764-43bc-85f8-6415abb24742" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_4091d3b0-c52f-4f1b-a08e-c771f77dc5f2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_abc202c7-0fa4-4b89-9ece-467703918e32" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_4091d3b0-c52f-4f1b-a08e-c771f77dc5f2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_1d1b8162-2a7a-4b21-be67-b47d4d17bfb9" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_4091d3b0-c52f-4f1b-a08e-c771f77dc5f2" xlink:to="loc_srt_CounterpartyNameAxis_1d1b8162-2a7a-4b21-be67-b47d4d17bfb9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_1d1b8162-2a7a-4b21-be67-b47d4d17bfb9_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_1d1b8162-2a7a-4b21-be67-b47d4d17bfb9" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_1d1b8162-2a7a-4b21-be67-b47d4d17bfb9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_df8d2802-750a-4016-9a14-49e4ecfd52c2" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_1d1b8162-2a7a-4b21-be67-b47d4d17bfb9" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_df8d2802-750a-4016-9a14-49e4ecfd52c2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauLimitedMember_a93cafea-0404-4961-adae-9ee90334378f" xlink:href="wynn-20220930.xsd#wynn_WynnMacauLimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_df8d2802-750a-4016-9a14-49e4ecfd52c2" xlink:to="loc_wynn_WynnMacauLimitedMember_a93cafea-0404-4961-adae-9ee90334378f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualAxis_8ed4b374-5767-4ead-820d-2e231b68e150" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_TitleOfIndividualAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_4091d3b0-c52f-4f1b-a08e-c771f77dc5f2" xlink:to="loc_srt_TitleOfIndividualAxis_8ed4b374-5767-4ead-820d-2e231b68e150" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_8ed4b374-5767-4ead-820d-2e231b68e150_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_TitleOfIndividualAxis_8ed4b374-5767-4ead-820d-2e231b68e150" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_8ed4b374-5767-4ead-820d-2e231b68e150_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_481d1faa-c575-4b13-bcb3-330ccf7abce5" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_TitleOfIndividualAxis_8ed4b374-5767-4ead-820d-2e231b68e150" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_481d1faa-c575-4b13-bcb3-330ccf7abce5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_PresidentMember_9f3f48b0-8a58-4084-9495-ce92226bc0c4" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_PresidentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_481d1faa-c575-4b13-bcb3-330ccf7abce5" xlink:to="loc_srt_PresidentMember_9f3f48b0-8a58-4084-9495-ce92226bc0c4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_3728c414-8b3e-4339-a166-65273276ae48" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_4091d3b0-c52f-4f1b-a08e-c771f77dc5f2" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_3728c414-8b3e-4339-a166-65273276ae48" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_3728c414-8b3e-4339-a166-65273276ae48_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_3728c414-8b3e-4339-a166-65273276ae48" xlink:to="loc_us-gaap_RelatedPartyDomain_3728c414-8b3e-4339-a166-65273276ae48_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_b7285626-9568-491b-9381-894df8d1a005" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_3728c414-8b3e-4339-a166-65273276ae48" xlink:to="loc_us-gaap_RelatedPartyDomain_b7285626-9568-491b-9381-894df8d1a005" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_AffiliatedEntityMember_b00f872f-3338-476e-979e-2f6b01d96d5e" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_AffiliatedEntityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_b7285626-9568-491b-9381-894df8d1a005" xlink:to="loc_srt_AffiliatedEntityMember_b00f872f-3338-476e-979e-2f6b01d96d5e" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/RetailJointVentureAdditionalinformationDetails" xlink:type="simple" xlink:href="wynn-20220930.xsd#RetailJointVentureAdditionalinformationDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/RetailJointVentureAdditionalinformationDetails" xlink:type="extended" id="i88362b4570074cf5827dd0ac45e54c02_RetailJointVentureAdditionalinformationDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_4a1fbb08-b4a5-41bc-ae6b-570ddb43249b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_94d58db6-0d87-4c70-8ddb-5c1d8984b09e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Assets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_4a1fbb08-b4a5-41bc-ae6b-570ddb43249b" xlink:to="loc_us-gaap_Assets_94d58db6-0d87-4c70-8ddb-5c1d8984b09e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_80403afc-8839-4475-9b82-79ed44b888ad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_4a1fbb08-b4a5-41bc-ae6b-570ddb43249b" xlink:to="loc_us-gaap_Liabilities_80403afc-8839-4475-9b82-79ed44b888ad" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_de4c3bb1-dc7e-46ff-becc-df377b9b4da7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_4a1fbb08-b4a5-41bc-ae6b-570ddb43249b" xlink:to="loc_us-gaap_LongTermDebt_de4c3bb1-dc7e-46ff-becc-df377b9b4da7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_5cf0f573-171a-49b2-90c2-774f4d9f1085" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_4a1fbb08-b4a5-41bc-ae6b-570ddb43249b" xlink:to="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_5cf0f573-171a-49b2-90c2-774f4d9f1085" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_739c3b3b-e18d-4e53-be76-caef47677b3f" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_5cf0f573-171a-49b2-90c2-774f4d9f1085" xlink:to="loc_dei_LegalEntityAxis_739c3b3b-e18d-4e53-be76-caef47677b3f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_739c3b3b-e18d-4e53-be76-caef47677b3f_default" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_739c3b3b-e18d-4e53-be76-caef47677b3f" xlink:to="loc_dei_EntityDomain_739c3b3b-e18d-4e53-be76-caef47677b3f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_23e9a1e1-b758-4623-aa6c-7e14b6ff954e" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_739c3b3b-e18d-4e53-be76-caef47677b3f" xlink:to="loc_dei_EntityDomain_23e9a1e1-b758-4623-aa6c-7e14b6ff954e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailJointVentureMember_8113cfad-c37b-4eb7-a908-0bbeff3f1d3c" xlink:href="wynn-20220930.xsd#wynn_RetailJointVentureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_23e9a1e1-b758-4623-aa6c-7e14b6ff954e" xlink:to="loc_wynn_RetailJointVentureMember_8113cfad-c37b-4eb7-a908-0bbeff3f1d3c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_f171bf5b-a0da-40b6-a046-a3796c9f1f32" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_5cf0f573-171a-49b2-90c2-774f4d9f1085" xlink:to="loc_srt_ProductOrServiceAxis_f171bf5b-a0da-40b6-a046-a3796c9f1f32" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_f171bf5b-a0da-40b6-a046-a3796c9f1f32_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_f171bf5b-a0da-40b6-a046-a3796c9f1f32" xlink:to="loc_srt_ProductsAndServicesDomain_f171bf5b-a0da-40b6-a046-a3796c9f1f32_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_6a1dcce8-8f94-4682-a288-a143fdb78fa7" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_f171bf5b-a0da-40b6-a046-a3796c9f1f32" xlink:to="loc_srt_ProductsAndServicesDomain_6a1dcce8-8f94-4682-a288-a143fdb78fa7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetailMember_abf27f45-bce0-42d7-a21d-3dfdf4e90416" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetailMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_6a1dcce8-8f94-4682-a288-a143fdb78fa7" xlink:to="loc_us-gaap_RetailMember_abf27f45-bce0-42d7-a21d-3dfdf4e90416" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/SegmentInformationSummaryofResultsofOperationsbySegmentDetails" xlink:type="simple" xlink:href="wynn-20220930.xsd#SegmentInformationSummaryofResultsofOperationsbySegmentDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/SegmentInformationSummaryofResultsofOperationsbySegmentDetails" xlink:type="extended" id="icace784f32664584876128e1dd06a941_SegmentInformationSummaryofResultsofOperationsbySegmentDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_c5cbcda4-d609-466d-b517-f50a43de3d0b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_3a5a2209-9bb4-4b88-a460-f250263ad7a5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_c5cbcda4-d609-466d-b517-f50a43de3d0b" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_3a5a2209-9bb4-4b88-a460-f250263ad7a5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_AdjustedPropertyEbitda_bac162e7-7442-47be-8680-f90c753d866b" xlink:href="wynn-20220930.xsd#wynn_AdjustedPropertyEbitda"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_c5cbcda4-d609-466d-b517-f50a43de3d0b" xlink:to="loc_wynn_AdjustedPropertyEbitda_bac162e7-7442-47be-8680-f90c753d866b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OtherOperatingCostsAndExpensesAbstract_288868b3-de14-4750-a3a6-1025aee4238b" xlink:href="wynn-20220930.xsd#wynn_OtherOperatingCostsAndExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_c5cbcda4-d609-466d-b517-f50a43de3d0b" xlink:to="loc_wynn_OtherOperatingCostsAndExpensesAbstract_288868b3-de14-4750-a3a6-1025aee4238b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreOpeningCosts_1ee89d5a-57db-4cd7-9260-57e10de89be5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreOpeningCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_288868b3-de14-4750-a3a6-1025aee4238b" xlink:to="loc_us-gaap_PreOpeningCosts_1ee89d5a-57db-4cd7-9260-57e10de89be5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAndAmortization_43b55e7e-c6fb-4527-af6d-abe7944679ad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_288868b3-de14-4750-a3a6-1025aee4238b" xlink:to="loc_us-gaap_DepreciationAndAmortization_43b55e7e-c6fb-4527-af6d-abe7944679ad" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_ProjectAbandonmentCosts_d6a521c6-3e8c-4c2a-aae9-4cecd2c05c76" xlink:href="wynn-20220930.xsd#wynn_ProjectAbandonmentCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_288868b3-de14-4750-a3a6-1025aee4238b" xlink:to="loc_wynn_ProjectAbandonmentCosts_d6a521c6-3e8c-4c2a-aae9-4cecd2c05c76" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_CorporateExpensesAndOther_3f691152-1df3-44e7-a0db-135dcbd092a1" xlink:href="wynn-20220930.xsd#wynn_CorporateExpensesAndOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_288868b3-de14-4750-a3a6-1025aee4238b" xlink:to="loc_wynn_CorporateExpensesAndOther_3f691152-1df3-44e7-a0db-135dcbd092a1" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_30aa8edb-cb7c-462c-b6d4-c7e7057e8eb5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_288868b3-de14-4750-a3a6-1025aee4238b" xlink:to="loc_us-gaap_ShareBasedCompensation_30aa8edb-cb7c-462c-b6d4-c7e7057e8eb5" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCostAndExpenseOperating_856f86ef-f27b-46d8-a667-3650e76f27d8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherCostAndExpenseOperating"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_288868b3-de14-4750-a3a6-1025aee4238b" xlink:to="loc_us-gaap_OtherCostAndExpenseOperating_856f86ef-f27b-46d8-a667-3650e76f27d8" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_940c0772-46b6-41f3-80ca-449e10d616f5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_c5cbcda4-d609-466d-b517-f50a43de3d0b" xlink:to="loc_us-gaap_OperatingIncomeLoss_940c0772-46b6-41f3-80ca-449e10d616f5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_14ddde37-a197-454d-abb9-0466692be6f8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonoperatingIncomeExpenseAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_c5cbcda4-d609-466d-b517-f50a43de3d0b" xlink:to="loc_us-gaap_NonoperatingIncomeExpenseAbstract_14ddde37-a197-454d-abb9-0466692be6f8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_9233b8d8-b441-499e-88a9-6cf4f687dd32" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_14ddde37-a197-454d-abb9-0466692be6f8" xlink:to="loc_us-gaap_InvestmentIncomeInterest_9233b8d8-b441-499e-88a9-6cf4f687dd32" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_7f094d1d-4143-4b20-b7b2-ebc77016da55" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_14ddde37-a197-454d-abb9-0466692be6f8" xlink:to="loc_us-gaap_InterestExpense_7f094d1d-4143-4b20-b7b2-ebc77016da55" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_718f850c-8acb-4594-ae11-8213eba7799f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_14ddde37-a197-454d-abb9-0466692be6f8" xlink:to="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_718f850c-8acb-4594-ae11-8213eba7799f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_775826d4-6908-489d-bc59-640d0eca724f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_14ddde37-a197-454d-abb9-0466692be6f8" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_775826d4-6908-489d-bc59-640d0eca724f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_cf0f4d81-cb1a-40c6-b38b-4c87218cc632" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_14ddde37-a197-454d-abb9-0466692be6f8" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_cf0f4d81-cb1a-40c6-b38b-4c87218cc632" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_f4042ad5-ffb2-4816-905b-71474eb18950" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_14ddde37-a197-454d-abb9-0466692be6f8" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_f4042ad5-ffb2-4816-905b-71474eb18950" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_80fbbd91-a2e2-4ab7-b612-e9eecbd6441a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_c5cbcda4-d609-466d-b517-f50a43de3d0b" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_80fbbd91-a2e2-4ab7-b612-e9eecbd6441a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_a4e20aa9-adc6-49d0-a816-489aeb8a4298" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_c5cbcda4-d609-466d-b517-f50a43de3d0b" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_a4e20aa9-adc6-49d0-a816-489aeb8a4298" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_0669cca9-efb3-431d-978b-f0c8725f732c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_c5cbcda4-d609-466d-b517-f50a43de3d0b" xlink:to="loc_us-gaap_ProfitLoss_0669cca9-efb3-431d-978b-f0c8725f732c" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_6837a53b-4de2-46f0-adcf-2acf4d0b8fdf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_c5cbcda4-d609-466d-b517-f50a43de3d0b" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_6837a53b-4de2-46f0-adcf-2acf4d0b8fdf" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_aa60cfa2-47fd-4d2e-b1ce-919515e7f87d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_c5cbcda4-d609-466d-b517-f50a43de3d0b" xlink:to="loc_us-gaap_NetIncomeLoss_aa60cfa2-47fd-4d2e-b1ce-919515e7f87d" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_698d7a06-2c11-4cba-8abf-d43856ad5397" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_c5cbcda4-d609-466d-b517-f50a43de3d0b" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_698d7a06-2c11-4cba-8abf-d43856ad5397" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_c31e0781-8371-4c1d-9658-a5165974dd7b" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_698d7a06-2c11-4cba-8abf-d43856ad5397" xlink:to="loc_srt_ProductOrServiceAxis_c31e0781-8371-4c1d-9658-a5165974dd7b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_c31e0781-8371-4c1d-9658-a5165974dd7b_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_c31e0781-8371-4c1d-9658-a5165974dd7b" xlink:to="loc_srt_ProductsAndServicesDomain_c31e0781-8371-4c1d-9658-a5165974dd7b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_080313d2-49ed-4c97-83a2-1e3649ab31a6" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_c31e0781-8371-4c1d-9658-a5165974dd7b" xlink:to="loc_srt_ProductsAndServicesDomain_080313d2-49ed-4c97-83a2-1e3649ab31a6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CasinoMember_08fbe420-5d92-4e48-8957-af7436b3fa2e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CasinoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_080313d2-49ed-4c97-83a2-1e3649ab31a6" xlink:to="loc_us-gaap_CasinoMember_08fbe420-5d92-4e48-8957-af7436b3fa2e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OccupancyMember_2c17349e-60f1-4b3a-92fb-ac572e5cfb49" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OccupancyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_080313d2-49ed-4c97-83a2-1e3649ab31a6" xlink:to="loc_us-gaap_OccupancyMember_2c17349e-60f1-4b3a-92fb-ac572e5cfb49" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FoodAndBeverageMember_59a93fde-2f26-4064-87b3-986b39902aa1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FoodAndBeverageMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_080313d2-49ed-4c97-83a2-1e3649ab31a6" xlink:to="loc_us-gaap_FoodAndBeverageMember_59a93fde-2f26-4064-87b3-986b39902aa1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EntertainmentRetailAndOtherMember_94b9f2c7-bfe4-4599-b174-ac64d3b33f00" xlink:href="wynn-20220930.xsd#wynn_EntertainmentRetailAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_080313d2-49ed-4c97-83a2-1e3649ab31a6" xlink:to="loc_wynn_EntertainmentRetailAndOtherMember_94b9f2c7-bfe4-4599-b174-ac64d3b33f00" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_3acc9dce-b8f1-492d-8833-cf305a5e7cad" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_698d7a06-2c11-4cba-8abf-d43856ad5397" xlink:to="loc_srt_ConsolidationItemsAxis_3acc9dce-b8f1-492d-8833-cf305a5e7cad" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_3acc9dce-b8f1-492d-8833-cf305a5e7cad_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_3acc9dce-b8f1-492d-8833-cf305a5e7cad" xlink:to="loc_srt_ConsolidationItemsDomain_3acc9dce-b8f1-492d-8833-cf305a5e7cad_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_409fe411-5445-4f43-902a-ebb0aff13d49" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_3acc9dce-b8f1-492d-8833-cf305a5e7cad" xlink:to="loc_srt_ConsolidationItemsDomain_409fe411-5445-4f43-902a-ebb0aff13d49" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_42a3a0fa-dbb7-4128-ae0b-9c3ae916955a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingSegmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_409fe411-5445-4f43-902a-ebb0aff13d49" xlink:to="loc_us-gaap_OperatingSegmentsMember_42a3a0fa-dbb7-4128-ae0b-9c3ae916955a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateNonSegmentMember_93362dc8-a437-4467-afdc-dc3e850886be" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CorporateNonSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_409fe411-5445-4f43-902a-ebb0aff13d49" xlink:to="loc_us-gaap_CorporateNonSegmentMember_93362dc8-a437-4467-afdc-dc3e850886be" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_fc868aa6-20a4-4458-8aca-cb70a084f6bf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_698d7a06-2c11-4cba-8abf-d43856ad5397" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_fc868aa6-20a4-4458-8aca-cb70a084f6bf" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_fc868aa6-20a4-4458-8aca-cb70a084f6bf_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_fc868aa6-20a4-4458-8aca-cb70a084f6bf" xlink:to="loc_us-gaap_SegmentDomain_fc868aa6-20a4-4458-8aca-cb70a084f6bf_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_176dac6a-65d0-4b20-8843-2271980d9d2f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_fc868aa6-20a4-4458-8aca-cb70a084f6bf" xlink:to="loc_us-gaap_SegmentDomain_176dac6a-65d0-4b20-8843-2271980d9d2f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_MacauOperationsMember_284fb304-9ac7-4bd5-a951-a43d45703bbb" xlink:href="wynn-20220930.xsd#wynn_MacauOperationsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_176dac6a-65d0-4b20-8843-2271980d9d2f" xlink:to="loc_wynn_MacauOperationsMember_284fb304-9ac7-4bd5-a951-a43d45703bbb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnLasVegasMember_29fd47e2-2bc6-41d3-a720-b9ee86020c0b" xlink:href="wynn-20220930.xsd#wynn_WynnLasVegasMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_176dac6a-65d0-4b20-8843-2271980d9d2f" xlink:to="loc_wynn_WynnLasVegasMember_29fd47e2-2bc6-41d3-a720-b9ee86020c0b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EncoreBostonHarborMember_878849e2-1310-4559-a90c-76f3d3ce11cf" xlink:href="wynn-20220930.xsd#wynn_EncoreBostonHarborMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_176dac6a-65d0-4b20-8843-2271980d9d2f" xlink:to="loc_wynn_EncoreBostonHarborMember_878849e2-1310-4559-a90c-76f3d3ce11cf" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnInteractiveLtdMember_574d8e25-6864-4f76-9a5d-a6d3799c3dbf" xlink:href="wynn-20220930.xsd#wynn_WynnInteractiveLtdMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_176dac6a-65d0-4b20-8843-2271980d9d2f" xlink:to="loc_wynn_WynnInteractiveLtdMember_574d8e25-6864-4f76-9a5d-a6d3799c3dbf" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_91607403-7d1b-4bfb-a0fa-476a98c8d8d5" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_698d7a06-2c11-4cba-8abf-d43856ad5397" xlink:to="loc_dei_LegalEntityAxis_91607403-7d1b-4bfb-a0fa-476a98c8d8d5" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_91607403-7d1b-4bfb-a0fa-476a98c8d8d5_default" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_91607403-7d1b-4bfb-a0fa-476a98c8d8d5" xlink:to="loc_dei_EntityDomain_91607403-7d1b-4bfb-a0fa-476a98c8d8d5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_2d47722b-8e60-4562-81b7-149eb6352e11" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_91607403-7d1b-4bfb-a0fa-476a98c8d8d5" xlink:to="loc_dei_EntityDomain_2d47722b-8e60-4562-81b7-149eb6352e11" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnPalaceMember_81346201-ffcb-4cb5-82d2-ce162683f354" xlink:href="wynn-20220930.xsd#wynn_WynnPalaceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_2d47722b-8e60-4562-81b7-149eb6352e11" xlink:to="loc_wynn_WynnPalaceMember_81346201-ffcb-4cb5-82d2-ce162683f354" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauMember_fba84b25-61ad-4f9f-a590-e45f44c0b942" xlink:href="wynn-20220930.xsd#wynn_WynnMacauMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_2d47722b-8e60-4562-81b7-149eb6352e11" xlink:to="loc_wynn_WynnMacauMember_fba84b25-61ad-4f9f-a590-e45f44c0b942" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/SegmentInformationSummaryofAssetsbySegmentDetails" xlink:type="simple" xlink:href="wynn-20220930.xsd#SegmentInformationSummaryofAssetsbySegmentDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/SegmentInformationSummaryofAssetsbySegmentDetails" xlink:type="extended" id="ia037df11ed2b4be5b9d7eced6c27ccee_SegmentInformationSummaryofAssetsbySegmentDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_de7840af-992b-419b-86be-87efabbe9d30" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_3cf126ac-05bd-4fc7-8125-b12f2d7a1aa3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Assets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_de7840af-992b-419b-86be-87efabbe9d30" xlink:to="loc_us-gaap_Assets_3cf126ac-05bd-4fc7-8125-b12f2d7a1aa3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_0b81132e-25ac-42d5-9bc0-560d5009f117" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_de7840af-992b-419b-86be-87efabbe9d30" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_0b81132e-25ac-42d5-9bc0-560d5009f117" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_6216fd95-0389-4485-8a6c-de6db69171cd" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_0b81132e-25ac-42d5-9bc0-560d5009f117" xlink:to="loc_srt_ConsolidationItemsAxis_6216fd95-0389-4485-8a6c-de6db69171cd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_6216fd95-0389-4485-8a6c-de6db69171cd_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_6216fd95-0389-4485-8a6c-de6db69171cd" xlink:to="loc_srt_ConsolidationItemsDomain_6216fd95-0389-4485-8a6c-de6db69171cd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_7b3107f9-3649-4b84-9dd4-71dda75d3e33" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_6216fd95-0389-4485-8a6c-de6db69171cd" xlink:to="loc_srt_ConsolidationItemsDomain_7b3107f9-3649-4b84-9dd4-71dda75d3e33" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_33209187-9821-4a8a-88bf-08cdfac6fead" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingSegmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_7b3107f9-3649-4b84-9dd4-71dda75d3e33" xlink:to="loc_us-gaap_OperatingSegmentsMember_33209187-9821-4a8a-88bf-08cdfac6fead" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_0f14759b-95c6-4bf5-bf88-594748925ec4" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_0b81132e-25ac-42d5-9bc0-560d5009f117" xlink:to="loc_srt_StatementGeographicalAxis_0f14759b-95c6-4bf5-bf88-594748925ec4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_0f14759b-95c6-4bf5-bf88-594748925ec4_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_0f14759b-95c6-4bf5-bf88-594748925ec4" xlink:to="loc_srt_SegmentGeographicalDomain_0f14759b-95c6-4bf5-bf88-594748925ec4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_a5f853b2-593e-429c-9ba2-c9b65ab0abe4" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_0f14759b-95c6-4bf5-bf88-594748925ec4" xlink:to="loc_srt_SegmentGeographicalDomain_a5f853b2-593e-429c-9ba2-c9b65ab0abe4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_MO_41bf2eab-ad47-4c9d-b025-0deb8e333350" xlink:href="https://xbrl.sec.gov/country/2021/country-2021.xsd#country_MO"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_a5f853b2-593e-429c-9ba2-c9b65ab0abe4" xlink:to="loc_country_MO_41bf2eab-ad47-4c9d-b025-0deb8e333350" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_663b10ee-db31-45d7-afd7-7c305c5fdc7d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_0b81132e-25ac-42d5-9bc0-560d5009f117" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_663b10ee-db31-45d7-afd7-7c305c5fdc7d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_663b10ee-db31-45d7-afd7-7c305c5fdc7d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_663b10ee-db31-45d7-afd7-7c305c5fdc7d" xlink:to="loc_us-gaap_SegmentDomain_663b10ee-db31-45d7-afd7-7c305c5fdc7d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_c15de349-ca69-4128-80dc-2808835bbbc5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_663b10ee-db31-45d7-afd7-7c305c5fdc7d" xlink:to="loc_us-gaap_SegmentDomain_c15de349-ca69-4128-80dc-2808835bbbc5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnPalaceMember_136cf769-a1fa-4bdd-a6b2-f07904328d41" xlink:href="wynn-20220930.xsd#wynn_WynnPalaceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_c15de349-ca69-4128-80dc-2808835bbbc5" xlink:to="loc_wynn_WynnPalaceMember_136cf769-a1fa-4bdd-a6b2-f07904328d41" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauMember_398a508b-ccf0-4113-a026-90267fc20348" xlink:href="wynn-20220930.xsd#wynn_WynnMacauMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_c15de349-ca69-4128-80dc-2808835bbbc5" xlink:to="loc_wynn_WynnMacauMember_398a508b-ccf0-4113-a026-90267fc20348" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OtherMacauMember_9bb85a86-d69d-4571-91be-6dc3a118fae2" xlink:href="wynn-20220930.xsd#wynn_OtherMacauMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_c15de349-ca69-4128-80dc-2808835bbbc5" xlink:to="loc_wynn_OtherMacauMember_9bb85a86-d69d-4571-91be-6dc3a118fae2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_MacauOperationsMember_41319c28-8e29-4e7f-8fe7-ff81e422d3eb" xlink:href="wynn-20220930.xsd#wynn_MacauOperationsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_c15de349-ca69-4128-80dc-2808835bbbc5" xlink:to="loc_wynn_MacauOperationsMember_41319c28-8e29-4e7f-8fe7-ff81e422d3eb" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnLasVegasMember_bac5d2d2-45c5-477e-8673-9b18b609be5d" xlink:href="wynn-20220930.xsd#wynn_WynnLasVegasMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_c15de349-ca69-4128-80dc-2808835bbbc5" xlink:to="loc_wynn_WynnLasVegasMember_bac5d2d2-45c5-477e-8673-9b18b609be5d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EncoreBostonHarborMember_e7b867df-5908-467f-9a0a-8992e3fd0b7c" xlink:href="wynn-20220930.xsd#wynn_EncoreBostonHarborMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_c15de349-ca69-4128-80dc-2808835bbbc5" xlink:to="loc_wynn_EncoreBostonHarborMember_e7b867df-5908-467f-9a0a-8992e3fd0b7c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnInteractiveLtdMember_5a068520-6045-41ac-9da3-b16fcd95a111" xlink:href="wynn-20220930.xsd#wynn_WynnInteractiveLtdMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_c15de349-ca69-4128-80dc-2808835bbbc5" xlink:to="loc_wynn_WynnInteractiveLtdMember_5a068520-6045-41ac-9da3-b16fcd95a111" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateAndOtherMember_d83c03a1-206d-4435-bc2f-d1146ba7a037" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CorporateAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_c15de349-ca69-4128-80dc-2808835bbbc5" xlink:to="loc_us-gaap_CorporateAndOtherMember_d83c03a1-206d-4435-bc2f-d1146ba7a037" xlink:type="arc" order="7"/>
  </link:definitionLink>
</link:linkbase>
