<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2020 Workiva-->
<!--r:689587ac-b55c-494c-b784-dd8b0f201ccc,g:5a9eef1b-c0ae-4c68-81de-0d15651fafbc-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.wynnresorts.com/role/DocumentandEntityInformation" xlink:type="simple" xlink:href="wynn-20200625.xsd#DocumentandEntityInformation"/>
  <link:calculationLink xlink:role="http://www.wynnresorts.com/role/DocumentandEntityInformation" xlink:type="extended"/>
</link:linkbase>