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<!--Generated by DFIN XBRL Instance Document - http://www.dfinsolutions.com/ - Version R3.0 - on 19-March-2025 [11:33:28] {PM}-->
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<loc xlink:type="locator" xlink:href="wynn-20241231.xsd#wynn_ChangeInFairValueOfEquityAwardsAtTheVestingMember" xlink:label="loc_wynn_ChangeInFairValueOfEquityAwardsAtTheVestingMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_wynn_ChangeInFairValueOfEquityAwardsAtTheVestingMember" xml:lang="en-US">Change In Fair Value Of Equity Awards At The Vesting [Member]</label>
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<loc xlink:type="locator" xlink:href="wynn-20241231.xsd#wynn_AggregateGrantDateFairValueAChangeMember" xlink:label="loc_wynn_AggregateGrantDateFairValueAChangeMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_wynn_AggregateGrantDateFairValueAChangeMember" xml:lang="en-US">Aggregate Grant Date Fair Value A Change [Member]</label>
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<loc xlink:type="locator" xlink:href="wynn-20241231.xsd#wynn_AggregateGrantDateFairValueMember" xlink:label="loc_wynn_AggregateGrantDateFairValueMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_wynn_AggregateGrantDateFairValueMember" xml:lang="en-US">Aggregate Grant Date Fair Value [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_wynn_AggregateGrantDateFairValueMember" xlink:to="lab_wynn_AggregateGrantDateFairValueMember" />
<loc xlink:type="locator" xlink:href="wynn-20241231.xsd#wynn_AggregateGrantDateFairValueRemeasuredMember" xlink:label="loc_wynn_AggregateGrantDateFairValueRemeasuredMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_wynn_AggregateGrantDateFairValueRemeasuredMember" xml:lang="en-US">Aggregate Grant Date Fair Value Remeasured [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_wynn_AggregateGrantDateFairValueRemeasuredMember" xlink:to="lab_wynn_AggregateGrantDateFairValueRemeasuredMember" />
<loc xlink:type="locator" xlink:href="wynn-20241231.xsd#wynn_GrantedPriorTo2024AndVestedIn2024Member" xlink:label="loc_wynn_GrantedPriorTo2024AndVestedIn2024Member" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_wynn_GrantedPriorTo2024AndVestedIn2024Member" xml:lang="en-US">Granted Prior To 2024 And Vested In 2024 [Member]</label>
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<loc xlink:type="locator" xlink:href="wynn-20241231.xsd#wynn_GrantedPriorTo2024Member" xlink:label="loc_wynn_GrantedPriorTo2024Member" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_wynn_GrantedPriorTo2024Member" xml:lang="en-US">Granted Prior to 2024 [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_wynn_GrantedPriorTo2024Member" xlink:to="lab_wynn_GrantedPriorTo2024Member" />
<loc xlink:type="locator" xlink:href="wynn-20241231.xsd#wynn_MrBillingsMember" xlink:label="loc_wynn_MrBillingsMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_wynn_MrBillingsMember" xml:lang="en-US">Mr. Billings [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_wynn_MrBillingsMember" xlink:to="lab_wynn_MrBillingsMember" />
<loc xlink:type="locator" xlink:href="wynn-20241231.xsd#wynn_MrMaddoxMember" xlink:label="loc_wynn_MrMaddoxMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_wynn_MrMaddoxMember" xml:lang="en-US">Mr. Maddox [Member]</label>
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