<?xml version="1.0" encoding="US-ASCII"?>
<!--XBRL Document Created with Wdesk from Workiva-->
<!-- -->
<link:linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <link:roleRef roleURI="http://www.wynnresorts.com/role/DocumentAndEntityInformation" xlink:href="wynn-20190905.xsd#DocumentAndEntityInformation" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedNetLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedNetLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodEndLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodStartLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTerseLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTotalLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/netLabel" xlink:href="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd#netLabel" xlink:type="simple" />
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/DocumentAndEntityInformation" xlink:type="extended">
    <link:loc xlink:href="wynn-20190905.xsd#wynn_DEIAbstract" xlink:label="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:type="locator" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_Security12bTitle" xlink:label="loc_dei_Security12bTitle_D391A40BE9DB5B12ACFDA875A5A8F308" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_Security12bTitle_D391A40BE9DB5B12ACFDA875A5A8F308" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityIncorporationStateCountryCode" xlink:label="loc_dei_EntityIncorporationStateCountryCode_CBDBC50BDC9D58AB9A8F1621C7AFD92F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_EntityIncorporationStateCountryCode_CBDBC50BDC9D58AB9A8F1621C7AFD92F" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityFileNumber" xlink:label="loc_dei_EntityFileNumber_275747E6067951E88A9A33FA2D1ABD90" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_EntityFileNumber_275747E6067951E88A9A33FA2D1ABD90" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityTaxIdentificationNumber" xlink:label="loc_dei_EntityTaxIdentificationNumber_F2EDF328C0F9571DA55AB36A75EE1EDA" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_EntityTaxIdentificationNumber_F2EDF328C0F9571DA55AB36A75EE1EDA" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressAddressLine1" xlink:label="loc_dei_EntityAddressAddressLine1_DBA5A42167D95BD4AACC11638E0F4D9B" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_EntityAddressAddressLine1_DBA5A42167D95BD4AACC11638E0F4D9B" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressCityOrTown" xlink:label="loc_dei_EntityAddressCityOrTown_6BE5836EADFD5DE0ABC1EBB5A36FD7EE" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_EntityAddressCityOrTown_6BE5836EADFD5DE0ABC1EBB5A36FD7EE" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressStateOrProvince" xlink:label="loc_dei_EntityAddressStateOrProvince_57D10D2174FB5E7684E50906831F789C" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_EntityAddressStateOrProvince_57D10D2174FB5E7684E50906831F789C" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentType" xlink:label="loc_dei_DocumentType_8C67E8E40A09565996F352489B0326DF" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_DocumentType_8C67E8E40A09565996F352489B0326DF" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityRegistrantName" xlink:label="loc_dei_EntityRegistrantName_58F4CB85FA9451D7979E5DBAFE4B643C" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_EntityRegistrantName_58F4CB85FA9451D7979E5DBAFE4B643C" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCentralIndexKey" xlink:label="loc_dei_EntityCentralIndexKey_46A1914E610B5E038BC68950BEB66317" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_EntityCentralIndexKey_46A1914E610B5E038BC68950BEB66317" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentPeriodEndDate" xlink:label="loc_dei_DocumentPeriodEndDate_E28A9615E97C5A87BB6E27684BD891ED" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_DocumentPeriodEndDate_E28A9615E97C5A87BB6E27684BD891ED" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressPostalZipCode" xlink:label="loc_dei_EntityAddressPostalZipCode_4FAA239F6F58544EA8425981F4D9832B" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_EntityAddressPostalZipCode_4FAA239F6F58544EA8425981F4D9832B" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CityAreaCode" xlink:label="loc_dei_CityAreaCode_3B727BB88FA1540EB57B9370B8A32AFA" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_CityAreaCode_3B727BB88FA1540EB57B9370B8A32AFA" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_LocalPhoneNumber" xlink:label="loc_dei_LocalPhoneNumber_DB5FF8BCC03356C1BD3411889B497257" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_LocalPhoneNumber_DB5FF8BCC03356C1BD3411889B497257" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_WrittenCommunications" xlink:label="loc_dei_WrittenCommunications_69D0F72329245FD2A57492955690D346" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_WrittenCommunications_69D0F72329245FD2A57492955690D346" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_TradingSymbol" xlink:label="loc_dei_TradingSymbol_7A7ACA41EC2055D8856C3741C9D4077E" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_TradingSymbol_7A7ACA41EC2055D8856C3741C9D4077E" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SecurityExchangeName" xlink:label="loc_dei_SecurityExchangeName_5186AA9C93675857879CB50BC2C91322" xlink:type="locator" />
    <link:presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_SecurityExchangeName_5186AA9C93675857879CB50BC2C91322" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SolicitingMaterial" xlink:label="loc_dei_SolicitingMaterial_71934B660CA256C3BFBFB7955913BD41" xlink:type="locator" />
    <link:presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_SolicitingMaterial_71934B660CA256C3BFBFB7955913BD41" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_PreCommencementTenderOffer" xlink:label="loc_dei_PreCommencementTenderOffer_FFD6B39F016056E5BA0356992FA85025" xlink:type="locator" />
    <link:presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_PreCommencementTenderOffer_FFD6B39F016056E5BA0356992FA85025" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_PreCommencementIssuerTenderOffer" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_554FE6B320DD546C947B7184FBAC8AEB" xlink:type="locator" />
    <link:presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_554FE6B320DD546C947B7184FBAC8AEB" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityEmergingGrowthCompany" xlink:label="loc_dei_EntityEmergingGrowthCompany_E2BD8FEEEB0E565988987B5FD6360D6E" xlink:type="locator" />
    <link:presentationArc order="21" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_EntityEmergingGrowthCompany_E2BD8FEEEB0E565988987B5FD6360D6E" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_AmendmentFlag" xlink:label="loc_dei_AmendmentFlag_95A537F7DFBD5920B7A7348C483B1D34" xlink:type="locator" />
    <link:presentationArc order="22" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_8C1BEF8ED8E55745A49630C781B5AEEE" xlink:to="loc_dei_AmendmentFlag_95A537F7DFBD5920B7A7348C483B1D34" xlink:type="arc" />
  </link:presentationLink>
</link:linkbase>
