<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2023 Workiva-->
<!--r:30ccb136-cc67-40e8-b564-525d9ffa53a9,g:43703264-e7ad-4a38-9beb-7c78c0a4c340-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.wynnresorts.com/role/Cover" xlink:type="simple" xlink:href="wynn-20230331.xsd#Cover"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_0040a777-981e-4ba8-9f39-d034983484d3" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_DocumentType_0040a777-981e-4ba8-9f39-d034983484d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_a8dd8389-4a4c-40e2-9054-f8d13f1c03b1" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_DocumentQuarterlyReport"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_DocumentQuarterlyReport_a8dd8389-4a4c-40e2-9054-f8d13f1c03b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_6acfd1a2-4bad-4915-ba87-6b550e4e4d49" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_DocumentPeriodEndDate_6acfd1a2-4bad-4915-ba87-6b550e4e4d49" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_a318fc12-9ad9-4ec5-b75b-ee7759aada9a" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_DocumentTransitionReport"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_DocumentTransitionReport_a318fc12-9ad9-4ec5-b75b-ee7759aada9a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_c9484cf9-5e4c-4760-ad1e-3a38909e4a0f" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_EntityFileNumber_c9484cf9-5e4c-4760-ad1e-3a38909e4a0f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_121f3b16-ec60-406e-a772-f247f3e6d67e" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_EntityRegistrantName_121f3b16-ec60-406e-a772-f247f3e6d67e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_14f08c74-82f6-4203-9e7c-cdc5fa080d09" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_EntityIncorporationStateCountryCode_14f08c74-82f6-4203-9e7c-cdc5fa080d09" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_9f029808-5c19-4aa6-b800-dfcf75f646cf" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_EntityTaxIdentificationNumber_9f029808-5c19-4aa6-b800-dfcf75f646cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_b7922f35-5221-4935-8c58-da46cf12924e" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_EntityAddressAddressLine1_b7922f35-5221-4935-8c58-da46cf12924e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_98f37503-4459-4661-9e3d-01b6cfa5f6e8" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_EntityAddressCityOrTown_98f37503-4459-4661-9e3d-01b6cfa5f6e8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_6b8ce2cf-53cb-4540-b08a-c047d45112b7" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_EntityAddressStateOrProvince_6b8ce2cf-53cb-4540-b08a-c047d45112b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_d2edf269-07fb-462b-bcd2-b37cb4603eac" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_EntityAddressPostalZipCode_d2edf269-07fb-462b-bcd2-b37cb4603eac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_e5c59602-249c-477f-9a10-7869be57fa45" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_CityAreaCode_e5c59602-249c-477f-9a10-7869be57fa45" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_147c7d30-5283-48ab-86bc-0eb84f648346" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_LocalPhoneNumber_147c7d30-5283-48ab-86bc-0eb84f648346" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_72d42c26-4d5c-427a-af6a-4cd589c9527a" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_Security12bTitle_72d42c26-4d5c-427a-af6a-4cd589c9527a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_19f2135e-6ea9-4bfd-8259-e0d475d65465" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_TradingSymbol_19f2135e-6ea9-4bfd-8259-e0d475d65465" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_29ba6bb5-5aca-4fc9-a31e-7d3bd10ac306" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_SecurityExchangeName_29ba6bb5-5aca-4fc9-a31e-7d3bd10ac306" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_73ddcede-c183-428d-93ad-f8f55dad3c4e" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityCurrentReportingStatus"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_EntityCurrentReportingStatus_73ddcede-c183-428d-93ad-f8f55dad3c4e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_a32d841a-3e8e-4a89-935e-7eb2c01c7291" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_EntityInteractiveDataCurrent_a32d841a-3e8e-4a89-935e-7eb2c01c7291" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_1b70bac2-ad04-49eb-b69c-f557167a1c05" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityFilerCategory"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_EntityFilerCategory_1b70bac2-ad04-49eb-b69c-f557167a1c05" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_8842430c-9073-4c50-b85b-246633a5b492" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntitySmallBusiness"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_EntitySmallBusiness_8842430c-9073-4c50-b85b-246633a5b492" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_96ba8552-1798-4870-880b-9ec1de5f1835" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_EntityEmergingGrowthCompany_96ba8552-1798-4870-880b-9ec1de5f1835" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_2e6ab5a5-47aa-4be1-8117-1d82ee2c38ef" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityShellCompany"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_EntityShellCompany_2e6ab5a5-47aa-4be1-8117-1d82ee2c38ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_d816ca16-361e-4e01-aa47-b20c9b1ed672" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_d816ca16-361e-4e01-aa47-b20c9b1ed672" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_3542974c-c4c3-412d-b9dc-05c4b66122be" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_AmendmentFlag_3542974c-c4c3-412d-b9dc-05c4b66122be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_b25cbd1b-298e-4903-ab68-fb257f31d980" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_EntityCentralIndexKey_b25cbd1b-298e-4903-ab68-fb257f31d980" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_18bdff02-853f-4357-9672-e3ce52bf9ab9" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:presentationArc order="27" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_CurrentFiscalYearEndDate_18bdff02-853f-4357-9672-e3ce52bf9ab9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_8b315297-2f7f-4160-9a38-e3cbabf89b07" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_DocumentFiscalYearFocus"/>
    <link:presentationArc order="28" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_DocumentFiscalYearFocus_8b315297-2f7f-4160-9a38-e3cbabf89b07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_8a15b261-b003-444f-bf18-8efe823f04d5" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:presentationArc order="29" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_9713d741-9b27-4dc7-aa7c-3260595985b2" xlink:to="loc_dei_DocumentFiscalPeriodFocus_8a15b261-b003-444f-bf18-8efe823f04d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="wynn-20230331.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_6968671c-e9c6-42b7-aef0-90d693ad537b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract_8781402f-9ba3-4f43-9076-5aa22616f01b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_6968671c-e9c6-42b7-aef0-90d693ad537b" xlink:to="loc_us-gaap_AssetsAbstract_8781402f-9ba3-4f43-9076-5aa22616f01b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrentAbstract_819a8248-83af-45c6-8caf-af4e1f6bf0de" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_8781402f-9ba3-4f43-9076-5aa22616f01b" xlink:to="loc_us-gaap_AssetsCurrentAbstract_819a8248-83af-45c6-8caf-af4e1f6bf0de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_e09ebd51-57de-4297-bf88-3f3e00c6a10e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_819a8248-83af-45c6-8caf-af4e1f6bf0de" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_e09ebd51-57de-4297-bf88-3f3e00c6a10e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashCurrent_4a1291ee-ab2b-4fcb-9898-6a365b7252ef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCashCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_819a8248-83af-45c6-8caf-af4e1f6bf0de" xlink:to="loc_us-gaap_RestrictedCashCurrent_4a1291ee-ab2b-4fcb-9898-6a365b7252ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_2aff47b4-df8d-4a1a-8be5-392c2ea91d18" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_819a8248-83af-45c6-8caf-af4e1f6bf0de" xlink:to="loc_us-gaap_ReceivablesNetCurrent_2aff47b4-df8d-4a1a-8be5-392c2ea91d18" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_3bcadb01-d3cc-49a2-b3ff-941b6bc22bfb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryNet"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_819a8248-83af-45c6-8caf-af4e1f6bf0de" xlink:to="loc_us-gaap_InventoryNet_3bcadb01-d3cc-49a2-b3ff-941b6bc22bfb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_2b305767-04fc-4a72-be78-b3d985bd0ef2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_819a8248-83af-45c6-8caf-af4e1f6bf0de" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_2b305767-04fc-4a72-be78-b3d985bd0ef2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_1a00ad73-462b-4d5d-9d42-ba5b1c9f69f2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_819a8248-83af-45c6-8caf-af4e1f6bf0de" xlink:to="loc_us-gaap_AssetsCurrent_1a00ad73-462b-4d5d-9d42-ba5b1c9f69f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_554f4da6-41ae-43a2-9095-522e061315cd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_8781402f-9ba3-4f43-9076-5aa22616f01b" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_554f4da6-41ae-43a2-9095-522e061315cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_4fa2fe4c-e6d0-4be5-ada8-216455197d28" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_8781402f-9ba3-4f43-9076-5aa22616f01b" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_4fa2fe4c-e6d0-4be5-ada8-216455197d28" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_86d93375-04d3-42a1-bc03-272336cba0b1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_8781402f-9ba3-4f43-9076-5aa22616f01b" xlink:to="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_86d93375-04d3-42a1-bc03-272336cba0b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_4604c245-83a0-404d-a077-1dbb806e6f82" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_8781402f-9ba3-4f43-9076-5aa22616f01b" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_4604c245-83a0-404d-a077-1dbb806e6f82" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_1bde6eeb-5d30-49c3-a575-cbc08afc2eeb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_8781402f-9ba3-4f43-9076-5aa22616f01b" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_1bde6eeb-5d30-49c3-a575-cbc08afc2eeb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_ea844c9c-4555-449a-98a6-fd083e2186ff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Assets"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_8781402f-9ba3-4f43-9076-5aa22616f01b" xlink:to="loc_us-gaap_Assets_ea844c9c-4555-449a-98a6-fd083e2186ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d47782ec-cc8d-4c22-a565-50f90cdee6dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_6968671c-e9c6-42b7-aef0-90d693ad537b" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d47782ec-cc8d-4c22-a565-50f90cdee6dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_c5705641-6abe-4db0-bce6-f3f1cc2beba6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d47782ec-cc8d-4c22-a565-50f90cdee6dd" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_c5705641-6abe-4db0-bce6-f3f1cc2beba6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_cad243a4-f66a-4c8f-9ce0-a1d6cbf2b441" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_c5705641-6abe-4db0-bce6-f3f1cc2beba6" xlink:to="loc_us-gaap_AccountsPayableCurrent_cad243a4-f66a-4c8f-9ce0-a1d6cbf2b441" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_1686cc14-e56c-43ca-b5ff-fdc965029abb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_c5705641-6abe-4db0-bce6-f3f1cc2beba6" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_1686cc14-e56c-43ca-b5ff-fdc965029abb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_GamingTaxesPayableCurrent_ab61e3bd-ef6b-4184-9fad-9a23b25ff518" xlink:href="wynn-20230331.xsd#wynn_GamingTaxesPayableCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_c5705641-6abe-4db0-bce6-f3f1cc2beba6" xlink:to="loc_wynn_GamingTaxesPayableCurrent_ab61e3bd-ef6b-4184-9fad-9a23b25ff518" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_a5a658ea-465c-4eb3-9ea1-fac76de9c928" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_c5705641-6abe-4db0-bce6-f3f1cc2beba6" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_a5a658ea-465c-4eb3-9ea1-fac76de9c928" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPayableCurrent_46349db2-8137-4c7e-af28-00ba5864ec59" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestPayableCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_c5705641-6abe-4db0-bce6-f3f1cc2beba6" xlink:to="loc_us-gaap_InterestPayableCurrent_46349db2-8137-4c7e-af28-00ba5864ec59" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_0d543a0f-8bba-4494-b388-aa0ef2e1de11" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_c5705641-6abe-4db0-bce6-f3f1cc2beba6" xlink:to="loc_us-gaap_LongTermDebtCurrent_0d543a0f-8bba-4494-b388-aa0ef2e1de11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_59aca9b5-6567-4b4c-a1c8-bd38edd988c6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_c5705641-6abe-4db0-bce6-f3f1cc2beba6" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_59aca9b5-6567-4b4c-a1c8-bd38edd988c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_dc1f65dc-7df3-4b36-9727-d0823eae878b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_c5705641-6abe-4db0-bce6-f3f1cc2beba6" xlink:to="loc_us-gaap_LiabilitiesCurrent_dc1f65dc-7df3-4b36-9727-d0823eae878b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_ee13c2d6-6d42-4d1b-a593-532777767075" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d47782ec-cc8d-4c22-a565-50f90cdee6dd" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_ee13c2d6-6d42-4d1b-a593-532777767075" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_b773bcbb-9744-4e97-86ad-cecd36f5da68" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d47782ec-cc8d-4c22-a565-50f90cdee6dd" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_b773bcbb-9744-4e97-86ad-cecd36f5da68" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_5f5fc1ea-4c13-42ee-8a52-3d4dfc79f80d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d47782ec-cc8d-4c22-a565-50f90cdee6dd" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_5f5fc1ea-4c13-42ee-8a52-3d4dfc79f80d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_1ddb12f1-0fd6-490d-b92b-94cca9b7a807" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d47782ec-cc8d-4c22-a565-50f90cdee6dd" xlink:to="loc_us-gaap_Liabilities_1ddb12f1-0fd6-490d-b92b-94cca9b7a807" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_158d6533-1efe-46f0-914e-f66dc327eca1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d47782ec-cc8d-4c22-a565-50f90cdee6dd" xlink:to="loc_us-gaap_CommitmentsAndContingencies_158d6533-1efe-46f0-914e-f66dc327eca1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_c184bc28-4b08-40e4-9b58-2595ed989eff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d47782ec-cc8d-4c22-a565-50f90cdee6dd" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_c184bc28-4b08-40e4-9b58-2595ed989eff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_0885ff76-7eda-4195-94d8-2d51bd0cc1e7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_c184bc28-4b08-40e4-9b58-2595ed989eff" xlink:to="loc_us-gaap_PreferredStockValue_0885ff76-7eda-4195-94d8-2d51bd0cc1e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_f41d0a5f-e031-426c-ae93-3e01afe528b2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_c184bc28-4b08-40e4-9b58-2595ed989eff" xlink:to="loc_us-gaap_CommonStockValue_f41d0a5f-e031-426c-ae93-3e01afe528b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_d292d4da-1456-4c58-b01a-fdea7e08f2e7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockValue"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_c184bc28-4b08-40e4-9b58-2595ed989eff" xlink:to="loc_us-gaap_TreasuryStockValue_d292d4da-1456-4c58-b01a-fdea7e08f2e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_1c482333-c8f4-4d12-9e26-6f0c62c6f8b0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_c184bc28-4b08-40e4-9b58-2595ed989eff" xlink:to="loc_us-gaap_AdditionalPaidInCapital_1c482333-c8f4-4d12-9e26-6f0c62c6f8b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_1e856b97-0cf7-4126-9ea8-715906a0d49b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_c184bc28-4b08-40e4-9b58-2595ed989eff" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_1e856b97-0cf7-4126-9ea8-715906a0d49b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_8e2e9043-6dd6-4703-b5c7-7c3acfef4809" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_c184bc28-4b08-40e4-9b58-2595ed989eff" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_8e2e9043-6dd6-4703-b5c7-7c3acfef4809" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_931426cb-57bc-446a-ac3f-e2fbf4040a60" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_c184bc28-4b08-40e4-9b58-2595ed989eff" xlink:to="loc_us-gaap_StockholdersEquity_931426cb-57bc-446a-ac3f-e2fbf4040a60" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterest_dc10c154-fb4f-48d1-9314-33b81b832ea1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MinorityInterest"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_c184bc28-4b08-40e4-9b58-2595ed989eff" xlink:to="loc_us-gaap_MinorityInterest_dc10c154-fb4f-48d1-9314-33b81b832ea1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_e7099798-df4a-42d3-a7b7-9ed31fe5933f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_c184bc28-4b08-40e4-9b58-2595ed989eff" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_e7099798-df4a-42d3-a7b7-9ed31fe5933f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_f65a435a-da41-4fc3-a055-f542c4de694a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d47782ec-cc8d-4c22-a565-50f90cdee6dd" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_f65a435a-da41-4fc3-a055-f542c4de694a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="wynn-20230331.xsd#CondensedConsolidatedBalanceSheetsParenthetical"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_9e8b1deb-ea97-4694-adb9-f6aa4a9c4969" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_948a5cc0-daee-4594-adcf-333cbe65d27f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_9e8b1deb-ea97-4694-adb9-f6aa4a9c4969" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_948a5cc0-daee-4594-adcf-333cbe65d27f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_c2eab691-f705-4388-aa7c-b2e12841d07d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_9e8b1deb-ea97-4694-adb9-f6aa4a9c4969" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_c2eab691-f705-4388-aa7c-b2e12841d07d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_429796bd-e9f3-44a4-ab0e-d13f73e1620c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_9e8b1deb-ea97-4694-adb9-f6aa4a9c4969" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_429796bd-e9f3-44a4-ab0e-d13f73e1620c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesIssued_fd27129c-7342-4d2c-bb07-b1deb7474033" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockSharesIssued"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_9e8b1deb-ea97-4694-adb9-f6aa4a9c4969" xlink:to="loc_us-gaap_PreferredStockSharesIssued_fd27129c-7342-4d2c-bb07-b1deb7474033" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_cb432384-a0d2-416e-b20e-ca18a93e9838" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockSharesOutstanding"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_9e8b1deb-ea97-4694-adb9-f6aa4a9c4969" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_cb432384-a0d2-416e-b20e-ca18a93e9838" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_d4e7f27f-a4d8-4de1-af08-0be93ed5a840" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_9e8b1deb-ea97-4694-adb9-f6aa4a9c4969" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_d4e7f27f-a4d8-4de1-af08-0be93ed5a840" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_93843ccc-f33c-4b0d-8be5-18dd36291287" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_9e8b1deb-ea97-4694-adb9-f6aa4a9c4969" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_93843ccc-f33c-4b0d-8be5-18dd36291287" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_ffa9f73c-7527-49ee-81dc-bc67da84d07d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_9e8b1deb-ea97-4694-adb9-f6aa4a9c4969" xlink:to="loc_us-gaap_CommonStockSharesIssued_ffa9f73c-7527-49ee-81dc-bc67da84d07d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_d92db463-70c3-41e5-8e50-c78823530bc7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_9e8b1deb-ea97-4694-adb9-f6aa4a9c4969" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_d92db463-70c3-41e5-8e50-c78823530bc7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockShares_9d8fab70-ae47-42ed-a416-1ae364a81339" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockShares"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_9e8b1deb-ea97-4694-adb9-f6aa4a9c4969" xlink:to="loc_us-gaap_TreasuryStockShares_9d8fab70-ae47-42ed-a416-1ae364a81339" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsofOperationsunaudited" xlink:type="simple" xlink:href="wynn-20230331.xsd#CondensedConsolidatedStatementsofOperationsunaudited"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsofOperationsunaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementAbstract_f8619e5a-63a0-4d3f-85a7-c8f23e977fce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_9edf81be-cb87-4c1e-b0fb-76a15c4c7f01" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_f8619e5a-63a0-4d3f-85a7-c8f23e977fce" xlink:to="loc_us-gaap_StatementTable_9edf81be-cb87-4c1e-b0fb-76a15c4c7f01" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_caa2a9b5-2c34-4a26-a046-37f4243a994e" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_9edf81be-cb87-4c1e-b0fb-76a15c4c7f01" xlink:to="loc_srt_ProductOrServiceAxis_caa2a9b5-2c34-4a26-a046-37f4243a994e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_2e53fc23-7191-4a20-8a6c-a020e1a68b62" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_caa2a9b5-2c34-4a26-a046-37f4243a994e" xlink:to="loc_srt_ProductsAndServicesDomain_2e53fc23-7191-4a20-8a6c-a020e1a68b62" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CasinoMember_73cac047-8b38-433d-9a95-189446a0c290" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CasinoMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_2e53fc23-7191-4a20-8a6c-a020e1a68b62" xlink:to="loc_us-gaap_CasinoMember_73cac047-8b38-433d-9a95-189446a0c290" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OccupancyMember_29b1bbc0-c6ac-472a-b596-81e7523a8230" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OccupancyMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_2e53fc23-7191-4a20-8a6c-a020e1a68b62" xlink:to="loc_us-gaap_OccupancyMember_29b1bbc0-c6ac-472a-b596-81e7523a8230" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FoodAndBeverageMember_1edb7c84-2c2f-4ef9-881e-6e6b88ffc6a3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FoodAndBeverageMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_2e53fc23-7191-4a20-8a6c-a020e1a68b62" xlink:to="loc_us-gaap_FoodAndBeverageMember_1edb7c84-2c2f-4ef9-881e-6e6b88ffc6a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EntertainmentRetailAndOtherMember_b6ec26bf-665b-4b39-9ab0-1568d60bb29a" xlink:href="wynn-20230331.xsd#wynn_EntertainmentRetailAndOtherMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_2e53fc23-7191-4a20-8a6c-a020e1a68b62" xlink:to="loc_wynn_EntertainmentRetailAndOtherMember_b6ec26bf-665b-4b39-9ab0-1568d60bb29a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_f33324c4-ac81-462d-a16e-35d67e084a65" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_9edf81be-cb87-4c1e-b0fb-76a15c4c7f01" xlink:to="loc_us-gaap_StatementLineItems_f33324c4-ac81-462d-a16e-35d67e084a65" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_29c64a25-8b81-4ba4-af31-9bc302e0822b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenuesAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_f33324c4-ac81-462d-a16e-35d67e084a65" xlink:to="loc_us-gaap_RevenuesAbstract_29c64a25-8b81-4ba4-af31-9bc302e0822b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_b22dc681-cc44-4e46-af65-331a388642a0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_29c64a25-8b81-4ba4-af31-9bc302e0822b" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_b22dc681-cc44-4e46-af65-331a388642a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpensesAbstract_beb8ca1e-a34c-4b3b-abcb-59f73ccfb657" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostsAndExpensesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_f33324c4-ac81-462d-a16e-35d67e084a65" xlink:to="loc_us-gaap_CostsAndExpensesAbstract_beb8ca1e-a34c-4b3b-abcb-59f73ccfb657" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_569aa5ea-ba82-4a25-a40f-13dbef878c26" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_beb8ca1e-a34c-4b3b-abcb-59f73ccfb657" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_569aa5ea-ba82-4a25-a40f-13dbef878c26" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_f865b1f3-db3d-45e4-aef3-9246e8c41c4a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_beb8ca1e-a34c-4b3b-abcb-59f73ccfb657" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_f865b1f3-db3d-45e4-aef3-9246e8c41c4a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_980ca3c9-9834-413f-afb3-b04e57457fd6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProvisionForDoubtfulAccounts"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_beb8ca1e-a34c-4b3b-abcb-59f73ccfb657" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_980ca3c9-9834-413f-afb3-b04e57457fd6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreOpeningCosts_fc9076d8-c4bf-4364-9ae1-aea7470d176a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreOpeningCosts"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_beb8ca1e-a34c-4b3b-abcb-59f73ccfb657" xlink:to="loc_us-gaap_PreOpeningCosts_fc9076d8-c4bf-4364-9ae1-aea7470d176a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAndAmortization_99e5d66c-3041-4aab-9b3d-fa4fe9720bdf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepreciationAndAmortization"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_beb8ca1e-a34c-4b3b-abcb-59f73ccfb657" xlink:to="loc_us-gaap_DepreciationAndAmortization_99e5d66c-3041-4aab-9b3d-fa4fe9720bdf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_ProjectAbandonmentCosts_1bb72662-b928-495b-b2b9-2a2043e98f20" xlink:href="wynn-20230331.xsd#wynn_ProjectAbandonmentCosts"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_beb8ca1e-a34c-4b3b-abcb-59f73ccfb657" xlink:to="loc_wynn_ProjectAbandonmentCosts_1bb72662-b928-495b-b2b9-2a2043e98f20" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_0d149084-26f2-43b9-9e26-da0c3beff35c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostsAndExpenses"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_beb8ca1e-a34c-4b3b-abcb-59f73ccfb657" xlink:to="loc_us-gaap_CostsAndExpenses_0d149084-26f2-43b9-9e26-da0c3beff35c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_2b9f5401-08ad-48f4-bf35-536e13651d92" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_f33324c4-ac81-462d-a16e-35d67e084a65" xlink:to="loc_us-gaap_OperatingIncomeLoss_2b9f5401-08ad-48f4-bf35-536e13651d92" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_2262fe12-f2d9-4571-b05f-4b4f8aa6ac94" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonoperatingIncomeExpenseAbstract"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_f33324c4-ac81-462d-a16e-35d67e084a65" xlink:to="loc_us-gaap_NonoperatingIncomeExpenseAbstract_2262fe12-f2d9-4571-b05f-4b4f8aa6ac94" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_467e9792-ec64-4281-b7d4-fe33dc75f2a2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_2262fe12-f2d9-4571-b05f-4b4f8aa6ac94" xlink:to="loc_us-gaap_InvestmentIncomeInterest_467e9792-ec64-4281-b7d4-fe33dc75f2a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_cbe3d606-a0b8-4941-803a-efc8ed6c6f5d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_2262fe12-f2d9-4571-b05f-4b4f8aa6ac94" xlink:to="loc_us-gaap_InterestExpense_cbe3d606-a0b8-4941-803a-efc8ed6c6f5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_7ab849ef-fc50-4435-9a16-4bbe5f85dfd9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_2262fe12-f2d9-4571-b05f-4b4f8aa6ac94" xlink:to="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_7ab849ef-fc50-4435-9a16-4bbe5f85dfd9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_122e9bc5-5a11-4fa3-be3d-df6f532a28f2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_2262fe12-f2d9-4571-b05f-4b4f8aa6ac94" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_122e9bc5-5a11-4fa3-be3d-df6f532a28f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_8f8e44be-fb03-4abd-8b0c-c7f35f749944" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_2262fe12-f2d9-4571-b05f-4b4f8aa6ac94" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_8f8e44be-fb03-4abd-8b0c-c7f35f749944" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_56962512-6ec6-4528-b8a9-53368912ec0b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_2262fe12-f2d9-4571-b05f-4b4f8aa6ac94" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_56962512-6ec6-4528-b8a9-53368912ec0b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_5c369f74-8cbd-4426-ac23-6f4b95b1a51c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_f33324c4-ac81-462d-a16e-35d67e084a65" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_5c369f74-8cbd-4426-ac23-6f4b95b1a51c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_43379834-8322-40c7-904a-39b41dfaedcd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_f33324c4-ac81-462d-a16e-35d67e084a65" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_43379834-8322-40c7-904a-39b41dfaedcd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_f047ac08-5167-4bc1-8895-f2f3c95d4ddd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_f33324c4-ac81-462d-a16e-35d67e084a65" xlink:to="loc_us-gaap_ProfitLoss_f047ac08-5167-4bc1-8895-f2f3c95d4ddd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_ee5b8fc4-13d9-4334-af7e-8cee1e740acf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_f33324c4-ac81-462d-a16e-35d67e084a65" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_ee5b8fc4-13d9-4334-af7e-8cee1e740acf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_6e643c09-4e23-4abc-a123-de6be164008e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_f33324c4-ac81-462d-a16e-35d67e084a65" xlink:to="loc_us-gaap_NetIncomeLoss_6e643c09-4e23-4abc-a123-de6be164008e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_b6506340-8880-4168-a70e-7cf0f14b6bf7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareBasicAndDilutedAbstract"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_f33324c4-ac81-462d-a16e-35d67e084a65" xlink:to="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_b6506340-8880-4168-a70e-7cf0f14b6bf7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_f698ef2f-40d7-4fda-97f5-0ed17ab70261" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_b6506340-8880-4168-a70e-7cf0f14b6bf7" xlink:to="loc_us-gaap_EarningsPerShareAbstract_f698ef2f-40d7-4fda-97f5-0ed17ab70261" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_3e68dc55-13eb-4c6d-8989-8bc335082545" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_f698ef2f-40d7-4fda-97f5-0ed17ab70261" xlink:to="loc_us-gaap_EarningsPerShareBasic_3e68dc55-13eb-4c6d-8989-8bc335082545" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_881cd848-4cc7-429d-84bf-b24025064e34" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_f698ef2f-40d7-4fda-97f5-0ed17ab70261" xlink:to="loc_us-gaap_EarningsPerShareDiluted_881cd848-4cc7-429d-84bf-b24025064e34" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_89170092-70f9-4d2e-8eb2-fe305e579673" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_f33324c4-ac81-462d-a16e-35d67e084a65" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_89170092-70f9-4d2e-8eb2-fe305e579673" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_a0fc9cfb-bf05-41da-9cb9-f4081f8a42b0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_89170092-70f9-4d2e-8eb2-fe305e579673" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_a0fc9cfb-bf05-41da-9cb9-f4081f8a42b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_4b5d334c-25d7-4c47-bff7-8e473ee09e6b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_89170092-70f9-4d2e-8eb2-fe305e579673" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_4b5d334c-25d7-4c47-bff7-8e473ee09e6b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsofComprehensiveIncomeLossunaudited" xlink:type="simple" xlink:href="wynn-20230331.xsd#CondensedConsolidatedStatementsofComprehensiveIncomeLossunaudited"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsofComprehensiveIncomeLossunaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_1f2a88dc-fee4-4a15-9686-f8538e7ed53d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_218c90e3-4e36-4f6c-8447-1b2b6f0fdef7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_1f2a88dc-fee4-4a15-9686-f8538e7ed53d" xlink:to="loc_us-gaap_ProfitLoss_218c90e3-4e36-4f6c-8447-1b2b6f0fdef7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPeriodIncreaseDecreaseAbstract_471d492a-34a6-48ef-9832-ffdc55e382a8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPeriodIncreaseDecreaseAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_1f2a88dc-fee4-4a15-9686-f8538e7ed53d" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPeriodIncreaseDecreaseAbstract_471d492a-34a6-48ef-9832-ffdc55e382a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_08ac3532-e74e-4f82-8797-500c80a78e42" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPeriodIncreaseDecreaseAbstract_471d492a-34a6-48ef-9832-ffdc55e382a8" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_08ac3532-e74e-4f82-8797-500c80a78e42" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_164c7858-7ce3-425a-a327-dfd42fdde52f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_1f2a88dc-fee4-4a15-9686-f8538e7ed53d" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_164c7858-7ce3-425a-a327-dfd42fdde52f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_64f4237c-842d-4154-a590-01999e96afae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_1f2a88dc-fee4-4a15-9686-f8538e7ed53d" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_64f4237c-842d-4154-a590-01999e96afae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_d3ea95fe-9dc6-4e50-a4e2-25b1af026deb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_1f2a88dc-fee4-4a15-9686-f8538e7ed53d" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_d3ea95fe-9dc6-4e50-a4e2-25b1af026deb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementofStockholdersDeficitunaudited" xlink:type="simple" xlink:href="wynn-20230331.xsd#CondensedConsolidatedStatementofStockholdersDeficitunaudited"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedStatementofStockholdersDeficitunaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_183a02cf-b7c7-4aec-9643-2431940ed500" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_dd2e29a5-6ca5-4fb8-9bc1-0f80da2c4400" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_183a02cf-b7c7-4aec-9643-2431940ed500" xlink:to="loc_us-gaap_StatementTable_dd2e29a5-6ca5-4fb8-9bc1-0f80da2c4400" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_d2fed41f-b3a6-4863-8303-20b6beafd99e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_dd2e29a5-6ca5-4fb8-9bc1-0f80da2c4400" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_d2fed41f-b3a6-4863-8303-20b6beafd99e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_58282751-a839-4e2c-ad97-65ba3a5cf843" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_d2fed41f-b3a6-4863-8303-20b6beafd99e" xlink:to="loc_us-gaap_EquityComponentDomain_58282751-a839-4e2c-ad97-65ba3a5cf843" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ParentMember_e1f24f09-d9bb-4ced-9340-9282be698669" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ParentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_58282751-a839-4e2c-ad97-65ba3a5cf843" xlink:to="loc_us-gaap_ParentMember_e1f24f09-d9bb-4ced-9340-9282be698669" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_88192f33-22e0-45d1-96d6-9f48c1ea1605" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ParentMember_e1f24f09-d9bb-4ced-9340-9282be698669" xlink:to="loc_us-gaap_CommonStockMember_88192f33-22e0-45d1-96d6-9f48c1ea1605" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockMember_79992ecf-dd41-4c17-befe-34e585be93eb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ParentMember_e1f24f09-d9bb-4ced-9340-9282be698669" xlink:to="loc_us-gaap_TreasuryStockMember_79992ecf-dd41-4c17-befe-34e585be93eb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_f27dfa70-2d01-48ef-a079-eba1fd71126a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ParentMember_e1f24f09-d9bb-4ced-9340-9282be698669" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_f27dfa70-2d01-48ef-a079-eba1fd71126a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_29a7965a-aeaa-4340-af4e-4ba69ad85afb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ParentMember_e1f24f09-d9bb-4ced-9340-9282be698669" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_29a7965a-aeaa-4340-af4e-4ba69ad85afb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_cf0ce1a8-7ff4-4fc6-a6a2-3d4884105287" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ParentMember_e1f24f09-d9bb-4ced-9340-9282be698669" xlink:to="loc_us-gaap_RetainedEarningsMember_cf0ce1a8-7ff4-4fc6-a6a2-3d4884105287" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestMember_2d63c215-9e07-491e-b0e0-b5f1eeeca2b5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoncontrollingInterestMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_58282751-a839-4e2c-ad97-65ba3a5cf843" xlink:to="loc_us-gaap_NoncontrollingInterestMember_2d63c215-9e07-491e-b0e0-b5f1eeeca2b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_1a1e2fa2-9d72-4ba2-b7f3-33d83e13538e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_dd2e29a5-6ca5-4fb8-9bc1-0f80da2c4400" xlink:to="loc_us-gaap_StatementLineItems_1a1e2fa2-9d72-4ba2-b7f3-33d83e13538e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_07c6e04b-4fa2-47c4-b7aa-5d40ed9114c5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1a1e2fa2-9d72-4ba2-b7f3-33d83e13538e" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_07c6e04b-4fa2-47c4-b7aa-5d40ed9114c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_07ea8261-eef3-4293-9176-f2c6b77140e0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharesOutstanding"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_07c6e04b-4fa2-47c4-b7aa-5d40ed9114c5" xlink:to="loc_us-gaap_SharesOutstanding_07ea8261-eef3-4293-9176-f2c6b77140e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_a26556e8-e682-4053-a3e8-5601a5038aa2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_07c6e04b-4fa2-47c4-b7aa-5d40ed9114c5" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_a26556e8-e682-4053-a3e8-5601a5038aa2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_9d2894e5-41de-4e3f-81f5-03752d5e9f1b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_07c6e04b-4fa2-47c4-b7aa-5d40ed9114c5" xlink:to="loc_us-gaap_ProfitLoss_9d2894e5-41de-4e3f-81f5-03752d5e9f1b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_c2d138ac-db55-4ea0-9197-fb382440797e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_07c6e04b-4fa2-47c4-b7aa-5d40ed9114c5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_c2d138ac-db55-4ea0-9197-fb382440797e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_86ef5785-846e-4d3a-a0c9-8d672627c7fd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_07c6e04b-4fa2-47c4-b7aa-5d40ed9114c5" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_86ef5785-846e-4d3a-a0c9-8d672627c7fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures_f64d8746-d3cb-4668-ae73-7826cc10f2f3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_07c6e04b-4fa2-47c4-b7aa-5d40ed9114c5" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures_f64d8746-d3cb-4668-ae73-7826cc10f2f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited_fcb4a467-2ec9-436c-8791-b63923c5efc5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_07c6e04b-4fa2-47c4-b7aa-5d40ed9114c5" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited_fcb4a467-2ec9-436c-8791-b63923c5efc5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardForfeitures_3876ed41-417b-4df2-a385-9a68dc2a1134" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardForfeitures"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_07c6e04b-4fa2-47c4-b7aa-5d40ed9114c5" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardForfeitures_3876ed41-417b-4df2-a385-9a68dc2a1134" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_43f86c4d-72ff-41e0-a2f7-a6dd34506a0d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockSharesAcquired"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_07c6e04b-4fa2-47c4-b7aa-5d40ed9114c5" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_43f86c4d-72ff-41e0-a2f7-a6dd34506a0d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_f479f301-c096-49d7-bab6-030cef2a68aa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_07c6e04b-4fa2-47c4-b7aa-5d40ed9114c5" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_f479f301-c096-49d7-bab6-030cef2a68aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_e4aa56f9-11cc-4aed-a2d2-4ca48042d15c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_07c6e04b-4fa2-47c4-b7aa-5d40ed9114c5" xlink:to="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_e4aa56f9-11cc-4aed-a2d2-4ca48042d15c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_NoncontrollingInterestTransactionsWithSubsidiaryMinorityShareholdersShares_d392e590-1396-412a-857d-3dc8ef48322f" xlink:href="wynn-20230331.xsd#wynn_NoncontrollingInterestTransactionsWithSubsidiaryMinorityShareholdersShares"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_07c6e04b-4fa2-47c4-b7aa-5d40ed9114c5" xlink:to="loc_wynn_NoncontrollingInterestTransactionsWithSubsidiaryMinorityShareholdersShares_d392e590-1396-412a-857d-3dc8ef48322f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_NoncontrollingInterestTransactionsWithSubsidiaryMinorityShareholdersValue_24ae8199-ca2c-435b-9ccf-64dffa6ec4cd" xlink:href="wynn-20230331.xsd#wynn_NoncontrollingInterestTransactionsWithSubsidiaryMinorityShareholdersValue"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_07c6e04b-4fa2-47c4-b7aa-5d40ed9114c5" xlink:to="loc_wynn_NoncontrollingInterestTransactionsWithSubsidiaryMinorityShareholdersValue_24ae8199-ca2c-435b-9ccf-64dffa6ec4cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_NoncontrollingInterestIncreaseDecreaseToAdditionalPaidInCapital_1e6872a5-b391-4c56-ac2c-36026ea1fceb" xlink:href="wynn-20230331.xsd#wynn_NoncontrollingInterestIncreaseDecreaseToAdditionalPaidInCapital"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_07c6e04b-4fa2-47c4-b7aa-5d40ed9114c5" xlink:to="loc_wynn_NoncontrollingInterestIncreaseDecreaseToAdditionalPaidInCapital_1e6872a5-b391-4c56-ac2c-36026ea1fceb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_63610070-93ad-445c-a441-7699bb244853" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_07c6e04b-4fa2-47c4-b7aa-5d40ed9114c5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_63610070-93ad-445c-a441-7699bb244853" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_c8399576-e853-4e08-965f-243f2ddb8901" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_07c6e04b-4fa2-47c4-b7aa-5d40ed9114c5" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_c8399576-e853-4e08-965f-243f2ddb8901" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_12c86fac-5a18-4bc6-81a9-48017f40fc7a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharesOutstanding"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_07c6e04b-4fa2-47c4-b7aa-5d40ed9114c5" xlink:to="loc_us-gaap_SharesOutstanding_12c86fac-5a18-4bc6-81a9-48017f40fc7a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_f2fc172b-4570-4347-b21c-a934caa1a5f8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_07c6e04b-4fa2-47c4-b7aa-5d40ed9114c5" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_f2fc172b-4570-4347-b21c-a934caa1a5f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsofCashFlowsunaudited" xlink:type="simple" xlink:href="wynn-20230331.xsd#CondensedConsolidatedStatementsofCashFlowsunaudited"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsofCashFlowsunaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_512e3928-5086-47d9-a40f-71fe131060c6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_99daa40e-7945-4249-923d-9ea784024f6f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_512e3928-5086-47d9-a40f-71fe131060c6" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_99daa40e-7945-4249-923d-9ea784024f6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_b60b4e7a-1c2d-4450-8186-592baeac198f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_99daa40e-7945-4249-923d-9ea784024f6f" xlink:to="loc_us-gaap_ProfitLoss_b60b4e7a-1c2d-4450-8186-592baeac198f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_2c5536cd-ba85-4ae9-9dec-20654cc03087" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_99daa40e-7945-4249-923d-9ea784024f6f" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_2c5536cd-ba85-4ae9-9dec-20654cc03087" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAndAmortization_a24bc145-8b0f-4d23-9867-bc6a786b4259" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepreciationAndAmortization"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_2c5536cd-ba85-4ae9-9dec-20654cc03087" xlink:to="loc_us-gaap_DepreciationAndAmortization_a24bc145-8b0f-4d23-9867-bc6a786b4259" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_f331cd84-ad1f-41ce-9349-ef81aa546649" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_2c5536cd-ba85-4ae9-9dec-20654cc03087" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_f331cd84-ad1f-41ce-9349-ef81aa546649" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_836439d5-24cc-4cc5-89c1-1242ecc2d8a9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_2c5536cd-ba85-4ae9-9dec-20654cc03087" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_836439d5-24cc-4cc5-89c1-1242ecc2d8a9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_2809fc0e-f4a0-4025-8480-4fb9bd5b35a7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_2c5536cd-ba85-4ae9-9dec-20654cc03087" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_2809fc0e-f4a0-4025-8480-4fb9bd5b35a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_LossesOnExtinguishmentOfDebt_ad21cf3f-bf08-413b-b55b-5278c870c49f" xlink:href="wynn-20230331.xsd#wynn_LossesOnExtinguishmentOfDebt"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_2c5536cd-ba85-4ae9-9dec-20654cc03087" xlink:to="loc_wynn_LossesOnExtinguishmentOfDebt_ad21cf3f-bf08-413b-b55b-5278c870c49f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_8f29033e-3de0-4667-bfd3-27448ee284a1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProvisionForDoubtfulAccounts"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_2c5536cd-ba85-4ae9-9dec-20654cc03087" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_8f29033e-3de0-4667-bfd3-27448ee284a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrealizedGainLossOnDerivatives_33a11a3f-16c5-415c-97c2-dfab1e8315ea" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnrealizedGainLossOnDerivatives"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_2c5536cd-ba85-4ae9-9dec-20654cc03087" xlink:to="loc_us-gaap_UnrealizedGainLossOnDerivatives_33a11a3f-16c5-415c-97c2-dfab1e8315ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_PropertyChargesandOther_74e5acaf-4e87-4edc-bf5e-5fddd9290c65" xlink:href="wynn-20230331.xsd#wynn_PropertyChargesandOther"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_2c5536cd-ba85-4ae9-9dec-20654cc03087" xlink:to="loc_wynn_PropertyChargesandOther_74e5acaf-4e87-4edc-bf5e-5fddd9290c65" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_673f109a-9830-4a02-96d7-feb15989793e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_2c5536cd-ba85-4ae9-9dec-20654cc03087" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_673f109a-9830-4a02-96d7-feb15989793e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInReceivables_648389c7-d7c4-4542-b82b-3fa7ad63ad05" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInReceivables"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_673f109a-9830-4a02-96d7-feb15989793e" xlink:to="loc_us-gaap_IncreaseDecreaseInReceivables_648389c7-d7c4-4542-b82b-3fa7ad63ad05" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_IncreaseDecreaseInInventoriesPrepaidExpensesAndOtherCurrentAssets_74172281-4876-49eb-86fe-aead2ff9a54f" xlink:href="wynn-20230331.xsd#wynn_IncreaseDecreaseInInventoriesPrepaidExpensesAndOtherCurrentAssets"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_673f109a-9830-4a02-96d7-feb15989793e" xlink:to="loc_wynn_IncreaseDecreaseInInventoriesPrepaidExpensesAndOtherCurrentAssets_74172281-4876-49eb-86fe-aead2ff9a54f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_8070b685-0cc9-45a9-9fc4-855e247d5637" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_673f109a-9830-4a02-96d7-feb15989793e" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_8070b685-0cc9-45a9-9fc4-855e247d5637" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_c5200c11-d0c9-4c4f-8234-f707409b7aec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_673f109a-9830-4a02-96d7-feb15989793e" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_c5200c11-d0c9-4c4f-8234-f707409b7aec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9271c13e-e958-4722-a239-5061e2069fea" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_99daa40e-7945-4249-923d-9ea784024f6f" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9271c13e-e958-4722-a239-5061e2069fea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_c271d3c3-ac93-45a0-8a16-5261832944a7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_512e3928-5086-47d9-a40f-71fe131060c6" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_c271d3c3-ac93-45a0-8a16-5261832944a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_a5f2e70b-fcad-4ffd-9c55-451940bcff1b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_c271d3c3-ac93-45a0-8a16-5261832944a7" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_a5f2e70b-fcad-4ffd-9c55-451940bcff1b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireIntangibleAssets_0a6e194e-9f22-4840-ab6b-35c41a35b47e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireIntangibleAssets"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_c271d3c3-ac93-45a0-8a16-5261832944a7" xlink:to="loc_us-gaap_PaymentsToAcquireIntangibleAssets_0a6e194e-9f22-4840-ab6b-35c41a35b47e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfProductiveAssets_7759fcfe-fdd8-437b-97ea-aaba2c75b2b7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfProductiveAssets"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_c271d3c3-ac93-45a0-8a16-5261832944a7" xlink:to="loc_us-gaap_ProceedsFromSaleOfProductiveAssets_7759fcfe-fdd8-437b-97ea-aaba2c75b2b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_533d2dc8-29f1-41fa-a572-78d7f2901bb6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_c271d3c3-ac93-45a0-8a16-5261832944a7" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_533d2dc8-29f1-41fa-a572-78d7f2901bb6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dc017f2f-7e07-44d8-b72d-62cec6a74f72" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_512e3928-5086-47d9-a40f-71fe131060c6" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dc017f2f-7e07-44d8-b72d-62cec6a74f72" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_3528945f-89bd-4bae-b9dd-0fb8c0d3bc57" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dc017f2f-7e07-44d8-b72d-62cec6a74f72" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_3528945f-89bd-4bae-b9dd-0fb8c0d3bc57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_1b991ffd-fa8a-4b3c-a871-24c70d37c3e7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dc017f2f-7e07-44d8-b72d-62cec6a74f72" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_1b991ffd-fa8a-4b3c-a871-24c70d37c3e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_39604661-7f0e-42f5-b355-55f47ad1cfe9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dc017f2f-7e07-44d8-b72d-62cec6a74f72" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_39604661-7f0e-42f5-b355-55f47ad1cfe9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_ProceedsFromDivestitureOfInterestInJointVentureFinancingActivities_3482090e-ae2a-4572-b407-e6cca753effc" xlink:href="wynn-20230331.xsd#wynn_ProceedsFromDivestitureOfInterestInJointVentureFinancingActivities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dc017f2f-7e07-44d8-b72d-62cec6a74f72" xlink:to="loc_wynn_ProceedsFromDivestitureOfInterestInJointVentureFinancingActivities_3482090e-ae2a-4572-b407-e6cca753effc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDistributionsToAffiliates_6684f4f0-89ff-4372-8e89-ea0c4914ffad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDistributionsToAffiliates"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dc017f2f-7e07-44d8-b72d-62cec6a74f72" xlink:to="loc_us-gaap_PaymentsOfDistributionsToAffiliates_6684f4f0-89ff-4372-8e89-ea0c4914ffad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividends_f34f626b-fb79-48d7-84cf-b51b472ee334" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDividends"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dc017f2f-7e07-44d8-b72d-62cec6a74f72" xlink:to="loc_us-gaap_PaymentsOfDividends_f34f626b-fb79-48d7-84cf-b51b472ee334" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeasePrincipalPayments_311b9c87-bdc0-4d56-b85f-b06513f38b05" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinanceLeasePrincipalPayments"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dc017f2f-7e07-44d8-b72d-62cec6a74f72" xlink:to="loc_us-gaap_FinanceLeasePrincipalPayments_311b9c87-bdc0-4d56-b85f-b06513f38b05" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_9bd4e8da-cf35-4004-80ee-88dbff6f1e09" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dc017f2f-7e07-44d8-b72d-62cec6a74f72" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_9bd4e8da-cf35-4004-80ee-88dbff6f1e09" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_6ce7b42b-2d69-410f-9c4b-9e9426531c86" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dc017f2f-7e07-44d8-b72d-62cec6a74f72" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_6ce7b42b-2d69-410f-9c4b-9e9426531c86" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_266ed47b-f1a9-42bb-a253-2ebb400f29ba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dc017f2f-7e07-44d8-b72d-62cec6a74f72" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_266ed47b-f1a9-42bb-a253-2ebb400f29ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_4984d47d-b0e0-4b5d-bc4c-1dce343a198a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_512e3928-5086-47d9-a40f-71fe131060c6" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_4984d47d-b0e0-4b5d-bc4c-1dce343a198a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_e4d03243-9b5b-4c61-a979-592584731b7f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_512e3928-5086-47d9-a40f-71fe131060c6" xlink:to="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_e4d03243-9b5b-4c61-a979-592584731b7f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_7f6a6636-de99-4dec-911a-4539c946b4c3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_e4d03243-9b5b-4c61-a979-592584731b7f" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_7f6a6636-de99-4dec-911a-4539c946b4c3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_f7503336-ac79-4676-89b1-378b83c38a2d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_e4d03243-9b5b-4c61-a979-592584731b7f" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_f7503336-ac79-4676-89b1-378b83c38a2d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_d273e2be-7a7d-4047-934b-3bb10542a13e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_e4d03243-9b5b-4c61-a979-592584731b7f" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_d273e2be-7a7d-4047-934b-3bb10542a13e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/Organization" xlink:type="simple" xlink:href="wynn-20230331.xsd#Organization"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/Organization" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_f73c625b-077e-419a-b10d-af73d3e63e9e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_1e4e580b-c28f-476f-88da-afd972504b54" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_f73c625b-077e-419a-b10d-af73d3e63e9e" xlink:to="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_1e4e580b-c28f-476f-88da-afd972504b54" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/BasisofPresentationandSignificantAccountingPolicies" xlink:type="simple" xlink:href="wynn-20230331.xsd#BasisofPresentationandSignificantAccountingPolicies"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/BasisofPresentationandSignificantAccountingPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_06932098-7998-4435-9688-ed7876f9bcea" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SignificantAccountingPoliciesTextBlock_33bb700c-9024-42b8-887c-0e1f3b3ba61a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SignificantAccountingPoliciesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_06932098-7998-4435-9688-ed7876f9bcea" xlink:to="loc_us-gaap_SignificantAccountingPoliciesTextBlock_33bb700c-9024-42b8-887c-0e1f3b3ba61a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CashCashEquivalentsandRestrictedCash" xlink:type="simple" xlink:href="wynn-20230331.xsd#CashCashEquivalentsandRestrictedCash"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/CashCashEquivalentsandRestrictedCash" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAbstract_cdd179ae-8a31-4555-8f32-c355d9b1d88a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsDisclosureTextBlock_047be5ba-6136-464c-98d3-4e38b79f2340" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_cdd179ae-8a31-4555-8f32-c355d9b1d88a" xlink:to="loc_us-gaap_CashAndCashEquivalentsDisclosureTextBlock_047be5ba-6136-464c-98d3-4e38b79f2340" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/Receivablesnet" xlink:type="simple" xlink:href="wynn-20230331.xsd#Receivablesnet"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/Receivablesnet" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesAbstract_097f536d-16bc-4b6a-a838-a3631b0d80b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansNotesTradeAndOtherReceivablesExcludingAllowanceForCreditLossesTextBlock_23032a67-9bb9-4302-9dc6-1488ff8c21d5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansNotesTradeAndOtherReceivablesExcludingAllowanceForCreditLossesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_097f536d-16bc-4b6a-a838-a3631b0d80b4" xlink:to="loc_us-gaap_LoansNotesTradeAndOtherReceivablesExcludingAllowanceForCreditLossesTextBlock_23032a67-9bb9-4302-9dc6-1488ff8c21d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/PropertyandEquipmentnet" xlink:type="simple" xlink:href="wynn-20230331.xsd#PropertyandEquipmentnet"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/PropertyandEquipmentnet" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_797442f4-ba4c-49ff-a40e-a1e4a7f28bd9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock_6bff3380-ff32-454e-ae6d-37c2e71e44d9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_797442f4-ba4c-49ff-a40e-a1e4a7f28bd9" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock_6bff3380-ff32-454e-ae6d-37c2e71e44d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/GoodwillandIntangibleAssetsnet" xlink:type="simple" xlink:href="wynn-20230331.xsd#GoodwillandIntangibleAssetsnet"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/GoodwillandIntangibleAssetsnet" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_ff87f09e-6f7e-4ba1-9bcb-faef125d2c4e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillDisclosureTextBlock_4ab58331-97c7-4255-9576-1cb5f4c65a3a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_ff87f09e-6f7e-4ba1-9bcb-faef125d2c4e" xlink:to="loc_us-gaap_GoodwillDisclosureTextBlock_4ab58331-97c7-4255-9576-1cb5f4c65a3a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebt" xlink:type="simple" xlink:href="wynn-20230331.xsd#LongTermDebt"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/LongTermDebt" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_7e09b51d-c1c2-4235-8075-ea8407d5f3c7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtTextBlock_03382987-5dd7-4a8f-9583-997c097ccd8f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_7e09b51d-c1c2-4235-8075-ea8407d5f3c7" xlink:to="loc_us-gaap_LongTermDebtTextBlock_03382987-5dd7-4a8f-9583-997c097ccd8f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/WMLConvertibleBondConversionOptionDerivative" xlink:type="simple" xlink:href="wynn-20230331.xsd#WMLConvertibleBondConversionOptionDerivative"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/WMLConvertibleBondConversionOptionDerivative" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_32d59ce5-aec3-495b-a119-ab954cc05d6a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_e1e4ced8-ff36-4392-974f-749aa1a62d4b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_32d59ce5-aec3-495b-a119-ab954cc05d6a" xlink:to="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_e1e4ced8-ff36-4392-974f-749aa1a62d4b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/StockholdersDeficit" xlink:type="simple" xlink:href="wynn-20230331.xsd#StockholdersDeficit"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/StockholdersDeficit" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_91e6452e-ea74-47a4-ad04-02058b49e7a3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_6e009a8d-e156-4337-969f-ea11e0d2882f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_91e6452e-ea74-47a4-ad04-02058b49e7a3" xlink:to="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_6e009a8d-e156-4337-969f-ea11e0d2882f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/FairValueMeasurements" xlink:type="simple" xlink:href="wynn-20230331.xsd#FairValueMeasurements"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/FairValueMeasurements" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_0718328b-d061-493b-ad14-b69e8c949fd1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_a680386d-c1da-4a46-810c-d6820c613efb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueDisclosuresTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_0718328b-d061-493b-ad14-b69e8c949fd1" xlink:to="loc_us-gaap_FairValueDisclosuresTextBlock_a680386d-c1da-4a46-810c-d6820c613efb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CustomerContractLiabilities" xlink:type="simple" xlink:href="wynn-20230331.xsd#CustomerContractLiabilities"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/CustomerContractLiabilities" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRecognitionAbstract_c4587a03-6413-47bf-804b-fad92dd90788" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueRecognitionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RevenueRecognitionTextBlock_1e88b47c-b4dc-43a9-9bcf-b92a03819698" xlink:href="wynn-20230331.xsd#wynn_RevenueRecognitionTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueRecognitionAbstract_c4587a03-6413-47bf-804b-fad92dd90788" xlink:to="loc_wynn_RevenueRecognitionTextBlock_1e88b47c-b4dc-43a9-9bcf-b92a03819698" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/StockBasedCompensation" xlink:type="simple" xlink:href="wynn-20230331.xsd#StockBasedCompensation"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/StockBasedCompensation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_006e6e5f-7bd2-4630-abcd-d4e0764d3b1d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_897612d6-3a29-424d-b1d8-8c43658a6587" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_006e6e5f-7bd2-4630-abcd-d4e0764d3b1d" xlink:to="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_897612d6-3a29-424d-b1d8-8c43658a6587" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/IncomeTaxes" xlink:type="simple" xlink:href="wynn-20230331.xsd#IncomeTaxes"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/IncomeTaxes" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_6162da43-014b-402e-9b4f-f2cac6bf1b18" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureTextBlock_b3ebf26e-0083-40d0-af77-2acdf2afb5ac" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_6162da43-014b-402e-9b4f-f2cac6bf1b18" xlink:to="loc_us-gaap_IncomeTaxDisclosureTextBlock_b3ebf26e-0083-40d0-af77-2acdf2afb5ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/EarningsPerShare" xlink:type="simple" xlink:href="wynn-20230331.xsd#EarningsPerShare"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/EarningsPerShare" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_da082bab-7a76-4748-a2a2-13ae8612dbd0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareTextBlock_6d3508cb-be83-420b-acc4-7439b094ffa3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_da082bab-7a76-4748-a2a2-13ae8612dbd0" xlink:to="loc_us-gaap_EarningsPerShareTextBlock_6d3508cb-be83-420b-acc4-7439b094ffa3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/Leases" xlink:type="simple" xlink:href="wynn-20230331.xsd#Leases"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/Leases" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_757c712c-1f7e-4d86-ad0a-d3a15fd952be" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesOfLessorDisclosureTextBlock_de772e33-8171-4c7d-845c-7fa000820b2c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeasesOfLessorDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_757c712c-1f7e-4d86-ad0a-d3a15fd952be" xlink:to="loc_us-gaap_OperatingLeasesOfLessorDisclosureTextBlock_de772e33-8171-4c7d-845c-7fa000820b2c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CommitmentsandContingencies" xlink:type="simple" xlink:href="wynn-20230331.xsd#CommitmentsandContingencies"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/CommitmentsandContingencies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_78f027c7-b1c8-4afd-8a77-c3af33040c01" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_b75a174f-a879-4f26-92b0-575d5463b79b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_78f027c7-b1c8-4afd-8a77-c3af33040c01" xlink:to="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_b75a174f-a879-4f26-92b0-575d5463b79b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/RetailJointVenture" xlink:type="simple" xlink:href="wynn-20230331.xsd#RetailJointVenture"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/RetailJointVenture" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentsAndJointVenturesAbstract_1cff8058-e9d2-41a3-9a02-88ee36b37287" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityMethodInvestmentsAndJointVenturesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableInterestEntityDisclosureTextBlock_0c8ffdf4-2ded-4079-b50f-d6193dd2d5ad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_VariableInterestEntityDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityMethodInvestmentsAndJointVenturesAbstract_1cff8058-e9d2-41a3-9a02-88ee36b37287" xlink:to="loc_us-gaap_VariableInterestEntityDisclosureTextBlock_0c8ffdf4-2ded-4079-b50f-d6193dd2d5ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/SegmentInformation" xlink:type="simple" xlink:href="wynn-20230331.xsd#SegmentInformation"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/SegmentInformation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingAbstract_201be030-5a67-4f46-9b86-2aa751502510" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentReportingAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingDisclosureTextBlock_dabb06f8-3cb9-4375-a1ec-e73ffac9a2a7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentReportingDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_201be030-5a67-4f46-9b86-2aa751502510" xlink:to="loc_us-gaap_SegmentReportingDisclosureTextBlock_dabb06f8-3cb9-4375-a1ec-e73ffac9a2a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/BasisofPresentationandSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="wynn-20230331.xsd#BasisofPresentationandSignificantAccountingPoliciesPolicies"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/BasisofPresentationandSignificantAccountingPoliciesPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_3657713b-5a2d-411b-b0c5-7c3fc9672680" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConsolidationPolicyTextBlock_06a195a2-6702-480e-895b-a6571fa2dcfc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConsolidationPolicyTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_3657713b-5a2d-411b-b0c5-7c3fc9672680" xlink:to="loc_us-gaap_ConsolidationPolicyTextBlock_06a195a2-6702-480e-895b-a6571fa2dcfc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_GamingTaxesPolicyPolicyTextBlock_df3df110-1f80-4302-820f-2d37f0ffb214" xlink:href="wynn-20230331.xsd#wynn_GamingTaxesPolicyPolicyTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_3657713b-5a2d-411b-b0c5-7c3fc9672680" xlink:to="loc_wynn_GamingTaxesPolicyPolicyTextBlock_df3df110-1f80-4302-820f-2d37f0ffb214" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_32c8f6cd-5861-4bbf-923e-1e2633c33b62" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_3657713b-5a2d-411b-b0c5-7c3fc9672680" xlink:to="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_32c8f6cd-5861-4bbf-923e-1e2633c33b62" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CashCashEquivalentsandRestrictedCashTables" xlink:type="simple" xlink:href="wynn-20230331.xsd#CashCashEquivalentsandRestrictedCashTables"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/CashCashEquivalentsandRestrictedCashTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAbstract_5f3922f7-cf75-46bb-84a1-24c6d194f23b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCashAndCashEquivalentsTableTextBlock_cbec906a-a5cb-410f-ac24-d83b23f70b23" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfCashAndCashEquivalentsTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_5f3922f7-cf75-46bb-84a1-24c6d194f23b" xlink:to="loc_us-gaap_ScheduleOfCashAndCashEquivalentsTableTextBlock_cbec906a-a5cb-410f-ac24-d83b23f70b23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTextBlock_0ac9165d-a29c-4998-b71e-7cb44c9d5404" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_5f3922f7-cf75-46bb-84a1-24c6d194f23b" xlink:to="loc_us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTextBlock_0ac9165d-a29c-4998-b71e-7cb44c9d5404" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCashFlowSupplementalDisclosuresTableTextBlock_83f6db36-0fd2-4ca7-bddb-c5d177348602" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfCashFlowSupplementalDisclosuresTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_5f3922f7-cf75-46bb-84a1-24c6d194f23b" xlink:to="loc_us-gaap_ScheduleOfCashFlowSupplementalDisclosuresTableTextBlock_83f6db36-0fd2-4ca7-bddb-c5d177348602" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/ReceivablesnetTables" xlink:type="simple" xlink:href="wynn-20230331.xsd#ReceivablesnetTables"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/ReceivablesnetTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesAbstract_d6026863-d932-443d-ad67-e608909d6d68" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTextBlock_338a6918-346a-47ca-bbb9-81c80894c629" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_d6026863-d932-443d-ad67-e608909d6d68" xlink:to="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTextBlock_338a6918-346a-47ca-bbb9-81c80894c629" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/PropertyandEquipmentnetTables" xlink:type="simple" xlink:href="wynn-20230331.xsd#PropertyandEquipmentnetTables"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/PropertyandEquipmentnetTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_5ddf0a76-7642-4c32-b6b3-33aea32899dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_1bc50b15-8670-4fd6-b0bf-8d87b7030ef5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_5ddf0a76-7642-4c32-b6b3-33aea32899dd" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_1bc50b15-8670-4fd6-b0bf-8d87b7030ef5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/GoodwillandIntangibleAssetsnetTables" xlink:type="simple" xlink:href="wynn-20230331.xsd#GoodwillandIntangibleAssetsnetTables"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/GoodwillandIntangibleAssetsnetTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_4fdadfd6-7c09-4292-9b0a-394b8c559953" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfGoodwillTextBlock_6aac3038-d150-40c2-b9fe-17585bd24ce1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfGoodwillTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_4fdadfd6-7c09-4292-9b0a-394b8c559953" xlink:to="loc_us-gaap_ScheduleOfGoodwillTextBlock_6aac3038-d150-40c2-b9fe-17585bd24ce1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTableTextBlock_3db1097d-c52b-4d81-805b-02abc0e7b956" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_4fdadfd6-7c09-4292-9b0a-394b8c559953" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTableTextBlock_3db1097d-c52b-4d81-805b-02abc0e7b956" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfIndefiniteLivedIntangibleAssetsTableTextBlock_f4f2b53f-0457-4f3f-a54d-1b3fa8bc58c5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfIndefiniteLivedIntangibleAssetsTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_4fdadfd6-7c09-4292-9b0a-394b8c559953" xlink:to="loc_us-gaap_ScheduleOfIndefiniteLivedIntangibleAssetsTableTextBlock_f4f2b53f-0457-4f3f-a54d-1b3fa8bc58c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebtTables" xlink:type="simple" xlink:href="wynn-20230331.xsd#LongTermDebtTables"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/LongTermDebtTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_c1e35cb9-bfac-4beb-b858-0ea907dcdf69" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDebtInstrumentsTextBlock_3b67438e-1c14-4391-8235-aea3c9fe55c0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfDebtInstrumentsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_c1e35cb9-bfac-4beb-b858-0ea907dcdf69" xlink:to="loc_us-gaap_ScheduleOfDebtInstrumentsTextBlock_3b67438e-1c14-4391-8235-aea3c9fe55c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/WMLConvertibleBondConversionOptionDerivativeTables" xlink:type="simple" xlink:href="wynn-20230331.xsd#WMLConvertibleBondConversionOptionDerivativeTables"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/WMLConvertibleBondConversionOptionDerivativeTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_e734c0ee-5a12-45f4-9983-d9f1c7cafb7b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_9f683f45-2914-41cf-bc49-34b6b82bfa7e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_e734c0ee-5a12-45f4-9983-d9f1c7cafb7b" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_9f683f45-2914-41cf-bc49-34b6b82bfa7e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/FairValueMeasurementsTables" xlink:type="simple" xlink:href="wynn-20230331.xsd#FairValueMeasurementsTables"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/FairValueMeasurementsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_4e75ee76-66e8-4c83-ab16-40ea3acf9ab9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_c251e7d1-2cd4-4042-96ce-79fd09c67556" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_4e75ee76-66e8-4c83-ab16-40ea3acf9ab9" xlink:to="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_c251e7d1-2cd4-4042-96ce-79fd09c67556" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CustomerContractLiabilitiesTables" xlink:type="simple" xlink:href="wynn-20230331.xsd#CustomerContractLiabilitiesTables"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/CustomerContractLiabilitiesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRecognitionAbstract_0ef7e1df-5189-4912-b722-5da07b79a198" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueRecognitionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_ScheduleofCustomerContractLiabilitiesTableTextBlock_cab5533c-bcb8-477f-b1ee-19a4a8fdd81f" xlink:href="wynn-20230331.xsd#wynn_ScheduleofCustomerContractLiabilitiesTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueRecognitionAbstract_0ef7e1df-5189-4912-b722-5da07b79a198" xlink:to="loc_wynn_ScheduleofCustomerContractLiabilitiesTableTextBlock_cab5533c-bcb8-477f-b1ee-19a4a8fdd81f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/StockBasedCompensationTables" xlink:type="simple" xlink:href="wynn-20230331.xsd#StockBasedCompensationTables"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/StockBasedCompensationTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_38c3f8d5-2f51-4d5d-ab42-ab36a644142f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_df8d8efd-ae9d-4f96-9558-1134e4908ade" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_38c3f8d5-2f51-4d5d-ab42-ab36a644142f" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_df8d8efd-ae9d-4f96-9558-1134e4908ade" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/EarningsPerShareTables" xlink:type="simple" xlink:href="wynn-20230331.xsd#EarningsPerShareTables"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/EarningsPerShareTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_4d8cac26-882a-4e86-b7bd-b78283607f43" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_3df8cc7f-11c8-4944-8edc-071293b801ab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_4d8cac26-882a-4e86-b7bd-b78283607f43" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_3df8cc7f-11c8-4944-8edc-071293b801ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/LeasesTables" xlink:type="simple" xlink:href="wynn-20230331.xsd#LeasesTables"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/LeasesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_8e17d07c-77fe-4798-a471-1f43169dfcc7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLeaseIncomeTableTextBlock_0f32db3e-8188-4e98-8eb0-98b4ccff12b7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLeaseIncomeTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_8e17d07c-77fe-4798-a471-1f43169dfcc7" xlink:to="loc_us-gaap_OperatingLeaseLeaseIncomeTableTextBlock_0f32db3e-8188-4e98-8eb0-98b4ccff12b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/SegmentInformationTables" xlink:type="simple" xlink:href="wynn-20230331.xsd#SegmentInformationTables"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/SegmentInformationTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingAbstract_101b7b10-c596-4f1d-9e31-361c57388dec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentReportingAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReconciliationOfOperatingProfitLossFromSegmentsToConsolidatedTextBlock_5aacdbb3-db99-42be-952a-5de14c3d0632" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReconciliationOfOperatingProfitLossFromSegmentsToConsolidatedTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_101b7b10-c596-4f1d-9e31-361c57388dec" xlink:to="loc_us-gaap_ReconciliationOfOperatingProfitLossFromSegmentsToConsolidatedTextBlock_5aacdbb3-db99-42be-952a-5de14c3d0632" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReconciliationOfAssetsFromSegmentToConsolidatedTextBlock_b9f4cbaa-cf1c-47e0-aca8-d31a1639c59e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReconciliationOfAssetsFromSegmentToConsolidatedTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_101b7b10-c596-4f1d-9e31-361c57388dec" xlink:to="loc_us-gaap_ReconciliationOfAssetsFromSegmentToConsolidatedTextBlock_b9f4cbaa-cf1c-47e0-aca8-d31a1639c59e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/OrganizationDetails" xlink:type="simple" xlink:href="wynn-20230331.xsd#OrganizationDetails"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/OrganizationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_ff089835-cd52-4fa4-b891-318dba9b6050" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_9192ebe6-3cd7-411c-80f4-54e48abab346" xlink:href="wynn-20230331.xsd#wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_ff089835-cd52-4fa4-b891-318dba9b6050" xlink:to="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_9192ebe6-3cd7-411c-80f4-54e48abab346" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipAxis_af355533-4e51-4448-bc3c-ceb99790cd71" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_OwnershipAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_9192ebe6-3cd7-411c-80f4-54e48abab346" xlink:to="loc_srt_OwnershipAxis_af355533-4e51-4448-bc3c-ceb99790cd71" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_f89dc3a1-14dc-40a9-ba42-bf68d5594b13" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_OwnershipDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_OwnershipAxis_af355533-4e51-4448-bc3c-ceb99790cd71" xlink:to="loc_srt_OwnershipDomain_f89dc3a1-14dc-40a9-ba42-bf68d5594b13" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnPalaceandWynnMacauMember_e6ed7c02-bb39-4fa4-8a90-e67b4ffe0e1b" xlink:href="wynn-20230331.xsd#wynn_WynnPalaceandWynnMacauMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_OwnershipDomain_f89dc3a1-14dc-40a9-ba42-bf68d5594b13" xlink:to="loc_wynn_WynnPalaceandWynnMacauMember_e6ed7c02-bb39-4fa4-8a90-e67b4ffe0e1b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnLasVegasMember_b5ec822c-b036-48bf-bca6-d43d3de5ff8d" xlink:href="wynn-20230331.xsd#wynn_WynnLasVegasMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_OwnershipDomain_f89dc3a1-14dc-40a9-ba42-bf68d5594b13" xlink:to="loc_wynn_WynnLasVegasMember_b5ec822c-b036-48bf-bca6-d43d3de5ff8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailJointVentureMember_0adc58bb-471d-4976-8cea-535719be2fef" xlink:href="wynn-20230331.xsd#wynn_RetailJointVentureMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_OwnershipDomain_f89dc3a1-14dc-40a9-ba42-bf68d5594b13" xlink:to="loc_wynn_RetailJointVentureMember_0adc58bb-471d-4976-8cea-535719be2fef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnInteractiveLtdMember_78bad920-4444-4c69-898e-c8efee17f93e" xlink:href="wynn-20230331.xsd#wynn_WynnInteractiveLtdMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_OwnershipDomain_f89dc3a1-14dc-40a9-ba42-bf68d5594b13" xlink:to="loc_wynn_WynnInteractiveLtdMember_78bad920-4444-4c69-898e-c8efee17f93e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_6abb1bf0-f46c-4ede-a9eb-45f05eda1d39" xlink:href="wynn-20230331.xsd#wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_9192ebe6-3cd7-411c-80f4-54e48abab346" xlink:to="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_6abb1bf0-f46c-4ede-a9eb-45f05eda1d39" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_97e57b7a-ac58-4773-854b-f13699c9a0a0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MinorityInterestOwnershipPercentageByParent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_6abb1bf0-f46c-4ede-a9eb-45f05eda1d39" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_97e57b7a-ac58-4773-854b-f13699c9a0a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/BasisofPresentationandSignificantAccountingPoliciesAdditionalInformationDetails" xlink:type="simple" xlink:href="wynn-20230331.xsd#BasisofPresentationandSignificantAccountingPoliciesAdditionalInformationDetails"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/BasisofPresentationandSignificantAccountingPoliciesAdditionalInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_08ab8904-d516-45bc-a965-e1d486713a2f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_GamingTaxExpenses_e171e7cf-6328-4f52-9f30-28ef715a57e1" xlink:href="wynn-20230331.xsd#wynn_GamingTaxExpenses"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_08ab8904-d516-45bc-a965-e1d486713a2f" xlink:to="loc_wynn_GamingTaxExpenses_e171e7cf-6328-4f52-9f30-28ef715a57e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CashCashEquivalentsandRestrictedCashScheduleofCashCashEquivalentsandRestrictedCashDetails" xlink:type="simple" xlink:href="wynn-20230331.xsd#CashCashEquivalentsandRestrictedCashScheduleofCashCashEquivalentsandRestrictedCashDetails"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/CashCashEquivalentsandRestrictedCashScheduleofCashCashEquivalentsandRestrictedCashDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAbstract_2f118dca-bbae-455d-95ae-090ea064d947" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Cash_818427e0-2cbb-44f5-a073-1c649ba638dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Cash"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_2f118dca-bbae-455d-95ae-090ea064d947" xlink:to="loc_us-gaap_Cash_818427e0-2cbb-44f5-a073-1c649ba638dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValue_9e69b717-63f4-4fb2-b182-22dbbaab2927" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_2f118dca-bbae-455d-95ae-090ea064d947" xlink:to="loc_us-gaap_CashEquivalentsAtCarryingValue_9e69b717-63f4-4fb2-b182-22dbbaab2927" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_33db44bb-13a8-417b-9b97-3ac3d93c6c25" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_2f118dca-bbae-455d-95ae-090ea064d947" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_33db44bb-13a8-417b-9b97-3ac3d93c6c25" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCash_447dae1f-6a06-400d-a810-187d5ae56e85" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCash"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_2f118dca-bbae-455d-95ae-090ea064d947" xlink:to="loc_us-gaap_RestrictedCash_447dae1f-6a06-400d-a810-187d5ae56e85" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_af7ba79e-76c5-4c2c-8faf-e4582e741aed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_2f118dca-bbae-455d-95ae-090ea064d947" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_af7ba79e-76c5-4c2c-8faf-e4582e741aed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RestrictedCashBankGuarantee_fedf420c-5483-4625-a982-182a504c3a04" xlink:href="wynn-20230331.xsd#wynn_RestrictedCashBankGuarantee"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_2f118dca-bbae-455d-95ae-090ea064d947" xlink:to="loc_wynn_RestrictedCashBankGuarantee_fedf420c-5483-4625-a982-182a504c3a04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CashCashEquivalentsandRestrictedCashScheduleofCashFlowSupplementalDisclosuresDetails" xlink:type="simple" xlink:href="wynn-20230331.xsd#CashCashEquivalentsandRestrictedCashScheduleofCashFlowSupplementalDisclosuresDetails"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/CashCashEquivalentsandRestrictedCashScheduleofCashFlowSupplementalDisclosuresDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAbstract_db48af36-907f-4e60-a080-e18a4c056666" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPaidNet_10e1959c-dfaa-4351-a603-a3f2b82e0d6e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestPaidNet"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_db48af36-907f-4e60-a080-e18a4c056666" xlink:to="loc_us-gaap_InterestPaidNet_10e1959c-dfaa-4351-a603-a3f2b82e0d6e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssued1_4b68bfcd-a416-42ed-9849-8c14834f2951" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssued1"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_db48af36-907f-4e60-a080-e18a4c056666" xlink:to="loc_us-gaap_StockIssued1_4b68bfcd-a416-42ed-9849-8c14834f2951" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_AccountsPayableCurrentAmountRelatedtoPropertyPlantandEquipment_52568a32-2ac4-45d4-ab7e-4f5719964517" xlink:href="wynn-20230331.xsd#wynn_AccountsPayableCurrentAmountRelatedtoPropertyPlantandEquipment"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_db48af36-907f-4e60-a080-e18a4c056666" xlink:to="loc_wynn_AccountsPayableCurrentAmountRelatedtoPropertyPlantandEquipment_52568a32-2ac4-45d4-ab7e-4f5719964517" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_IntangibleAssetsOtherLiabilitiesIncurred_24503e22-70a8-4d61-8c0f-3f5068c6b712" xlink:href="wynn-20230331.xsd#wynn_IntangibleAssetsOtherLiabilitiesIncurred"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_db48af36-907f-4e60-a080-e18a4c056666" xlink:to="loc_wynn_IntangibleAssetsOtherLiabilitiesIncurred_24503e22-70a8-4d61-8c0f-3f5068c6b712" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtIssuanceCostsIncurredDuringNoncashOrPartialNoncashTransaction_c2fba851-6c63-4cf7-b919-c17c7f173f6d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtIssuanceCostsIncurredDuringNoncashOrPartialNoncashTransaction"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_db48af36-907f-4e60-a080-e18a4c056666" xlink:to="loc_us-gaap_DebtIssuanceCostsIncurredDuringNoncashOrPartialNoncashTransaction_c2fba851-6c63-4cf7-b919-c17c7f173f6d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability_022e5ca2-a93b-412a-98d9-7a5afddea7ef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_db48af36-907f-4e60-a080-e18a4c056666" xlink:to="loc_us-gaap_RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability_022e5ca2-a93b-412a-98d9-7a5afddea7ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_IntangibleAssetsOtherLiabilitiesIncurredGamingPremium_181f05a8-a604-4dbc-835c-0a81ab4932a8" xlink:href="wynn-20230331.xsd#wynn_IntangibleAssetsOtherLiabilitiesIncurredGamingPremium"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_db48af36-907f-4e60-a080-e18a4c056666" xlink:to="loc_wynn_IntangibleAssetsOtherLiabilitiesIncurredGamingPremium_181f05a8-a604-4dbc-835c-0a81ab4932a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/ReceivablesnetDetails" xlink:type="simple" xlink:href="wynn-20230331.xsd#ReceivablesnetDetails"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/ReceivablesnetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesAbstract_c35990a6-ccbd-432f-bf2e-5677ba3920ca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_5e40169d-fc20-45dc-9a8c-cfdba7498b2b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_c35990a6-ccbd-432f-bf2e-5677ba3920ca" xlink:to="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_5e40169d-fc20-45dc-9a8c-cfdba7498b2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_c192c296-ec46-484c-a5cd-e335d369f6bc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_5e40169d-fc20-45dc-9a8c-cfdba7498b2b" xlink:to="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_c192c296-ec46-484c-a5cd-e335d369f6bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_4f3f6226-f00a-47b3-8f71-d51c7f5fa491" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LegalEntityTypeOfCounterpartyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_c192c296-ec46-484c-a5cd-e335d369f6bc" xlink:to="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_4f3f6226-f00a-47b3-8f71-d51c7f5fa491" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CasinoMember_75d68629-d2c2-4255-9cd3-9f73f80489fa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CasinoMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_4f3f6226-f00a-47b3-8f71-d51c7f5fa491" xlink:to="loc_us-gaap_CasinoMember_75d68629-d2c2-4255-9cd3-9f73f80489fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_HotelMember_9c42a390-8990-4426-8148-111b9b66a49c" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_HotelMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_4f3f6226-f00a-47b3-8f71-d51c7f5fa491" xlink:to="loc_srt_HotelMember_9c42a390-8990-4426-8148-111b9b66a49c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailLeasesAndOtherMember_83f58932-5cdf-40cf-a865-4ce160c5bbdd" xlink:href="wynn-20230331.xsd#wynn_RetailLeasesAndOtherMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_4f3f6226-f00a-47b3-8f71-d51c7f5fa491" xlink:to="loc_wynn_RetailLeasesAndOtherMember_83f58932-5cdf-40cf-a865-4ce160c5bbdd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_86c990e0-05cf-4aa2-946b-4888a4f47bf7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_5e40169d-fc20-45dc-9a8c-cfdba7498b2b" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_86c990e0-05cf-4aa2-946b-4888a4f47bf7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_d07454fd-4f49-4fc5-9b95-11ba40004857" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_86c990e0-05cf-4aa2-946b-4888a4f47bf7" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_d07454fd-4f49-4fc5-9b95-11ba40004857" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeographicConcentrationRiskMember_fc9aab59-a2c7-443d-a7c4-81f212b3bce7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GeographicConcentrationRiskMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_d07454fd-4f49-4fc5-9b95-11ba40004857" xlink:to="loc_us-gaap_GeographicConcentrationRiskMember_fc9aab59-a2c7-443d-a7c4-81f212b3bce7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_010fdc59-fc32-4f38-be53-5bbfaea2e24e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_5e40169d-fc20-45dc-9a8c-cfdba7498b2b" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_010fdc59-fc32-4f38-be53-5bbfaea2e24e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_ede3ed30-fd1e-4dd3-a18b-b11fc77e95f2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_010fdc59-fc32-4f38-be53-5bbfaea2e24e" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_ede3ed30-fd1e-4dd3-a18b-b11fc77e95f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableMember_ca81f3d0-87bc-4b1f-9989-7d77d31200cc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsReceivableMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_ede3ed30-fd1e-4dd3-a18b-b11fc77e95f2" xlink:to="loc_us-gaap_AccountsReceivableMember_ca81f3d0-87bc-4b1f-9989-7d77d31200cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_f7478699-a790-462a-add7-ed02c6a03177" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_StatementGeographicalAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_5e40169d-fc20-45dc-9a8c-cfdba7498b2b" xlink:to="loc_srt_StatementGeographicalAxis_f7478699-a790-462a-add7-ed02c6a03177" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_d90a63ee-976c-4302-8b0a-e3a95a8d9ca2" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_SegmentGeographicalDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_StatementGeographicalAxis_f7478699-a790-462a-add7-ed02c6a03177" xlink:to="loc_srt_SegmentGeographicalDomain_d90a63ee-976c-4302-8b0a-e3a95a8d9ca2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_AsiaMember_a93355a0-3e9c-48d5-ba37-117bbb99e7ff" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_AsiaMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_d90a63ee-976c-4302-8b0a-e3a95a8d9ca2" xlink:to="loc_srt_AsiaMember_a93355a0-3e9c-48d5-ba37-117bbb99e7ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_f29ab7f8-c67c-4ce2-9fa7-67a6e116f3bf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_5e40169d-fc20-45dc-9a8c-cfdba7498b2b" xlink:to="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_f29ab7f8-c67c-4ce2-9fa7-67a6e116f3bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableGrossCurrent_42a756e5-5465-42b9-9fb2-72bf3fe5cdd2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsReceivableGrossCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_f29ab7f8-c67c-4ce2-9fa7-67a6e116f3bf" xlink:to="loc_us-gaap_AccountsReceivableGrossCurrent_42a756e5-5465-42b9-9fb2-72bf3fe5cdd2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_509022d6-1d54-49a6-bb75-ea635c28c698" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_f29ab7f8-c67c-4ce2-9fa7-67a6e116f3bf" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_509022d6-1d54-49a6-bb75-ea635c28c698" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_f551bcab-307c-42c9-97da-b64e6d9ac3d0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_f29ab7f8-c67c-4ce2-9fa7-67a6e116f3bf" xlink:to="loc_us-gaap_ReceivablesNetCurrent_f551bcab-307c-42c9-97da-b64e6d9ac3d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_18331233-5c8e-4c73-8ab8-bda1b9383220" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_f29ab7f8-c67c-4ce2-9fa7-67a6e116f3bf" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_18331233-5c8e-4c73-8ab8-bda1b9383220" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_AccountsReceivableAllowanceForCreditLossPercentOfGrossCasinoReceivables_1092839f-5ea2-44a3-a8a6-722812b5c80d" xlink:href="wynn-20230331.xsd#wynn_AccountsReceivableAllowanceForCreditLossPercentOfGrossCasinoReceivables"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_f29ab7f8-c67c-4ce2-9fa7-67a6e116f3bf" xlink:to="loc_wynn_AccountsReceivableAllowanceForCreditLossPercentOfGrossCasinoReceivables_1092839f-5ea2-44a3-a8a6-722812b5c80d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/ReceivablesnetScheduleofMovementinAllowanceforCreditLossesRecognizedforReceivablesDetails" xlink:type="simple" xlink:href="wynn-20230331.xsd#ReceivablesnetScheduleofMovementinAllowanceforCreditLossesRecognizedforReceivablesDetails"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/ReceivablesnetScheduleofMovementinAllowanceforCreditLossesRecognizedforReceivablesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesAbstract_d8d5f297-005a-473f-8cd5-9a59c9983dff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward_e82a26fc-c99e-4317-982d-15374ae79fc7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_d8d5f297-005a-473f-8cd5-9a59c9983dff" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward_e82a26fc-c99e-4317-982d-15374ae79fc7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivable_fdc656db-6fbe-457f-a794-f64524fdf9c2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward_e82a26fc-c99e-4317-982d-15374ae79fc7" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivable_fdc656db-6fbe-457f-a794-f64524fdf9c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_d4fdd8c9-58f8-4f65-93b1-3887694aa044" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProvisionForDoubtfulAccounts"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward_e82a26fc-c99e-4317-982d-15374ae79fc7" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_d4fdd8c9-58f8-4f65-93b1-3887694aa044" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableWriteOffs_8d1a5efa-0a49-4e2d-b176-c74f6f9f1746" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableWriteOffs"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward_e82a26fc-c99e-4317-982d-15374ae79fc7" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableWriteOffs_8d1a5efa-0a49-4e2d-b176-c74f6f9f1746" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableRecoveries_26b623e4-c21f-437c-b31b-a879ba757a69" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableRecoveries"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward_e82a26fc-c99e-4317-982d-15374ae79fc7" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableRecoveries_26b623e4-c21f-437c-b31b-a879ba757a69" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_AccountsReceivableAllowanceForCreditLossEffectOfExchangeRate_394d0cfc-2828-4915-ab81-94974a9d7560" xlink:href="wynn-20230331.xsd#wynn_AccountsReceivableAllowanceForCreditLossEffectOfExchangeRate"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward_e82a26fc-c99e-4317-982d-15374ae79fc7" xlink:to="loc_wynn_AccountsReceivableAllowanceForCreditLossEffectOfExchangeRate_394d0cfc-2828-4915-ab81-94974a9d7560" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivable_2e031016-4f44-4465-93f9-b84561b853d1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivable"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableRollforward_e82a26fc-c99e-4317-982d-15374ae79fc7" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivable_2e031016-4f44-4465-93f9-b84561b853d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/PropertyandEquipmentnetScheduleofPropertyandEquipmentNetDetail" xlink:type="simple" xlink:href="wynn-20230331.xsd#PropertyandEquipmentnetScheduleofPropertyandEquipmentNetDetail"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/PropertyandEquipmentnetScheduleofPropertyandEquipmentNetDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_80c2c440-8955-4b29-87f2-efe84f8f9476" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BuildingsAndImprovementsGross_990da670-7b0d-441b-adb5-e139320fe3ed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BuildingsAndImprovementsGross"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_80c2c440-8955-4b29-87f2-efe84f8f9476" xlink:to="loc_us-gaap_BuildingsAndImprovementsGross_990da670-7b0d-441b-adb5-e139320fe3ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LandAndLandImprovements_c37b940d-fc2b-41cd-a9b9-dac170df15b5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LandAndLandImprovements"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_80c2c440-8955-4b29-87f2-efe84f8f9476" xlink:to="loc_us-gaap_LandAndLandImprovements_c37b940d-fc2b-41cd-a9b9-dac170df15b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FurnitureAndFixturesGross_4f7bec87-cd8b-4d1c-9030-c4fc3fcd4e91" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FurnitureAndFixturesGross"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_80c2c440-8955-4b29-87f2-efe84f8f9476" xlink:to="loc_us-gaap_FurnitureAndFixturesGross_4f7bec87-cd8b-4d1c-9030-c4fc3fcd4e91" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FlightEquipmentGross_e9bfb972-e0d3-48df-b168-be05c81ea5bf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FlightEquipmentGross"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_80c2c440-8955-4b29-87f2-efe84f8f9476" xlink:to="loc_us-gaap_FlightEquipmentGross_e9bfb972-e0d3-48df-b168-be05c81ea5bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressGross_5433a132-7011-4a5e-80e3-bfccefbcd7c1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConstructionInProgressGross"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_80c2c440-8955-4b29-87f2-efe84f8f9476" xlink:to="loc_us-gaap_ConstructionInProgressGross_5433a132-7011-4a5e-80e3-bfccefbcd7c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_1567cd84-a34f-44c8-a0a0-70d61553a3d6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_80c2c440-8955-4b29-87f2-efe84f8f9476" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_1567cd84-a34f-44c8-a0a0-70d61553a3d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_1975f4ee-7c92-4e74-96ba-c0e6e369bbf3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_80c2c440-8955-4b29-87f2-efe84f8f9476" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_1975f4ee-7c92-4e74-96ba-c0e6e369bbf3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_4e511753-4455-4c67-9302-604d7f09d382" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_80c2c440-8955-4b29-87f2-efe84f8f9476" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_4e511753-4455-4c67-9302-604d7f09d382" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/PropertyandEquipmentnetNarrativeDetails" xlink:type="simple" xlink:href="wynn-20230331.xsd#PropertyandEquipmentnetNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/PropertyandEquipmentnetNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_72fe2e7b-5e7d-417d-a0b2-d8ec1caffd61" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_5c3e71c6-27fc-437d-871f-2d407ddcadc6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Depreciation"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_72fe2e7b-5e7d-417d-a0b2-d8ec1caffd61" xlink:to="loc_us-gaap_Depreciation_5c3e71c6-27fc-437d-871f-2d407ddcadc6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/GoodwillandIntangibleAssetsnetScheduleofIntangibleAssetsNetDetails" xlink:type="simple" xlink:href="wynn-20230331.xsd#GoodwillandIntangibleAssetsnetScheduleofIntangibleAssetsNetDetails"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/GoodwillandIntangibleAssetsnetScheduleofIntangibleAssetsNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_96f32afa-a6b8-4b97-a3a5-f26d935bafff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_ScheduleOfIntangibleAssetsTable_35efd186-1466-419e-ad83-1795a79a5578" xlink:href="wynn-20230331.xsd#wynn_ScheduleOfIntangibleAssetsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_96f32afa-a6b8-4b97-a3a5-f26d935bafff" xlink:to="loc_wynn_ScheduleOfIntangibleAssetsTable_35efd186-1466-419e-ad83-1795a79a5578" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_bf873cad-14c2-499b-89aa-30cc6b30803a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsTable_35efd186-1466-419e-ad83-1795a79a5578" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_bf873cad-14c2-499b-89aa-30cc6b30803a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5a5d3572-c74b-4ed0-a104-b64781df9870" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_bf873cad-14c2-499b-89aa-30cc6b30803a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5a5d3572-c74b-4ed0-a104-b64781df9870" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_MacauGamingConcessionMember_52aaebfa-635a-4f87-b69a-62cc746d4222" xlink:href="wynn-20230331.xsd#wynn_MacauGamingConcessionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5a5d3572-c74b-4ed0-a104-b64781df9870" xlink:to="loc_wynn_MacauGamingConcessionMember_52aaebfa-635a-4f87-b69a-62cc746d4222" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_MassachusettsGamingLicenseMember_8521ec59-af6e-4e73-8ebd-e3cace01c173" xlink:href="wynn-20230331.xsd#wynn_MassachusettsGamingLicenseMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5a5d3572-c74b-4ed0-a104-b64781df9870" xlink:to="loc_wynn_MassachusettsGamingLicenseMember_8521ec59-af6e-4e73-8ebd-e3cace01c173" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIntangibleAssetsMember_482e2969-8b81-431b-982b-48fc4a4a5ab3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherIntangibleAssetsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5a5d3572-c74b-4ed0-a104-b64781df9870" xlink:to="loc_us-gaap_OtherIntangibleAssetsMember_482e2969-8b81-431b-982b-48fc4a4a5ab3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_500ba2c7-b04b-4268-8d3f-869764a80e57" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsTable_35efd186-1466-419e-ad83-1795a79a5578" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_500ba2c7-b04b-4268-8d3f-869764a80e57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_7df1e849-be1c-4541-93a4-097f12079bc3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_500ba2c7-b04b-4268-8d3f-869764a80e57" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_7df1e849-be1c-4541-93a4-097f12079bc3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WaterRightsAndOtherMember_bf760472-0f30-41f8-932c-12da1840cf59" xlink:href="wynn-20230331.xsd#wynn_WaterRightsAndOtherMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_7df1e849-be1c-4541-93a4-097f12079bc3" xlink:to="loc_wynn_WaterRightsAndOtherMember_bf760472-0f30-41f8-932c-12da1840cf59" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_ScheduleOfIntangibleAssetsLineItems_3ccbe3a9-b9e9-48ed-9fd5-0bbf3078aba8" xlink:href="wynn-20230331.xsd#wynn_ScheduleOfIntangibleAssetsLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsTable_35efd186-1466-419e-ad83-1795a79a5578" xlink:to="loc_wynn_ScheduleOfIntangibleAssetsLineItems_3ccbe3a9-b9e9-48ed-9fd5-0bbf3078aba8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_34b2a6ce-2c2a-4ed3-9365-9838fd2cbfbb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_3ccbe3a9-b9e9-48ed-9fd5-0bbf3078aba8" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_34b2a6ce-2c2a-4ed3-9365-9838fd2cbfbb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_324d50c6-e535-4eea-8471-869a530d8d1e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_3ccbe3a9-b9e9-48ed-9fd5-0bbf3078aba8" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_324d50c6-e535-4eea-8471-869a530d8d1e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_b82af83f-c3b5-4f77-9150-707c62b18963" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_3ccbe3a9-b9e9-48ed-9fd5-0bbf3078aba8" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_b82af83f-c3b5-4f77-9150-707c62b18963" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_7473ea84-a687-4ff5-93e0-f601e6a15c04" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_3ccbe3a9-b9e9-48ed-9fd5-0bbf3078aba8" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_7473ea84-a687-4ff5-93e0-f601e6a15c04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillRollForward_990cd2eb-275d-4ec4-8ca4-1539e52dc42a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillRollForward"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_3ccbe3a9-b9e9-48ed-9fd5-0bbf3078aba8" xlink:to="loc_us-gaap_GoodwillRollForward_990cd2eb-275d-4ec4-8ca4-1539e52dc42a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_0e6c22dc-e8fe-47e1-9473-b963e9ef0b96" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillRollForward_990cd2eb-275d-4ec4-8ca4-1539e52dc42a" xlink:to="loc_us-gaap_Goodwill_0e6c22dc-e8fe-47e1-9473-b963e9ef0b96" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_39677226-38a0-451e-b4ec-74cf12b4379b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillForeignCurrencyTranslationGainLoss"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillRollForward_990cd2eb-275d-4ec4-8ca4-1539e52dc42a" xlink:to="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_39677226-38a0-451e-b4ec-74cf12b4379b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_3fc074ce-b18d-4858-989b-18e60787a947" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillRollForward_990cd2eb-275d-4ec4-8ca4-1539e52dc42a" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_3fc074ce-b18d-4858-989b-18e60787a947" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_64947eae-6f29-40d1-9ee3-a43b1a31b118" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillRollForward_990cd2eb-275d-4ec4-8ca4-1539e52dc42a" xlink:to="loc_us-gaap_Goodwill_64947eae-6f29-40d1-9ee3-a43b1a31b118" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_40510a4f-7d9f-4ee1-a362-d28717c5e835" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_3ccbe3a9-b9e9-48ed-9fd5-0bbf3078aba8" xlink:to="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_40510a4f-7d9f-4ee1-a362-d28717c5e835" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/GoodwillandIntangibleAssetsnetNarrativeDetails" xlink:type="simple" xlink:href="wynn-20230331.xsd#GoodwillandIntangibleAssetsnetNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/GoodwillandIntangibleAssetsnetNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_a59a2b3b-cb9f-448e-ac4c-f49aef836554" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_ScheduleOfIntangibleAssetsTable_25e07fe8-d14b-4135-9f94-bdfbfd7e4862" xlink:href="wynn-20230331.xsd#wynn_ScheduleOfIntangibleAssetsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_a59a2b3b-cb9f-448e-ac4c-f49aef836554" xlink:to="loc_wynn_ScheduleOfIntangibleAssetsTable_25e07fe8-d14b-4135-9f94-bdfbfd7e4862" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsAxis_254858ce-6d42-445a-9208-dff6bde15750" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherCommitmentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsTable_25e07fe8-d14b-4135-9f94-bdfbfd7e4862" xlink:to="loc_us-gaap_OtherCommitmentsAxis_254858ce-6d42-445a-9208-dff6bde15750" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsDomain_e9fd67c5-721a-4bfa-8e21-aac19e1dcbf4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherCommitmentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsAxis_254858ce-6d42-445a-9208-dff6bde15750" xlink:to="loc_us-gaap_OtherCommitmentsDomain_e9fd67c5-721a-4bfa-8e21-aac19e1dcbf4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_MacauGamingAndNonGamingInvestmentsMember_983637fa-d94a-45f4-b046-db45c4233722" xlink:href="wynn-20230331.xsd#wynn_MacauGamingAndNonGamingInvestmentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsDomain_e9fd67c5-721a-4bfa-8e21-aac19e1dcbf4" xlink:to="loc_wynn_MacauGamingAndNonGamingInvestmentsMember_983637fa-d94a-45f4-b046-db45c4233722" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_MacauGamingConcessionMember_71de4914-1987-4910-8d88-f604d0820a04" xlink:href="wynn-20230331.xsd#wynn_MacauGamingConcessionMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsDomain_e9fd67c5-721a-4bfa-8e21-aac19e1dcbf4" xlink:to="loc_wynn_MacauGamingConcessionMember_71de4914-1987-4910-8d88-f604d0820a04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_bd39b3c9-6519-4b10-85e5-7541c3faaf43" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_LegalEntityAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsTable_25e07fe8-d14b-4135-9f94-bdfbfd7e4862" xlink:to="loc_dei_LegalEntityAxis_bd39b3c9-6519-4b10-85e5-7541c3faaf43" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_ed87e26e-0066-478c-811b-b8b56b915cb8" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_bd39b3c9-6519-4b10-85e5-7541c3faaf43" xlink:to="loc_dei_EntityDomain_ed87e26e-0066-478c-811b-b8b56b915cb8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauSAMember_eed0c714-a467-4cbe-90b1-63c1940e3fa2" xlink:href="wynn-20230331.xsd#wynn_WynnMacauSAMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_ed87e26e-0066-478c-811b-b8b56b915cb8" xlink:to="loc_wynn_WynnMacauSAMember_eed0c714-a467-4cbe-90b1-63c1940e3fa2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OtherCommitmentScenarioAxis_381cd92d-9798-41a5-82ef-c3b7e59063c0" xlink:href="wynn-20230331.xsd#wynn_OtherCommitmentScenarioAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsTable_25e07fe8-d14b-4135-9f94-bdfbfd7e4862" xlink:to="loc_wynn_OtherCommitmentScenarioAxis_381cd92d-9798-41a5-82ef-c3b7e59063c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OtherCommitmentScenarioDomain_e541d95d-af48-45b1-aac0-7fc4c5d5df94" xlink:href="wynn-20230331.xsd#wynn_OtherCommitmentScenarioDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_OtherCommitmentScenarioAxis_381cd92d-9798-41a5-82ef-c3b7e59063c0" xlink:to="loc_wynn_OtherCommitmentScenarioDomain_e541d95d-af48-45b1-aac0-7fc4c5d5df94" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OtherCommitmentScenarioOneMember_eca62baf-097f-4434-ae27-cf8c6f72f580" xlink:href="wynn-20230331.xsd#wynn_OtherCommitmentScenarioOneMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_OtherCommitmentScenarioDomain_e541d95d-af48-45b1-aac0-7fc4c5d5df94" xlink:to="loc_wynn_OtherCommitmentScenarioOneMember_eca62baf-097f-4434-ae27-cf8c6f72f580" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OtherCommitmentScenarioTwoMember_7316e474-044f-4364-a899-eb667b43fc2b" xlink:href="wynn-20230331.xsd#wynn_OtherCommitmentScenarioTwoMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_OtherCommitmentScenarioDomain_e541d95d-af48-45b1-aac0-7fc4c5d5df94" xlink:to="loc_wynn_OtherCommitmentScenarioTwoMember_7316e474-044f-4364-a899-eb667b43fc2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OtherCommitmentScenarioThreeMember_6224a3b3-9d7c-4153-87c7-97d52314d51a" xlink:href="wynn-20230331.xsd#wynn_OtherCommitmentScenarioThreeMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_OtherCommitmentScenarioDomain_e541d95d-af48-45b1-aac0-7fc4c5d5df94" xlink:to="loc_wynn_OtherCommitmentScenarioThreeMember_6224a3b3-9d7c-4153-87c7-97d52314d51a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_ScheduleOfIntangibleAssetsLineItems_f65307e9-678b-4e83-a6bf-42c11d7f30c6" xlink:href="wynn-20230331.xsd#wynn_ScheduleOfIntangibleAssetsLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsTable_25e07fe8-d14b-4135-9f94-bdfbfd7e4862" xlink:to="loc_wynn_ScheduleOfIntangibleAssetsLineItems_f65307e9-678b-4e83-a6bf-42c11d7f30c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OtherCommitmentTerm_580e7d31-77c8-4860-9979-89fed26f0e33" xlink:href="wynn-20230331.xsd#wynn_OtherCommitmentTerm"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_f65307e9-678b-4e83-a6bf-42c11d7f30c6" xlink:to="loc_wynn_OtherCommitmentTerm_580e7d31-77c8-4860-9979-89fed26f0e33" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OtherCommitmentFixedPortion_94a45150-d0e1-4def-a6a4-6f94be3c6b49" xlink:href="wynn-20230331.xsd#wynn_OtherCommitmentFixedPortion"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_f65307e9-678b-4e83-a6bf-42c11d7f30c6" xlink:to="loc_wynn_OtherCommitmentFixedPortion_94a45150-d0e1-4def-a6a4-6f94be3c6b49" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OtherCommitmentVariablePortion_5cbe889b-63c9-49c4-9814-c478c82fbfde" xlink:href="wynn-20230331.xsd#wynn_OtherCommitmentVariablePortion"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_f65307e9-678b-4e83-a6bf-42c11d7f30c6" xlink:to="loc_wynn_OtherCommitmentVariablePortion_5cbe889b-63c9-49c4-9814-c478c82fbfde" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OtherCommitmentToBePaidYearsOneThroughThree_41e3f3a3-f3ed-47ba-b838-759c0d1f4784" xlink:href="wynn-20230331.xsd#wynn_OtherCommitmentToBePaidYearsOneThroughThree"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_f65307e9-678b-4e83-a6bf-42c11d7f30c6" xlink:to="loc_wynn_OtherCommitmentToBePaidYearsOneThroughThree_41e3f3a3-f3ed-47ba-b838-759c0d1f4784" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OtherCommitmentToBePaidYearsFourThroughTen_038439a1-f56c-40e0-bbd7-ac130f6469a5" xlink:href="wynn-20230331.xsd#wynn_OtherCommitmentToBePaidYearsFourThroughTen"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_f65307e9-678b-4e83-a6bf-42c11d7f30c6" xlink:to="loc_wynn_OtherCommitmentToBePaidYearsFourThroughTen_038439a1-f56c-40e0-bbd7-ac130f6469a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FinancialLiabilityRelatedToGamingConcession_a2efe45a-4db5-47b5-9de0-b6e75328832c" xlink:href="wynn-20230331.xsd#wynn_FinancialLiabilityRelatedToGamingConcession"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_f65307e9-678b-4e83-a6bf-42c11d7f30c6" xlink:to="loc_wynn_FinancialLiabilityRelatedToGamingConcession_a2efe45a-4db5-47b5-9de0-b6e75328832c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_5028b7a4-1075-477e-9b3b-eb9a188b5821" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_f65307e9-678b-4e83-a6bf-42c11d7f30c6" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_5028b7a4-1075-477e-9b3b-eb9a188b5821" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiniteLivedIntangibleAssetExpectedAmortizationYearsOneThroughNine_9e066501-2b1b-4be6-b981-b704a12ff50f" xlink:href="wynn-20230331.xsd#wynn_FiniteLivedIntangibleAssetExpectedAmortizationYearsOneThroughNine"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_f65307e9-678b-4e83-a6bf-42c11d7f30c6" xlink:to="loc_wynn_FiniteLivedIntangibleAssetExpectedAmortizationYearsOneThroughNine_9e066501-2b1b-4be6-b981-b704a12ff50f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_71ce5b47-14a0-4120-9092-4d53133fa707" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_ScheduleOfIntangibleAssetsLineItems_f65307e9-678b-4e83-a6bf-42c11d7f30c6" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_71ce5b47-14a0-4120-9092-4d53133fa707" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebtSummaryofLongTermDebtDetail" xlink:type="simple" xlink:href="wynn-20230331.xsd#LongTermDebtSummaryofLongTermDebtDetail"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/LongTermDebtSummaryofLongTermDebtDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_2cc3b6dc-b029-4719-bb92-a83de50dd043" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_58f0f470-0f77-4a68-97e9-0e4bb1bc5561" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_2cc3b6dc-b029-4719-bb92-a83de50dd043" xlink:to="loc_us-gaap_DebtInstrumentTable_58f0f470-0f77-4a68-97e9-0e4bb1bc5561" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_aeaa5ab9-9293-4c8d-8062-32d476d1ccd0" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_LegalEntityAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_58f0f470-0f77-4a68-97e9-0e4bb1bc5561" xlink:to="loc_dei_LegalEntityAxis_aeaa5ab9-9293-4c8d-8062-32d476d1ccd0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_90128426-1202-4f64-b19b-965e83537842" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_aeaa5ab9-9293-4c8d-8062-32d476d1ccd0" xlink:to="loc_dei_EntityDomain_90128426-1202-4f64-b19b-965e83537842" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMCaymanHoldingsLimitedIIMember_5636cd92-fee7-4d0c-85fb-64639c9d0f8d" xlink:href="wynn-20230331.xsd#wynn_WMCaymanHoldingsLimitedIIMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_90128426-1202-4f64-b19b-965e83537842" xlink:to="loc_wynn_WMCaymanHoldingsLimitedIIMember_5636cd92-fee7-4d0c-85fb-64639c9d0f8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauLimitedMember_e6913d3f-3f32-42e2-9460-2f5f4a404b5f" xlink:href="wynn-20230331.xsd#wynn_WynnMacauLimitedMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_90128426-1202-4f64-b19b-965e83537842" xlink:to="loc_wynn_WynnMacauLimitedMember_e6913d3f-3f32-42e2-9460-2f5f4a404b5f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnResortsFinanceLLCMember_84b5b53e-5133-4e98-8ced-9be284cbf253" xlink:href="wynn-20230331.xsd#wynn_WynnResortsFinanceLLCMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_90128426-1202-4f64-b19b-965e83537842" xlink:to="loc_wynn_WynnResortsFinanceLLCMember_84b5b53e-5133-4e98-8ced-9be284cbf253" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember_0f29115e-e5d8-4cc1-a4e7-96bb4b383d34" xlink:href="wynn-20230331.xsd#wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_90128426-1202-4f64-b19b-965e83537842" xlink:to="loc_wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember_0f29115e-e5d8-4cc1-a4e7-96bb4b383d34" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember_986d79a3-4565-4740-b25c-002fceeab04c" xlink:href="wynn-20230331.xsd#wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_90128426-1202-4f64-b19b-965e83537842" xlink:to="loc_wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember_986d79a3-4565-4740-b25c-002fceeab04c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_da969209-a752-4a3b-bda4-62f4a45155d1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_58f0f470-0f77-4a68-97e9-0e4bb1bc5561" xlink:to="loc_us-gaap_DebtInstrumentAxis_da969209-a752-4a3b-bda4-62f4a45155d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_f1cb75dc-4a9d-42f4-acbd-c4501837f424" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_da969209-a752-4a3b-bda4-62f4a45155d1" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_f1cb75dc-4a9d-42f4-acbd-c4501837f424" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMCaymanIIRevolverDue2025Member_7e5fa841-eafc-4dec-8f7b-ce846689429a" xlink:href="wynn-20230331.xsd#wynn_WMCaymanIIRevolverDue2025Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f1cb75dc-4a9d-42f4-acbd-c4501837f424" xlink:to="loc_wynn_WMCaymanIIRevolverDue2025Member_7e5fa841-eafc-4dec-8f7b-ce846689429a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FourandSevenOverEightPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentyFourMember_e4f7d02f-86e4-45f9-817a-0c1435d41fa2" xlink:href="wynn-20230331.xsd#wynn_FourandSevenOverEightPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentyFourMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f1cb75dc-4a9d-42f4-acbd-c4501837f424" xlink:to="loc_wynn_FourandSevenOverEightPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentyFourMember_e4f7d02f-86e4-45f9-817a-0c1435d41fa2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentySixMember_6a387614-075c-4d88-8882-711a87f9c46f" xlink:href="wynn-20230331.xsd#wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentySixMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f1cb75dc-4a9d-42f4-acbd-c4501837f424" xlink:to="loc_wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentySixMember_6a387614-075c-4d88-8882-711a87f9c46f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentySevenMember_cf7f0ba2-755d-46ac-bdfa-742ca42d88d7" xlink:href="wynn-20230331.xsd#wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentySevenMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f1cb75dc-4a9d-42f4-acbd-c4501837f424" xlink:to="loc_wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentySevenMember_cf7f0ba2-755d-46ac-bdfa-742ca42d88d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyNineMember_b740ed37-a8b7-4726-9b97-a5a41fb1cc01" xlink:href="wynn-20230331.xsd#wynn_FiveAndOneOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyNineMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f1cb75dc-4a9d-42f4-acbd-c4501837f424" xlink:to="loc_wynn_FiveAndOneOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyNineMember_b740ed37-a8b7-4726-9b97-a5a41fb1cc01" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndFiveOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyEightMember_d878412f-194a-4a74-98aa-5c0432277bc8" xlink:href="wynn-20230331.xsd#wynn_FiveAndFiveOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyEightMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f1cb75dc-4a9d-42f4-acbd-c4501837f424" xlink:to="loc_wynn_FiveAndFiveOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyEightMember_d878412f-194a-4a74-98aa-5c0432277bc8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FourAndOneOverTwoPercentageWynnMacauLimitedConvertibleBondsDueTwoThousandTwentyNineMember_da598458-d0a0-4643-895d-de1e9c0cf42b" xlink:href="wynn-20230331.xsd#wynn_FourAndOneOverTwoPercentageWynnMacauLimitedConvertibleBondsDueTwoThousandTwentyNineMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f1cb75dc-4a9d-42f4-acbd-c4501837f424" xlink:to="loc_wynn_FourAndOneOverTwoPercentageWynnMacauLimitedConvertibleBondsDueTwoThousandTwentyNineMember_da598458-d0a0-4643-895d-de1e9c0cf42b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_66717c4f-1a2d-4067-aa1d-593d7363c021" xlink:href="wynn-20230331.xsd#wynn_WRFSeniorSecuredCreditFacilitiesMember"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f1cb75dc-4a9d-42f4-acbd-c4501837f424" xlink:to="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_66717c4f-1a2d-4067-aa1d-593d7363c021" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorTermLoanFacilityDue2024Member_bdee0f24-4c36-4bd2-8f51-e3d91ddf9549" xlink:href="wynn-20230331.xsd#wynn_SeniorTermLoanFacilityDue2024Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_66717c4f-1a2d-4067-aa1d-593d7363c021" xlink:to="loc_wynn_SeniorTermLoanFacilityDue2024Member_bdee0f24-4c36-4bd2-8f51-e3d91ddf9549" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_031facf4-330a-4329-8daa-563cee85652a" xlink:href="wynn-20230331.xsd#wynn_SeniorRevolvingCreditFacilityDue2024Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_66717c4f-1a2d-4067-aa1d-593d7363c021" xlink:to="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_031facf4-330a-4329-8daa-563cee85652a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FourAndOneOverFourPercentageWynnLasVegasSeniorNotesDueMayThirtyTwoThousandTwentyThreeMember_b2e994a9-4906-4c28-9a56-c8dbf835806c" xlink:href="wynn-20230331.xsd#wynn_FourAndOneOverFourPercentageWynnLasVegasSeniorNotesDueMayThirtyTwoThousandTwentyThreeMember"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f1cb75dc-4a9d-42f4-acbd-c4501837f424" xlink:to="loc_wynn_FourAndOneOverFourPercentageWynnLasVegasSeniorNotesDueMayThirtyTwoThousandTwentyThreeMember_b2e994a9-4906-4c28-9a56-c8dbf835806c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember_d4032e51-691d-4bab-8fe5-8821d5030456" xlink:href="wynn-20230331.xsd#wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f1cb75dc-4a9d-42f4-acbd-c4501837f424" xlink:to="loc_wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember_d4032e51-691d-4bab-8fe5-8821d5030456" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverFourPercentageSeniorNotesDueMay152027Member_80025aa7-865a-4f1c-8ad8-c9911a35ac74" xlink:href="wynn-20230331.xsd#wynn_FiveAndOneOverFourPercentageSeniorNotesDueMay152027Member"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f1cb75dc-4a9d-42f4-acbd-c4501837f424" xlink:to="loc_wynn_FiveAndOneOverFourPercentageSeniorNotesDueMay152027Member_80025aa7-865a-4f1c-8ad8-c9911a35ac74" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SevenAndThreeOverFourPercentageWRFSeniorNotesDue2025Member_4384cc7d-b5e4-4f69-8863-37b91c95002f" xlink:href="wynn-20230331.xsd#wynn_SevenAndThreeOverFourPercentageWRFSeniorNotesDue2025Member"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f1cb75dc-4a9d-42f4-acbd-c4501837f424" xlink:to="loc_wynn_SevenAndThreeOverFourPercentageWRFSeniorNotesDue2025Member_4384cc7d-b5e4-4f69-8863-37b91c95002f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverEightPercentageSeniorNotesDue2029Member_51e6284e-6960-49ae-b272-e1ce3a6d289c" xlink:href="wynn-20230331.xsd#wynn_FiveAndOneOverEightPercentageSeniorNotesDue2029Member"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f1cb75dc-4a9d-42f4-acbd-c4501837f424" xlink:to="loc_wynn_FiveAndOneOverEightPercentageSeniorNotesDue2029Member_51e6284e-6960-49ae-b272-e1ce3a6d289c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SevenAndOneOverEightPercentageSeniorNotesDue2031Member_cae8fdb4-c877-4a73-b869-ba7a1fb8c27c" xlink:href="wynn-20230331.xsd#wynn_SevenAndOneOverEightPercentageSeniorNotesDue2031Member"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f1cb75dc-4a9d-42f4-acbd-c4501837f424" xlink:to="loc_wynn_SevenAndOneOverEightPercentageSeniorNotesDue2031Member_cae8fdb4-c877-4a73-b869-ba7a1fb8c27c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailTermLoanAgreementMember_dfb54604-a38f-4dc1-8878-43078ac045a3" xlink:href="wynn-20230331.xsd#wynn_RetailTermLoanAgreementMember"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f1cb75dc-4a9d-42f4-acbd-c4501837f424" xlink:to="loc_wynn_RetailTermLoanAgreementMember_dfb54604-a38f-4dc1-8878-43078ac045a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_ee832c64-0625-4a71-ba60-61c5cee36b74" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_58f0f470-0f77-4a68-97e9-0e4bb1bc5561" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_ee832c64-0625-4a71-ba60-61c5cee36b74" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_1407d5b8-a850-4f68-8417-dd1eb2d7c393" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_ee832c64-0625-4a71-ba60-61c5cee36b74" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_1407d5b8-a850-4f68-8417-dd1eb2d7c393" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_8906cc39-d798-4ff6-b9b6-901726b31864" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1407d5b8-a850-4f68-8417-dd1eb2d7c393" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_8906cc39-d798-4ff6-b9b6-901726b31864" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_3967b6fc-5a37-4ae1-97da-07bccc686823" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeniorNotesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1407d5b8-a850-4f68-8417-dd1eb2d7c393" xlink:to="loc_us-gaap_SeniorNotesMember_3967b6fc-5a37-4ae1-97da-07bccc686823" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_06587b1f-ab92-4e83-aa27-a1fe1aa3ef89" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1407d5b8-a850-4f68-8417-dd1eb2d7c393" xlink:to="loc_us-gaap_ConvertibleDebtMember_06587b1f-ab92-4e83-aa27-a1fe1aa3ef89" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredDebtMember_32d09156-def5-4965-a8ea-24a81362c6e9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuredDebtMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1407d5b8-a850-4f68-8417-dd1eb2d7c393" xlink:to="loc_us-gaap_SecuredDebtMember_32d09156-def5-4965-a8ea-24a81362c6e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MediumTermNotesMember_8e71f77b-c50c-420c-8f37-ab94384d4d2b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MediumTermNotesMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1407d5b8-a850-4f68-8417-dd1eb2d7c393" xlink:to="loc_us-gaap_MediumTermNotesMember_8e71f77b-c50c-420c-8f37-ab94384d4d2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_912d46d9-ce0f-4b96-826b-9c04ba030392" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_58f0f470-0f77-4a68-97e9-0e4bb1bc5561" xlink:to="loc_us-gaap_DebtInstrumentLineItems_912d46d9-ce0f-4b96-826b-9c04ba030392" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_c21fd8ed-7a5d-45a0-a547-601165bfe891" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_912d46d9-ce0f-4b96-826b-9c04ba030392" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_c21fd8ed-7a5d-45a0-a547-601165bfe891" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_3e94b9dc-f0e1-4551-a3ec-36fb452176ed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_912d46d9-ce0f-4b96-826b-9c04ba030392" xlink:to="loc_us-gaap_DerivativeLiabilities_3e94b9dc-f0e1-4551-a3ec-36fb452176ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_847007ae-7f3b-4439-aebf-fcd62ed9e342" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_912d46d9-ce0f-4b96-826b-9c04ba030392" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_847007ae-7f3b-4439-aebf-fcd62ed9e342" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_658a7a54-a2b7-4fdc-890d-d57a941f15c0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_912d46d9-ce0f-4b96-826b-9c04ba030392" xlink:to="loc_us-gaap_LongTermDebt_658a7a54-a2b7-4fdc-890d-d57a941f15c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_6c94bd54-9cac-47c7-9d25-5f9cc3b38868" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_912d46d9-ce0f-4b96-826b-9c04ba030392" xlink:to="loc_us-gaap_LongTermDebtCurrent_6c94bd54-9cac-47c7-9d25-5f9cc3b38868" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_a28f5375-aca0-41a7-8140-1b37305e0987" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_912d46d9-ce0f-4b96-826b-9c04ba030392" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_a28f5375-aca0-41a7-8140-1b37305e0987" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_2fdc4260-65aa-425b-ab3b-d27789e84688" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_912d46d9-ce0f-4b96-826b-9c04ba030392" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_2fdc4260-65aa-425b-ab3b-d27789e84688" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebtSummaryofLongTermDebtAdditionalInformationDetail" xlink:type="simple" xlink:href="wynn-20230331.xsd#LongTermDebtSummaryofLongTermDebtAdditionalInformationDetail"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/LongTermDebtSummaryofLongTermDebtAdditionalInformationDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_83ca8f37-6e18-4d60-9b8e-272756cd55e6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_4eaafc7f-5288-44bb-be2b-5aa9868a8226" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_83ca8f37-6e18-4d60-9b8e-272756cd55e6" xlink:to="loc_us-gaap_DebtInstrumentTable_4eaafc7f-5288-44bb-be2b-5aa9868a8226" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_c99479fe-9cbe-4274-a2b1-5a5d5992a524" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_VariableRateAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_4eaafc7f-5288-44bb-be2b-5aa9868a8226" xlink:to="loc_us-gaap_VariableRateAxis_c99479fe-9cbe-4274-a2b1-5a5d5992a524" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_c09bc2eb-54cd-48f7-bc98-3189f0cf01bf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_VariableRateDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateAxis_c99479fe-9cbe-4274-a2b1-5a5d5992a524" xlink:to="loc_us-gaap_VariableRateDomain_c09bc2eb-54cd-48f7-bc98-3189f0cf01bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_HIBOROrLIBORMember_b1bb79dc-d394-40a6-bec5-ba0c9470a0b8" xlink:href="wynn-20230331.xsd#wynn_HIBOROrLIBORMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateDomain_c09bc2eb-54cd-48f7-bc98-3189f0cf01bf" xlink:to="loc_wynn_HIBOROrLIBORMember_b1bb79dc-d394-40a6-bec5-ba0c9470a0b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BaseRateMember_4aeac1ec-f061-4226-93e8-acea5099e736" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BaseRateMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateDomain_c09bc2eb-54cd-48f7-bc98-3189f0cf01bf" xlink:to="loc_us-gaap_BaseRateMember_4aeac1ec-f061-4226-93e8-acea5099e736" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_f382b0ea-abe6-4a2c-be6a-4ae32163058e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LondonInterbankOfferedRateLIBORMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateDomain_c09bc2eb-54cd-48f7-bc98-3189f0cf01bf" xlink:to="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_f382b0ea-abe6-4a2c-be6a-4ae32163058e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_HIBORMember_1351a38d-b69c-4d0c-9af8-fa028553d7a3" xlink:href="wynn-20230331.xsd#wynn_HIBORMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateDomain_c09bc2eb-54cd-48f7-bc98-3189f0cf01bf" xlink:to="loc_wynn_HIBORMember_1351a38d-b69c-4d0c-9af8-fa028553d7a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_7f6b8f70-8645-473a-88bc-e63e6327d17a" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_LegalEntityAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_4eaafc7f-5288-44bb-be2b-5aa9868a8226" xlink:to="loc_dei_LegalEntityAxis_7f6b8f70-8645-473a-88bc-e63e6327d17a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_84960b02-10a8-4513-a69a-397c4be6f6a3" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_7f6b8f70-8645-473a-88bc-e63e6327d17a" xlink:to="loc_dei_EntityDomain_84960b02-10a8-4513-a69a-397c4be6f6a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnResortsFinanceLLCMember_c625a015-8457-42ae-b4c7-4bd87ac92178" xlink:href="wynn-20230331.xsd#wynn_WynnResortsFinanceLLCMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_84960b02-10a8-4513-a69a-397c4be6f6a3" xlink:to="loc_wynn_WynnResortsFinanceLLCMember_c625a015-8457-42ae-b4c7-4bd87ac92178" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember_e71280c5-af46-4795-bd12-44c541385183" xlink:href="wynn-20230331.xsd#wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_84960b02-10a8-4513-a69a-397c4be6f6a3" xlink:to="loc_wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember_e71280c5-af46-4795-bd12-44c541385183" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMCaymanHoldingsLimitedIIMember_4395253b-9f98-4d6d-ae8e-b6a12a603f9d" xlink:href="wynn-20230331.xsd#wynn_WMCaymanHoldingsLimitedIIMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_84960b02-10a8-4513-a69a-397c4be6f6a3" xlink:to="loc_wynn_WMCaymanHoldingsLimitedIIMember_4395253b-9f98-4d6d-ae8e-b6a12a603f9d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauLimitedMember_835ff2ac-eb13-43d0-9593-92db2e700568" xlink:href="wynn-20230331.xsd#wynn_WynnMacauLimitedMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_84960b02-10a8-4513-a69a-397c4be6f6a3" xlink:to="loc_wynn_WynnMacauLimitedMember_835ff2ac-eb13-43d0-9593-92db2e700568" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_cdbcbeda-d280-4e03-8dea-550f040d9a63" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_4eaafc7f-5288-44bb-be2b-5aa9868a8226" xlink:to="loc_us-gaap_DebtInstrumentAxis_cdbcbeda-d280-4e03-8dea-550f040d9a63" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_a503863c-80e3-409f-aa0a-3dfba7b8372a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_cdbcbeda-d280-4e03-8dea-550f040d9a63" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_a503863c-80e3-409f-aa0a-3dfba7b8372a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMCaymanIIRevolverDue2025Member_098c8767-bd02-4435-a1e3-99c9cd9464a1" xlink:href="wynn-20230331.xsd#wynn_WMCaymanIIRevolverDue2025Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_a503863c-80e3-409f-aa0a-3dfba7b8372a" xlink:to="loc_wynn_WMCaymanIIRevolverDue2025Member_098c8767-bd02-4435-a1e3-99c9cd9464a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_d0262c24-acd2-4197-b204-5831f4f09d25" xlink:href="wynn-20230331.xsd#wynn_WRFSeniorSecuredCreditFacilitiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_a503863c-80e3-409f-aa0a-3dfba7b8372a" xlink:to="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_d0262c24-acd2-4197-b204-5831f4f09d25" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_7b53cd2b-7330-4d20-ab69-78e8fd496494" xlink:href="wynn-20230331.xsd#wynn_SeniorRevolvingCreditFacilityDue2024Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_d0262c24-acd2-4197-b204-5831f4f09d25" xlink:to="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_7b53cd2b-7330-4d20-ab69-78e8fd496494" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailTermLoanAgreementMember_f3b44cc4-25b9-44df-af55-f98b9144fdd7" xlink:href="wynn-20230331.xsd#wynn_RetailTermLoanAgreementMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_a503863c-80e3-409f-aa0a-3dfba7b8372a" xlink:to="loc_wynn_RetailTermLoanAgreementMember_f3b44cc4-25b9-44df-af55-f98b9144fdd7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FourAndOneOverTwoPercentageWynnMacauLimitedConvertibleBondsDueTwoThousandTwentyNineMember_8f0f82e7-1f6f-45ca-a140-b2add7571f59" xlink:href="wynn-20230331.xsd#wynn_FourAndOneOverTwoPercentageWynnMacauLimitedConvertibleBondsDueTwoThousandTwentyNineMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_a503863c-80e3-409f-aa0a-3dfba7b8372a" xlink:to="loc_wynn_FourAndOneOverTwoPercentageWynnMacauLimitedConvertibleBondsDueTwoThousandTwentyNineMember_8f0f82e7-1f6f-45ca-a140-b2add7571f59" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_5e147254-1a7d-405d-a4f4-2ac14c5f59e5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_4eaafc7f-5288-44bb-be2b-5aa9868a8226" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_5e147254-1a7d-405d-a4f4-2ac14c5f59e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_2d125e74-0463-41ab-9206-5cc56c492f88" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_5e147254-1a7d-405d-a4f4-2ac14c5f59e5" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_2d125e74-0463-41ab-9206-5cc56c492f88" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_4560578d-c18f-4f44-994c-bea989448eea" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_2d125e74-0463-41ab-9206-5cc56c492f88" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_4560578d-c18f-4f44-994c-bea989448eea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MediumTermNotesMember_34d4e470-aa15-40bb-b601-c24c4267d4e6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MediumTermNotesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_2d125e74-0463-41ab-9206-5cc56c492f88" xlink:to="loc_us-gaap_MediumTermNotesMember_34d4e470-aa15-40bb-b601-c24c4267d4e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_9c1b0368-bec6-4570-b9a3-bf6cf49f8668" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_2d125e74-0463-41ab-9206-5cc56c492f88" xlink:to="loc_us-gaap_ConvertibleDebtMember_9c1b0368-bec6-4570-b9a3-bf6cf49f8668" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_28c04027-a243-4820-8e48-d4b3aff8f28a" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_4eaafc7f-5288-44bb-be2b-5aa9868a8226" xlink:to="loc_srt_RangeAxis_28c04027-a243-4820-8e48-d4b3aff8f28a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_93313bbd-f8fa-4e86-83eb-dec3a1a228f3" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_28c04027-a243-4820-8e48-d4b3aff8f28a" xlink:to="loc_srt_RangeMember_93313bbd-f8fa-4e86-83eb-dec3a1a228f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_e1b84870-383c-407a-8b4b-d7ed82cc4f16" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_93313bbd-f8fa-4e86-83eb-dec3a1a228f3" xlink:to="loc_srt_MinimumMember_e1b84870-383c-407a-8b4b-d7ed82cc4f16" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_6f34c7f4-1313-421f-b140-58ce1d060738" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_93313bbd-f8fa-4e86-83eb-dec3a1a228f3" xlink:to="loc_srt_MaximumMember_6f34c7f4-1313-421f-b140-58ce1d060738" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_d9a1c153-2cfc-47bb-8e94-c0a3b3cc19b7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_4eaafc7f-5288-44bb-be2b-5aa9868a8226" xlink:to="loc_us-gaap_DebtInstrumentLineItems_d9a1c153-2cfc-47bb-8e94-c0a3b3cc19b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_90e753ce-b6b6-4ce2-b90e-89cb7679d92a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_d9a1c153-2cfc-47bb-8e94-c0a3b3cc19b7" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_90e753ce-b6b6-4ce2-b90e-89cb7679d92a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_c2b3a72d-c95c-45bf-bbf8-406fa94d0f4a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_d9a1c153-2cfc-47bb-8e94-c0a3b3cc19b7" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_c2b3a72d-c95c-45bf-bbf8-406fa94d0f4a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtWeightedAverageInterestRate_61398da3-feeb-4285-9c98-8d33992e5daf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtWeightedAverageInterestRate"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_d9a1c153-2cfc-47bb-8e94-c0a3b3cc19b7" xlink:to="loc_us-gaap_DebtWeightedAverageInterestRate_61398da3-feeb-4285-9c98-8d33992e5daf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_8163c70b-9a0f-4a2e-a641-8233e07d5b10" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_d9a1c153-2cfc-47bb-8e94-c0a3b3cc19b7" xlink:to="loc_us-gaap_LongTermDebt_8163c70b-9a0f-4a2e-a641-8233e07d5b10" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_64d7ac84-daeb-494a-8d77-967618c90a6f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_d9a1c153-2cfc-47bb-8e94-c0a3b3cc19b7" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_64d7ac84-daeb-494a-8d77-967618c90a6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_7cdd5008-6fe0-4721-a8af-d176ada1d497" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_d9a1c153-2cfc-47bb-8e94-c0a3b3cc19b7" xlink:to="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_7cdd5008-6fe0-4721-a8af-d176ada1d497" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LettersOfCreditOutstandingAmount_1853dc47-1534-4269-973e-123f3de83f2b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LettersOfCreditOutstandingAmount"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_d9a1c153-2cfc-47bb-8e94-c0a3b3cc19b7" xlink:to="loc_us-gaap_LettersOfCreditOutstandingAmount_1853dc47-1534-4269-973e-123f3de83f2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_94bcef45-6015-484c-bf01-1fad948989f8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentInterestRateDuringPeriod"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_d9a1c153-2cfc-47bb-8e94-c0a3b3cc19b7" xlink:to="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_94bcef45-6015-484c-bf01-1fad948989f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebtAdditionalInformationDetail" xlink:type="simple" xlink:href="wynn-20230331.xsd#LongTermDebtAdditionalInformationDetail"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/LongTermDebtAdditionalInformationDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_f16b9825-7d8e-4b9c-b320-7de56bc48dd6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_41d595eb-b57c-47b2-85ef-fe9d78c16705" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_f16b9825-7d8e-4b9c-b320-7de56bc48dd6" xlink:to="loc_us-gaap_DebtInstrumentTable_41d595eb-b57c-47b2-85ef-fe9d78c16705" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_762d2ada-99f7-4646-85cb-2e6e5b7cc6e7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_41d595eb-b57c-47b2-85ef-fe9d78c16705" xlink:to="loc_us-gaap_DebtInstrumentAxis_762d2ada-99f7-4646-85cb-2e6e5b7cc6e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_32d0996f-d370-466d-9913-fe6d1dacd711" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_762d2ada-99f7-4646-85cb-2e6e5b7cc6e7" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_32d0996f-d370-466d-9913-fe6d1dacd711" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMLConvertibleBondsMember_ca1c9c03-aa7c-46c0-a848-aab80606f114" xlink:href="wynn-20230331.xsd#wynn_WMLConvertibleBondsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_32d0996f-d370-466d-9913-fe6d1dacd711" xlink:to="loc_wynn_WMLConvertibleBondsMember_ca1c9c03-aa7c-46c0-a848-aab80606f114" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SevenAndOneOverEightPercentageSeniorNotesDue2031Member_6f4c6fe4-8aa4-4240-a8bf-bf678a78b6df" xlink:href="wynn-20230331.xsd#wynn_SevenAndOneOverEightPercentageSeniorNotesDue2031Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_32d0996f-d370-466d-9913-fe6d1dacd711" xlink:to="loc_wynn_SevenAndOneOverEightPercentageSeniorNotesDue2031Member_6f4c6fe4-8aa4-4240-a8bf-bf678a78b6df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SevenAndThreeOverFourPercentageWRFSeniorNotesDue2025Member_1efda92e-e5d1-468e-8a66-08512a740e7e" xlink:href="wynn-20230331.xsd#wynn_SevenAndThreeOverFourPercentageWRFSeniorNotesDue2025Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_32d0996f-d370-466d-9913-fe6d1dacd711" xlink:to="loc_wynn_SevenAndThreeOverFourPercentageWRFSeniorNotesDue2025Member_1efda92e-e5d1-468e-8a66-08512a740e7e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FourAndOneOverFourPercentageWynnLasVegasSeniorNotesDueMayThirtyTwoThousandTwentyThreeMember_dfe16db8-be3f-45b2-b516-8d1aa06a9c7a" xlink:href="wynn-20230331.xsd#wynn_FourAndOneOverFourPercentageWynnLasVegasSeniorNotesDueMayThirtyTwoThousandTwentyThreeMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_32d0996f-d370-466d-9913-fe6d1dacd711" xlink:to="loc_wynn_FourAndOneOverFourPercentageWynnLasVegasSeniorNotesDueMayThirtyTwoThousandTwentyThreeMember_dfe16db8-be3f-45b2-b516-8d1aa06a9c7a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_f86b666d-11c1-4af6-a340-986708cd433d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_41d595eb-b57c-47b2-85ef-fe9d78c16705" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_f86b666d-11c1-4af6-a340-986708cd433d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_bc63417d-705a-4e22-96a0-4a564bbc07b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_f86b666d-11c1-4af6-a340-986708cd433d" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_bc63417d-705a-4e22-96a0-4a564bbc07b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_69e9bc64-4694-476c-ad6c-0a4d6f8cfe20" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_bc63417d-705a-4e22-96a0-4a564bbc07b4" xlink:to="loc_us-gaap_ConvertibleDebtMember_69e9bc64-4694-476c-ad6c-0a4d6f8cfe20" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_a0fff786-7537-476e-abe7-4d011eb4c555" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeniorNotesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_bc63417d-705a-4e22-96a0-4a564bbc07b4" xlink:to="loc_us-gaap_SeniorNotesMember_a0fff786-7537-476e-abe7-4d011eb4c555" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_ccba922e-b986-47e9-8999-0989762d1d2b" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_LegalEntityAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_41d595eb-b57c-47b2-85ef-fe9d78c16705" xlink:to="loc_dei_LegalEntityAxis_ccba922e-b986-47e9-8999-0989762d1d2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_afce7715-7796-49a1-8808-283ef132139f" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_ccba922e-b986-47e9-8999-0989762d1d2b" xlink:to="loc_dei_EntityDomain_afce7715-7796-49a1-8808-283ef132139f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauLimitedMember_92403295-5f2e-4d96-b419-ed22bb031e9b" xlink:href="wynn-20230331.xsd#wynn_WynnMacauLimitedMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_afce7715-7796-49a1-8808-283ef132139f" xlink:to="loc_wynn_WynnMacauLimitedMember_92403295-5f2e-4d96-b419-ed22bb031e9b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_9ce802b5-2069-4897-9462-4141549b891d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_41d595eb-b57c-47b2-85ef-fe9d78c16705" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_9ce802b5-2069-4897-9462-4141549b891d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_8fe6e3fd-eef7-4913-a97b-8e763a9dc552" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_9ce802b5-2069-4897-9462-4141549b891d" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_8fe6e3fd-eef7-4913-a97b-8e763a9dc552" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_f8c9b195-1789-4d38-bfe8-a282d57c5077" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_8fe6e3fd-eef7-4913-a97b-8e763a9dc552" xlink:to="loc_us-gaap_SubsequentEventMember_f8c9b195-1789-4d38-bfe8-a282d57c5077" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_ba198380-975b-4cbe-8328-6014cebf6ab2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_41d595eb-b57c-47b2-85ef-fe9d78c16705" xlink:to="loc_us-gaap_DebtInstrumentLineItems_ba198380-975b-4cbe-8328-6014cebf6ab2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_3047ebca-982f-4d4d-81f4-73cb2694e240" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_ba198380-975b-4cbe-8328-6014cebf6ab2" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_3047ebca-982f-4d4d-81f4-73cb2694e240" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_132a4602-fbdb-4c0b-97e6-b3ad4ea2b816" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_ba198380-975b-4cbe-8328-6014cebf6ab2" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_132a4602-fbdb-4c0b-97e6-b3ad4ea2b816" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromConvertibleDebt_d6b6893e-20a0-48a5-9fc5-8ccd311c2fcf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromConvertibleDebt"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_ba198380-975b-4cbe-8328-6014cebf6ab2" xlink:to="loc_us-gaap_ProceedsFromConvertibleDebt_d6b6893e-20a0-48a5-9fc5-8ccd311c2fcf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharePrice_df61f3d5-1bde-4a20-9e8c-d5b9c3c40f5f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharePrice"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_ba198380-975b-4cbe-8328-6014cebf6ab2" xlink:to="loc_us-gaap_SharePrice_df61f3d5-1bde-4a20-9e8c-d5b9c3c40f5f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_4b87526f-9ebb-42c3-8b3e-3f330441251a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_ba198380-975b-4cbe-8328-6014cebf6ab2" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_4b87526f-9ebb-42c3-8b3e-3f330441251a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_289cf408-a0ba-4371-abf8-05b9473afb3c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionRatio1"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_ba198380-975b-4cbe-8328-6014cebf6ab2" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_289cf408-a0ba-4371-abf8-05b9473afb3c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_dc2887f8-1d40-4eb5-a1d8-36f5539fd181" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_ba198380-975b-4cbe-8328-6014cebf6ab2" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_dc2887f8-1d40-4eb5-a1d8-36f5539fd181" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_b24e6be9-d0b6-4221-9dbe-424929e093ce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_ba198380-975b-4cbe-8328-6014cebf6ab2" xlink:to="loc_us-gaap_DerivativeLiabilities_b24e6be9-d0b6-4221-9dbe-424929e093ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_5b6a73c7-3d82-4a16-b855-c157ea55ab73" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_ba198380-975b-4cbe-8328-6014cebf6ab2" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_5b6a73c7-3d82-4a16-b855-c157ea55ab73" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_f7822411-d460-4f40-ac21-f92c8267fd6f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_ba198380-975b-4cbe-8328-6014cebf6ab2" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_f7822411-d460-4f40-ac21-f92c8267fd6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRepurchaseAmount_67de0d8b-d55b-46c7-aec9-a498135d0222" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentRepurchaseAmount"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_ba198380-975b-4cbe-8328-6014cebf6ab2" xlink:to="loc_us-gaap_DebtInstrumentRepurchaseAmount_67de0d8b-d55b-46c7-aec9-a498135d0222" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_DebtInstrumentEarlyTenderPremium_6ef6e161-2954-467f-a6ac-3704d5a40c79" xlink:href="wynn-20230331.xsd#wynn_DebtInstrumentEarlyTenderPremium"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_ba198380-975b-4cbe-8328-6014cebf6ab2" xlink:to="loc_wynn_DebtInstrumentEarlyTenderPremium_6ef6e161-2954-467f-a6ac-3704d5a40c79" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_345f4248-5187-40c9-9b6c-694eaf1ccea9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_ba198380-975b-4cbe-8328-6014cebf6ab2" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_345f4248-5187-40c9-9b6c-694eaf1ccea9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_279bd5af-ae03-4068-a2e0-1f9855ed53ba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_ba198380-975b-4cbe-8328-6014cebf6ab2" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_279bd5af-ae03-4068-a2e0-1f9855ed53ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_c339ae31-2993-4614-a68a-668cec365b21" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentRedemptionPricePercentage"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_ba198380-975b-4cbe-8328-6014cebf6ab2" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_c339ae31-2993-4614-a68a-668cec365b21" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFairValue_79feaae8-ca4e-4938-ab4f-fcc32224f40e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentFairValue"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_ba198380-975b-4cbe-8328-6014cebf6ab2" xlink:to="loc_us-gaap_DebtInstrumentFairValue_79feaae8-ca4e-4938-ab4f-fcc32224f40e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/WMLConvertibleBondConversionOptionDerivativeValuationTechniquesforEmbeddedDerivativeDetails" xlink:type="simple" xlink:href="wynn-20230331.xsd#WMLConvertibleBondConversionOptionDerivativeValuationTechniquesforEmbeddedDerivativeDetails"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/WMLConvertibleBondConversionOptionDerivativeValuationTechniquesforEmbeddedDerivativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_3d851103-a17f-4167-9e37-c755a5ef8ef7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_f52f599b-bd5f-40f1-82db-52eb785b3417" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_3d851103-a17f-4167-9e37-c755a5ef8ef7" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_f52f599b-bd5f-40f1-82db-52eb785b3417" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_da03ef12-2045-42fa-bb0a-fc755330b8ae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MeasurementInputTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_f52f599b-bd5f-40f1-82db-52eb785b3417" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_da03ef12-2045-42fa-bb0a-fc755330b8ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_ad38dc9d-498b-40ff-baf2-84c8c11db704" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_da03ef12-2045-42fa-bb0a-fc755330b8ae" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_ad38dc9d-498b-40ff-baf2-84c8c11db704" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputSharePriceMember_bbc4fe8e-6f97-4515-81dd-ca33b22cca25" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MeasurementInputSharePriceMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_ad38dc9d-498b-40ff-baf2-84c8c11db704" xlink:to="loc_us-gaap_MeasurementInputSharePriceMember_bbc4fe8e-6f97-4515-81dd-ca33b22cca25" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputPriceVolatilityMember_83c1831f-5408-496d-90ed-631a678250a5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MeasurementInputPriceVolatilityMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_ad38dc9d-498b-40ff-baf2-84c8c11db704" xlink:to="loc_us-gaap_MeasurementInputPriceVolatilityMember_83c1831f-5408-496d-90ed-631a678250a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember_20db026a-ae2a-42be-b613-91d70d22f2e5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MeasurementInputRiskFreeInterestRateMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_ad38dc9d-498b-40ff-baf2-84c8c11db704" xlink:to="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember_20db026a-ae2a-42be-b613-91d70d22f2e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputExpectedTermMember_faf0bcb9-ca3f-4aac-85dd-d96b74993d62" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MeasurementInputExpectedTermMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_ad38dc9d-498b-40ff-baf2-84c8c11db704" xlink:to="loc_us-gaap_MeasurementInputExpectedTermMember_faf0bcb9-ca3f-4aac-85dd-d96b74993d62" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputExpectedDividendRateMember_3fc785b7-f43f-4aa9-9652-9d833347d327" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MeasurementInputExpectedDividendRateMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_ad38dc9d-498b-40ff-baf2-84c8c11db704" xlink:to="loc_us-gaap_MeasurementInputExpectedDividendRateMember_3fc785b7-f43f-4aa9-9652-9d833347d327" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_41e9827c-87f2-435e-a60c-dd2576d345df" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_f52f599b-bd5f-40f1-82db-52eb785b3417" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_41e9827c-87f2-435e-a60c-dd2576d345df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmbeddedDerivativeLiabilityMeasurementInput_83e12d47-0c0b-495d-bb4f-b631c5889c21" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmbeddedDerivativeLiabilityMeasurementInput"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_41e9827c-87f2-435e-a60c-dd2576d345df" xlink:to="loc_us-gaap_EmbeddedDerivativeLiabilityMeasurementInput_83e12d47-0c0b-495d-bb4f-b631c5889c21" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/WMLConvertibleBondConversionOptionDerivativeNarrativeDetails" xlink:type="simple" xlink:href="wynn-20230331.xsd#WMLConvertibleBondConversionOptionDerivativeNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/WMLConvertibleBondConversionOptionDerivativeNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_75cd7825-395c-4c7c-9cd1-b17f84b48d93" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_e64e05f6-ba10-4666-8894-fd869c200e78" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_75cd7825-395c-4c7c-9cd1-b17f84b48d93" xlink:to="loc_us-gaap_DerivativeTable_e64e05f6-ba10-4666-8894-fd869c200e78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_703a264a-d47f-4e54-af8b-f9ee11b8db6d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_e64e05f6-ba10-4666-8894-fd869c200e78" xlink:to="loc_us-gaap_DebtInstrumentAxis_703a264a-d47f-4e54-af8b-f9ee11b8db6d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_4c0d8c58-5727-4b08-b0f7-e82c8d8f9a80" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_703a264a-d47f-4e54-af8b-f9ee11b8db6d" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_4c0d8c58-5727-4b08-b0f7-e82c8d8f9a80" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMLConvertibleBondsMember_15b13dda-d6f5-479d-9fc9-24757221b277" xlink:href="wynn-20230331.xsd#wynn_WMLConvertibleBondsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_4c0d8c58-5727-4b08-b0f7-e82c8d8f9a80" xlink:to="loc_wynn_WMLConvertibleBondsMember_15b13dda-d6f5-479d-9fc9-24757221b277" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_3247a47f-7ba5-4d58-bdec-d8e64c2eaf2b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_e64e05f6-ba10-4666-8894-fd869c200e78" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_3247a47f-7ba5-4d58-bdec-d8e64c2eaf2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_1d6ad8ca-ef9e-4b70-9451-546894a960aa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_3247a47f-7ba5-4d58-bdec-d8e64c2eaf2b" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_1d6ad8ca-ef9e-4b70-9451-546894a960aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_cee0f167-bbe1-4073-a44c-6193fbf54975" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1d6ad8ca-ef9e-4b70-9451-546894a960aa" xlink:to="loc_us-gaap_ConvertibleDebtMember_cee0f167-bbe1-4073-a44c-6193fbf54975" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_91f23731-b938-45cd-ac1f-52bc609ccf74" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_LegalEntityAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_e64e05f6-ba10-4666-8894-fd869c200e78" xlink:to="loc_dei_LegalEntityAxis_91f23731-b938-45cd-ac1f-52bc609ccf74" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_ed80f6f2-7d21-4042-96c6-dd4a0c259ffb" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_91f23731-b938-45cd-ac1f-52bc609ccf74" xlink:to="loc_dei_EntityDomain_ed80f6f2-7d21-4042-96c6-dd4a0c259ffb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauLimitedMember_92bf3c24-3eb0-4b1b-87f3-84173dd8f652" xlink:href="wynn-20230331.xsd#wynn_WynnMacauLimitedMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_ed80f6f2-7d21-4042-96c6-dd4a0c259ffb" xlink:to="loc_wynn_WynnMacauLimitedMember_92bf3c24-3eb0-4b1b-87f3-84173dd8f652" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_4bb34839-41f6-4314-9f26-25b6986a992f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_e64e05f6-ba10-4666-8894-fd869c200e78" xlink:to="loc_us-gaap_DerivativeLineItems_4bb34839-41f6-4314-9f26-25b6986a992f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_53214fc7-0c83-4ae5-a165-45ed5047a9a0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_4bb34839-41f6-4314-9f26-25b6986a992f" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_53214fc7-0c83-4ae5-a165-45ed5047a9a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_8dc4fa79-40ee-499a-acc4-964cacec1780" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_4bb34839-41f6-4314-9f26-25b6986a992f" xlink:to="loc_us-gaap_DerivativeLiabilities_8dc4fa79-40ee-499a-acc4-964cacec1780" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmbeddedDerivativeGainOnEmbeddedDerivative_2b4e2516-79ff-4549-afca-1c44ad863ec9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmbeddedDerivativeGainOnEmbeddedDerivative"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_4bb34839-41f6-4314-9f26-25b6986a992f" xlink:to="loc_us-gaap_EmbeddedDerivativeGainOnEmbeddedDerivative_2b4e2516-79ff-4549-afca-1c44ad863ec9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/StockholdersDeficitDetails" xlink:type="simple" xlink:href="wynn-20230331.xsd#StockholdersDeficitDetails"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/StockholdersDeficitDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_35dd0114-0260-4ccf-9647-a69315831d6e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_26300caa-3d2c-4446-a29e-e6e196a64194" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_35dd0114-0260-4ccf-9647-a69315831d6e" xlink:to="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_26300caa-3d2c-4446-a29e-e6e196a64194" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionAxis_3f2c1182-00ec-48c2-a204-d2959d26346e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyTransactionAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_26300caa-3d2c-4446-a29e-e6e196a64194" xlink:to="loc_us-gaap_RelatedPartyTransactionAxis_3f2c1182-00ec-48c2-a204-d2959d26346e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_67cc485e-81a4-40a6-9aa2-93e41268312e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyTransactionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_3f2c1182-00ec-48c2-a204-d2959d26346e" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_67cc485e-81a4-40a6-9aa2-93e41268312e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailJointVentureMember_da0adb58-cf36-470b-9810-ee01234f67c2" xlink:href="wynn-20230331.xsd#wynn_RetailJointVentureMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_67cc485e-81a4-40a6-9aa2-93e41268312e" xlink:to="loc_wynn_RetailJointVentureMember_da0adb58-cf36-470b-9810-ee01234f67c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_76dbb184-ad92-4a82-93f5-f924986f6c0e" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_LegalEntityAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_26300caa-3d2c-4446-a29e-e6e196a64194" xlink:to="loc_dei_LegalEntityAxis_76dbb184-ad92-4a82-93f5-f924986f6c0e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_c998bbc7-6a45-4b03-ad76-625cab353c95" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_76dbb184-ad92-4a82-93f5-f924986f6c0e" xlink:to="loc_dei_EntityDomain_c998bbc7-6a45-4b03-ad76-625cab353c95" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_CrownAcquisitionsIncMember_6c9d4c1c-c734-43f3-98eb-a7371473ff8d" xlink:href="wynn-20230331.xsd#wynn_CrownAcquisitionsIncMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_c998bbc7-6a45-4b03-ad76-625cab353c95" xlink:to="loc_wynn_CrownAcquisitionsIncMember_6c9d4c1c-c734-43f3-98eb-a7371473ff8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMCaymanIMember_f01f376d-3f80-4b08-b7bc-47c43c210424" xlink:href="wynn-20230331.xsd#wynn_WMCaymanIMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_c998bbc7-6a45-4b03-ad76-625cab353c95" xlink:to="loc_wynn_WMCaymanIMember_f01f376d-3f80-4b08-b7bc-47c43c210424" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipAxis_00200d3c-d53d-4d10-9876-0398ca7361c0" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_OwnershipAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_26300caa-3d2c-4446-a29e-e6e196a64194" xlink:to="loc_srt_OwnershipAxis_00200d3c-d53d-4d10-9876-0398ca7361c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_c173d140-fdbd-481f-b477-dfdfd9bd8da0" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_OwnershipDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_OwnershipAxis_00200d3c-d53d-4d10-9876-0398ca7361c0" xlink:to="loc_srt_OwnershipDomain_c173d140-fdbd-481f-b477-dfdfd9bd8da0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnResortsLtdMember_ada08a66-66fd-4a6b-b607-0894a5efb320" xlink:href="wynn-20230331.xsd#wynn_WynnResortsLtdMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_OwnershipDomain_c173d140-fdbd-481f-b477-dfdfd9bd8da0" xlink:to="loc_wynn_WynnResortsLtdMember_ada08a66-66fd-4a6b-b607-0894a5efb320" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnPalaceandWynnMacauMember_6c670979-8498-456d-ba90-6a957c1a1f38" xlink:href="wynn-20230331.xsd#wynn_WynnPalaceandWynnMacauMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_OwnershipDomain_c173d140-fdbd-481f-b477-dfdfd9bd8da0" xlink:to="loc_wynn_WynnPalaceandWynnMacauMember_6c670979-8498-456d-ba90-6a957c1a1f38" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_d254ee49-543e-4210-9d1c-29af937ead47" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_26300caa-3d2c-4446-a29e-e6e196a64194" xlink:to="loc_srt_CounterpartyNameAxis_d254ee49-543e-4210-9d1c-29af937ead47" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_5cf17171-7fd2-46bf-a617-9a7c38e20ad3" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_d254ee49-543e-4210-9d1c-29af937ead47" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_5cf17171-7fd2-46bf-a617-9a7c38e20ad3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_GoldmanSachsInternationalMember_0d525954-d3a0-4a27-9174-d44cec3888fe" xlink:href="wynn-20230331.xsd#wynn_GoldmanSachsInternationalMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_5cf17171-7fd2-46bf-a617-9a7c38e20ad3" xlink:to="loc_wynn_GoldmanSachsInternationalMember_0d525954-d3a0-4a27-9174-d44cec3888fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseAxis_07e8c48d-9852-461e-8029-a06c82951567" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_26300caa-3d2c-4446-a29e-e6e196a64194" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseAxis_07e8c48d-9852-461e-8029-a06c82951567" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_48ee050b-f81f-423b-86be-0cd27146fe34" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseAxis_07e8c48d-9852-461e-8029-a06c82951567" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_48ee050b-f81f-423b-86be-0cd27146fe34" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SecuritiesLendingAgreementMember_296b2aee-e6b4-4755-990a-8f8f3f710136" xlink:href="wynn-20230331.xsd#wynn_SecuritiesLendingAgreementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_48ee050b-f81f-423b-86be-0cd27146fe34" xlink:to="loc_wynn_SecuritiesLendingAgreementMember_296b2aee-e6b4-4755-990a-8f8f3f710136" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_85d8e822-1e1a-4dfd-88fa-9e817bc8f4b3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_26300caa-3d2c-4446-a29e-e6e196a64194" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_85d8e822-1e1a-4dfd-88fa-9e817bc8f4b3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_3e3d2569-5aea-4089-984a-d8dfcec97a00" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_85d8e822-1e1a-4dfd-88fa-9e817bc8f4b3" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_3e3d2569-5aea-4089-984a-d8dfcec97a00" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_7fb029f9-7ea7-4946-96ea-f5305ccf6333" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_3e3d2569-5aea-4089-984a-d8dfcec97a00" xlink:to="loc_us-gaap_SubsequentEventMember_7fb029f9-7ea7-4946-96ea-f5305ccf6333" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockLineItems_8f0bfc77-ab42-40ae-8b4c-7e79ec47ad55" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsidiarySaleOfStockLineItems"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_26300caa-3d2c-4446-a29e-e6e196a64194" xlink:to="loc_us-gaap_SubsidiarySaleOfStockLineItems_8f0bfc77-ab42-40ae-8b4c-7e79ec47ad55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPayableAmountPerShare_f560f3d5-1c42-49a9-a364-be51584e8e01" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendsPayableAmountPerShare"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_8f0bfc77-ab42-40ae-8b4c-7e79ec47ad55" xlink:to="loc_us-gaap_DividendsPayableAmountPerShare_f560f3d5-1c42-49a9-a364-be51584e8e01" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDistributionsToAffiliates_80fe3aa7-3371-49cc-b2aa-4a1a94892f12" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDistributionsToAffiliates"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_8f0bfc77-ab42-40ae-8b4c-7e79ec47ad55" xlink:to="loc_us-gaap_PaymentsOfDistributionsToAffiliates_80fe3aa7-3371-49cc-b2aa-4a1a94892f12" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRealEstateAndRealEstateJointVentures_5844c43d-29bc-44ce-b620-959d067ea9be" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromRealEstateAndRealEstateJointVentures"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_8f0bfc77-ab42-40ae-8b4c-7e79ec47ad55" xlink:to="loc_us-gaap_ProceedsFromRealEstateAndRealEstateJointVentures_5844c43d-29bc-44ce-b620-959d067ea9be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_6bf4425d-74e8-4cb3-9dd0-250f0be25e82" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MinorityInterestOwnershipPercentageByParent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_8f0bfc77-ab42-40ae-8b4c-7e79ec47ad55" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_6bf4425d-74e8-4cb3-9dd0-250f0be25e82" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_48bbd1e0-995a-4809-b91b-5bfb823f147b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_8f0bfc77-ab42-40ae-8b4c-7e79ec47ad55" xlink:to="loc_us-gaap_AdditionalPaidInCapital_48bbd1e0-995a-4809-b91b-5bfb823f147b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestIncreaseFromSubsidiaryEquityIssuance_8aabe6ac-cad1-4c96-ad9c-a956a99b7584" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoncontrollingInterestIncreaseFromSubsidiaryEquityIssuance"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_8f0bfc77-ab42-40ae-8b4c-7e79ec47ad55" xlink:to="loc_us-gaap_NoncontrollingInterestIncreaseFromSubsidiaryEquityIssuance_8aabe6ac-cad1-4c96-ad9c-a956a99b7584" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_364ba5d2-5865-4554-aff3-c82e7a97c43b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_8f0bfc77-ab42-40ae-8b4c-7e79ec47ad55" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_364ba5d2-5865-4554-aff3-c82e7a97c43b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_fcc86219-fd3a-4778-82cf-a95dd66c750a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_8f0bfc77-ab42-40ae-8b4c-7e79ec47ad55" xlink:to="loc_us-gaap_CommonStockSharesIssued_fcc86219-fd3a-4778-82cf-a95dd66c750a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_CommonStockSharesReturned_78500098-ffa6-49fe-bfc8-3c24a5bce7dc" xlink:href="wynn-20230331.xsd#wynn_CommonStockSharesReturned"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_8f0bfc77-ab42-40ae-8b4c-7e79ec47ad55" xlink:to="loc_wynn_CommonStockSharesReturned_78500098-ffa6-49fe-bfc8-3c24a5bce7dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_1b0cb99d-3517-42cd-a2fe-3850a7ee7167" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_8f0bfc77-ab42-40ae-8b4c-7e79ec47ad55" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_1b0cb99d-3517-42cd-a2fe-3850a7ee7167" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/FairValueMeasurementsDetails" xlink:type="simple" xlink:href="wynn-20230331.xsd#FairValueMeasurementsDetails"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/FairValueMeasurementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_c0b8e321-44cc-45ae-a79c-a9d18441e119" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_d0e6806b-6afb-4abb-8e78-774378a9d7c1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_c0b8e321-44cc-45ae-a79c-a9d18441e119" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_d0e6806b-6afb-4abb-8e78-774378a9d7c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_cb58b255-2977-46d0-a775-7b952404fe50" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_d0e6806b-6afb-4abb-8e78-774378a9d7c1" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_cb58b255-2977-46d0-a775-7b952404fe50" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_bb76b0a3-192c-4154-ab72-1507aa765c1e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_cb58b255-2977-46d0-a775-7b952404fe50" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_bb76b0a3-192c-4154-ab72-1507aa765c1e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_1f1b7412-9d1b-4896-bb32-201dbc41b9f9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_bb76b0a3-192c-4154-ab72-1507aa765c1e" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_1f1b7412-9d1b-4896-bb32-201dbc41b9f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_a6710326-6ec2-456f-a9aa-73c336a5eb11" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_d0e6806b-6afb-4abb-8e78-774378a9d7c1" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_a6710326-6ec2-456f-a9aa-73c336a5eb11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b04068f7-ca17-4ded-a011-28d02929f9f9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_a6710326-6ec2-456f-a9aa-73c336a5eb11" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b04068f7-ca17-4ded-a011-28d02929f9f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_c355d068-1f0e-4729-92e5-2965ca597818" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b04068f7-ca17-4ded-a011-28d02929f9f9" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_c355d068-1f0e-4729-92e5-2965ca597818" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_04c6f718-608b-4065-a0fc-d246ad28aa02" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b04068f7-ca17-4ded-a011-28d02929f9f9" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_04c6f718-608b-4065-a0fc-d246ad28aa02" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_8181b849-3361-4d32-a613-f478318a132d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b04068f7-ca17-4ded-a011-28d02929f9f9" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_8181b849-3361-4d32-a613-f478318a132d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_99315ddc-7540-4576-89d6-dd9ef4ee8746" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_d0e6806b-6afb-4abb-8e78-774378a9d7c1" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_99315ddc-7540-4576-89d6-dd9ef4ee8746" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosureAbstract_2a66da15-6294-4958-a395-de5c3fbccb50" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsFairValueDisclosureAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_99315ddc-7540-4576-89d6-dd9ef4ee8746" xlink:to="loc_us-gaap_AssetsFairValueDisclosureAbstract_2a66da15-6294-4958-a395-de5c3fbccb50" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValue_108c1d57-6921-43a1-a0b1-f6af21af5012" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_2a66da15-6294-4958-a395-de5c3fbccb50" xlink:to="loc_us-gaap_CashEquivalentsAtCarryingValue_108c1d57-6921-43a1-a0b1-f6af21af5012" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_8e272691-cbe8-484f-a4c3-fc80fedb4618" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_2a66da15-6294-4958-a395-de5c3fbccb50" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_8e272691-cbe8-484f-a4c3-fc80fedb4618" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_31af7b63-04a4-4e36-a896-640841f415fb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_2a66da15-6294-4958-a395-de5c3fbccb50" xlink:to="loc_us-gaap_DerivativeAssets_31af7b63-04a4-4e36-a896-640841f415fb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_08550eb9-9ab8-4695-b15d-32477f7aa168" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosureAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_99315ddc-7540-4576-89d6-dd9ef4ee8746" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_08550eb9-9ab8-4695-b15d-32477f7aa168" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_a3163114-5f21-4b1e-b325-858a8402e0d5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_08550eb9-9ab8-4695-b15d-32477f7aa168" xlink:to="loc_us-gaap_DerivativeLiabilities_a3163114-5f21-4b1e-b325-858a8402e0d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CustomerContractLiabilitiesScheduleofCustomerContractLiabilitiesDetails" xlink:type="simple" xlink:href="wynn-20230331.xsd#CustomerContractLiabilitiesScheduleofCustomerContractLiabilitiesDetails"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/CustomerContractLiabilitiesScheduleofCustomerContractLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRecognitionAbstract_808e7c73-b5bb-4184-af37-d157bf384086" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueRecognitionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_Casinooutstandingchipsandfrontmoneydeposits_34587873-19bc-4b7d-b29c-93ed3db602f9" xlink:href="wynn-20230331.xsd#wynn_Casinooutstandingchipsandfrontmoneydeposits"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueRecognitionAbstract_808e7c73-b5bb-4184-af37-d157bf384086" xlink:to="loc_wynn_Casinooutstandingchipsandfrontmoneydeposits_34587873-19bc-4b7d-b29c-93ed3db602f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_IncreaseDecreaseinoutstandingchipsandfrontmoneydeposits_1006959d-b508-4b12-8bbe-73857dfb8a2b" xlink:href="wynn-20230331.xsd#wynn_IncreaseDecreaseinoutstandingchipsandfrontmoneydeposits"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueRecognitionAbstract_808e7c73-b5bb-4184-af37-d157bf384086" xlink:to="loc_wynn_IncreaseDecreaseinoutstandingchipsandfrontmoneydeposits_1006959d-b508-4b12-8bbe-73857dfb8a2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_Advancedroomdepositsandticketsales_0b7056b2-ffd1-41fb-9cd3-0197d63d9a30" xlink:href="wynn-20230331.xsd#wynn_Advancedroomdepositsandticketsales"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueRecognitionAbstract_808e7c73-b5bb-4184-af37-d157bf384086" xlink:to="loc_wynn_Advancedroomdepositsandticketsales_0b7056b2-ffd1-41fb-9cd3-0197d63d9a30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_Changeinadvancedroomdepositsandticketsales_7263e1e9-a212-4dcb-b54f-ba44cc808da1" xlink:href="wynn-20230331.xsd#wynn_Changeinadvancedroomdepositsandticketsales"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueRecognitionAbstract_808e7c73-b5bb-4184-af37-d157bf384086" xlink:to="loc_wynn_Changeinadvancedroomdepositsandticketsales_7263e1e9-a212-4dcb-b54f-ba44cc808da1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_Othergamingrelatedliabilities_cc6fdc32-624f-4fa2-80fe-33ac50b3e106" xlink:href="wynn-20230331.xsd#wynn_Othergamingrelatedliabilities"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueRecognitionAbstract_808e7c73-b5bb-4184-af37-d157bf384086" xlink:to="loc_wynn_Othergamingrelatedliabilities_cc6fdc32-624f-4fa2-80fe-33ac50b3e106" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_Changeinothergamingrelatedliabilities_03ad0732-dc9f-433f-bf70-847d3ef03aa8" xlink:href="wynn-20230331.xsd#wynn_Changeinothergamingrelatedliabilities"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueRecognitionAbstract_808e7c73-b5bb-4184-af37-d157bf384086" xlink:to="loc_wynn_Changeinothergamingrelatedliabilities_03ad0732-dc9f-433f-bf70-847d3ef03aa8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_Loyaltyprograms_53a137e2-370e-4d65-aa43-230ca8a4d213" xlink:href="wynn-20230331.xsd#wynn_Loyaltyprograms"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueRecognitionAbstract_808e7c73-b5bb-4184-af37-d157bf384086" xlink:to="loc_wynn_Loyaltyprograms_53a137e2-370e-4d65-aa43-230ca8a4d213" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_Changeinloyaltyprogramliabilities_9e349c35-ccba-40fe-bcab-9d7fa854c7f9" xlink:href="wynn-20230331.xsd#wynn_Changeinloyaltyprogramliabilities"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueRecognitionAbstract_808e7c73-b5bb-4184-af37-d157bf384086" xlink:to="loc_wynn_Changeinloyaltyprogramliabilities_9e349c35-ccba-40fe-bcab-9d7fa854c7f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_TotalCustomerContractLiabilities_f483ca42-2545-4436-99c5-f97157e54377" xlink:href="wynn-20230331.xsd#wynn_TotalCustomerContractLiabilities"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueRecognitionAbstract_808e7c73-b5bb-4184-af37-d157bf384086" xlink:to="loc_wynn_TotalCustomerContractLiabilities_f483ca42-2545-4436-99c5-f97157e54377" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_Changeintotalcustomercontractliabilities_74e1d647-214b-41c6-b469-e9838abbc877" xlink:href="wynn-20230331.xsd#wynn_Changeintotalcustomercontractliabilities"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueRecognitionAbstract_808e7c73-b5bb-4184-af37-d157bf384086" xlink:to="loc_wynn_Changeintotalcustomercontractliabilities_74e1d647-214b-41c6-b469-e9838abbc877" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/StockBasedCompensationShareBasedCompensationAllocatedCostsDetail" xlink:type="simple" xlink:href="wynn-20230331.xsd#StockBasedCompensationShareBasedCompensationAllocatedCostsDetail"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/StockBasedCompensationShareBasedCompensationAllocatedCostsDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_cbaf2665-ff88-4025-9feb-524d973d04e6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_84baa1e2-5dc8-402a-b4f9-257c4b729435" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_cbaf2665-ff88-4025-9feb-524d973d04e6" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_84baa1e2-5dc8-402a-b4f9-257c4b729435" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_a2d24ab7-76e8-463d-852b-4c6f5b280a26" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_84baa1e2-5dc8-402a-b4f9-257c4b729435" xlink:to="loc_srt_ProductOrServiceAxis_a2d24ab7-76e8-463d-852b-4c6f5b280a26" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_590db569-2b7e-45fe-92b1-bb363416d83a" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_a2d24ab7-76e8-463d-852b-4c6f5b280a26" xlink:to="loc_srt_ProductsAndServicesDomain_590db569-2b7e-45fe-92b1-bb363416d83a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CasinoMember_71a691c1-f094-4799-9ceb-3981d1cc291c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CasinoMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_590db569-2b7e-45fe-92b1-bb363416d83a" xlink:to="loc_us-gaap_CasinoMember_71a691c1-f094-4799-9ceb-3981d1cc291c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RoomsMember_fc474c4f-09d3-493f-9119-e9ef64013111" xlink:href="wynn-20230331.xsd#wynn_RoomsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_590db569-2b7e-45fe-92b1-bb363416d83a" xlink:to="loc_wynn_RoomsMember_fc474c4f-09d3-493f-9119-e9ef64013111" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FoodAndBeverageMember_4a4ee841-8171-4f5f-9fb1-ec022747bf2d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FoodAndBeverageMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_590db569-2b7e-45fe-92b1-bb363416d83a" xlink:to="loc_us-gaap_FoodAndBeverageMember_4a4ee841-8171-4f5f-9fb1-ec022747bf2d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EntertainmentRetailAndOtherMember_b00a0c22-30a4-42d4-b17d-5add3ab4b9d7" xlink:href="wynn-20230331.xsd#wynn_EntertainmentRetailAndOtherMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_590db569-2b7e-45fe-92b1-bb363416d83a" xlink:to="loc_wynn_EntertainmentRetailAndOtherMember_b00a0c22-30a4-42d4-b17d-5add3ab4b9d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_GeneralAndAdministrativeMember_ecfab154-5061-4643-bd82-65f3e4d62bf8" xlink:href="wynn-20230331.xsd#wynn_GeneralAndAdministrativeMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_590db569-2b7e-45fe-92b1-bb363416d83a" xlink:to="loc_wynn_GeneralAndAdministrativeMember_ecfab154-5061-4643-bd82-65f3e4d62bf8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_e055c307-ca72-4722-bb06-1448f954331f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_84baa1e2-5dc8-402a-b4f9-257c4b729435" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_e055c307-ca72-4722-bb06-1448f954331f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_11b5d4af-60aa-491b-99c2-c80796272705" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_e055c307-ca72-4722-bb06-1448f954331f" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_11b5d4af-60aa-491b-99c2-c80796272705" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount_5a2a0936-9c5a-4a5c-acb0-548fc0566c8f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_e055c307-ca72-4722-bb06-1448f954331f" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount_5a2a0936-9c5a-4a5c-acb0-548fc0566c8f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_5b2fa1df-36bd-4fc8-a51e-62df1a9b6e08" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_e055c307-ca72-4722-bb06-1448f954331f" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_5b2fa1df-36bd-4fc8-a51e-62df1a9b6e08" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/IncomeTaxesAdditionalInformationDetail" xlink:type="simple" xlink:href="wynn-20230331.xsd#IncomeTaxesAdditionalInformationDetail"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/IncomeTaxesAdditionalInformationDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_78593629-ee6c-4a69-ac67-b8e3775fab20" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_b4bb1e30-1119-4492-949c-39161fcf58e7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_78593629-ee6c-4a69-ac67-b8e3775fab20" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_b4bb1e30-1119-4492-949c-39161fcf58e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/EarningsPerShareScheduleofSharesusedinCalculationofEarningsPerShareDetail" xlink:type="simple" xlink:href="wynn-20230331.xsd#EarningsPerShareScheduleofSharesusedinCalculationofEarningsPerShareDetail"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/EarningsPerShareScheduleofSharesusedinCalculationofEarningsPerShareDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_e88d9382-8212-4c2a-8139-c9575cce007b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_NetIncomeLossAvailableCommonStockholdersBasicAndDilutedAbstract_79672251-b8c7-4ecd-ab90-84e582e8fb37" xlink:href="wynn-20230331.xsd#wynn_NetIncomeLossAvailableCommonStockholdersBasicAndDilutedAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_e88d9382-8212-4c2a-8139-c9575cce007b" xlink:to="loc_wynn_NetIncomeLossAvailableCommonStockholdersBasicAndDilutedAbstract_79672251-b8c7-4ecd-ab90-84e582e8fb37" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_fae4dfc1-a97e-4493-9c14-822d89c3aeef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_NetIncomeLossAvailableCommonStockholdersBasicAndDilutedAbstract_79672251-b8c7-4ecd-ab90-84e582e8fb37" xlink:to="loc_us-gaap_NetIncomeLoss_fae4dfc1-a97e-4493-9c14-822d89c3aeef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_AssumedConversionOfWMLConvertibleBonds_53b11382-fd6e-432f-b64d-818fa3e71b45" xlink:href="wynn-20230331.xsd#wynn_AssumedConversionOfWMLConvertibleBonds"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_NetIncomeLossAvailableCommonStockholdersBasicAndDilutedAbstract_79672251-b8c7-4ecd-ab90-84e582e8fb37" xlink:to="loc_wynn_AssumedConversionOfWMLConvertibleBonds_53b11382-fd6e-432f-b64d-818fa3e71b45" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToParentDiluted_413e2053-88a4-47a8-8c26-9a96cf282c2e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAttributableToParentDiluted"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_NetIncomeLossAvailableCommonStockholdersBasicAndDilutedAbstract_79672251-b8c7-4ecd-ab90-84e582e8fb37" xlink:to="loc_us-gaap_NetIncomeLossAttributableToParentDiluted_413e2053-88a4-47a8-8c26-9a96cf282c2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WeightedAverageNumberOfSharesOutstandingBasicAndDilutedAbstract_76a244f6-b2c5-4980-a3df-71d68bd1a0c9" xlink:href="wynn-20230331.xsd#wynn_WeightedAverageNumberOfSharesOutstandingBasicAndDilutedAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_e88d9382-8212-4c2a-8139-c9575cce007b" xlink:to="loc_wynn_WeightedAverageNumberOfSharesOutstandingBasicAndDilutedAbstract_76a244f6-b2c5-4980-a3df-71d68bd1a0c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_ad6e34e2-7632-4cf9-a19d-a8f7a120b506" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_WeightedAverageNumberOfSharesOutstandingBasicAndDilutedAbstract_76a244f6-b2c5-4980-a3df-71d68bd1a0c9" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_ad6e34e2-7632-4cf9-a19d-a8f7a120b506" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_47da5190-c863-4bf2-a53c-fab531966126" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_WeightedAverageNumberOfSharesOutstandingBasicAndDilutedAbstract_76a244f6-b2c5-4980-a3df-71d68bd1a0c9" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_47da5190-c863-4bf2-a53c-fab531966126" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_e9adfb67-4694-4a53-b959-544aac9a91d4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_WeightedAverageNumberOfSharesOutstandingBasicAndDilutedAbstract_76a244f6-b2c5-4980-a3df-71d68bd1a0c9" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_e9adfb67-4694-4a53-b959-544aac9a91d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_a1efbb16-132a-4569-9944-f7a55a4be928" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_e88d9382-8212-4c2a-8139-c9575cce007b" xlink:to="loc_us-gaap_EarningsPerShareBasic_a1efbb16-132a-4569-9944-f7a55a4be928" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_ef940f4d-9cb7-4a58-9c5b-66837b87f279" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_e88d9382-8212-4c2a-8139-c9575cce007b" xlink:to="loc_us-gaap_EarningsPerShareDiluted_ef940f4d-9cb7-4a58-9c5b-66837b87f279" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_0198b9af-4535-4098-9011-3fb7518d84a8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_e88d9382-8212-4c2a-8139-c9575cce007b" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_0198b9af-4535-4098-9011-3fb7518d84a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/LeasesMinimumandContingentOperatingLeaseIncomeDetails" xlink:type="simple" xlink:href="wynn-20230331.xsd#LeasesMinimumandContingentOperatingLeaseIncomeDetails"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/LeasesMinimumandContingentOperatingLeaseIncomeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_f4e0c98f-32e5-41a4-8c68-d8fb9a5b2cdb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLeaseIncomeLeasePayments_2132e14b-9d31-49a8-8531-a70da4073445" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLeaseIncomeLeasePayments"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_f4e0c98f-32e5-41a4-8c68-d8fb9a5b2cdb" xlink:to="loc_us-gaap_OperatingLeaseLeaseIncomeLeasePayments_2132e14b-9d31-49a8-8531-a70da4073445" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseVariableLeaseIncome_5132a6d5-8594-4b13-988e-ab726987d69d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseVariableLeaseIncome"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_f4e0c98f-32e5-41a4-8c68-d8fb9a5b2cdb" xlink:to="loc_us-gaap_OperatingLeaseVariableLeaseIncome_5132a6d5-8594-4b13-988e-ab726987d69d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLeaseIncome_7e891a3c-8cf1-48ee-8247-12bfd54493ff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLeaseIncome"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_f4e0c98f-32e5-41a4-8c68-d8fb9a5b2cdb" xlink:to="loc_us-gaap_OperatingLeaseLeaseIncome_7e891a3c-8cf1-48ee-8247-12bfd54493ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/RetailJointVentureAdditionalinformationDetails" xlink:type="simple" xlink:href="wynn-20230331.xsd#RetailJointVentureAdditionalinformationDetails"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/RetailJointVentureAdditionalinformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentsAndJointVenturesAbstract_8d601630-0e65-410e-8301-9d6ab20a5df6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityMethodInvestmentsAndJointVenturesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_1ac62007-4a13-417b-9530-a7a9d006ac62" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityMethodInvestmentsAndJointVenturesAbstract_8d601630-0e65-410e-8301-9d6ab20a5df6" xlink:to="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_1ac62007-4a13-417b-9530-a7a9d006ac62" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_c00806d9-53b0-4f0c-bd24-c0481302f98a" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_LegalEntityAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_1ac62007-4a13-417b-9530-a7a9d006ac62" xlink:to="loc_dei_LegalEntityAxis_c00806d9-53b0-4f0c-bd24-c0481302f98a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_5fd8ef52-870c-41e3-b8aa-e39a48c101ff" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_c00806d9-53b0-4f0c-bd24-c0481302f98a" xlink:to="loc_dei_EntityDomain_5fd8ef52-870c-41e3-b8aa-e39a48c101ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailJointVentureMember_debd6851-9a47-4aa4-b8aa-0f27d37d5bd8" xlink:href="wynn-20230331.xsd#wynn_RetailJointVentureMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_5fd8ef52-870c-41e3-b8aa-e39a48c101ff" xlink:to="loc_wynn_RetailJointVentureMember_debd6851-9a47-4aa4-b8aa-0f27d37d5bd8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_380b364a-83cd-472d-beb5-098e70c3f0e5" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_1ac62007-4a13-417b-9530-a7a9d006ac62" xlink:to="loc_srt_ProductOrServiceAxis_380b364a-83cd-472d-beb5-098e70c3f0e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_dcaf4a53-38ee-4246-9b8b-1134bb0e2adf" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_380b364a-83cd-472d-beb5-098e70c3f0e5" xlink:to="loc_srt_ProductsAndServicesDomain_dcaf4a53-38ee-4246-9b8b-1134bb0e2adf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetailMember_2dfd3494-1d4d-4c53-a579-07a28af58809" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetailMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_dcaf4a53-38ee-4246-9b8b-1134bb0e2adf" xlink:to="loc_us-gaap_RetailMember_2dfd3494-1d4d-4c53-a579-07a28af58809" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_5187ba98-49a1-4578-8001-c07a9763bb5a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_1ac62007-4a13-417b-9530-a7a9d006ac62" xlink:to="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_5187ba98-49a1-4578-8001-c07a9763bb5a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_e81b90d0-966b-43fa-90e7-e78122b39806" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Assets"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_5187ba98-49a1-4578-8001-c07a9763bb5a" xlink:to="loc_us-gaap_Assets_e81b90d0-966b-43fa-90e7-e78122b39806" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_3d78409f-551c-4e2f-b1bd-25f608de868d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_5187ba98-49a1-4578-8001-c07a9763bb5a" xlink:to="loc_us-gaap_Liabilities_3d78409f-551c-4e2f-b1bd-25f608de868d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_5dece968-95c9-4b83-b2fe-c045ff3fb5dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_5187ba98-49a1-4578-8001-c07a9763bb5a" xlink:to="loc_us-gaap_LongTermDebt_5dece968-95c9-4b83-b2fe-c045ff3fb5dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/SegmentInformationSummaryofResultsofOperationsbySegmentDetails" xlink:type="simple" xlink:href="wynn-20230331.xsd#SegmentInformationSummaryofResultsofOperationsbySegmentDetails"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/SegmentInformationSummaryofResultsofOperationsbySegmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingAbstract_033af8c6-cb5d-4bd7-98e5-fc1730b52a18" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentReportingAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_ce82eb40-5051-48cd-a4a9-211c3947ce7a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_033af8c6-cb5d-4bd7-98e5-fc1730b52a18" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_ce82eb40-5051-48cd-a4a9-211c3947ce7a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_e2f40175-1c29-4271-9cda-ced40bc46171" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_ce82eb40-5051-48cd-a4a9-211c3947ce7a" xlink:to="loc_srt_ProductOrServiceAxis_e2f40175-1c29-4271-9cda-ced40bc46171" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_3e47c3b1-03a2-40c1-85a2-7efd85043e6e" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_e2f40175-1c29-4271-9cda-ced40bc46171" xlink:to="loc_srt_ProductsAndServicesDomain_3e47c3b1-03a2-40c1-85a2-7efd85043e6e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CasinoMember_0df2df8f-b2ba-4741-8f7c-81f272dcffa0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CasinoMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_3e47c3b1-03a2-40c1-85a2-7efd85043e6e" xlink:to="loc_us-gaap_CasinoMember_0df2df8f-b2ba-4741-8f7c-81f272dcffa0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OccupancyMember_cc3a02d2-ab6d-41f2-82b0-fdc59e185af9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OccupancyMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_3e47c3b1-03a2-40c1-85a2-7efd85043e6e" xlink:to="loc_us-gaap_OccupancyMember_cc3a02d2-ab6d-41f2-82b0-fdc59e185af9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FoodAndBeverageMember_2b1c8890-9637-4f9c-b629-e3243d7dd882" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FoodAndBeverageMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_3e47c3b1-03a2-40c1-85a2-7efd85043e6e" xlink:to="loc_us-gaap_FoodAndBeverageMember_2b1c8890-9637-4f9c-b629-e3243d7dd882" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EntertainmentRetailAndOtherMember_3846546f-f3b6-4715-b819-e65019b17eb7" xlink:href="wynn-20230331.xsd#wynn_EntertainmentRetailAndOtherMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_3e47c3b1-03a2-40c1-85a2-7efd85043e6e" xlink:to="loc_wynn_EntertainmentRetailAndOtherMember_3846546f-f3b6-4715-b819-e65019b17eb7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_69c94e45-7e86-4117-a1e3-6a803d261aa1" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_ce82eb40-5051-48cd-a4a9-211c3947ce7a" xlink:to="loc_srt_ConsolidationItemsAxis_69c94e45-7e86-4117-a1e3-6a803d261aa1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_1a4512bf-cca2-4462-9ba1-d38f38cb9415" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ConsolidationItemsAxis_69c94e45-7e86-4117-a1e3-6a803d261aa1" xlink:to="loc_srt_ConsolidationItemsDomain_1a4512bf-cca2-4462-9ba1-d38f38cb9415" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_9be5088d-b146-4fea-a475-2b419102f4f9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingSegmentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ConsolidationItemsDomain_1a4512bf-cca2-4462-9ba1-d38f38cb9415" xlink:to="loc_us-gaap_OperatingSegmentsMember_9be5088d-b146-4fea-a475-2b419102f4f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateNonSegmentMember_534768c0-ee20-485e-afd3-0b946738f9d4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CorporateNonSegmentMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ConsolidationItemsDomain_1a4512bf-cca2-4462-9ba1-d38f38cb9415" xlink:to="loc_us-gaap_CorporateNonSegmentMember_534768c0-ee20-485e-afd3-0b946738f9d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_10da4f9c-00b5-4471-acfc-769ce346c0f1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_ce82eb40-5051-48cd-a4a9-211c3947ce7a" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_10da4f9c-00b5-4471-acfc-769ce346c0f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_b8840356-72e6-4ac4-84e4-64b18ee8c088" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_10da4f9c-00b5-4471-acfc-769ce346c0f1" xlink:to="loc_us-gaap_SegmentDomain_b8840356-72e6-4ac4-84e4-64b18ee8c088" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_MacauOperationsMember_68974e15-073b-4aaa-b23c-28c2774c29ed" xlink:href="wynn-20230331.xsd#wynn_MacauOperationsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_b8840356-72e6-4ac4-84e4-64b18ee8c088" xlink:to="loc_wynn_MacauOperationsMember_68974e15-073b-4aaa-b23c-28c2774c29ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnLasVegasMember_def4b4c6-dba6-4d16-a4cd-a19f8be517d0" xlink:href="wynn-20230331.xsd#wynn_WynnLasVegasMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_b8840356-72e6-4ac4-84e4-64b18ee8c088" xlink:to="loc_wynn_WynnLasVegasMember_def4b4c6-dba6-4d16-a4cd-a19f8be517d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EncoreBostonHarborMember_f2bb1020-5a3f-455e-b51a-5b9b9470dfd0" xlink:href="wynn-20230331.xsd#wynn_EncoreBostonHarborMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_b8840356-72e6-4ac4-84e4-64b18ee8c088" xlink:to="loc_wynn_EncoreBostonHarborMember_f2bb1020-5a3f-455e-b51a-5b9b9470dfd0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnInteractiveLtdMember_1f0cf65c-f2d1-4208-a507-66bf9c557913" xlink:href="wynn-20230331.xsd#wynn_WynnInteractiveLtdMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_b8840356-72e6-4ac4-84e4-64b18ee8c088" xlink:to="loc_wynn_WynnInteractiveLtdMember_1f0cf65c-f2d1-4208-a507-66bf9c557913" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_013a6b47-186c-44e8-b363-e73e09a33dd5" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_LegalEntityAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_ce82eb40-5051-48cd-a4a9-211c3947ce7a" xlink:to="loc_dei_LegalEntityAxis_013a6b47-186c-44e8-b363-e73e09a33dd5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_1af7975d-ce6b-4460-bf5e-499d4878ecc9" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_013a6b47-186c-44e8-b363-e73e09a33dd5" xlink:to="loc_dei_EntityDomain_1af7975d-ce6b-4460-bf5e-499d4878ecc9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnPalaceMember_5f7230e9-286a-4f02-9aa0-9ab57bb03c83" xlink:href="wynn-20230331.xsd#wynn_WynnPalaceMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_1af7975d-ce6b-4460-bf5e-499d4878ecc9" xlink:to="loc_wynn_WynnPalaceMember_5f7230e9-286a-4f02-9aa0-9ab57bb03c83" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauMember_56c9266e-763c-464d-8f97-030eb0636683" xlink:href="wynn-20230331.xsd#wynn_WynnMacauMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_1af7975d-ce6b-4460-bf5e-499d4878ecc9" xlink:to="loc_wynn_WynnMacauMember_56c9266e-763c-464d-8f97-030eb0636683" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_499bf949-9345-48ab-875b-8bf996dd0a2e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_ce82eb40-5051-48cd-a4a9-211c3947ce7a" xlink:to="loc_us-gaap_SegmentReportingInformationLineItems_499bf949-9345-48ab-875b-8bf996dd0a2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_64b8eb72-2e38-4a4c-a5c1-5c75fa5a1630" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_499bf949-9345-48ab-875b-8bf996dd0a2e" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_64b8eb72-2e38-4a4c-a5c1-5c75fa5a1630" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_AdjustedPropertyEbitda_d522ea33-c6b0-4382-8a5a-98c90f3d514b" xlink:href="wynn-20230331.xsd#wynn_AdjustedPropertyEbitda"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_499bf949-9345-48ab-875b-8bf996dd0a2e" xlink:to="loc_wynn_AdjustedPropertyEbitda_d522ea33-c6b0-4382-8a5a-98c90f3d514b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OtherOperatingCostsAndExpensesAbstract_0c5cd2b4-4ea0-4049-bc3f-5cfa9bf41224" xlink:href="wynn-20230331.xsd#wynn_OtherOperatingCostsAndExpensesAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_499bf949-9345-48ab-875b-8bf996dd0a2e" xlink:to="loc_wynn_OtherOperatingCostsAndExpensesAbstract_0c5cd2b4-4ea0-4049-bc3f-5cfa9bf41224" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreOpeningCosts_f977899f-e02b-4dcc-a3a5-61d91b39075b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreOpeningCosts"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_0c5cd2b4-4ea0-4049-bc3f-5cfa9bf41224" xlink:to="loc_us-gaap_PreOpeningCosts_f977899f-e02b-4dcc-a3a5-61d91b39075b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAndAmortization_8d315703-48de-4346-92a1-c103c6dff11f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepreciationAndAmortization"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_0c5cd2b4-4ea0-4049-bc3f-5cfa9bf41224" xlink:to="loc_us-gaap_DepreciationAndAmortization_8d315703-48de-4346-92a1-c103c6dff11f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_ProjectAbandonmentCosts_3e8dd275-d67d-44ac-a7d2-96f0c957c959" xlink:href="wynn-20230331.xsd#wynn_ProjectAbandonmentCosts"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_0c5cd2b4-4ea0-4049-bc3f-5cfa9bf41224" xlink:to="loc_wynn_ProjectAbandonmentCosts_3e8dd275-d67d-44ac-a7d2-96f0c957c959" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_CorporateExpensesAndOther_8ba9d8a2-ffd9-4a64-b2d5-5be9b7e95de6" xlink:href="wynn-20230331.xsd#wynn_CorporateExpensesAndOther"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_0c5cd2b4-4ea0-4049-bc3f-5cfa9bf41224" xlink:to="loc_wynn_CorporateExpensesAndOther_8ba9d8a2-ffd9-4a64-b2d5-5be9b7e95de6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_2cc7a38f-d860-4b8b-810b-5f2750d56f03" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_0c5cd2b4-4ea0-4049-bc3f-5cfa9bf41224" xlink:to="loc_us-gaap_ShareBasedCompensation_2cc7a38f-d860-4b8b-810b-5f2750d56f03" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OperatingLeaseTripleNetCost_0ea9656e-2a7f-4e20-a83a-10b202216e35" xlink:href="wynn-20230331.xsd#wynn_OperatingLeaseTripleNetCost"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_0c5cd2b4-4ea0-4049-bc3f-5cfa9bf41224" xlink:to="loc_wynn_OperatingLeaseTripleNetCost_0ea9656e-2a7f-4e20-a83a-10b202216e35" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCostAndExpenseOperating_21512a9a-34e0-4f4a-90c7-7e3f1e5cb1fc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherCostAndExpenseOperating"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_0c5cd2b4-4ea0-4049-bc3f-5cfa9bf41224" xlink:to="loc_us-gaap_OtherCostAndExpenseOperating_21512a9a-34e0-4f4a-90c7-7e3f1e5cb1fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_ad39c608-cd42-4863-a784-680f92393f4c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_499bf949-9345-48ab-875b-8bf996dd0a2e" xlink:to="loc_us-gaap_OperatingIncomeLoss_ad39c608-cd42-4863-a784-680f92393f4c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_6e80f103-1880-4f83-81ac-f205c6b0efd0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonoperatingIncomeExpenseAbstract"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_499bf949-9345-48ab-875b-8bf996dd0a2e" xlink:to="loc_us-gaap_NonoperatingIncomeExpenseAbstract_6e80f103-1880-4f83-81ac-f205c6b0efd0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_f91088d6-399b-4b5b-9e52-058e851ea2c0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_6e80f103-1880-4f83-81ac-f205c6b0efd0" xlink:to="loc_us-gaap_InvestmentIncomeInterest_f91088d6-399b-4b5b-9e52-058e851ea2c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_7727b4ed-8159-4b69-ba1b-6ad3cee767bc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_6e80f103-1880-4f83-81ac-f205c6b0efd0" xlink:to="loc_us-gaap_InterestExpense_7727b4ed-8159-4b69-ba1b-6ad3cee767bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_0c0499c8-727d-42f0-895f-ba1da6281297" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_6e80f103-1880-4f83-81ac-f205c6b0efd0" xlink:to="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_0c0499c8-727d-42f0-895f-ba1da6281297" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_cd1f57b3-ad47-4182-8f95-791c9c1f4c7f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_6e80f103-1880-4f83-81ac-f205c6b0efd0" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_cd1f57b3-ad47-4182-8f95-791c9c1f4c7f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_a2f66aad-5ab5-487b-9bdf-e324de2be400" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_6e80f103-1880-4f83-81ac-f205c6b0efd0" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_a2f66aad-5ab5-487b-9bdf-e324de2be400" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_c89615d2-f0a0-4bca-bd5e-a80d41271851" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_6e80f103-1880-4f83-81ac-f205c6b0efd0" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_c89615d2-f0a0-4bca-bd5e-a80d41271851" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_233e8dbf-8a7b-44e8-a1cc-c96e7b03fcbc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_499bf949-9345-48ab-875b-8bf996dd0a2e" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_233e8dbf-8a7b-44e8-a1cc-c96e7b03fcbc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_2fff6c77-dba2-4f9a-8e8a-c81118dbd462" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_499bf949-9345-48ab-875b-8bf996dd0a2e" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_2fff6c77-dba2-4f9a-8e8a-c81118dbd462" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_8cef6cb5-5b86-4617-93fa-ace865024d37" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_499bf949-9345-48ab-875b-8bf996dd0a2e" xlink:to="loc_us-gaap_ProfitLoss_8cef6cb5-5b86-4617-93fa-ace865024d37" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_1689f2e8-0310-46e7-a28b-c995d97aecc8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_499bf949-9345-48ab-875b-8bf996dd0a2e" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_1689f2e8-0310-46e7-a28b-c995d97aecc8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_74ffaf94-3db7-4c31-97b1-c86e22a0952b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_499bf949-9345-48ab-875b-8bf996dd0a2e" xlink:to="loc_us-gaap_NetIncomeLoss_74ffaf94-3db7-4c31-97b1-c86e22a0952b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/SegmentInformationSummaryofAssetsbySegmentDetails" xlink:type="simple" xlink:href="wynn-20230331.xsd#SegmentInformationSummaryofAssetsbySegmentDetails"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/SegmentInformationSummaryofAssetsbySegmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingAbstract_32675505-fba0-4c55-852b-09164f573c2b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentReportingAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d6c275b7-f342-4f4e-afe5-bc2bd2498b0c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_32675505-fba0-4c55-852b-09164f573c2b" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d6c275b7-f342-4f4e-afe5-bc2bd2498b0c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_a7bd7c62-a0f8-482d-bd78-5be95de3c37c" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d6c275b7-f342-4f4e-afe5-bc2bd2498b0c" xlink:to="loc_srt_ConsolidationItemsAxis_a7bd7c62-a0f8-482d-bd78-5be95de3c37c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_1e5da453-0eb1-44fd-bbc2-7a7978c18329" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ConsolidationItemsAxis_a7bd7c62-a0f8-482d-bd78-5be95de3c37c" xlink:to="loc_srt_ConsolidationItemsDomain_1e5da453-0eb1-44fd-bbc2-7a7978c18329" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_ccb1a81d-6d7d-4a9c-8ae7-4729321863eb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingSegmentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ConsolidationItemsDomain_1e5da453-0eb1-44fd-bbc2-7a7978c18329" xlink:to="loc_us-gaap_OperatingSegmentsMember_ccb1a81d-6d7d-4a9c-8ae7-4729321863eb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_7dce2f4e-7fee-447e-9ef0-9c38b9c19f98" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_StatementGeographicalAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d6c275b7-f342-4f4e-afe5-bc2bd2498b0c" xlink:to="loc_srt_StatementGeographicalAxis_7dce2f4e-7fee-447e-9ef0-9c38b9c19f98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_7c9499b6-7fe0-4116-83f0-691f7ca06676" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_SegmentGeographicalDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_StatementGeographicalAxis_7dce2f4e-7fee-447e-9ef0-9c38b9c19f98" xlink:to="loc_srt_SegmentGeographicalDomain_7c9499b6-7fe0-4116-83f0-691f7ca06676" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_MO_2a868703-1f99-4a1f-93b0-97e365e512af" xlink:href="https://xbrl.sec.gov/country/2021/country-2021.xsd#country_MO"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_7c9499b6-7fe0-4116-83f0-691f7ca06676" xlink:to="loc_country_MO_2a868703-1f99-4a1f-93b0-97e365e512af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_6d8944b5-0d24-4965-9b7c-657e10b4fbce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d6c275b7-f342-4f4e-afe5-bc2bd2498b0c" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_6d8944b5-0d24-4965-9b7c-657e10b4fbce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_13976b85-1f39-4aec-b7c0-c72136295485" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_6d8944b5-0d24-4965-9b7c-657e10b4fbce" xlink:to="loc_us-gaap_SegmentDomain_13976b85-1f39-4aec-b7c0-c72136295485" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnPalaceMember_dee2cd2c-b7b1-44e5-ad0f-e41c417dde8e" xlink:href="wynn-20230331.xsd#wynn_WynnPalaceMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_13976b85-1f39-4aec-b7c0-c72136295485" xlink:to="loc_wynn_WynnPalaceMember_dee2cd2c-b7b1-44e5-ad0f-e41c417dde8e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauMember_13a4ca3e-8529-4ac4-8e25-d0f255c997b6" xlink:href="wynn-20230331.xsd#wynn_WynnMacauMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_13976b85-1f39-4aec-b7c0-c72136295485" xlink:to="loc_wynn_WynnMacauMember_13a4ca3e-8529-4ac4-8e25-d0f255c997b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OtherMacauMember_09f056d9-0116-4f26-96fe-93833705a8e2" xlink:href="wynn-20230331.xsd#wynn_OtherMacauMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_13976b85-1f39-4aec-b7c0-c72136295485" xlink:to="loc_wynn_OtherMacauMember_09f056d9-0116-4f26-96fe-93833705a8e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_MacauOperationsMember_190efad2-8024-40d2-b8ec-c99b135a51f4" xlink:href="wynn-20230331.xsd#wynn_MacauOperationsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_13976b85-1f39-4aec-b7c0-c72136295485" xlink:to="loc_wynn_MacauOperationsMember_190efad2-8024-40d2-b8ec-c99b135a51f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnLasVegasMember_4709c59b-fe6e-4328-8779-d67692cc96bd" xlink:href="wynn-20230331.xsd#wynn_WynnLasVegasMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_13976b85-1f39-4aec-b7c0-c72136295485" xlink:to="loc_wynn_WynnLasVegasMember_4709c59b-fe6e-4328-8779-d67692cc96bd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EncoreBostonHarborMember_705936cf-b780-4d86-a16e-421e899a406c" xlink:href="wynn-20230331.xsd#wynn_EncoreBostonHarborMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_13976b85-1f39-4aec-b7c0-c72136295485" xlink:to="loc_wynn_EncoreBostonHarborMember_705936cf-b780-4d86-a16e-421e899a406c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnInteractiveLtdMember_692610a1-6a9a-44a8-88ad-546694ee103d" xlink:href="wynn-20230331.xsd#wynn_WynnInteractiveLtdMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_13976b85-1f39-4aec-b7c0-c72136295485" xlink:to="loc_wynn_WynnInteractiveLtdMember_692610a1-6a9a-44a8-88ad-546694ee103d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateAndOtherMember_c64fce6d-c3fd-45ba-9274-b0b8cf47dfdf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CorporateAndOtherMember"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_13976b85-1f39-4aec-b7c0-c72136295485" xlink:to="loc_us-gaap_CorporateAndOtherMember_c64fce6d-c3fd-45ba-9274-b0b8cf47dfdf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_9d110fe7-3767-4503-a7c9-09d49492f275" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d6c275b7-f342-4f4e-afe5-bc2bd2498b0c" xlink:to="loc_us-gaap_SegmentReportingInformationLineItems_9d110fe7-3767-4503-a7c9-09d49492f275" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_4415ab86-db5d-477e-a28e-61a667f7630e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Assets"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_9d110fe7-3767-4503-a7c9-09d49492f275" xlink:to="loc_us-gaap_Assets_4415ab86-db5d-477e-a28e-61a667f7630e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
