<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2020 Workiva-->
<!--r:3a348748-d0b9-4e3e-ab13-b519038d6594,g:70ae9f10-deda-4a9f-88a4-82e02f32bbac-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.wynnresorts.com/role/DocumentandEntityInformation" xlink:type="simple" xlink:href="wynn-20200804.xsd#DocumentandEntityInformation"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/DocumentandEntityInformation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_0d3c9f59-901a-4b6a-82c9-dcf595a0a5ff" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_Security12bTitle_0d3c9f59-901a-4b6a-82c9-dcf595a0a5ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_ddc3827a-6aa9-440c-8183-cd6a52649bea" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_EntityIncorporationStateCountryCode_ddc3827a-6aa9-440c-8183-cd6a52649bea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_dacee71f-2a13-40ec-ad8b-c8404b09ef5d" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_EntityFileNumber_dacee71f-2a13-40ec-ad8b-c8404b09ef5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_01c8763d-369e-44af-bc02-2917d06b2f2c" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_EntityTaxIdentificationNumber_01c8763d-369e-44af-bc02-2917d06b2f2c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_ab209b18-e0c8-40a2-8975-661f0e868c8d" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_EntityAddressAddressLine1_ab209b18-e0c8-40a2-8975-661f0e868c8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_40cc0e6b-01e3-424a-a040-f38ee9a5f0f4" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_EntityAddressCityOrTown_40cc0e6b-01e3-424a-a040-f38ee9a5f0f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_e7294ede-be93-498f-9ceb-771971b4782f" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_EntityAddressStateOrProvince_e7294ede-be93-498f-9ceb-771971b4782f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_02ad6431-5649-44cd-bd35-8f2f3785870b" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentType"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_DocumentType_02ad6431-5649-44cd-bd35-8f2f3785870b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_df45f290-ad99-410f-900f-c439a666ed12" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_EntityRegistrantName_df45f290-ad99-410f-900f-c439a666ed12" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_65b4d2c7-ab31-4a6a-b3cf-76862037c0c7" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_EntityCentralIndexKey_65b4d2c7-ab31-4a6a-b3cf-76862037c0c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_9781e648-ca6d-445e-8489-80e69621ba02" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_DocumentPeriodEndDate_9781e648-ca6d-445e-8489-80e69621ba02" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_4bb2c7be-fda8-49f0-816f-692e87f5e1b7" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_EntityAddressPostalZipCode_4bb2c7be-fda8-49f0-816f-692e87f5e1b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_beae0af6-f838-47b5-a186-d8ab02d38ce3" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_CityAreaCode_beae0af6-f838-47b5-a186-d8ab02d38ce3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_49af09f1-3be7-4deb-bcfa-7c0b5c3e4b3b" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_LocalPhoneNumber_49af09f1-3be7-4deb-bcfa-7c0b5c3e4b3b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_53a46846-b91f-4cd2-93f8-91ee50127025" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_WrittenCommunications_53a46846-b91f-4cd2-93f8-91ee50127025" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_6ae5972e-11b0-4205-b33e-5aa0880eafdf" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_TradingSymbol_6ae5972e-11b0-4205-b33e-5aa0880eafdf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_f8236114-a1ce-4c1c-ba76-d285b893d7e7" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_SecurityExchangeName_f8236114-a1ce-4c1c-ba76-d285b893d7e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_878888e9-bb45-4c21-8e3b-158a111c705f" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_SolicitingMaterial_878888e9-bb45-4c21-8e3b-158a111c705f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_0e09a008-d301-4d28-8bcb-1397e6aaa922" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_PreCommencementTenderOffer_0e09a008-d301-4d28-8bcb-1397e6aaa922" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_c0676ae6-fa16-4779-bf4f-55e129ebdb2d" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_c0676ae6-fa16-4779-bf4f-55e129ebdb2d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_08383b17-bdd9-49d2-a43d-1f7bf154329e" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_EntityEmergingGrowthCompany_08383b17-bdd9-49d2-a43d-1f7bf154329e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_0d4b8ddb-9c78-466e-a6b7-58b5bcdf41f3" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fe703e3c-0b5e-4edd-a1b2-d91693099485" xlink:to="loc_dei_AmendmentFlag_0d4b8ddb-9c78-466e-a6b7-58b5bcdf41f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
