<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2020 Workiva-->
<!--r:e14b3f54-917c-4330-9c1c-74bd4c19fd46,g:b443ffc5-d507-4522-ab11-18f1a70df390-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/Cover" xlink:type="simple" xlink:href="wynn-20200930.xsd#Cover"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/Cover" xlink:type="extended" id="i9ebf27cc7e08478d8b5a3a48ae800756_Cover"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="wynn-20200930.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended" id="i120dccce6288458a85e3ed6b0b89ecc9_CondensedConsolidatedBalanceSheets"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="wynn-20200930.xsd#CondensedConsolidatedBalanceSheetsParenthetical"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="extended" id="i3b4a1eb1e12b4968bf837912179e41a0_CondensedConsolidatedBalanceSheetsParenthetical"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsOfOperationsunaudited" xlink:type="simple" xlink:href="wynn-20200930.xsd#CondensedConsolidatedStatementsOfOperationsunaudited"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsOfOperationsunaudited" xlink:type="extended" id="i2f5f7be1326446c6a4ed3ccedacf93f9_CondensedConsolidatedStatementsOfOperationsunaudited">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_7c9424a9-1d5a-46cf-9155-f6fbfd65db83" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_566c2350-91b5-48db-8edc-88c20b80d1c4" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7c9424a9-1d5a-46cf-9155-f6fbfd65db83" xlink:to="loc_us-gaap_RevenuesAbstract_566c2350-91b5-48db-8edc-88c20b80d1c4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_178d49cc-c7a4-46cc-8478-c2335b677516" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_566c2350-91b5-48db-8edc-88c20b80d1c4" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_178d49cc-c7a4-46cc-8478-c2335b677516" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpensesAbstract_20cb9639-4cf2-483f-bc12-e298e561ffb0" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CostsAndExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7c9424a9-1d5a-46cf-9155-f6fbfd65db83" xlink:to="loc_us-gaap_CostsAndExpensesAbstract_20cb9639-4cf2-483f-bc12-e298e561ffb0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_58f9ab23-058f-47a4-b963-91ba9b4a0502" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_20cb9639-4cf2-483f-bc12-e298e561ffb0" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_58f9ab23-058f-47a4-b963-91ba9b4a0502" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_99b87a70-0e32-4769-8e0d-67aaa5755c4e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_20cb9639-4cf2-483f-bc12-e298e561ffb0" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_99b87a70-0e32-4769-8e0d-67aaa5755c4e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_93836834-6c03-4957-9941-2fd76ad183de" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProvisionForDoubtfulAccounts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_20cb9639-4cf2-483f-bc12-e298e561ffb0" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_93836834-6c03-4957-9941-2fd76ad183de" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreOpeningCosts_2620e0e9-77b0-4ddc-978b-aa58571893c6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreOpeningCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_20cb9639-4cf2-483f-bc12-e298e561ffb0" xlink:to="loc_us-gaap_PreOpeningCosts_2620e0e9-77b0-4ddc-978b-aa58571893c6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAndAmortization_28af8c07-32c6-440a-8699-a6820eced4d2" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_20cb9639-4cf2-483f-bc12-e298e561ffb0" xlink:to="loc_us-gaap_DepreciationAndAmortization_28af8c07-32c6-440a-8699-a6820eced4d2" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_ProjectAbandonmentCosts_9efeb49e-75c4-4112-9282-b01c05d7389c" xlink:href="wynn-20200930.xsd#wynn_ProjectAbandonmentCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_20cb9639-4cf2-483f-bc12-e298e561ffb0" xlink:to="loc_wynn_ProjectAbandonmentCosts_9efeb49e-75c4-4112-9282-b01c05d7389c" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_161b7ae9-98ac-4a3c-b22b-dca37e2f482f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CostsAndExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_20cb9639-4cf2-483f-bc12-e298e561ffb0" xlink:to="loc_us-gaap_CostsAndExpenses_161b7ae9-98ac-4a3c-b22b-dca37e2f482f" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_8625115a-112a-47dd-83d1-e4850b4b48bc" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7c9424a9-1d5a-46cf-9155-f6fbfd65db83" xlink:to="loc_us-gaap_OperatingIncomeLoss_8625115a-112a-47dd-83d1-e4850b4b48bc" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_95c558cf-9b94-4355-b428-cb9776d90f26" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NonoperatingIncomeExpenseAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7c9424a9-1d5a-46cf-9155-f6fbfd65db83" xlink:to="loc_us-gaap_NonoperatingIncomeExpenseAbstract_95c558cf-9b94-4355-b428-cb9776d90f26" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_68d1f6cc-c041-4b36-a3b6-c86e78a8242a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_95c558cf-9b94-4355-b428-cb9776d90f26" xlink:to="loc_us-gaap_InvestmentIncomeInterest_68d1f6cc-c041-4b36-a3b6-c86e78a8242a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_fac0b61b-9c1e-4e03-9537-08a60911636f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_95c558cf-9b94-4355-b428-cb9776d90f26" xlink:to="loc_us-gaap_InterestExpense_fac0b61b-9c1e-4e03-9537-08a60911636f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_a3df87f3-0735-4512-8db6-2c9cc35370cc" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_95c558cf-9b94-4355-b428-cb9776d90f26" xlink:to="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_a3df87f3-0735-4512-8db6-2c9cc35370cc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_dbdcd911-d00a-4cc9-984f-2d332c2d0bcd" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_95c558cf-9b94-4355-b428-cb9776d90f26" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_dbdcd911-d00a-4cc9-984f-2d332c2d0bcd" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_f75cbab1-542a-4293-9e3a-93983cd940c3" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_95c558cf-9b94-4355-b428-cb9776d90f26" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_f75cbab1-542a-4293-9e3a-93983cd940c3" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_eb072fba-87f5-4eb1-bdaf-9212bae4d9f3" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_95c558cf-9b94-4355-b428-cb9776d90f26" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_eb072fba-87f5-4eb1-bdaf-9212bae4d9f3" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_6e8ea5f3-6861-4a48-b4e3-a949e05254d9" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7c9424a9-1d5a-46cf-9155-f6fbfd65db83" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_6e8ea5f3-6861-4a48-b4e3-a949e05254d9" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_a8907e09-3b19-4e25-8ee8-30e4b3fce7f8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7c9424a9-1d5a-46cf-9155-f6fbfd65db83" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_a8907e09-3b19-4e25-8ee8-30e4b3fce7f8" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_637c7f8b-9901-41b5-93c6-b600441399d2" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7c9424a9-1d5a-46cf-9155-f6fbfd65db83" xlink:to="loc_us-gaap_ProfitLoss_637c7f8b-9901-41b5-93c6-b600441399d2" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_cfce9571-ca38-4855-8173-9be4b9c54ff8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7c9424a9-1d5a-46cf-9155-f6fbfd65db83" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_cfce9571-ca38-4855-8173-9be4b9c54ff8" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_62ddfc90-0ec9-4358-9b15-8ca9c24d02e0" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7c9424a9-1d5a-46cf-9155-f6fbfd65db83" xlink:to="loc_us-gaap_NetIncomeLoss_62ddfc90-0ec9-4358-9b15-8ca9c24d02e0" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_4a66e859-6835-4970-a4d2-d16a3ce58af5" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareBasicAndDilutedAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7c9424a9-1d5a-46cf-9155-f6fbfd65db83" xlink:to="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_4a66e859-6835-4970-a4d2-d16a3ce58af5" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_db5f8b0a-a75f-45b8-a9f9-a3069c53c9b9" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_4a66e859-6835-4970-a4d2-d16a3ce58af5" xlink:to="loc_us-gaap_EarningsPerShareAbstract_db5f8b0a-a75f-45b8-a9f9-a3069c53c9b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_3793dff6-c62f-47d4-972f-fd8498e05523" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_db5f8b0a-a75f-45b8-a9f9-a3069c53c9b9" xlink:to="loc_us-gaap_EarningsPerShareBasic_3793dff6-c62f-47d4-972f-fd8498e05523" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_c5944944-c22d-44a8-8c01-797815597d31" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_db5f8b0a-a75f-45b8-a9f9-a3069c53c9b9" xlink:to="loc_us-gaap_EarningsPerShareDiluted_c5944944-c22d-44a8-8c01-797815597d31" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_84bc84cf-ecb3-414b-a348-af0d57e8f379" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7c9424a9-1d5a-46cf-9155-f6fbfd65db83" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_84bc84cf-ecb3-414b-a348-af0d57e8f379" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_a1fe7e66-9045-47b4-bba7-ddc4f8d5bb5a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_84bc84cf-ecb3-414b-a348-af0d57e8f379" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_a1fe7e66-9045-47b4-bba7-ddc4f8d5bb5a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_7057f4f1-bc71-4130-861d-b52f72141018" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_84bc84cf-ecb3-414b-a348-af0d57e8f379" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_7057f4f1-bc71-4130-861d-b52f72141018" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared_50f15b44-2854-4f1a-8508-648bde85a562" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockDividendsPerShareDeclared"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7c9424a9-1d5a-46cf-9155-f6fbfd65db83" xlink:to="loc_us-gaap_CommonStockDividendsPerShareDeclared_50f15b44-2854-4f1a-8508-648bde85a562" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_07dd9ffc-6bc1-4cbf-abc9-156cba217e4a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_7c9424a9-1d5a-46cf-9155-f6fbfd65db83" xlink:to="loc_us-gaap_StatementTable_07dd9ffc-6bc1-4cbf-abc9-156cba217e4a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_f1a600f6-7548-401e-b183-977f127913d7" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_07dd9ffc-6bc1-4cbf-abc9-156cba217e4a" xlink:to="loc_srt_ProductOrServiceAxis_f1a600f6-7548-401e-b183-977f127913d7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_f1a600f6-7548-401e-b183-977f127913d7_default" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_f1a600f6-7548-401e-b183-977f127913d7" xlink:to="loc_srt_ProductsAndServicesDomain_f1a600f6-7548-401e-b183-977f127913d7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_5e47860e-a197-4831-a263-99fd2a28e2b1" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_f1a600f6-7548-401e-b183-977f127913d7" xlink:to="loc_srt_ProductsAndServicesDomain_5e47860e-a197-4831-a263-99fd2a28e2b1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CasinoMember_dc58f9cc-17c5-4b21-a4f3-ba5f28a3d2c2" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CasinoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_5e47860e-a197-4831-a263-99fd2a28e2b1" xlink:to="loc_us-gaap_CasinoMember_dc58f9cc-17c5-4b21-a4f3-ba5f28a3d2c2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OccupancyMember_72bf3a6d-75aa-4d7d-997a-5d84063bce4c" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OccupancyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_5e47860e-a197-4831-a263-99fd2a28e2b1" xlink:to="loc_us-gaap_OccupancyMember_72bf3a6d-75aa-4d7d-997a-5d84063bce4c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FoodAndBeverageMember_6d382ede-a839-4780-b3cf-6633987fa3b9" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FoodAndBeverageMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_5e47860e-a197-4831-a263-99fd2a28e2b1" xlink:to="loc_us-gaap_FoodAndBeverageMember_6d382ede-a839-4780-b3cf-6633987fa3b9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EntertainmentRetailAndOtherMember_236f93b1-d16b-4ea5-b52a-6a1224e7d42b" xlink:href="wynn-20200930.xsd#wynn_EntertainmentRetailAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_5e47860e-a197-4831-a263-99fd2a28e2b1" xlink:to="loc_wynn_EntertainmentRetailAndOtherMember_236f93b1-d16b-4ea5-b52a-6a1224e7d42b" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsOfComprehensiveIncomeLossunaudited" xlink:type="simple" xlink:href="wynn-20200930.xsd#CondensedConsolidatedStatementsOfComprehensiveIncomeLossunaudited"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsOfComprehensiveIncomeLossunaudited" xlink:type="extended" id="i4c3d028ca04046808501d95daa379d4c_CondensedConsolidatedStatementsOfComprehensiveIncomeLossunaudited"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementOfStockholdersEquityunaudited" xlink:type="simple" xlink:href="wynn-20200930.xsd#CondensedConsolidatedStatementOfStockholdersEquityunaudited"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedStatementOfStockholdersEquityunaudited" xlink:type="extended" id="if66dab0921c1460090117708630e61ec_CondensedConsolidatedStatementOfStockholdersEquityunaudited">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_90efc5b4-8327-4d79-837a-3b76a027a35f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a9de26c6-5900-4c00-b24c-c93229ae7f16" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_90efc5b4-8327-4d79-837a-3b76a027a35f" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a9de26c6-5900-4c00-b24c-c93229ae7f16" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_3e0833d9-1bc4-4432-9d29-317439aa56a7" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a9de26c6-5900-4c00-b24c-c93229ae7f16" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_3e0833d9-1bc4-4432-9d29-317439aa56a7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_1ea3532a-6a14-45af-88b3-992b7f9b50e9" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a9de26c6-5900-4c00-b24c-c93229ae7f16" xlink:to="loc_us-gaap_SharesOutstanding_1ea3532a-6a14-45af-88b3-992b7f9b50e9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_e874d238-d3c1-4137-a628-f393085421c4" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a9de26c6-5900-4c00-b24c-c93229ae7f16" xlink:to="loc_us-gaap_ProfitLoss_e874d238-d3c1-4137-a628-f393085421c4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_3a95e087-a4e3-47dc-abfd-21ad4a4954ae" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a9de26c6-5900-4c00-b24c-c93229ae7f16" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_3a95e087-a4e3-47dc-abfd-21ad4a4954ae" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_793e7f14-1d58-4f81-ac63-97a802b04327" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a9de26c6-5900-4c00-b24c-c93229ae7f16" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_793e7f14-1d58-4f81-ac63-97a802b04327" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_a4acad1d-5a35-42dd-9d57-0a51d555aecc" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a9de26c6-5900-4c00-b24c-c93229ae7f16" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_a4acad1d-5a35-42dd-9d57-0a51d555aecc" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures_4dcb906b-1e1d-42fa-bdef-015f25b99b8a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a9de26c6-5900-4c00-b24c-c93229ae7f16" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures_4dcb906b-1e1d-42fa-bdef-015f25b99b8a" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_767b8749-61c6-466a-8fd1-63ec43bb680e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a9de26c6-5900-4c00-b24c-c93229ae7f16" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_767b8749-61c6-466a-8fd1-63ec43bb680e" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardForfeitures_5ebb3810-e67c-4d9f-b1eb-7d5805beeeaa" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardForfeitures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a9de26c6-5900-4c00-b24c-c93229ae7f16" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardForfeitures_5ebb3810-e67c-4d9f-b1eb-7d5805beeeaa" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited_68f1cdad-6783-4e2e-be92-05bfe8a771d8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a9de26c6-5900-4c00-b24c-c93229ae7f16" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited_68f1cdad-6783-4e2e-be92-05bfe8a771d8" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_8209ad20-e464-4a67-8a15-aa6f63e5f1e0" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a9de26c6-5900-4c00-b24c-c93229ae7f16" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_8209ad20-e464-4a67-8a15-aa6f63e5f1e0" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_e15a5598-afb7-4c1a-ab08-7ee5cd8d7e1b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TreasuryStockSharesAcquired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a9de26c6-5900-4c00-b24c-c93229ae7f16" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_e15a5598-afb7-4c1a-ab08-7ee5cd8d7e1b" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCash_427ded32-8b79-4f10-b7a7-c070d5191e1f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a9de26c6-5900-4c00-b24c-c93229ae7f16" xlink:to="loc_us-gaap_DividendsCash_427ded32-8b79-4f10-b7a7-c070d5191e1f" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_48cf3a81-cbcf-499a-ace3-5b2540835481" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a9de26c6-5900-4c00-b24c-c93229ae7f16" xlink:to="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_48cf3a81-cbcf-499a-ace3-5b2540835481" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_ad1a1aac-7991-4e5b-8e99-02bf0481c02a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a9de26c6-5900-4c00-b24c-c93229ae7f16" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_ad1a1aac-7991-4e5b-8e99-02bf0481c02a" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_ad3c2783-c710-41ed-aae3-852a3725a03b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_d38252e3-c54c-4dbb-b7d7-b8d420393ab4" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_f3c846a7-2b68-4873-8834-04dc7ec445bf" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_90efc5b4-8327-4d79-837a-3b76a027a35f" xlink:to="loc_us-gaap_StatementTable_f3c846a7-2b68-4873-8834-04dc7ec445bf" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_2c737dfb-6718-4b1c-8507-3b84eac520e6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_f3c846a7-2b68-4873-8834-04dc7ec445bf" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_2c737dfb-6718-4b1c-8507-3b84eac520e6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_2c737dfb-6718-4b1c-8507-3b84eac520e6_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_2c737dfb-6718-4b1c-8507-3b84eac520e6" xlink:to="loc_us-gaap_EquityComponentDomain_2c737dfb-6718-4b1c-8507-3b84eac520e6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_a5014714-0cb3-4e04-a086-7b3ad37c1f10" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_2c737dfb-6718-4b1c-8507-3b84eac520e6" xlink:to="loc_us-gaap_EquityComponentDomain_a5014714-0cb3-4e04-a086-7b3ad37c1f10" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ParentMember_f97e997a-db32-4acc-9b63-1cf680043961" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_a5014714-0cb3-4e04-a086-7b3ad37c1f10" xlink:to="loc_us-gaap_ParentMember_f97e997a-db32-4acc-9b63-1cf680043961" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_654e94f4-e6a9-4a92-8ec3-b2a7c7b4443b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_f97e997a-db32-4acc-9b63-1cf680043961" xlink:to="loc_us-gaap_CommonStockMember_654e94f4-e6a9-4a92-8ec3-b2a7c7b4443b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockMember_f61d3260-1da4-4d5d-8559-000d6eb05c48" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TreasuryStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_f97e997a-db32-4acc-9b63-1cf680043961" xlink:to="loc_us-gaap_TreasuryStockMember_f61d3260-1da4-4d5d-8559-000d6eb05c48" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_eaec878d-8987-459d-be7f-3dad4f5c47da" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_f97e997a-db32-4acc-9b63-1cf680043961" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_eaec878d-8987-459d-be7f-3dad4f5c47da" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_8331ac28-d85d-4c17-9a34-8bdf4fd4776f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_f97e997a-db32-4acc-9b63-1cf680043961" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_8331ac28-d85d-4c17-9a34-8bdf4fd4776f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_7c4ebc1b-2cfa-4ab4-ac2c-ab33433c4fbe" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_f97e997a-db32-4acc-9b63-1cf680043961" xlink:to="loc_us-gaap_RetainedEarningsMember_7c4ebc1b-2cfa-4ab4-ac2c-ab33433c4fbe" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestMember_7b4a95a6-e53a-41f7-85c2-5de8c18f1542" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_a5014714-0cb3-4e04-a086-7b3ad37c1f10" xlink:to="loc_us-gaap_NoncontrollingInterestMember_7b4a95a6-e53a-41f7-85c2-5de8c18f1542" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsOfCashFlowsunaudited" xlink:type="simple" xlink:href="wynn-20200930.xsd#CondensedConsolidatedStatementsOfCashFlowsunaudited"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsOfCashFlowsunaudited" xlink:type="extended" id="i026a224840924574bd17be76aa833cb8_CondensedConsolidatedStatementsOfCashFlowsunaudited"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/Organization" xlink:type="simple" xlink:href="wynn-20200930.xsd#Organization"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/Organization" xlink:type="extended" id="i01a8513c7670447dbe28de711c8d0483_Organization"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/OrganizationAdditionalInformationDetails" xlink:type="simple" xlink:href="wynn-20200930.xsd#OrganizationAdditionalInformationDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/OrganizationAdditionalInformationDetails" xlink:type="extended" id="id3b0b570dcab428296ec27defdfce090_OrganizationAdditionalInformationDetails">
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_b0439e98-503f-4438-bfe8-0710a1884110" xlink:href="wynn-20200930.xsd#wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_629badf0-1ca7-4732-ae4d-6cb78193b0ef" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MinorityInterestOwnershipPercentageByParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_b0439e98-503f-4438-bfe8-0710a1884110" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_629badf0-1ca7-4732-ae4d-6cb78193b0ef" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_d8aa9a8d-6234-4d26-83a2-5af76e75a1d3" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_b0439e98-503f-4438-bfe8-0710a1884110" xlink:to="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_d8aa9a8d-6234-4d26-83a2-5af76e75a1d3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_04ce5836-66fb-4fd2-90f4-50fc140e4f38" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_b0439e98-503f-4438-bfe8-0710a1884110" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_04ce5836-66fb-4fd2-90f4-50fc140e4f38" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_d98508b9-3db0-403a-91b9-93c9f38d3437" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_b0439e98-503f-4438-bfe8-0710a1884110" xlink:to="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_d98508b9-3db0-403a-91b9-93c9f38d3437" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_390e4f9c-8f40-4ce7-9745-4282f605885d" xlink:href="wynn-20200930.xsd#wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_b0439e98-503f-4438-bfe8-0710a1884110" xlink:to="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_390e4f9c-8f40-4ce7-9745-4282f605885d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipAxis_e8ca9065-2fec-4b22-bd35-913e4a4e7e7d" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_OwnershipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_390e4f9c-8f40-4ce7-9745-4282f605885d" xlink:to="loc_srt_OwnershipAxis_e8ca9065-2fec-4b22-bd35-913e4a4e7e7d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_e8ca9065-2fec-4b22-bd35-913e4a4e7e7d_default" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_OwnershipAxis_e8ca9065-2fec-4b22-bd35-913e4a4e7e7d" xlink:to="loc_srt_OwnershipDomain_e8ca9065-2fec-4b22-bd35-913e4a4e7e7d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_588b606a-a8de-4719-a3ed-cd3821f2b16b" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_OwnershipAxis_e8ca9065-2fec-4b22-bd35-913e4a4e7e7d" xlink:to="loc_srt_OwnershipDomain_588b606a-a8de-4719-a3ed-cd3821f2b16b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnLasVegasMember_20bcc1ca-655f-4fa4-a253-ba02d542a0b2" xlink:href="wynn-20200930.xsd#wynn_WynnLasVegasMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_588b606a-a8de-4719-a3ed-cd3821f2b16b" xlink:to="loc_wynn_WynnLasVegasMember_20bcc1ca-655f-4fa4-a253-ba02d542a0b2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnPalaceandWynnMacauMember_6555a0e2-4eb0-4ea0-a036-16777bf8054c" xlink:href="wynn-20200930.xsd#wynn_WynnPalaceandWynnMacauMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_588b606a-a8de-4719-a3ed-cd3821f2b16b" xlink:to="loc_wynn_WynnPalaceandWynnMacauMember_6555a0e2-4eb0-4ea0-a036-16777bf8054c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailJointVentureMember_75edbe3f-de20-4bb9-8351-7cdc4cc499dd" xlink:href="wynn-20200930.xsd#wynn_RetailJointVentureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_588b606a-a8de-4719-a3ed-cd3821f2b16b" xlink:to="loc_wynn_RetailJointVentureMember_75edbe3f-de20-4bb9-8351-7cdc4cc499dd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnInteractiveMember_fdb74dd1-3ad2-4cb7-bc4b-37cdfe68da21" xlink:href="wynn-20200930.xsd#wynn_WynnInteractiveMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_588b606a-a8de-4719-a3ed-cd3821f2b16b" xlink:to="loc_wynn_WynnInteractiveMember_fdb74dd1-3ad2-4cb7-bc4b-37cdfe68da21" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_126cd4b1-e89a-4e03-b5e2-414d043c4854" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_390e4f9c-8f40-4ce7-9745-4282f605885d" xlink:to="loc_us-gaap_DebtInstrumentAxis_126cd4b1-e89a-4e03-b5e2-414d043c4854" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_126cd4b1-e89a-4e03-b5e2-414d043c4854_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_126cd4b1-e89a-4e03-b5e2-414d043c4854" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_126cd4b1-e89a-4e03-b5e2-414d043c4854_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_4e27e1ad-a78a-4a45-8165-8c48c021e2e5" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_126cd4b1-e89a-4e03-b5e2-414d043c4854" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_4e27e1ad-a78a-4a45-8165-8c48c021e2e5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_9df8e633-4685-47da-b51a-4faf19a29bc1" xlink:href="wynn-20200930.xsd#wynn_SeniorRevolvingCreditFacilityDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_4e27e1ad-a78a-4a45-8165-8c48c021e2e5" xlink:to="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_9df8e633-4685-47da-b51a-4faf19a29bc1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorRevolvingCreditFacilityDue2022Member_6d834ce1-83f3-4f2c-85fe-15249c7351c9" xlink:href="wynn-20200930.xsd#wynn_SeniorRevolvingCreditFacilityDue2022Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_4e27e1ad-a78a-4a45-8165-8c48c021e2e5" xlink:to="loc_wynn_SeniorRevolvingCreditFacilityDue2022Member_6d834ce1-83f3-4f2c-85fe-15249c7351c9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_658f66a0-3542-4d7d-85b4-8de842f09042" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_390e4f9c-8f40-4ce7-9745-4282f605885d" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_658f66a0-3542-4d7d-85b4-8de842f09042" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_658f66a0-3542-4d7d-85b4-8de842f09042_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_658f66a0-3542-4d7d-85b4-8de842f09042" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_658f66a0-3542-4d7d-85b4-8de842f09042_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_4e1bc4ec-81d3-44bc-b079-0f79297f31d7" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_658f66a0-3542-4d7d-85b4-8de842f09042" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_4e1bc4ec-81d3-44bc-b079-0f79297f31d7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_4a23896a-53f3-4392-a2f0-51597b53e623" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_4e1bc4ec-81d3-44bc-b079-0f79297f31d7" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_4a23896a-53f3-4392-a2f0-51597b53e623" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_11a8c404-8d2b-4358-8d97-243278e2315b" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_390e4f9c-8f40-4ce7-9745-4282f605885d" xlink:to="loc_dei_LegalEntityAxis_11a8c404-8d2b-4358-8d97-243278e2315b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_11a8c404-8d2b-4358-8d97-243278e2315b_default" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_11a8c404-8d2b-4358-8d97-243278e2315b" xlink:to="loc_dei_EntityDomain_11a8c404-8d2b-4358-8d97-243278e2315b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_2753e6c4-001b-40f6-9770-b5538a1ab349" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_11a8c404-8d2b-4358-8d97-243278e2315b" xlink:to="loc_dei_EntityDomain_2753e6c4-001b-40f6-9770-b5538a1ab349" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnResortsFinanceLLCMember_75e4cc0b-5988-4e0b-8ac2-0c2df6423b4a" xlink:href="wynn-20200930.xsd#wynn_WynnResortsFinanceLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_2753e6c4-001b-40f6-9770-b5538a1ab349" xlink:to="loc_wynn_WynnResortsFinanceLLCMember_75e4cc0b-5988-4e0b-8ac2-0c2df6423b4a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauMember_c5d7887f-327b-47bc-adb8-0e3f3f71250f" xlink:href="wynn-20200930.xsd#wynn_WynnMacauMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_2753e6c4-001b-40f6-9770-b5538a1ab349" xlink:to="loc_wynn_WynnMacauMember_c5d7887f-327b-47bc-adb8-0e3f3f71250f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_1ae1768d-e44a-4a99-a902-83fd912cb5a8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_390e4f9c-8f40-4ce7-9745-4282f605885d" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_1ae1768d-e44a-4a99-a902-83fd912cb5a8" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_1ae1768d-e44a-4a99-a902-83fd912cb5a8_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_1ae1768d-e44a-4a99-a902-83fd912cb5a8" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_1ae1768d-e44a-4a99-a902-83fd912cb5a8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_6f2a5b86-23a8-4e13-bd64-008df18138b4" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_1ae1768d-e44a-4a99-a902-83fd912cb5a8" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_6f2a5b86-23a8-4e13-bd64-008df18138b4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_b82cbbd0-329c-464d-8a58-9dc896f3efa5" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_6f2a5b86-23a8-4e13-bd64-008df18138b4" xlink:to="loc_us-gaap_SubsequentEventMember_b82cbbd0-329c-464d-8a58-9dc896f3efa5" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/BasisofPresentationandSignificantAccountingPolicies" xlink:type="simple" xlink:href="wynn-20200930.xsd#BasisofPresentationandSignificantAccountingPolicies"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/BasisofPresentationandSignificantAccountingPolicies" xlink:type="extended" id="ia45429e1110e4602969d6eeff6bd8b04_BasisofPresentationandSignificantAccountingPolicies"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/BasisofPresentationandSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="wynn-20200930.xsd#BasisofPresentationandSignificantAccountingPoliciesPolicies"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/BasisofPresentationandSignificantAccountingPoliciesPolicies" xlink:type="extended" id="i5416283d276b4282b7ff15205b6985b9_BasisofPresentationandSignificantAccountingPoliciesPolicies"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/BasisofPresentationandSignificantAccountingPoliciesAdditionalInformationDetails" xlink:type="simple" xlink:href="wynn-20200930.xsd#BasisofPresentationandSignificantAccountingPoliciesAdditionalInformationDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/BasisofPresentationandSignificantAccountingPoliciesAdditionalInformationDetails" xlink:type="extended" id="ic2d763c2b2844420b1f0731656ed83ea_BasisofPresentationandSignificantAccountingPoliciesAdditionalInformationDetails"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CashCashEquivalentsandRestrictedCash" xlink:type="simple" xlink:href="wynn-20200930.xsd#CashCashEquivalentsandRestrictedCash"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/CashCashEquivalentsandRestrictedCash" xlink:type="extended" id="i07652af53c1949d9b83e070d10955267_CashCashEquivalentsandRestrictedCash"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CashCashEquivalentsandRestrictedCashTables" xlink:type="simple" xlink:href="wynn-20200930.xsd#CashCashEquivalentsandRestrictedCashTables"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/CashCashEquivalentsandRestrictedCashTables" xlink:type="extended" id="ia90d76e541fa44fea5535a0b70bd5883_CashCashEquivalentsandRestrictedCashTables"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CashCashEquivalentsandRestrictedCashDetails" xlink:type="simple" xlink:href="wynn-20200930.xsd#CashCashEquivalentsandRestrictedCashDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/CashCashEquivalentsandRestrictedCashDetails" xlink:type="extended" id="ia5139b5122b7408c8628ea227bb49072_CashCashEquivalentsandRestrictedCashDetails"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/Receivablesnet" xlink:type="simple" xlink:href="wynn-20200930.xsd#Receivablesnet"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/Receivablesnet" xlink:type="extended" id="i79fc4eb15e9743a6b61cfbd5acedc911_Receivablesnet"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/ReceivablesnetTables" xlink:type="simple" xlink:href="wynn-20200930.xsd#ReceivablesnetTables"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/ReceivablesnetTables" xlink:type="extended" id="i9dcc9385805145e780c91bc005af2810_ReceivablesnetTables"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/ReceivablesnetDetails" xlink:type="simple" xlink:href="wynn-20200930.xsd#ReceivablesnetDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/ReceivablesnetDetails" xlink:type="extended" id="i79100e65b9bb4392b93c710d7525a2d0_ReceivablesnetDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_e578aad1-de0d-45e7-b94e-2e5dd368861c" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableGrossCurrent_67fbb874-f972-45e0-8301-eb4269e681e3" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountsReceivableGrossCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_e578aad1-de0d-45e7-b94e-2e5dd368861c" xlink:to="loc_us-gaap_AccountsReceivableGrossCurrent_67fbb874-f972-45e0-8301-eb4269e681e3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_f9090c6a-45d2-4093-93ff-1ea6a753f3b0" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_e578aad1-de0d-45e7-b94e-2e5dd368861c" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_f9090c6a-45d2-4093-93ff-1ea6a753f3b0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_1a73b35b-dc87-45bb-9370-82b96cb47789" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_e578aad1-de0d-45e7-b94e-2e5dd368861c" xlink:to="loc_us-gaap_ReceivablesNetCurrent_1a73b35b-dc87-45bb-9370-82b96cb47789" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_a9d663aa-3adb-45f6-8d6c-cd54b72cf0fc" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_e578aad1-de0d-45e7-b94e-2e5dd368861c" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_a9d663aa-3adb-45f6-8d6c-cd54b72cf0fc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_AccountsReceivableAllowanceForCreditLossPercentOfGrossCasinoReceivables_b002f3f1-ac63-419c-ad28-86ada5618a08" xlink:href="wynn-20200930.xsd#wynn_AccountsReceivableAllowanceForCreditLossPercentOfGrossCasinoReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_e578aad1-de0d-45e7-b94e-2e5dd368861c" xlink:to="loc_wynn_AccountsReceivableAllowanceForCreditLossPercentOfGrossCasinoReceivables_b002f3f1-ac63-419c-ad28-86ada5618a08" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_d992cff3-efd0-4e43-b530-0c51a832b067" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_e578aad1-de0d-45e7-b94e-2e5dd368861c" xlink:to="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_d992cff3-efd0-4e43-b530-0c51a832b067" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_89de8d52-c92c-4b67-bf6d-cce16d3c9b65" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_d992cff3-efd0-4e43-b530-0c51a832b067" xlink:to="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_89de8d52-c92c-4b67-bf6d-cce16d3c9b65" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_89de8d52-c92c-4b67-bf6d-cce16d3c9b65_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LegalEntityTypeOfCounterpartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_89de8d52-c92c-4b67-bf6d-cce16d3c9b65" xlink:to="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_89de8d52-c92c-4b67-bf6d-cce16d3c9b65_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_06733039-f191-4c77-945e-915e8aeae251" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LegalEntityTypeOfCounterpartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_89de8d52-c92c-4b67-bf6d-cce16d3c9b65" xlink:to="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_06733039-f191-4c77-945e-915e8aeae251" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CasinoMember_2f70b990-6ac8-4613-806d-0233e13880bf" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CasinoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_06733039-f191-4c77-945e-915e8aeae251" xlink:to="loc_us-gaap_CasinoMember_2f70b990-6ac8-4613-806d-0233e13880bf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_HotelMember_2cf630a1-5e3d-4fd9-9626-90a8ae275538" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_HotelMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_06733039-f191-4c77-945e-915e8aeae251" xlink:to="loc_srt_HotelMember_2cf630a1-5e3d-4fd9-9626-90a8ae275538" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailLeasesAndOtherMember_16d3da4e-9218-458c-a770-1f81a0252caa" xlink:href="wynn-20200930.xsd#wynn_RetailLeasesAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_06733039-f191-4c77-945e-915e8aeae251" xlink:to="loc_wynn_RetailLeasesAndOtherMember_16d3da4e-9218-458c-a770-1f81a0252caa" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_36726456-f708-4add-888f-b1902de77e6d" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_d992cff3-efd0-4e43-b530-0c51a832b067" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_36726456-f708-4add-888f-b1902de77e6d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_36726456-f708-4add-888f-b1902de77e6d_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_36726456-f708-4add-888f-b1902de77e6d" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_36726456-f708-4add-888f-b1902de77e6d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_3b843bf2-8798-4f2b-be5b-f53a73b29aa6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_36726456-f708-4add-888f-b1902de77e6d" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_3b843bf2-8798-4f2b-be5b-f53a73b29aa6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeographicConcentrationRiskMember_09f78bc9-1eaf-4f3f-9073-5923f125f961" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GeographicConcentrationRiskMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_3b843bf2-8798-4f2b-be5b-f53a73b29aa6" xlink:to="loc_us-gaap_GeographicConcentrationRiskMember_09f78bc9-1eaf-4f3f-9073-5923f125f961" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_dd0743c1-5294-4ddb-a76b-5eee26a2fbec" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_d992cff3-efd0-4e43-b530-0c51a832b067" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_dd0743c1-5294-4ddb-a76b-5eee26a2fbec" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_dd0743c1-5294-4ddb-a76b-5eee26a2fbec_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_dd0743c1-5294-4ddb-a76b-5eee26a2fbec" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_dd0743c1-5294-4ddb-a76b-5eee26a2fbec_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_c2b781fd-29be-40d1-9363-a2e725e4426e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_dd0743c1-5294-4ddb-a76b-5eee26a2fbec" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_c2b781fd-29be-40d1-9363-a2e725e4426e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableMember_94012352-190d-486d-a94b-af6467d07b48" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountsReceivableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_c2b781fd-29be-40d1-9363-a2e725e4426e" xlink:to="loc_us-gaap_AccountsReceivableMember_94012352-190d-486d-a94b-af6467d07b48" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_f29eaed3-70e2-4b1f-9f25-9ef5d5c0cf6e" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_d992cff3-efd0-4e43-b530-0c51a832b067" xlink:to="loc_srt_StatementGeographicalAxis_f29eaed3-70e2-4b1f-9f25-9ef5d5c0cf6e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_f29eaed3-70e2-4b1f-9f25-9ef5d5c0cf6e_default" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_f29eaed3-70e2-4b1f-9f25-9ef5d5c0cf6e" xlink:to="loc_srt_SegmentGeographicalDomain_f29eaed3-70e2-4b1f-9f25-9ef5d5c0cf6e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_4cd08f33-33e5-42f2-9cc8-58e855e10762" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_f29eaed3-70e2-4b1f-9f25-9ef5d5c0cf6e" xlink:to="loc_srt_SegmentGeographicalDomain_4cd08f33-33e5-42f2-9cc8-58e855e10762" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_AsiaMember_4af3ca27-6919-435c-96f7-2d544a46bf42" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_AsiaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_4cd08f33-33e5-42f2-9cc8-58e855e10762" xlink:to="loc_srt_AsiaMember_4af3ca27-6919-435c-96f7-2d544a46bf42" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/ReceivablesnetScheduleofMovementinAllowanceforCreditLossesRecognizedforReceivablesDetails" xlink:type="simple" xlink:href="wynn-20200930.xsd#ReceivablesnetScheduleofMovementinAllowanceforCreditLossesRecognizedforReceivablesDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/ReceivablesnetScheduleofMovementinAllowanceforCreditLossesRecognizedforReceivablesDetails" xlink:type="extended" id="ica0b56b7db274693b90434d54d3a65ee_ReceivablesnetScheduleofMovementinAllowanceforCreditLossesRecognizedforReceivablesDetails"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/PropertyandEquipmentnet" xlink:type="simple" xlink:href="wynn-20200930.xsd#PropertyandEquipmentnet"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/PropertyandEquipmentnet" xlink:type="extended" id="iec0cd4257418457f9815a5076e9070a9_PropertyandEquipmentnet"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/PropertyandEquipmentnetTables" xlink:type="simple" xlink:href="wynn-20200930.xsd#PropertyandEquipmentnetTables"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/PropertyandEquipmentnetTables" xlink:type="extended" id="i606a42b82fd348189c6ffb03301b4f56_PropertyandEquipmentnetTables"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/PropertyandEquipmentnetScheduleofPropertyandEquipmentNetDetail" xlink:type="simple" xlink:href="wynn-20200930.xsd#PropertyandEquipmentnetScheduleofPropertyandEquipmentNetDetail"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/PropertyandEquipmentnetScheduleofPropertyandEquipmentNetDetail" xlink:type="extended" id="i94d076be434e433da85e21f78d84ea81_PropertyandEquipmentnetScheduleofPropertyandEquipmentNetDetail"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebt" xlink:type="simple" xlink:href="wynn-20200930.xsd#LongTermDebt"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/LongTermDebt" xlink:type="extended" id="i342f4d8052c445d9b967317846eef8e1_LongTermDebt"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebtTables" xlink:type="simple" xlink:href="wynn-20200930.xsd#LongTermDebtTables"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/LongTermDebtTables" xlink:type="extended" id="ibe2cc60c5fb9484f944e6ebddccf35f4_LongTermDebtTables"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebtSummaryofLongTermDebtDetail" xlink:type="simple" xlink:href="wynn-20200930.xsd#LongTermDebtSummaryofLongTermDebtDetail"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/LongTermDebtSummaryofLongTermDebtDetail" xlink:type="extended" id="i46d30acf25de465e86f98fcfabc0dcc4_LongTermDebtSummaryofLongTermDebtDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_603e798d-71d6-43ad-b32e-ca76870ee39b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_920c9905-8a07-4155-8f8a-45c12a165c2a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_603e798d-71d6-43ad-b32e-ca76870ee39b" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_920c9905-8a07-4155-8f8a-45c12a165c2a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_f36f1726-e376-4e57-b93b-85dcf30fa3b6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_603e798d-71d6-43ad-b32e-ca76870ee39b" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_f36f1726-e376-4e57-b93b-85dcf30fa3b6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_a5e0d473-b190-47f8-9809-795ec5d9120c" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_603e798d-71d6-43ad-b32e-ca76870ee39b" xlink:to="loc_us-gaap_LongTermDebt_a5e0d473-b190-47f8-9809-795ec5d9120c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_f168fc44-2abd-4118-8797-064d2729c1ed" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_603e798d-71d6-43ad-b32e-ca76870ee39b" xlink:to="loc_us-gaap_LongTermDebtCurrent_f168fc44-2abd-4118-8797-064d2729c1ed" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_bf8180bb-4e86-410b-8cb9-c9233c326202" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_603e798d-71d6-43ad-b32e-ca76870ee39b" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_bf8180bb-4e86-410b-8cb9-c9233c326202" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_09ab0185-bdbc-488c-8363-a6aa2f172b3b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_603e798d-71d6-43ad-b32e-ca76870ee39b" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_09ab0185-bdbc-488c-8363-a6aa2f172b3b" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_ced41525-b6f8-4801-ae84-7c13da44e675" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_603e798d-71d6-43ad-b32e-ca76870ee39b" xlink:to="loc_us-gaap_DebtInstrumentTable_ced41525-b6f8-4801-ae84-7c13da44e675" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_c35544bc-1458-477b-bbd0-3d8c509539bb" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_ced41525-b6f8-4801-ae84-7c13da44e675" xlink:to="loc_dei_LegalEntityAxis_c35544bc-1458-477b-bbd0-3d8c509539bb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_c35544bc-1458-477b-bbd0-3d8c509539bb_default" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_c35544bc-1458-477b-bbd0-3d8c509539bb" xlink:to="loc_dei_EntityDomain_c35544bc-1458-477b-bbd0-3d8c509539bb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_a9ba6d3c-350a-4b27-ae59-2937e3d0723f" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_c35544bc-1458-477b-bbd0-3d8c509539bb" xlink:to="loc_dei_EntityDomain_a9ba6d3c-350a-4b27-ae59-2937e3d0723f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauMember_cc925b3c-f9fb-4db4-9dfa-9747d72e5196" xlink:href="wynn-20200930.xsd#wynn_WynnMacauMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_a9ba6d3c-350a-4b27-ae59-2937e3d0723f" xlink:to="loc_wynn_WynnMacauMember_cc925b3c-f9fb-4db4-9dfa-9747d72e5196" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauLimitedMember_2079909a-7f3f-4883-b645-8149b6299a18" xlink:href="wynn-20200930.xsd#wynn_WynnMacauLimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_a9ba6d3c-350a-4b27-ae59-2937e3d0723f" xlink:to="loc_wynn_WynnMacauLimitedMember_2079909a-7f3f-4883-b645-8149b6299a18" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnResortsFinanceLLCMember_e63cd755-a337-4e78-8f01-e325c46226f7" xlink:href="wynn-20200930.xsd#wynn_WynnResortsFinanceLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_a9ba6d3c-350a-4b27-ae59-2937e3d0723f" xlink:to="loc_wynn_WynnResortsFinanceLLCMember_e63cd755-a337-4e78-8f01-e325c46226f7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember_4b6ece00-c4a6-4c07-b007-c02f49f35e66" xlink:href="wynn-20200930.xsd#wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_a9ba6d3c-350a-4b27-ae59-2937e3d0723f" xlink:to="loc_wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember_4b6ece00-c4a6-4c07-b007-c02f49f35e66" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember_7f1f90fc-84fb-4135-b30e-9ee029a9bb7b" xlink:href="wynn-20200930.xsd#wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_a9ba6d3c-350a-4b27-ae59-2937e3d0723f" xlink:to="loc_wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember_7f1f90fc-84fb-4135-b30e-9ee029a9bb7b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_90f781b1-d88d-49d2-8692-4afcf9bc2ddd" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_ced41525-b6f8-4801-ae84-7c13da44e675" xlink:to="loc_us-gaap_DebtInstrumentAxis_90f781b1-d88d-49d2-8692-4afcf9bc2ddd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_90f781b1-d88d-49d2-8692-4afcf9bc2ddd_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_90f781b1-d88d-49d2-8692-4afcf9bc2ddd" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_90f781b1-d88d-49d2-8692-4afcf9bc2ddd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_c9563cc0-0340-478b-8245-0be3f15702fb" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_90f781b1-d88d-49d2-8692-4afcf9bc2ddd" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_c9563cc0-0340-478b-8245-0be3f15702fb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorTermLoanFacilityDue2022Member_6dc01ce7-5215-4fed-9b81-0f96219bf0c5" xlink:href="wynn-20200930.xsd#wynn_SeniorTermLoanFacilityDue2022Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_c9563cc0-0340-478b-8245-0be3f15702fb" xlink:to="loc_wynn_SeniorTermLoanFacilityDue2022Member_6dc01ce7-5215-4fed-9b81-0f96219bf0c5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorRevolvingCreditFacilityDue2022Member_9b71e389-030d-4e85-87cd-8ad8dc9d014d" xlink:href="wynn-20200930.xsd#wynn_SeniorRevolvingCreditFacilityDue2022Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_c9563cc0-0340-478b-8245-0be3f15702fb" xlink:to="loc_wynn_SeniorRevolvingCreditFacilityDue2022Member_9b71e389-030d-4e85-87cd-8ad8dc9d014d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FourandSevenOverEightPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentyFourMember_5886081d-a653-48b0-b272-f2b0865594bf" xlink:href="wynn-20200930.xsd#wynn_FourandSevenOverEightPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentyFourMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_c9563cc0-0340-478b-8245-0be3f15702fb" xlink:to="loc_wynn_FourandSevenOverEightPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentyFourMember_5886081d-a653-48b0-b272-f2b0865594bf" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentySixMember_25d334e0-37f8-4a3a-ae73-70cb4e0d2012" xlink:href="wynn-20200930.xsd#wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentySixMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_c9563cc0-0340-478b-8245-0be3f15702fb" xlink:to="loc_wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentySixMember_25d334e0-37f8-4a3a-ae73-70cb4e0d2012" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentySevenMember_82fecad8-0614-44b6-9506-a3849a8ccd29" xlink:href="wynn-20200930.xsd#wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentySevenMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_c9563cc0-0340-478b-8245-0be3f15702fb" xlink:to="loc_wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentySevenMember_82fecad8-0614-44b6-9506-a3849a8ccd29" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyNineMember_cac4d1d0-d13d-49c1-bedf-d52c6edfcc52" xlink:href="wynn-20200930.xsd#wynn_FiveAndOneOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyNineMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_c9563cc0-0340-478b-8245-0be3f15702fb" xlink:to="loc_wynn_FiveAndOneOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyNineMember_cac4d1d0-d13d-49c1-bedf-d52c6edfcc52" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndFiveOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyEightMember_270dbb87-f61f-48ab-a9d3-cac4594f8d39" xlink:href="wynn-20200930.xsd#wynn_FiveAndFiveOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyEightMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_c9563cc0-0340-478b-8245-0be3f15702fb" xlink:to="loc_wynn_FiveAndFiveOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyEightMember_270dbb87-f61f-48ab-a9d3-cac4594f8d39" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_f5146171-8054-4563-a3cb-24355c571fa4" xlink:href="wynn-20200930.xsd#wynn_WRFSeniorSecuredCreditFacilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_c9563cc0-0340-478b-8245-0be3f15702fb" xlink:to="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_f5146171-8054-4563-a3cb-24355c571fa4" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorTermLoanFacilityDue2024Member_6af0a722-8d32-4ad6-af36-8df9a254f539" xlink:href="wynn-20200930.xsd#wynn_SeniorTermLoanFacilityDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_f5146171-8054-4563-a3cb-24355c571fa4" xlink:to="loc_wynn_SeniorTermLoanFacilityDue2024Member_6af0a722-8d32-4ad6-af36-8df9a254f539" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_eb6ce8f3-58c8-44d2-9509-0f450dd9d44f" xlink:href="wynn-20200930.xsd#wynn_SeniorRevolvingCreditFacilityDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_f5146171-8054-4563-a3cb-24355c571fa4" xlink:to="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_eb6ce8f3-58c8-44d2-9509-0f450dd9d44f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FourAndOneOverFourPercentageWynnLasVegasSeniorNotesDueMayThirtyTwoThousandTwentyThreeMember_78143527-19c4-407c-bc3e-c049b5089774" xlink:href="wynn-20200930.xsd#wynn_FourAndOneOverFourPercentageWynnLasVegasSeniorNotesDueMayThirtyTwoThousandTwentyThreeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_c9563cc0-0340-478b-8245-0be3f15702fb" xlink:to="loc_wynn_FourAndOneOverFourPercentageWynnLasVegasSeniorNotesDueMayThirtyTwoThousandTwentyThreeMember_78143527-19c4-407c-bc3e-c049b5089774" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember_52696e47-3e29-4246-bbe4-c4ec536ed379" xlink:href="wynn-20200930.xsd#wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_c9563cc0-0340-478b-8245-0be3f15702fb" xlink:to="loc_wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember_52696e47-3e29-4246-bbe4-c4ec536ed379" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverFourPercentageSeniorNotesDueMay152027Member_66e05226-ef46-4221-869b-a68edb701ee0" xlink:href="wynn-20200930.xsd#wynn_FiveAndOneOverFourPercentageSeniorNotesDueMay152027Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_c9563cc0-0340-478b-8245-0be3f15702fb" xlink:to="loc_wynn_FiveAndOneOverFourPercentageSeniorNotesDueMay152027Member_66e05226-ef46-4221-869b-a68edb701ee0" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverEightPercentageSeniorNotesDue2029Member_184d4242-4eb8-4c65-a8c8-80989326bb7e" xlink:href="wynn-20200930.xsd#wynn_FiveAndOneOverEightPercentageSeniorNotesDue2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_c9563cc0-0340-478b-8245-0be3f15702fb" xlink:to="loc_wynn_FiveAndOneOverEightPercentageSeniorNotesDue2029Member_184d4242-4eb8-4c65-a8c8-80989326bb7e" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SevenAndThreeOverFourPercentageWRFSeniorNotesDue2025Member_8cbbd705-84b7-486b-8938-e33ea986d3b3" xlink:href="wynn-20200930.xsd#wynn_SevenAndThreeOverFourPercentageWRFSeniorNotesDue2025Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_c9563cc0-0340-478b-8245-0be3f15702fb" xlink:to="loc_wynn_SevenAndThreeOverFourPercentageWRFSeniorNotesDue2025Member_8cbbd705-84b7-486b-8938-e33ea986d3b3" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailTermLoanAgreementMember_042e6c4b-2519-4b11-a97f-bdfe426238e8" xlink:href="wynn-20200930.xsd#wynn_RetailTermLoanAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_c9563cc0-0340-478b-8245-0be3f15702fb" xlink:to="loc_wynn_RetailTermLoanAgreementMember_042e6c4b-2519-4b11-a97f-bdfe426238e8" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_99cf9efc-0591-4624-a41c-cc8c16655643" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_ced41525-b6f8-4801-ae84-7c13da44e675" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_99cf9efc-0591-4624-a41c-cc8c16655643" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_99cf9efc-0591-4624-a41c-cc8c16655643_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_99cf9efc-0591-4624-a41c-cc8c16655643" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_99cf9efc-0591-4624-a41c-cc8c16655643_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_9b91bc2a-d62d-4d01-a2b3-17a5bcc64ea8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_99cf9efc-0591-4624-a41c-cc8c16655643" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_9b91bc2a-d62d-4d01-a2b3-17a5bcc64ea8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredDebtMember_fb320126-1772-4859-95af-682487584a51" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuredDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_9b91bc2a-d62d-4d01-a2b3-17a5bcc64ea8" xlink:to="loc_us-gaap_SecuredDebtMember_fb320126-1772-4859-95af-682487584a51" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_dc134ba7-5484-400a-aa06-6c0f1ba529b6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_9b91bc2a-d62d-4d01-a2b3-17a5bcc64ea8" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_dc134ba7-5484-400a-aa06-6c0f1ba529b6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_544a74f5-c408-4904-ad0b-91fd1ff38e9f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_9b91bc2a-d62d-4d01-a2b3-17a5bcc64ea8" xlink:to="loc_us-gaap_SeniorNotesMember_544a74f5-c408-4904-ad0b-91fd1ff38e9f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MediumTermNotesMember_4d9ac1e9-c424-49b5-be84-c780f0687e5b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MediumTermNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_9b91bc2a-d62d-4d01-a2b3-17a5bcc64ea8" xlink:to="loc_us-gaap_MediumTermNotesMember_4d9ac1e9-c424-49b5-be84-c780f0687e5b" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebtSummaryofLongTermDebtAdditionalInformationDetail" xlink:type="simple" xlink:href="wynn-20200930.xsd#LongTermDebtSummaryofLongTermDebtAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/LongTermDebtSummaryofLongTermDebtAdditionalInformationDetail" xlink:type="extended" id="iaed91bc9799f4f8b94413a3a1b459e6f_LongTermDebtSummaryofLongTermDebtAdditionalInformationDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_9444d2a9-2e53-446f-849a-6eaa792a4584" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_cff082b3-9329-4cbe-b77d-1e5211559461" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_9444d2a9-2e53-446f-849a-6eaa792a4584" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_cff082b3-9329-4cbe-b77d-1e5211559461" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_d90f0d27-8709-4e70-b55d-0e4c2fd4dfc9" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_9444d2a9-2e53-446f-849a-6eaa792a4584" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_d90f0d27-8709-4e70-b55d-0e4c2fd4dfc9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_17de4c83-d87b-47f8-ac84-434f24f2e8a1" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentInterestRateDuringPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_9444d2a9-2e53-446f-849a-6eaa792a4584" xlink:to="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_17de4c83-d87b-47f8-ac84-434f24f2e8a1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_a4357805-ca0b-41da-82c6-5f0d52637046" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_9444d2a9-2e53-446f-849a-6eaa792a4584" xlink:to="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_a4357805-ca0b-41da-82c6-5f0d52637046" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LettersOfCreditOutstandingAmount_e791afe7-82da-455e-9f7d-77043189ec44" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LettersOfCreditOutstandingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_9444d2a9-2e53-446f-849a-6eaa792a4584" xlink:to="loc_us-gaap_LettersOfCreditOutstandingAmount_e791afe7-82da-455e-9f7d-77043189ec44" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_a079b1f6-aa97-483b-bc3c-6d759f8eb767" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_9444d2a9-2e53-446f-849a-6eaa792a4584" xlink:to="loc_us-gaap_DebtInstrumentTable_a079b1f6-aa97-483b-bc3c-6d759f8eb767" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_ce6c987f-1a42-4fab-a80e-5a6ec24b2454" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableRateAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_a079b1f6-aa97-483b-bc3c-6d759f8eb767" xlink:to="loc_us-gaap_VariableRateAxis_ce6c987f-1a42-4fab-a80e-5a6ec24b2454" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_ce6c987f-1a42-4fab-a80e-5a6ec24b2454_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableRateAxis_ce6c987f-1a42-4fab-a80e-5a6ec24b2454" xlink:to="loc_us-gaap_VariableRateDomain_ce6c987f-1a42-4fab-a80e-5a6ec24b2454_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_d386e2f2-34f2-4432-b6fb-90a239abc925" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableRateAxis_ce6c987f-1a42-4fab-a80e-5a6ec24b2454" xlink:to="loc_us-gaap_VariableRateDomain_d386e2f2-34f2-4432-b6fb-90a239abc925" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_1cb55224-9ece-4714-ba33-f3413ff32f4c" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LondonInterbankOfferedRateLIBORMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_d386e2f2-34f2-4432-b6fb-90a239abc925" xlink:to="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_1cb55224-9ece-4714-ba33-f3413ff32f4c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_HIBORMember_fddc2a76-b181-4eee-89c8-c0603820e3dc" xlink:href="wynn-20200930.xsd#wynn_HIBORMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_d386e2f2-34f2-4432-b6fb-90a239abc925" xlink:to="loc_wynn_HIBORMember_fddc2a76-b181-4eee-89c8-c0603820e3dc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_0a297336-e663-4a96-afb7-1b1b5fa7fabb" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_a079b1f6-aa97-483b-bc3c-6d759f8eb767" xlink:to="loc_dei_LegalEntityAxis_0a297336-e663-4a96-afb7-1b1b5fa7fabb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_0a297336-e663-4a96-afb7-1b1b5fa7fabb_default" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_0a297336-e663-4a96-afb7-1b1b5fa7fabb" xlink:to="loc_dei_EntityDomain_0a297336-e663-4a96-afb7-1b1b5fa7fabb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_8703e766-0182-4378-9d56-ec96eddcf339" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_0a297336-e663-4a96-afb7-1b1b5fa7fabb" xlink:to="loc_dei_EntityDomain_8703e766-0182-4378-9d56-ec96eddcf339" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauMember_d03f60d7-38f7-4d70-912d-7e64252ad41f" xlink:href="wynn-20200930.xsd#wynn_WynnMacauMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_8703e766-0182-4378-9d56-ec96eddcf339" xlink:to="loc_wynn_WynnMacauMember_d03f60d7-38f7-4d70-912d-7e64252ad41f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnResortsFinanceLLCMember_d0d5535c-a345-4b7f-b943-dca2345566be" xlink:href="wynn-20200930.xsd#wynn_WynnResortsFinanceLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_8703e766-0182-4378-9d56-ec96eddcf339" xlink:to="loc_wynn_WynnResortsFinanceLLCMember_d0d5535c-a345-4b7f-b943-dca2345566be" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember_d720f295-2b59-4445-932f-c30f8cf7b92c" xlink:href="wynn-20200930.xsd#wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_8703e766-0182-4378-9d56-ec96eddcf339" xlink:to="loc_wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember_d720f295-2b59-4445-932f-c30f8cf7b92c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_2a3e030f-026a-4c48-af2a-0fc6ad36a747" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_a079b1f6-aa97-483b-bc3c-6d759f8eb767" xlink:to="loc_us-gaap_DebtInstrumentAxis_2a3e030f-026a-4c48-af2a-0fc6ad36a747" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_2a3e030f-026a-4c48-af2a-0fc6ad36a747_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_2a3e030f-026a-4c48-af2a-0fc6ad36a747" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_2a3e030f-026a-4c48-af2a-0fc6ad36a747_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_be5e497e-aa47-40ca-91bc-70c87beba9c2" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_2a3e030f-026a-4c48-af2a-0fc6ad36a747" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_be5e497e-aa47-40ca-91bc-70c87beba9c2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauCreditFacilitiesMember_01df8afd-7d15-4e60-b1c0-4374328f1c5c" xlink:href="wynn-20200930.xsd#wynn_WynnMacauCreditFacilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_be5e497e-aa47-40ca-91bc-70c87beba9c2" xlink:to="loc_wynn_WynnMacauCreditFacilitiesMember_01df8afd-7d15-4e60-b1c0-4374328f1c5c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorTermLoanFacilityDue2022Member_a18112ee-4901-4ea9-ae65-73654ee2dfc2" xlink:href="wynn-20200930.xsd#wynn_SeniorTermLoanFacilityDue2022Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_WynnMacauCreditFacilitiesMember_01df8afd-7d15-4e60-b1c0-4374328f1c5c" xlink:to="loc_wynn_SeniorTermLoanFacilityDue2022Member_a18112ee-4901-4ea9-ae65-73654ee2dfc2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorRevolvingCreditFacilityDue2022Member_383b557f-8fcb-4db2-80fd-80a2e51162cd" xlink:href="wynn-20200930.xsd#wynn_SeniorRevolvingCreditFacilityDue2022Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_WynnMacauCreditFacilitiesMember_01df8afd-7d15-4e60-b1c0-4374328f1c5c" xlink:to="loc_wynn_SeniorRevolvingCreditFacilityDue2022Member_383b557f-8fcb-4db2-80fd-80a2e51162cd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_f926fe60-bef8-4a52-b28c-b242f4f6b702" xlink:href="wynn-20200930.xsd#wynn_WRFSeniorSecuredCreditFacilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_be5e497e-aa47-40ca-91bc-70c87beba9c2" xlink:to="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_f926fe60-bef8-4a52-b28c-b242f4f6b702" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_516fb983-8bcd-4f02-bc97-ee498dd67240" xlink:href="wynn-20200930.xsd#wynn_SeniorRevolvingCreditFacilityDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_f926fe60-bef8-4a52-b28c-b242f4f6b702" xlink:to="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_516fb983-8bcd-4f02-bc97-ee498dd67240" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailTermLoanAgreementMember_ee8fa44d-a3ad-4513-b8a9-aef6df78aa27" xlink:href="wynn-20200930.xsd#wynn_RetailTermLoanAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_be5e497e-aa47-40ca-91bc-70c87beba9c2" xlink:to="loc_wynn_RetailTermLoanAgreementMember_ee8fa44d-a3ad-4513-b8a9-aef6df78aa27" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_0a2e5fa2-73ee-42fa-9b9a-ffe7485d5631" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_a079b1f6-aa97-483b-bc3c-6d759f8eb767" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_0a2e5fa2-73ee-42fa-9b9a-ffe7485d5631" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_0a2e5fa2-73ee-42fa-9b9a-ffe7485d5631_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_0a2e5fa2-73ee-42fa-9b9a-ffe7485d5631" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_0a2e5fa2-73ee-42fa-9b9a-ffe7485d5631_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_522ae39d-80df-4740-9175-b938e3a55fdd" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_0a2e5fa2-73ee-42fa-9b9a-ffe7485d5631" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_522ae39d-80df-4740-9175-b938e3a55fdd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredDebtMember_ddce3abf-1988-44e2-8a8c-348c688b8a4e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuredDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_522ae39d-80df-4740-9175-b938e3a55fdd" xlink:to="loc_us-gaap_SecuredDebtMember_ddce3abf-1988-44e2-8a8c-348c688b8a4e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_4aed8127-4ef2-480c-8055-de236dbd8032" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_522ae39d-80df-4740-9175-b938e3a55fdd" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_4aed8127-4ef2-480c-8055-de236dbd8032" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MediumTermNotesMember_b94ebdfa-2a10-4585-b39f-e54353a4b3ef" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MediumTermNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_522ae39d-80df-4740-9175-b938e3a55fdd" xlink:to="loc_us-gaap_MediumTermNotesMember_b94ebdfa-2a10-4585-b39f-e54353a4b3ef" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebtAdditionalInformationDetail" xlink:type="simple" xlink:href="wynn-20200930.xsd#LongTermDebtAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/LongTermDebtAdditionalInformationDetail" xlink:type="extended" id="i9d35ba54de924de590e9661dc937466d_LongTermDebtAdditionalInformationDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_7d6172b3-7b7b-419a-a9e7-6054f33bb938" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_61822bcd-9fd8-49d0-8237-f46d2f47017c" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7d6172b3-7b7b-419a-a9e7-6054f33bb938" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_61822bcd-9fd8-49d0-8237-f46d2f47017c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_b5bcc5aa-d67c-45b3-ba7a-1edadd43aea6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7d6172b3-7b7b-419a-a9e7-6054f33bb938" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_b5bcc5aa-d67c-45b3-ba7a-1edadd43aea6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_DebtInstrumentRedemptionPercentageRedeemableFromCashProceedsFromEquityOfferingsMaximum_d2cad9f4-27b8-4ad1-bd03-f14af1de4947" xlink:href="wynn-20200930.xsd#wynn_DebtInstrumentRedemptionPercentageRedeemableFromCashProceedsFromEquityOfferingsMaximum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7d6172b3-7b7b-419a-a9e7-6054f33bb938" xlink:to="loc_wynn_DebtInstrumentRedemptionPercentageRedeemableFromCashProceedsFromEquityOfferingsMaximum_d2cad9f4-27b8-4ad1-bd03-f14af1de4947" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_DebtInstrumentRedemptionPricePercentageRedeemableFromCashProceedsFromEquityOfferings_c021b00f-615e-419d-a71b-4e228e8cbbc8" xlink:href="wynn-20200930.xsd#wynn_DebtInstrumentRedemptionPricePercentageRedeemableFromCashProceedsFromEquityOfferings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7d6172b3-7b7b-419a-a9e7-6054f33bb938" xlink:to="loc_wynn_DebtInstrumentRedemptionPricePercentageRedeemableFromCashProceedsFromEquityOfferings_c021b00f-615e-419d-a71b-4e228e8cbbc8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_86d1722d-6cd9-4b02-981d-fa4de4b83a09" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentRedemptionPricePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7d6172b3-7b7b-419a-a9e7-6054f33bb938" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_86d1722d-6cd9-4b02-981d-fa4de4b83a09" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_DebtInstrumentCovenantRequiredRedemptionMinimumConsecutivePeriod_0cad8472-3241-421d-aa88-24b05e3581d5" xlink:href="wynn-20200930.xsd#wynn_DebtInstrumentCovenantRequiredRedemptionMinimumConsecutivePeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7d6172b3-7b7b-419a-a9e7-6054f33bb938" xlink:to="loc_wynn_DebtInstrumentCovenantRequiredRedemptionMinimumConsecutivePeriod_0cad8472-3241-421d-aa88-24b05e3581d5" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_PaymentDefaultClassificationPeriodForInterestPayment_e2995eed-3d96-466b-9a92-1de14b7af6bb" xlink:href="wynn-20200930.xsd#wynn_PaymentDefaultClassificationPeriodForInterestPayment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7d6172b3-7b7b-419a-a9e7-6054f33bb938" xlink:to="loc_wynn_PaymentDefaultClassificationPeriodForInterestPayment_e2995eed-3d96-466b-9a92-1de14b7af6bb" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_DebtInstrumentEventOfDefaultFailureToPayUnfavorableJudgementsMaximumAllowableAmount_e2f058c1-8ca5-4824-89f6-d12e6e15f469" xlink:href="wynn-20200930.xsd#wynn_DebtInstrumentEventOfDefaultFailureToPayUnfavorableJudgementsMaximumAllowableAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7d6172b3-7b7b-419a-a9e7-6054f33bb938" xlink:to="loc_wynn_DebtInstrumentEventOfDefaultFailureToPayUnfavorableJudgementsMaximumAllowableAmount_e2f058c1-8ca5-4824-89f6-d12e6e15f469" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_d77caf46-8bb8-4dd6-9cab-81ca59555192" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7d6172b3-7b7b-419a-a9e7-6054f33bb938" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_d77caf46-8bb8-4dd6-9cab-81ca59555192" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_15177b3b-a7dd-44be-b6c3-9aeb75521455" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7d6172b3-7b7b-419a-a9e7-6054f33bb938" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_15177b3b-a7dd-44be-b6c3-9aeb75521455" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_DebtInstrumentDebtDefaultOptiontoAccelerateAmountsDueMinimumPercentageofAggregatePrincipalAmountofDebtHeld_a00222ba-c934-4fb9-8215-a50c84bc008c" xlink:href="wynn-20200930.xsd#wynn_DebtInstrumentDebtDefaultOptiontoAccelerateAmountsDueMinimumPercentageofAggregatePrincipalAmountofDebtHeld"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7d6172b3-7b7b-419a-a9e7-6054f33bb938" xlink:to="loc_wynn_DebtInstrumentDebtDefaultOptiontoAccelerateAmountsDueMinimumPercentageofAggregatePrincipalAmountofDebtHeld_a00222ba-c934-4fb9-8215-a50c84bc008c" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_DebtInstrumentCovenantTermsMinimumLiquidityRequirement_27df0709-fc4e-4b73-9a97-8b7fc0231e86" xlink:href="wynn-20200930.xsd#wynn_DebtInstrumentCovenantTermsMinimumLiquidityRequirement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7d6172b3-7b7b-419a-a9e7-6054f33bb938" xlink:to="loc_wynn_DebtInstrumentCovenantTermsMinimumLiquidityRequirement_27df0709-fc4e-4b73-9a97-8b7fc0231e86" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_DebtInstrumentCovenantTermsMaximumConsolidatedFirstLienNetLeverageRatio_5b4da838-f61c-4da9-af8c-1759ab78ff72" xlink:href="wynn-20200930.xsd#wynn_DebtInstrumentCovenantTermsMaximumConsolidatedFirstLienNetLeverageRatio"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7d6172b3-7b7b-419a-a9e7-6054f33bb938" xlink:to="loc_wynn_DebtInstrumentCovenantTermsMaximumConsolidatedFirstLienNetLeverageRatio_5b4da838-f61c-4da9-af8c-1759ab78ff72" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_DebtInstrumentFairValueExcludingTheRedemptionNote_97064d39-86b6-4854-83bb-10339824fd30" xlink:href="wynn-20200930.xsd#wynn_DebtInstrumentFairValueExcludingTheRedemptionNote"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7d6172b3-7b7b-419a-a9e7-6054f33bb938" xlink:to="loc_wynn_DebtInstrumentFairValueExcludingTheRedemptionNote_97064d39-86b6-4854-83bb-10339824fd30" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_LongTermDebtExcludingRedemptionNote_8bf118ee-f5c6-4d62-bb08-4578f82ebe27" xlink:href="wynn-20200930.xsd#wynn_LongTermDebtExcludingRedemptionNote"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7d6172b3-7b7b-419a-a9e7-6054f33bb938" xlink:to="loc_wynn_LongTermDebtExcludingRedemptionNote_8bf118ee-f5c6-4d62-bb08-4578f82ebe27" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_cf992d09-7874-4143-8823-51ba3ff98755" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7d6172b3-7b7b-419a-a9e7-6054f33bb938" xlink:to="loc_us-gaap_DebtInstrumentTable_cf992d09-7874-4143-8823-51ba3ff98755" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_dfe44155-211c-400e-99e0-f67d8964dda3" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_cf992d09-7874-4143-8823-51ba3ff98755" xlink:to="loc_dei_LegalEntityAxis_dfe44155-211c-400e-99e0-f67d8964dda3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_dfe44155-211c-400e-99e0-f67d8964dda3_default" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_dfe44155-211c-400e-99e0-f67d8964dda3" xlink:to="loc_dei_EntityDomain_dfe44155-211c-400e-99e0-f67d8964dda3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_aaa34458-f4ba-492a-bde0-58ba5c24d9c1" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_dfe44155-211c-400e-99e0-f67d8964dda3" xlink:to="loc_dei_EntityDomain_aaa34458-f4ba-492a-bde0-58ba5c24d9c1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauLimitedMember_8a909055-017d-4006-87c3-37ea1895927a" xlink:href="wynn-20200930.xsd#wynn_WynnMacauLimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_aaa34458-f4ba-492a-bde0-58ba5c24d9c1" xlink:to="loc_wynn_WynnMacauLimitedMember_8a909055-017d-4006-87c3-37ea1895927a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnResortsFinanceLLCMember_26ed75e3-1e05-46fa-a81a-393dbdb88924" xlink:href="wynn-20200930.xsd#wynn_WynnResortsFinanceLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_aaa34458-f4ba-492a-bde0-58ba5c24d9c1" xlink:to="loc_wynn_WynnResortsFinanceLLCMember_26ed75e3-1e05-46fa-a81a-393dbdb88924" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauMember_9d18ae24-bd68-4898-ae88-930913146ff8" xlink:href="wynn-20200930.xsd#wynn_WynnMacauMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_aaa34458-f4ba-492a-bde0-58ba5c24d9c1" xlink:to="loc_wynn_WynnMacauMember_9d18ae24-bd68-4898-ae88-930913146ff8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_ac75d402-398e-45bc-a150-3fad70c01936" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_cf992d09-7874-4143-8823-51ba3ff98755" xlink:to="loc_us-gaap_DebtInstrumentAxis_ac75d402-398e-45bc-a150-3fad70c01936" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_ac75d402-398e-45bc-a150-3fad70c01936_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_ac75d402-398e-45bc-a150-3fad70c01936" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_ac75d402-398e-45bc-a150-3fad70c01936_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_1266fa72-7de6-4c35-8094-13ccb0831c40" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_ac75d402-398e-45bc-a150-3fad70c01936" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_1266fa72-7de6-4c35-8094-13ccb0831c40" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_TwoThousandAndTwentySixAndTwoThousandAndTwentyEightWMLNotesMember_8d957928-94cd-40a2-8b67-b3a9fceaa419" xlink:href="wynn-20200930.xsd#wynn_TwoThousandAndTwentySixAndTwoThousandAndTwentyEightWMLNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1266fa72-7de6-4c35-8094-13ccb0831c40" xlink:to="loc_wynn_TwoThousandAndTwentySixAndTwoThousandAndTwentyEightWMLNotesMember_8d957928-94cd-40a2-8b67-b3a9fceaa419" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentySixMember_3a8db6ba-cafb-46bd-8d33-b51995f51a59" xlink:href="wynn-20200930.xsd#wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentySixMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_TwoThousandAndTwentySixAndTwoThousandAndTwentyEightWMLNotesMember_8d957928-94cd-40a2-8b67-b3a9fceaa419" xlink:to="loc_wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentySixMember_3a8db6ba-cafb-46bd-8d33-b51995f51a59" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndFiveOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyEightMember_016e48d6-dbf1-45ce-bb88-9936fcaa2e5f" xlink:href="wynn-20200930.xsd#wynn_FiveAndFiveOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyEightMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_TwoThousandAndTwentySixAndTwoThousandAndTwentyEightWMLNotesMember_8d957928-94cd-40a2-8b67-b3a9fceaa419" xlink:to="loc_wynn_FiveAndFiveOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyEightMember_016e48d6-dbf1-45ce-bb88-9936fcaa2e5f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorTermLoanFacilityDue2022Member_35f2866f-7e0c-4908-9067-4df593b20545" xlink:href="wynn-20200930.xsd#wynn_SeniorTermLoanFacilityDue2022Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1266fa72-7de6-4c35-8094-13ccb0831c40" xlink:to="loc_wynn_SeniorTermLoanFacilityDue2022Member_35f2866f-7e0c-4908-9067-4df593b20545" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_ade5b4e3-578c-46ff-9e43-4270b7b07784" xlink:href="wynn-20200930.xsd#wynn_WRFSeniorSecuredCreditFacilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1266fa72-7de6-4c35-8094-13ccb0831c40" xlink:to="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_ade5b4e3-578c-46ff-9e43-4270b7b07784" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverEightPercentageSeniorNotesDue2029Member_3a695143-a92e-4cf5-a18b-ab1690925cff" xlink:href="wynn-20200930.xsd#wynn_FiveAndOneOverEightPercentageSeniorNotesDue2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_ade5b4e3-578c-46ff-9e43-4270b7b07784" xlink:to="loc_wynn_FiveAndOneOverEightPercentageSeniorNotesDue2029Member_3a695143-a92e-4cf5-a18b-ab1690925cff" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SevenAndThreeOverFourPercentageWRFSeniorNotesDue2025Member_39d04a09-19f6-44c7-a2a7-3c561474450a" xlink:href="wynn-20200930.xsd#wynn_SevenAndThreeOverFourPercentageWRFSeniorNotesDue2025Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_ade5b4e3-578c-46ff-9e43-4270b7b07784" xlink:to="loc_wynn_SevenAndThreeOverFourPercentageWRFSeniorNotesDue2025Member_39d04a09-19f6-44c7-a2a7-3c561474450a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_b5699f57-614c-4b0b-9845-07fa76a5cd9f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_cf992d09-7874-4143-8823-51ba3ff98755" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_b5699f57-614c-4b0b-9845-07fa76a5cd9f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_b5699f57-614c-4b0b-9845-07fa76a5cd9f_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_b5699f57-614c-4b0b-9845-07fa76a5cd9f" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_b5699f57-614c-4b0b-9845-07fa76a5cd9f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_66154762-ed23-48f7-b679-f4fbd77b6ade" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_b5699f57-614c-4b0b-9845-07fa76a5cd9f" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_66154762-ed23-48f7-b679-f4fbd77b6ade" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_5b36b4e3-4de2-40ca-ae8d-86bd5904a0f5" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_66154762-ed23-48f7-b679-f4fbd77b6ade" xlink:to="loc_us-gaap_SeniorNotesMember_5b36b4e3-4de2-40ca-ae8d-86bd5904a0f5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_9802668c-7719-409e-9265-a9fc4e771f26" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_66154762-ed23-48f7-b679-f4fbd77b6ade" xlink:to="loc_us-gaap_LineOfCreditMember_9802668c-7719-409e-9265-a9fc4e771f26" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredDebtMember_b32f64a6-1710-48eb-a846-219c02cfd253" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuredDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_66154762-ed23-48f7-b679-f4fbd77b6ade" xlink:to="loc_us-gaap_SecuredDebtMember_b32f64a6-1710-48eb-a846-219c02cfd253" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_c59b6cf2-fa53-43f6-9cd0-cadbc673fb66" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_cf992d09-7874-4143-8823-51ba3ff98755" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_c59b6cf2-fa53-43f6-9cd0-cadbc673fb66" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_c59b6cf2-fa53-43f6-9cd0-cadbc673fb66_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_c59b6cf2-fa53-43f6-9cd0-cadbc673fb66" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_c59b6cf2-fa53-43f6-9cd0-cadbc673fb66_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_357d91f1-c982-4a5c-8fe5-6f5decaf69a1" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_c59b6cf2-fa53-43f6-9cd0-cadbc673fb66" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_357d91f1-c982-4a5c-8fe5-6f5decaf69a1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_c72427c4-a313-407e-b17b-f1d75c22e76d" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_357d91f1-c982-4a5c-8fe5-6f5decaf69a1" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_c72427c4-a313-407e-b17b-f1d75c22e76d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_16fcc8b1-368b-4530-87c1-8525a757ff59" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_357d91f1-c982-4a5c-8fe5-6f5decaf69a1" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_16fcc8b1-368b-4530-87c1-8525a757ff59" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodThreeMember_4259c86d-d0a3-46fb-98f6-c624e40f492e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodThreeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_357d91f1-c982-4a5c-8fe5-6f5decaf69a1" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodThreeMember_4259c86d-d0a3-46fb-98f6-c624e40f492e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodFourMember_71994a70-4f22-42cb-be18-18f3145f9337" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodFourMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_357d91f1-c982-4a5c-8fe5-6f5decaf69a1" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodFourMember_71994a70-4f22-42cb-be18-18f3145f9337" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodFiveMember_926d2098-2e10-42f6-9484-7850f45f0533" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodFiveMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_357d91f1-c982-4a5c-8fe5-6f5decaf69a1" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodFiveMember_926d2098-2e10-42f6-9484-7850f45f0533" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_f7e36412-eafa-4258-8daf-7ad9666f9f4a" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_cf992d09-7874-4143-8823-51ba3ff98755" xlink:to="loc_srt_RangeAxis_f7e36412-eafa-4258-8daf-7ad9666f9f4a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_f7e36412-eafa-4258-8daf-7ad9666f9f4a_default" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_f7e36412-eafa-4258-8daf-7ad9666f9f4a" xlink:to="loc_srt_RangeMember_f7e36412-eafa-4258-8daf-7ad9666f9f4a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_cbef2650-940e-4372-915f-64cc0597649c" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_f7e36412-eafa-4258-8daf-7ad9666f9f4a" xlink:to="loc_srt_RangeMember_cbef2650-940e-4372-915f-64cc0597649c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_66f625d1-4687-4742-a0ef-60f4c4af4c8b" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_cbef2650-940e-4372-915f-64cc0597649c" xlink:to="loc_srt_MaximumMember_66f625d1-4687-4742-a0ef-60f4c4af4c8b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_fd91de62-4dca-44ab-8f1e-2ce788e0cb58" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_cbef2650-940e-4372-915f-64cc0597649c" xlink:to="loc_srt_MinimumMember_fd91de62-4dca-44ab-8f1e-2ce788e0cb58" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_DebtInstrumentCovenantPeriodInEffectAxis_55fee578-ae56-4b52-94b6-f3039b328175" xlink:href="wynn-20200930.xsd#wynn_DebtInstrumentCovenantPeriodInEffectAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_cf992d09-7874-4143-8823-51ba3ff98755" xlink:to="loc_wynn_DebtInstrumentCovenantPeriodInEffectAxis_55fee578-ae56-4b52-94b6-f3039b328175" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_DebtInstrumentCovenantPeriodInEffectDomain_55fee578-ae56-4b52-94b6-f3039b328175_default" xlink:href="wynn-20200930.xsd#wynn_DebtInstrumentCovenantPeriodInEffectDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_wynn_DebtInstrumentCovenantPeriodInEffectAxis_55fee578-ae56-4b52-94b6-f3039b328175" xlink:to="loc_wynn_DebtInstrumentCovenantPeriodInEffectDomain_55fee578-ae56-4b52-94b6-f3039b328175_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_DebtInstrumentCovenantPeriodInEffectDomain_18c0fc14-6d22-4144-b438-6a1966c44787" xlink:href="wynn-20200930.xsd#wynn_DebtInstrumentCovenantPeriodInEffectDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_wynn_DebtInstrumentCovenantPeriodInEffectAxis_55fee578-ae56-4b52-94b6-f3039b328175" xlink:to="loc_wynn_DebtInstrumentCovenantPeriodInEffectDomain_18c0fc14-6d22-4144-b438-6a1966c44787" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_DuringFinancialCovenantReliefPeriodMember_452e7e6e-5bab-43cd-b20f-fd0f8855f3f5" xlink:href="wynn-20200930.xsd#wynn_DuringFinancialCovenantReliefPeriodMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_DebtInstrumentCovenantPeriodInEffectDomain_18c0fc14-6d22-4144-b438-6a1966c44787" xlink:to="loc_wynn_DuringFinancialCovenantReliefPeriodMember_452e7e6e-5bab-43cd-b20f-fd0f8855f3f5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FirstFiscalQuarterOfTheFinancialCovenantIncreasePeriodMember_7a3d0f50-41f9-4718-a1e4-00e5032ebe94" xlink:href="wynn-20200930.xsd#wynn_FirstFiscalQuarterOfTheFinancialCovenantIncreasePeriodMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_DebtInstrumentCovenantPeriodInEffectDomain_18c0fc14-6d22-4144-b438-6a1966c44787" xlink:to="loc_wynn_FirstFiscalQuarterOfTheFinancialCovenantIncreasePeriodMember_7a3d0f50-41f9-4718-a1e4-00e5032ebe94" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SecondFiscalQuarterOfTheFinancialCovenantIncreasePeriodMember_fd909602-c09c-4f36-ae34-26eefe27dc13" xlink:href="wynn-20200930.xsd#wynn_SecondFiscalQuarterOfTheFinancialCovenantIncreasePeriodMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_DebtInstrumentCovenantPeriodInEffectDomain_18c0fc14-6d22-4144-b438-6a1966c44787" xlink:to="loc_wynn_SecondFiscalQuarterOfTheFinancialCovenantIncreasePeriodMember_fd909602-c09c-4f36-ae34-26eefe27dc13" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_ThirdFiscalQuarterOfTheFinancialCovenantIncreasePeriodMember_3c22d3c7-cc3f-4711-9c01-2c6274c48254" xlink:href="wynn-20200930.xsd#wynn_ThirdFiscalQuarterOfTheFinancialCovenantIncreasePeriodMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_DebtInstrumentCovenantPeriodInEffectDomain_18c0fc14-6d22-4144-b438-6a1966c44787" xlink:to="loc_wynn_ThirdFiscalQuarterOfTheFinancialCovenantIncreasePeriodMember_3c22d3c7-cc3f-4711-9c01-2c6274c48254" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FourthFiscalQuarterAndThereafterOfTheFinancialCovenantIncreasePeriodMember_12e0e580-6ea9-4e9e-9928-59928fb96e70" xlink:href="wynn-20200930.xsd#wynn_FourthFiscalQuarterAndThereafterOfTheFinancialCovenantIncreasePeriodMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_DebtInstrumentCovenantPeriodInEffectDomain_18c0fc14-6d22-4144-b438-6a1966c44787" xlink:to="loc_wynn_FourthFiscalQuarterAndThereafterOfTheFinancialCovenantIncreasePeriodMember_12e0e580-6ea9-4e9e-9928-59928fb96e70" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/StockholdersEquity" xlink:type="simple" xlink:href="wynn-20200930.xsd#StockholdersEquity"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/StockholdersEquity" xlink:type="extended" id="id6b7adc17e7043339e949286978d413f_StockholdersEquity"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/StockholdersEquityDetails" xlink:type="simple" xlink:href="wynn-20200930.xsd#StockholdersEquityDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/StockholdersEquityDetails" xlink:type="extended" id="iecadf06aeb274efea4921ffb66076b0c_StockholdersEquityDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestLineItems_3e410c6a-9fa0-48fb-a522-67e77395a3d8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MinorityInterestLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareCashPaid_3d3367b7-8a87-423a-9f93-0b676beb1aba" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockDividendsPerShareCashPaid"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MinorityInterestLineItems_3e410c6a-9fa0-48fb-a522-67e77395a3d8" xlink:to="loc_us-gaap_CommonStockDividendsPerShareCashPaid_3d3367b7-8a87-423a-9f93-0b676beb1aba" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCash_08656618-a7fd-4c89-b63d-d48cb03b4ba6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MinorityInterestLineItems_3e410c6a-9fa0-48fb-a522-67e77395a3d8" xlink:to="loc_us-gaap_DividendsCash_08656618-a7fd-4c89-b63d-d48cb03b4ba6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromDividendsReceived_d82bffa1-2a8f-4e6f-924a-430bb752d634" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromDividendsReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MinorityInterestLineItems_3e410c6a-9fa0-48fb-a522-67e77395a3d8" xlink:to="loc_us-gaap_ProceedsFromDividendsReceived_d82bffa1-2a8f-4e6f-924a-430bb752d634" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_cd586622-63a1-47e4-a289-c884a19a7e10" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MinorityInterestLineItems_3e410c6a-9fa0-48fb-a522-67e77395a3d8" xlink:to="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_cd586622-63a1-47e4-a289-c884a19a7e10" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestTable_11226760-c137-447f-a4d4-170e36f44b53" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MinorityInterestTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_MinorityInterestLineItems_3e410c6a-9fa0-48fb-a522-67e77395a3d8" xlink:to="loc_us-gaap_MinorityInterestTable_11226760-c137-447f-a4d4-170e36f44b53" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_3b738659-cab8-4810-9416-c644b91be298" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_MinorityInterestTable_11226760-c137-447f-a4d4-170e36f44b53" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_3b738659-cab8-4810-9416-c644b91be298" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_3b738659-cab8-4810-9416-c644b91be298_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_3b738659-cab8-4810-9416-c644b91be298" xlink:to="loc_us-gaap_EquityComponentDomain_3b738659-cab8-4810-9416-c644b91be298_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_d4c46078-3bde-4300-8d20-c080858d80ed" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_3b738659-cab8-4810-9416-c644b91be298" xlink:to="loc_us-gaap_EquityComponentDomain_d4c46078-3bde-4300-8d20-c080858d80ed" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_222130bc-b125-4788-8c8b-b227048ccf16" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_d4c46078-3bde-4300-8d20-c080858d80ed" xlink:to="loc_us-gaap_RetainedEarningsMember_222130bc-b125-4788-8c8b-b227048ccf16" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesAxis_bf4b0354-f7ec-4a55-b0b2-98454a2815a3" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ConsolidatedEntitiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_MinorityInterestTable_11226760-c137-447f-a4d4-170e36f44b53" xlink:to="loc_srt_ConsolidatedEntitiesAxis_bf4b0354-f7ec-4a55-b0b2-98454a2815a3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesDomain_bf4b0354-f7ec-4a55-b0b2-98454a2815a3_default" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ConsolidatedEntitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidatedEntitiesAxis_bf4b0354-f7ec-4a55-b0b2-98454a2815a3" xlink:to="loc_srt_ConsolidatedEntitiesDomain_bf4b0354-f7ec-4a55-b0b2-98454a2815a3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesDomain_467b672a-abe0-44be-82a5-ed29241f6d88" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ConsolidatedEntitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidatedEntitiesAxis_bf4b0354-f7ec-4a55-b0b2-98454a2815a3" xlink:to="loc_srt_ConsolidatedEntitiesDomain_467b672a-abe0-44be-82a5-ed29241f6d88" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SubsidiariesMember_693739d2-7dfb-4273-ab55-f904f0306385" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SubsidiariesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidatedEntitiesDomain_467b672a-abe0-44be-82a5-ed29241f6d88" xlink:to="loc_srt_SubsidiariesMember_693739d2-7dfb-4273-ab55-f904f0306385" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_125e0865-ab71-4f91-aa8c-84d4b8f74f02" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_MinorityInterestTable_11226760-c137-447f-a4d4-170e36f44b53" xlink:to="loc_dei_LegalEntityAxis_125e0865-ab71-4f91-aa8c-84d4b8f74f02" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_125e0865-ab71-4f91-aa8c-84d4b8f74f02_default" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_125e0865-ab71-4f91-aa8c-84d4b8f74f02" xlink:to="loc_dei_EntityDomain_125e0865-ab71-4f91-aa8c-84d4b8f74f02_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_6e5bf4ee-76ed-47bc-8ec5-37ccd79a1a31" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_125e0865-ab71-4f91-aa8c-84d4b8f74f02" xlink:to="loc_dei_EntityDomain_6e5bf4ee-76ed-47bc-8ec5-37ccd79a1a31" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauLimitedMember_16eaa853-90a2-4502-aa70-12e1cde57cf8" xlink:href="wynn-20200930.xsd#wynn_WynnMacauLimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_6e5bf4ee-76ed-47bc-8ec5-37ccd79a1a31" xlink:to="loc_wynn_WynnMacauLimitedMember_16eaa853-90a2-4502-aa70-12e1cde57cf8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_d6aa2423-1db9-4f51-bb7c-78112a0065b8" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_MinorityInterestTable_11226760-c137-447f-a4d4-170e36f44b53" xlink:to="loc_srt_CounterpartyNameAxis_d6aa2423-1db9-4f51-bb7c-78112a0065b8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_d6aa2423-1db9-4f51-bb7c-78112a0065b8_default" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_d6aa2423-1db9-4f51-bb7c-78112a0065b8" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_d6aa2423-1db9-4f51-bb7c-78112a0065b8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_4f6307da-4572-4420-991c-44f6be8ceb05" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_d6aa2423-1db9-4f51-bb7c-78112a0065b8" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_4f6307da-4572-4420-991c-44f6be8ceb05" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauLimitedMember_42107e0d-c883-4b54-9e7c-b1862e9cd61f" xlink:href="wynn-20200930.xsd#wynn_WynnMacauLimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_4f6307da-4572-4420-991c-44f6be8ceb05" xlink:to="loc_wynn_WynnMacauLimitedMember_42107e0d-c883-4b54-9e7c-b1862e9cd61f" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/FairValueMeasurements" xlink:type="simple" xlink:href="wynn-20200930.xsd#FairValueMeasurements"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/FairValueMeasurements" xlink:type="extended" id="i18e780a248564c9983df418deb4c50c0_FairValueMeasurements"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/FairValueMeasurementsTables" xlink:type="simple" xlink:href="wynn-20200930.xsd#FairValueMeasurementsTables"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/FairValueMeasurementsTables" xlink:type="extended" id="idf43ac08c9b44d7fa3961dbf3190c1e8_FairValueMeasurementsTables"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/FairValueMeasurementsDetails" xlink:type="simple" xlink:href="wynn-20200930.xsd#FairValueMeasurementsDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/FairValueMeasurementsDetails" xlink:type="extended" id="i1358646c86764f88a5548198661627a5_FairValueMeasurementsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_89174e40-1314-41ee-b066-01dd6e35de73" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosureAbstract_866d0716-d2dd-4d6c-ab0f-11660ebec44f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsFairValueDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_89174e40-1314-41ee-b066-01dd6e35de73" xlink:to="loc_us-gaap_AssetsFairValueDisclosureAbstract_866d0716-d2dd-4d6c-ab0f-11660ebec44f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValue_095db060-70a4-4bff-8b1c-fdbea5eeb508" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_866d0716-d2dd-4d6c-ab0f-11660ebec44f" xlink:to="loc_us-gaap_CashEquivalentsAtCarryingValue_095db060-70a4-4bff-8b1c-fdbea5eeb508" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_09fee8a3-81b5-4af5-99ad-8bf553137eda" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_866d0716-d2dd-4d6c-ab0f-11660ebec44f" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_09fee8a3-81b5-4af5-99ad-8bf553137eda" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_6f60be92-fe68-46bf-ad18-60974ecd53ec" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_89174e40-1314-41ee-b066-01dd6e35de73" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_6f60be92-fe68-46bf-ad18-60974ecd53ec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_7a529df1-6d7d-4c44-afb9-ec355f72fa2b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_6f60be92-fe68-46bf-ad18-60974ecd53ec" xlink:to="loc_us-gaap_DerivativeLiabilities_7a529df1-6d7d-4c44-afb9-ec355f72fa2b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_8f570be2-ea9e-4049-b4ec-ac9e1d8e60d8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_89174e40-1314-41ee-b066-01dd6e35de73" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_8f570be2-ea9e-4049-b4ec-ac9e1d8e60d8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_f5757b8a-5844-47ad-b1ba-0ddcd5b5b3a6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_8f570be2-ea9e-4049-b4ec-ac9e1d8e60d8" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_f5757b8a-5844-47ad-b1ba-0ddcd5b5b3a6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_f5757b8a-5844-47ad-b1ba-0ddcd5b5b3a6_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_f5757b8a-5844-47ad-b1ba-0ddcd5b5b3a6" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_f5757b8a-5844-47ad-b1ba-0ddcd5b5b3a6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_6556fc00-1dc9-40a4-a2f4-e84d7a6d40c6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_f5757b8a-5844-47ad-b1ba-0ddcd5b5b3a6" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_6556fc00-1dc9-40a4-a2f4-e84d7a6d40c6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_263aba1d-3a02-455e-b2a5-3d4581d0e34f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_6556fc00-1dc9-40a4-a2f4-e84d7a6d40c6" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_263aba1d-3a02-455e-b2a5-3d4581d0e34f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_2cbc5988-a8fc-4acc-a58b-33c52148e807" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_8f570be2-ea9e-4049-b4ec-ac9e1d8e60d8" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_2cbc5988-a8fc-4acc-a58b-33c52148e807" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2cbc5988-a8fc-4acc-a58b-33c52148e807_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_2cbc5988-a8fc-4acc-a58b-33c52148e807" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2cbc5988-a8fc-4acc-a58b-33c52148e807_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_25700594-5267-45d2-bc81-082a5da56ca7" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_2cbc5988-a8fc-4acc-a58b-33c52148e807" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_25700594-5267-45d2-bc81-082a5da56ca7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_c24057fc-cd53-4152-ab07-73a2f197843b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_25700594-5267-45d2-bc81-082a5da56ca7" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_c24057fc-cd53-4152-ab07-73a2f197843b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_0abfda16-95d5-4efe-b5a5-ba14107bc07f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_25700594-5267-45d2-bc81-082a5da56ca7" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_0abfda16-95d5-4efe-b5a5-ba14107bc07f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_f8521b5a-0ca3-4876-8992-1b05ca39ab41" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_25700594-5267-45d2-bc81-082a5da56ca7" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_f8521b5a-0ca3-4876-8992-1b05ca39ab41" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CustomerContractLiabilities" xlink:type="simple" xlink:href="wynn-20200930.xsd#CustomerContractLiabilities"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/CustomerContractLiabilities" xlink:type="extended" id="i598716f528884dd7b8f158282f18603f_CustomerContractLiabilities"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CustomerContractLiabilitiesTables" xlink:type="simple" xlink:href="wynn-20200930.xsd#CustomerContractLiabilitiesTables"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/CustomerContractLiabilitiesTables" xlink:type="extended" id="ieeeb4f102d324c61ab6a18f6904f7bf6_CustomerContractLiabilitiesTables"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CustomerContractLiabilitiesScheduleofCustomerContractLiabilitiesDetails" xlink:type="simple" xlink:href="wynn-20200930.xsd#CustomerContractLiabilitiesScheduleofCustomerContractLiabilitiesDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/CustomerContractLiabilitiesScheduleofCustomerContractLiabilitiesDetails" xlink:type="extended" id="i3df9ae2789034d4e8a588bef6a324b1b_CustomerContractLiabilitiesScheduleofCustomerContractLiabilitiesDetails"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/StockBasedCompensation" xlink:type="simple" xlink:href="wynn-20200930.xsd#StockBasedCompensation"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/StockBasedCompensation" xlink:type="extended" id="i5317b52239fe4e5c826e7d36f3155da1_StockBasedCompensation"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/StockBasedCompensationTables" xlink:type="simple" xlink:href="wynn-20200930.xsd#StockBasedCompensationTables"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/StockBasedCompensationTables" xlink:type="extended" id="if98c6e815cd24734ad237f00aa959b43_StockBasedCompensationTables"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/StockBasedCompensationShareBasedCompensationAllocatedCostsDetail" xlink:type="simple" xlink:href="wynn-20200930.xsd#StockBasedCompensationShareBasedCompensationAllocatedCostsDetail"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/StockBasedCompensationShareBasedCompensationAllocatedCostsDetail" xlink:type="extended" id="i2bd98513ffee4b12b276851e51cf42c9_StockBasedCompensationShareBasedCompensationAllocatedCostsDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_092b2d4a-8bd1-4644-b022-c6fb60b492ab" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_456e70cb-bc8a-4900-b5cd-bbd0ef0144d3" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_092b2d4a-8bd1-4644-b022-c6fb60b492ab" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_456e70cb-bc8a-4900-b5cd-bbd0ef0144d3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount_63112bb4-2132-4ff1-83ed-5c662e351d70" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_092b2d4a-8bd1-4644-b022-c6fb60b492ab" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount_63112bb4-2132-4ff1-83ed-5c662e351d70" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_6e093461-a4ec-40d6-ac84-4aca1907b3ac" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_092b2d4a-8bd1-4644-b022-c6fb60b492ab" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_6e093461-a4ec-40d6-ac84-4aca1907b3ac" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionAndOtherPostretirementBenefitsExpenseReversalOfExpenseNoncash_b00f0c28-4b21-4e84-8fc0-eeae9e144c8f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PensionAndOtherPostretirementBenefitsExpenseReversalOfExpenseNoncash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_092b2d4a-8bd1-4644-b022-c6fb60b492ab" xlink:to="loc_us-gaap_PensionAndOtherPostretirementBenefitsExpenseReversalOfExpenseNoncash_b00f0c28-4b21-4e84-8fc0-eeae9e144c8f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockExpense_ab251874-14e3-4002-99a8-0bb5f1fc2c22" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedStockExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_092b2d4a-8bd1-4644-b022-c6fb60b492ab" xlink:to="loc_us-gaap_RestrictedStockExpense_ab251874-14e3-4002-99a8-0bb5f1fc2c22" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_6d1cb398-737c-410b-ba49-894c7124560c" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_092b2d4a-8bd1-4644-b022-c6fb60b492ab" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_6d1cb398-737c-410b-ba49-894c7124560c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_5154ec47-22d7-4f6a-a1e3-0b162d122b28" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_6d1cb398-737c-410b-ba49-894c7124560c" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_5154ec47-22d7-4f6a-a1e3-0b162d122b28" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_5154ec47-22d7-4f6a-a1e3-0b162d122b28_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_5154ec47-22d7-4f6a-a1e3-0b162d122b28" xlink:to="loc_us-gaap_SegmentDomain_5154ec47-22d7-4f6a-a1e3-0b162d122b28_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_ca0122bc-ccd1-4145-80d8-d813cecd0f47" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_5154ec47-22d7-4f6a-a1e3-0b162d122b28" xlink:to="loc_us-gaap_SegmentDomain_ca0122bc-ccd1-4145-80d8-d813cecd0f47" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CasinoMember_5669ac3d-2817-46f6-a913-abec0494e739" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CasinoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_ca0122bc-ccd1-4145-80d8-d813cecd0f47" xlink:to="loc_us-gaap_CasinoMember_5669ac3d-2817-46f6-a913-abec0494e739" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RoomsMember_0b4639bf-0a42-4f35-a96f-df7cea6f9b32" xlink:href="wynn-20200930.xsd#wynn_RoomsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_ca0122bc-ccd1-4145-80d8-d813cecd0f47" xlink:to="loc_wynn_RoomsMember_0b4639bf-0a42-4f35-a96f-df7cea6f9b32" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FoodAndBeverageMember_74f60a80-9ff7-4c78-a59d-e412f2254bc8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FoodAndBeverageMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_ca0122bc-ccd1-4145-80d8-d813cecd0f47" xlink:to="loc_us-gaap_FoodAndBeverageMember_74f60a80-9ff7-4c78-a59d-e412f2254bc8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EntertainmentRetailAndOtherMember_662c24ea-b755-4b57-9769-5368b574f4ed" xlink:href="wynn-20200930.xsd#wynn_EntertainmentRetailAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_ca0122bc-ccd1-4145-80d8-d813cecd0f47" xlink:to="loc_wynn_EntertainmentRetailAndOtherMember_662c24ea-b755-4b57-9769-5368b574f4ed" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_GeneralAndAdministrativeMember_152a4312-8bc8-4870-a21b-d7b50076a104" xlink:href="wynn-20200930.xsd#wynn_GeneralAndAdministrativeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_ca0122bc-ccd1-4145-80d8-d813cecd0f47" xlink:to="loc_wynn_GeneralAndAdministrativeMember_152a4312-8bc8-4870-a21b-d7b50076a104" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_PreopeningMember_f27d7264-6322-4bd8-9352-4b3a66cd0fab" xlink:href="wynn-20200930.xsd#wynn_PreopeningMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_ca0122bc-ccd1-4145-80d8-d813cecd0f47" xlink:to="loc_wynn_PreopeningMember_f27d7264-6322-4bd8-9352-4b3a66cd0fab" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/IncomeTaxes" xlink:type="simple" xlink:href="wynn-20200930.xsd#IncomeTaxes"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/IncomeTaxes" xlink:type="extended" id="i705d9f1dc4974ed6b2490d8fbe97ca49_IncomeTaxes"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/IncomeTaxesAdditionalInformationDetail" xlink:type="simple" xlink:href="wynn-20200930.xsd#IncomeTaxesAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/IncomeTaxesAdditionalInformationDetail" xlink:type="extended" id="ieb248423555140368037cb132525bd8c_IncomeTaxesAdditionalInformationDetail"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/EarningsPerShare" xlink:type="simple" xlink:href="wynn-20200930.xsd#EarningsPerShare"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/EarningsPerShare" xlink:type="extended" id="i8b7f127ba56b43c097e4839f48e2b98b_EarningsPerShare"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/EarningsPerShareTables" xlink:type="simple" xlink:href="wynn-20200930.xsd#EarningsPerShareTables"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/EarningsPerShareTables" xlink:type="extended" id="i3c4fa9da91c548a9a265dbb54ec0e749_EarningsPerShareTables"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/EarningsPerShareScheduleofSharesusedinCalculationofEarningsPerShareDetail" xlink:type="simple" xlink:href="wynn-20200930.xsd#EarningsPerShareScheduleofSharesusedinCalculationofEarningsPerShareDetail"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/EarningsPerShareScheduleofSharesusedinCalculationofEarningsPerShareDetail" xlink:type="extended" id="i208036f5943e4f9bb275e924f7329b9a_EarningsPerShareScheduleofSharesusedinCalculationofEarningsPerShareDetail"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/Leases" xlink:type="simple" xlink:href="wynn-20200930.xsd#Leases"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/Leases" xlink:type="extended" id="i6cc001a56d284555ba4bd2eccbca1c45_Leases"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/LeasesTables" xlink:type="simple" xlink:href="wynn-20200930.xsd#LeasesTables"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/LeasesTables" xlink:type="extended" id="if6d9a542eb944708b40599de7de9c4b1_LeasesTables"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/LeasesMinimumandContingentOperatingLeaseIncomeDetails" xlink:type="simple" xlink:href="wynn-20200930.xsd#LeasesMinimumandContingentOperatingLeaseIncomeDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/LeasesMinimumandContingentOperatingLeaseIncomeDetails" xlink:type="extended" id="ic9c991d9513b4cb49e0fc32dcbe24aef_LeasesMinimumandContingentOperatingLeaseIncomeDetails"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CommitmentsandContingencies" xlink:type="simple" xlink:href="wynn-20200930.xsd#CommitmentsandContingencies"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/CommitmentsandContingencies" xlink:type="extended" id="i2a0c6b1c7269421ea6f4a53990aebe8f_CommitmentsandContingencies"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CommitmentsandContingenciesAdditionalInformationDetail" xlink:type="simple" xlink:href="wynn-20200930.xsd#CommitmentsandContingenciesAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/CommitmentsandContingenciesAdditionalInformationDetail" xlink:type="extended" id="i7c0bc0d6c90d4d51b4062415cd4c3bbd_CommitmentsandContingenciesAdditionalInformationDetail">
    <link:loc xlink:type="locator" xlink:label="loc_wynn_CommitmentsAndContingenciesLineItems_81686e8d-b40e-4009-b209-2a6df0bbe097" xlink:href="wynn-20200930.xsd#wynn_CommitmentsAndContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromLegalSettlements_e432490a-0b93-47de-a9eb-cdd9543ec62e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromLegalSettlements"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_CommitmentsAndContingenciesLineItems_81686e8d-b40e-4009-b209-2a6df0bbe097" xlink:to="loc_us-gaap_ProceedsFromLegalSettlements_e432490a-0b93-47de-a9eb-cdd9543ec62e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossRelatedToLitigationSettlement_d8ebe932-b663-4767-8928-09a560d73690" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossRelatedToLitigationSettlement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_CommitmentsAndContingenciesLineItems_81686e8d-b40e-4009-b209-2a6df0bbe097" xlink:to="loc_us-gaap_GainLossRelatedToLitigationSettlement_d8ebe932-b663-4767-8928-09a560d73690" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_CommitmentsAndContingenciesTable_366b88dd-68c3-4075-bf85-d856202ace36" xlink:href="wynn-20200930.xsd#wynn_CommitmentsAndContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_wynn_CommitmentsAndContingenciesLineItems_81686e8d-b40e-4009-b209-2a6df0bbe097" xlink:to="loc_wynn_CommitmentsAndContingenciesTable_366b88dd-68c3-4075-bf85-d856202ace36" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_85999e95-6819-4152-9e44-a2482767262a" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_LitigationCaseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_CommitmentsAndContingenciesTable_366b88dd-68c3-4075-bf85-d856202ace36" xlink:to="loc_srt_LitigationCaseAxis_85999e95-6819-4152-9e44-a2482767262a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_85999e95-6819-4152-9e44-a2482767262a_default" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_LitigationCaseAxis_85999e95-6819-4152-9e44-a2482767262a" xlink:to="loc_srt_LitigationCaseTypeDomain_85999e95-6819-4152-9e44-a2482767262a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_6c6e8747-7231-4300-9920-d781c673e49f" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_LitigationCaseAxis_85999e95-6819-4152-9e44-a2482767262a" xlink:to="loc_srt_LitigationCaseTypeDomain_6c6e8747-7231-4300-9920-d781c673e49f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_DerivativeLitigationMember_1016a1a4-983c-4a72-9ce0-076c74c34056" xlink:href="wynn-20200930.xsd#wynn_DerivativeLitigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_6c6e8747-7231-4300-9920-d781c673e49f" xlink:to="loc_wynn_DerivativeLitigationMember_1016a1a4-983c-4a72-9ce0-076c74c34056" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainContingenciesByNatureAxis_500aadaa-4581-44f3-ae15-923b8e1b12c8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainContingenciesByNatureAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_CommitmentsAndContingenciesTable_366b88dd-68c3-4075-bf85-d856202ace36" xlink:to="loc_us-gaap_GainContingenciesByNatureAxis_500aadaa-4581-44f3-ae15-923b8e1b12c8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainContingencyNatureDomain_500aadaa-4581-44f3-ae15-923b8e1b12c8_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_GainContingenciesByNatureAxis_500aadaa-4581-44f3-ae15-923b8e1b12c8" xlink:to="loc_us-gaap_GainContingencyNatureDomain_500aadaa-4581-44f3-ae15-923b8e1b12c8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainContingencyNatureDomain_61f2e4e7-4b7f-4658-ba3d-c118c8f54747" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_GainContingenciesByNatureAxis_500aadaa-4581-44f3-ae15-923b8e1b12c8" xlink:to="loc_us-gaap_GainContingencyNatureDomain_61f2e4e7-4b7f-4658-ba3d-c118c8f54747" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositiveOutcomeOfLitigationMember_981535f9-59c7-458b-94c0-169fe0bbbc10" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositiveOutcomeOfLitigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GainContingencyNatureDomain_61f2e4e7-4b7f-4658-ba3d-c118c8f54747" xlink:to="loc_us-gaap_PositiveOutcomeOfLitigationMember_981535f9-59c7-458b-94c0-169fe0bbbc10" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_41844dab-a517-4093-93b7-b8929c09916d" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_CommitmentsAndContingenciesTable_366b88dd-68c3-4075-bf85-d856202ace36" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_41844dab-a517-4093-93b7-b8929c09916d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_41844dab-a517-4093-93b7-b8929c09916d_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_41844dab-a517-4093-93b7-b8929c09916d" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_41844dab-a517-4093-93b7-b8929c09916d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_efb61e5f-a011-43d2-b082-8d25fa5b340b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_41844dab-a517-4093-93b7-b8929c09916d" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_efb61e5f-a011-43d2-b082-8d25fa5b340b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_6f08d08f-f5ed-478d-b3c0-64663f9bdcdb" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_efb61e5f-a011-43d2-b082-8d25fa5b340b" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_6f08d08f-f5ed-478d-b3c0-64663f9bdcdb" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/RetailJointVenture" xlink:type="simple" xlink:href="wynn-20200930.xsd#RetailJointVenture"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/RetailJointVenture" xlink:type="extended" id="if068f82fdd0243739e6861601bac130a_RetailJointVenture"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/RetailJointVentureAdditionalinformationDetails" xlink:type="simple" xlink:href="wynn-20200930.xsd#RetailJointVentureAdditionalinformationDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/RetailJointVentureAdditionalinformationDetails" xlink:type="extended" id="i75da28d5fc4047cdb5a033b704f50e71_RetailJointVentureAdditionalinformationDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_59481c84-b7cd-4660-acc2-6c16604331f6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_62455932-afdd-46d9-9194-8e5e239adb7f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Assets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_59481c84-b7cd-4660-acc2-6c16604331f6" xlink:to="loc_us-gaap_Assets_62455932-afdd-46d9-9194-8e5e239adb7f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_e95c9f98-bc7b-42d4-ab93-188c3e3f1842" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Liabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_59481c84-b7cd-4660-acc2-6c16604331f6" xlink:to="loc_us-gaap_Liabilities_e95c9f98-bc7b-42d4-ab93-188c3e3f1842" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_10d4d285-2d04-4031-85c1-f54432ebcdee" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_59481c84-b7cd-4660-acc2-6c16604331f6" xlink:to="loc_us-gaap_LongTermDebt_10d4d285-2d04-4031-85c1-f54432ebcdee" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_d5add585-e325-4e5d-aa4f-1fe12aaf0ab6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_59481c84-b7cd-4660-acc2-6c16604331f6" xlink:to="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_d5add585-e325-4e5d-aa4f-1fe12aaf0ab6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_1bfb4b75-999b-4f57-b287-b656ab53bc5a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_d5add585-e325-4e5d-aa4f-1fe12aaf0ab6" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_1bfb4b75-999b-4f57-b287-b656ab53bc5a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_1bfb4b75-999b-4f57-b287-b656ab53bc5a_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_1bfb4b75-999b-4f57-b287-b656ab53bc5a" xlink:to="loc_us-gaap_SegmentDomain_1bfb4b75-999b-4f57-b287-b656ab53bc5a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_bac285dd-c06c-4309-9799-eb0bc325934f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_1bfb4b75-999b-4f57-b287-b656ab53bc5a" xlink:to="loc_us-gaap_SegmentDomain_bac285dd-c06c-4309-9799-eb0bc325934f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetailMember_b7a6698e-c75c-4bcb-b598-cf3781e6e6aa" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetailMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_bac285dd-c06c-4309-9799-eb0bc325934f" xlink:to="loc_us-gaap_RetailMember_b7a6698e-c75c-4bcb-b598-cf3781e6e6aa" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_66526890-43de-454e-a7f6-bd00706ebdf0" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_d5add585-e325-4e5d-aa4f-1fe12aaf0ab6" xlink:to="loc_dei_LegalEntityAxis_66526890-43de-454e-a7f6-bd00706ebdf0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_66526890-43de-454e-a7f6-bd00706ebdf0_default" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_66526890-43de-454e-a7f6-bd00706ebdf0" xlink:to="loc_dei_EntityDomain_66526890-43de-454e-a7f6-bd00706ebdf0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_030bfb23-2c2e-4472-ae0c-eeed8f38b2ec" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_66526890-43de-454e-a7f6-bd00706ebdf0" xlink:to="loc_dei_EntityDomain_030bfb23-2c2e-4472-ae0c-eeed8f38b2ec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailJointVentureMember_95ab90b6-aa16-4f47-a62e-c5e5a9d75e31" xlink:href="wynn-20200930.xsd#wynn_RetailJointVentureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_030bfb23-2c2e-4472-ae0c-eeed8f38b2ec" xlink:to="loc_wynn_RetailJointVentureMember_95ab90b6-aa16-4f47-a62e-c5e5a9d75e31" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/SegmentInformation" xlink:type="simple" xlink:href="wynn-20200930.xsd#SegmentInformation"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/SegmentInformation" xlink:type="extended" id="ibf63aa21d43c45498cbbdc80d4cf29fb_SegmentInformation"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/SegmentInformationTables" xlink:type="simple" xlink:href="wynn-20200930.xsd#SegmentInformationTables"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/SegmentInformationTables" xlink:type="extended" id="i5715a623e91f41ceba87858fdec54cb6_SegmentInformationTables"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/SegmentInformationSummaryofResultsofOperationsbySegmentDetail" xlink:type="simple" xlink:href="wynn-20200930.xsd#SegmentInformationSummaryofResultsofOperationsbySegmentDetail"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/SegmentInformationSummaryofResultsofOperationsbySegmentDetail" xlink:type="extended" id="ic9a3540e6e084ee2b29a63cde524d9f4_SegmentInformationSummaryofResultsofOperationsbySegmentDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_62e6b32e-237f-4188-a689-c1d6149a5759" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_6a517c46-73d6-4fa4-b12f-a8871d97f9ba" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_62e6b32e-237f-4188-a689-c1d6149a5759" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_6a517c46-73d6-4fa4-b12f-a8871d97f9ba" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_AdjustedPropertyEbitda_b249bf48-0752-4919-a964-d0bc8f320102" xlink:href="wynn-20200930.xsd#wynn_AdjustedPropertyEbitda"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_62e6b32e-237f-4188-a689-c1d6149a5759" xlink:to="loc_wynn_AdjustedPropertyEbitda_b249bf48-0752-4919-a964-d0bc8f320102" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OtherOperatingCostsAndExpensesAbstract_f216352c-254b-42f3-94f9-9fc4ad9b9fbb" xlink:href="wynn-20200930.xsd#wynn_OtherOperatingCostsAndExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_62e6b32e-237f-4188-a689-c1d6149a5759" xlink:to="loc_wynn_OtherOperatingCostsAndExpensesAbstract_f216352c-254b-42f3-94f9-9fc4ad9b9fbb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreOpeningCosts_68e0708c-6c01-4a58-bcbf-63ca0b714a40" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreOpeningCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_f216352c-254b-42f3-94f9-9fc4ad9b9fbb" xlink:to="loc_us-gaap_PreOpeningCosts_68e0708c-6c01-4a58-bcbf-63ca0b714a40" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAndAmortization_db9f408b-b440-4739-80fc-e243ba378289" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_f216352c-254b-42f3-94f9-9fc4ad9b9fbb" xlink:to="loc_us-gaap_DepreciationAndAmortization_db9f408b-b440-4739-80fc-e243ba378289" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_ProjectAbandonmentCosts_ca08a286-089d-4143-992d-e8dc49f1de69" xlink:href="wynn-20200930.xsd#wynn_ProjectAbandonmentCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_f216352c-254b-42f3-94f9-9fc4ad9b9fbb" xlink:to="loc_wynn_ProjectAbandonmentCosts_ca08a286-089d-4143-992d-e8dc49f1de69" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_CorporateExpensesAndOther_a9e194bb-9a6e-46ba-9463-71b82a897376" xlink:href="wynn-20200930.xsd#wynn_CorporateExpensesAndOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_f216352c-254b-42f3-94f9-9fc4ad9b9fbb" xlink:to="loc_wynn_CorporateExpensesAndOther_a9e194bb-9a6e-46ba-9463-71b82a897376" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_9e0b9673-171a-49e7-8369-afa9d7392830" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_f216352c-254b-42f3-94f9-9fc4ad9b9fbb" xlink:to="loc_us-gaap_ShareBasedCompensation_9e0b9673-171a-49e7-8369-afa9d7392830" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCostAndExpenseOperating_0d309eee-6e8f-410d-8980-a18cf0873865" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherCostAndExpenseOperating"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_f216352c-254b-42f3-94f9-9fc4ad9b9fbb" xlink:to="loc_us-gaap_OtherCostAndExpenseOperating_0d309eee-6e8f-410d-8980-a18cf0873865" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_aa4f066b-e143-49c3-bbd6-a2569fcf3009" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_62e6b32e-237f-4188-a689-c1d6149a5759" xlink:to="loc_us-gaap_OperatingIncomeLoss_aa4f066b-e143-49c3-bbd6-a2569fcf3009" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_ba0acd86-f2e8-4c77-b408-562279d84339" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NonoperatingIncomeExpenseAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_62e6b32e-237f-4188-a689-c1d6149a5759" xlink:to="loc_us-gaap_NonoperatingIncomeExpenseAbstract_ba0acd86-f2e8-4c77-b408-562279d84339" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_a8b805ed-2d29-4456-a279-7957dad20b27" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_ba0acd86-f2e8-4c77-b408-562279d84339" xlink:to="loc_us-gaap_InvestmentIncomeInterest_a8b805ed-2d29-4456-a279-7957dad20b27" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_2ccc91ed-8217-4657-b078-cadc9fc36fa3" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_ba0acd86-f2e8-4c77-b408-562279d84339" xlink:to="loc_us-gaap_InterestExpense_2ccc91ed-8217-4657-b078-cadc9fc36fa3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_c006cabd-a0ae-4c2c-b78d-3d1da9ba3377" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_ba0acd86-f2e8-4c77-b408-562279d84339" xlink:to="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_c006cabd-a0ae-4c2c-b78d-3d1da9ba3377" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_f70322fe-228d-4119-9bbf-475c4c01d5d4" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_ba0acd86-f2e8-4c77-b408-562279d84339" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_f70322fe-228d-4119-9bbf-475c4c01d5d4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_4577db6b-7973-4d81-8258-c2b37d7f1251" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_ba0acd86-f2e8-4c77-b408-562279d84339" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_4577db6b-7973-4d81-8258-c2b37d7f1251" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_3767da12-10d3-4065-9eb7-3171580576ed" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_ba0acd86-f2e8-4c77-b408-562279d84339" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_3767da12-10d3-4065-9eb7-3171580576ed" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_660bd63b-48ad-4f63-8489-8d28697951b8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_62e6b32e-237f-4188-a689-c1d6149a5759" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_660bd63b-48ad-4f63-8489-8d28697951b8" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_6556e5ed-6813-434f-a9d1-b53f45773df7" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_62e6b32e-237f-4188-a689-c1d6149a5759" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_6556e5ed-6813-434f-a9d1-b53f45773df7" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_5f0c11e4-85fb-496e-a984-8610c373873f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_62e6b32e-237f-4188-a689-c1d6149a5759" xlink:to="loc_us-gaap_ProfitLoss_5f0c11e4-85fb-496e-a984-8610c373873f" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_4ecbb0ea-ee8f-41f5-8f79-3555b89df7c6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_62e6b32e-237f-4188-a689-c1d6149a5759" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_4ecbb0ea-ee8f-41f5-8f79-3555b89df7c6" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_5b42d675-57b9-4c24-ae0b-d58655b79735" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_62e6b32e-237f-4188-a689-c1d6149a5759" xlink:to="loc_us-gaap_NetIncomeLoss_5b42d675-57b9-4c24-ae0b-d58655b79735" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossRelatedToLitigationSettlement_2dd1850b-1089-404b-921e-ef80dd01d741" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossRelatedToLitigationSettlement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_62e6b32e-237f-4188-a689-c1d6149a5759" xlink:to="loc_us-gaap_GainLossRelatedToLitigationSettlement_2dd1850b-1089-404b-921e-ef80dd01d741" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_NonrecurringRegulatoryExpense_a0da373f-f592-4bc3-82be-0f6022be454a" xlink:href="wynn-20200930.xsd#wynn_NonrecurringRegulatoryExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_62e6b32e-237f-4188-a689-c1d6149a5759" xlink:to="loc_wynn_NonrecurringRegulatoryExpense_a0da373f-f592-4bc3-82be-0f6022be454a" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_PreOpeningCostsExcludedfromSharebasedCompensation_8901562e-a07e-4052-b7dc-684126408153" xlink:href="wynn-20200930.xsd#wynn_PreOpeningCostsExcludedfromSharebasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_62e6b32e-237f-4188-a689-c1d6149a5759" xlink:to="loc_wynn_PreOpeningCostsExcludedfromSharebasedCompensation_8901562e-a07e-4052-b7dc-684126408153" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_b577e966-d6fe-45e7-bbe6-09866773c180" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_62e6b32e-237f-4188-a689-c1d6149a5759" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_b577e966-d6fe-45e7-bbe6-09866773c180" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_e41db98c-cd09-477f-a42b-1d1ff6b5798a" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_b577e966-d6fe-45e7-bbe6-09866773c180" xlink:to="loc_srt_ProductOrServiceAxis_e41db98c-cd09-477f-a42b-1d1ff6b5798a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_e41db98c-cd09-477f-a42b-1d1ff6b5798a_default" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_e41db98c-cd09-477f-a42b-1d1ff6b5798a" xlink:to="loc_srt_ProductsAndServicesDomain_e41db98c-cd09-477f-a42b-1d1ff6b5798a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_01ab6b64-a99c-49f2-97f8-8c3e3695396a" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_e41db98c-cd09-477f-a42b-1d1ff6b5798a" xlink:to="loc_srt_ProductsAndServicesDomain_01ab6b64-a99c-49f2-97f8-8c3e3695396a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CasinoMember_522cd7eb-6bb5-4701-9c62-1da58c7ec2bd" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CasinoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_01ab6b64-a99c-49f2-97f8-8c3e3695396a" xlink:to="loc_us-gaap_CasinoMember_522cd7eb-6bb5-4701-9c62-1da58c7ec2bd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OccupancyMember_6f176dc8-d1b3-491c-a31e-097dc69435c6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OccupancyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_01ab6b64-a99c-49f2-97f8-8c3e3695396a" xlink:to="loc_us-gaap_OccupancyMember_6f176dc8-d1b3-491c-a31e-097dc69435c6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FoodAndBeverageMember_c953c526-a32f-40c5-b648-0ebbcdda71db" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FoodAndBeverageMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_01ab6b64-a99c-49f2-97f8-8c3e3695396a" xlink:to="loc_us-gaap_FoodAndBeverageMember_c953c526-a32f-40c5-b648-0ebbcdda71db" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EntertainmentRetailAndOtherMember_4930ec66-f79e-4953-b7e1-9285e6014175" xlink:href="wynn-20200930.xsd#wynn_EntertainmentRetailAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_01ab6b64-a99c-49f2-97f8-8c3e3695396a" xlink:to="loc_wynn_EntertainmentRetailAndOtherMember_4930ec66-f79e-4953-b7e1-9285e6014175" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_727737d2-f48f-43ca-a18f-56f7aebbc4e5" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_b577e966-d6fe-45e7-bbe6-09866773c180" xlink:to="loc_srt_ConsolidationItemsAxis_727737d2-f48f-43ca-a18f-56f7aebbc4e5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_727737d2-f48f-43ca-a18f-56f7aebbc4e5_default" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_727737d2-f48f-43ca-a18f-56f7aebbc4e5" xlink:to="loc_srt_ConsolidationItemsDomain_727737d2-f48f-43ca-a18f-56f7aebbc4e5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_a686dcb0-5f7a-4476-a602-8c963c2911e3" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_727737d2-f48f-43ca-a18f-56f7aebbc4e5" xlink:to="loc_srt_ConsolidationItemsDomain_a686dcb0-5f7a-4476-a602-8c963c2911e3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_d58d7db5-7733-4e05-a4a9-290723047655" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingSegmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_a686dcb0-5f7a-4476-a602-8c963c2911e3" xlink:to="loc_us-gaap_OperatingSegmentsMember_d58d7db5-7733-4e05-a4a9-290723047655" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_5c2e0ad9-ddd6-4561-b903-bd0e4a34d632" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_b577e966-d6fe-45e7-bbe6-09866773c180" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_5c2e0ad9-ddd6-4561-b903-bd0e4a34d632" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_5c2e0ad9-ddd6-4561-b903-bd0e4a34d632_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_5c2e0ad9-ddd6-4561-b903-bd0e4a34d632" xlink:to="loc_us-gaap_SegmentDomain_5c2e0ad9-ddd6-4561-b903-bd0e4a34d632_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_b40a39c1-78e3-4cc5-a80f-78757d9d7703" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_5c2e0ad9-ddd6-4561-b903-bd0e4a34d632" xlink:to="loc_us-gaap_SegmentDomain_b40a39c1-78e3-4cc5-a80f-78757d9d7703" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_MacauOperationsDomain_ecf20f23-d162-4da0-a263-da9604058e98" xlink:href="wynn-20200930.xsd#wynn_MacauOperationsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_b40a39c1-78e3-4cc5-a80f-78757d9d7703" xlink:to="loc_wynn_MacauOperationsDomain_ecf20f23-d162-4da0-a263-da9604058e98" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnLasVegasMember_d89d9b8f-ccce-4539-940d-a0dc1768e099" xlink:href="wynn-20200930.xsd#wynn_WynnLasVegasMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_b40a39c1-78e3-4cc5-a80f-78757d9d7703" xlink:to="loc_wynn_WynnLasVegasMember_d89d9b8f-ccce-4539-940d-a0dc1768e099" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EncoreBostonHarborMember_51437660-343a-4c03-bbcd-3201265f37ef" xlink:href="wynn-20200930.xsd#wynn_EncoreBostonHarborMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_b40a39c1-78e3-4cc5-a80f-78757d9d7703" xlink:to="loc_wynn_EncoreBostonHarborMember_51437660-343a-4c03-bbcd-3201265f37ef" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_285d86b1-dbce-4a09-893c-9d7b19fe74fd" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_b577e966-d6fe-45e7-bbe6-09866773c180" xlink:to="loc_dei_LegalEntityAxis_285d86b1-dbce-4a09-893c-9d7b19fe74fd" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_285d86b1-dbce-4a09-893c-9d7b19fe74fd_default" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_285d86b1-dbce-4a09-893c-9d7b19fe74fd" xlink:to="loc_dei_EntityDomain_285d86b1-dbce-4a09-893c-9d7b19fe74fd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_f77cb7f8-4a60-43df-b5cd-f8205c473598" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_285d86b1-dbce-4a09-893c-9d7b19fe74fd" xlink:to="loc_dei_EntityDomain_f77cb7f8-4a60-43df-b5cd-f8205c473598" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnPalaceMember_3fb66924-9c8a-4f01-a06e-29ec8fe02fc7" xlink:href="wynn-20200930.xsd#wynn_WynnPalaceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_f77cb7f8-4a60-43df-b5cd-f8205c473598" xlink:to="loc_wynn_WynnPalaceMember_3fb66924-9c8a-4f01-a06e-29ec8fe02fc7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauMember_0455c7c2-fa66-4858-a55c-821772bd57c2" xlink:href="wynn-20200930.xsd#wynn_WynnMacauMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_f77cb7f8-4a60-43df-b5cd-f8205c473598" xlink:to="loc_wynn_WynnMacauMember_0455c7c2-fa66-4858-a55c-821772bd57c2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_1705234b-bea0-4945-b9aa-f159f4eafdbe" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_LitigationCaseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_b577e966-d6fe-45e7-bbe6-09866773c180" xlink:to="loc_srt_LitigationCaseAxis_1705234b-bea0-4945-b9aa-f159f4eafdbe" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_1705234b-bea0-4945-b9aa-f159f4eafdbe_default" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_LitigationCaseAxis_1705234b-bea0-4945-b9aa-f159f4eafdbe" xlink:to="loc_srt_LitigationCaseTypeDomain_1705234b-bea0-4945-b9aa-f159f4eafdbe_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_c37fc88b-c73d-404e-a2f5-89671bc24900" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_LitigationCaseAxis_1705234b-bea0-4945-b9aa-f159f4eafdbe" xlink:to="loc_srt_LitigationCaseTypeDomain_c37fc88b-c73d-404e-a2f5-89671bc24900" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_DerivativeLitigationMember_487785e1-2bd9-4c95-a0da-5f8a78b23d8f" xlink:href="wynn-20200930.xsd#wynn_DerivativeLitigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_c37fc88b-c73d-404e-a2f5-89671bc24900" xlink:to="loc_wynn_DerivativeLitigationMember_487785e1-2bd9-4c95-a0da-5f8a78b23d8f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainContingenciesByNatureAxis_43780084-0d6e-4ce6-8bc2-61650acbe9f8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainContingenciesByNatureAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_b577e966-d6fe-45e7-bbe6-09866773c180" xlink:to="loc_us-gaap_GainContingenciesByNatureAxis_43780084-0d6e-4ce6-8bc2-61650acbe9f8" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainContingencyNatureDomain_43780084-0d6e-4ce6-8bc2-61650acbe9f8_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_GainContingenciesByNatureAxis_43780084-0d6e-4ce6-8bc2-61650acbe9f8" xlink:to="loc_us-gaap_GainContingencyNatureDomain_43780084-0d6e-4ce6-8bc2-61650acbe9f8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainContingencyNatureDomain_0e56e7b2-ca06-4efc-92d2-142aee7f17e5" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_GainContingenciesByNatureAxis_43780084-0d6e-4ce6-8bc2-61650acbe9f8" xlink:to="loc_us-gaap_GainContingencyNatureDomain_0e56e7b2-ca06-4efc-92d2-142aee7f17e5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PositiveOutcomeOfLitigationMember_7ffcbf8d-4040-47da-a582-453d60521c9d" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PositiveOutcomeOfLitigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GainContingencyNatureDomain_0e56e7b2-ca06-4efc-92d2-142aee7f17e5" xlink:to="loc_us-gaap_PositiveOutcomeOfLitigationMember_7ffcbf8d-4040-47da-a582-453d60521c9d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_ad5c9fff-92e8-4b2e-8870-a5d67c97d284" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_b577e966-d6fe-45e7-bbe6-09866773c180" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_ad5c9fff-92e8-4b2e-8870-a5d67c97d284" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_ad5c9fff-92e8-4b2e-8870-a5d67c97d284_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_ad5c9fff-92e8-4b2e-8870-a5d67c97d284" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_ad5c9fff-92e8-4b2e-8870-a5d67c97d284_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_a67354cd-5549-484a-ac33-70ff53e6678f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_ad5c9fff-92e8-4b2e-8870-a5d67c97d284" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_a67354cd-5549-484a-ac33-70ff53e6678f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_d6ed41b0-7f98-45f4-97f5-8949effeb538" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_a67354cd-5549-484a-ac33-70ff53e6678f" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_d6ed41b0-7f98-45f4-97f5-8949effeb538" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/SegmentInformationSummaryofAssetsbySegmentDetail" xlink:type="simple" xlink:href="wynn-20200930.xsd#SegmentInformationSummaryofAssetsbySegmentDetail"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/SegmentInformationSummaryofAssetsbySegmentDetail" xlink:type="extended" id="ib49f293abeb4473ca24e56080b6424c1_SegmentInformationSummaryofAssetsbySegmentDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_404ce234-887b-4d0d-aac5-08ee3ff19dcf" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_dfdf3905-f5ac-4b61-87b0-bddc81a7161d" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Assets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_404ce234-887b-4d0d-aac5-08ee3ff19dcf" xlink:to="loc_us-gaap_Assets_dfdf3905-f5ac-4b61-87b0-bddc81a7161d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_3420ea52-4aed-4912-ae9c-53a5ef1c3a33" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_404ce234-887b-4d0d-aac5-08ee3ff19dcf" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_3420ea52-4aed-4912-ae9c-53a5ef1c3a33" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_d347b8d9-faa8-495f-b645-03a8831e61d6" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_3420ea52-4aed-4912-ae9c-53a5ef1c3a33" xlink:to="loc_srt_ConsolidationItemsAxis_d347b8d9-faa8-495f-b645-03a8831e61d6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_d347b8d9-faa8-495f-b645-03a8831e61d6_default" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_d347b8d9-faa8-495f-b645-03a8831e61d6" xlink:to="loc_srt_ConsolidationItemsDomain_d347b8d9-faa8-495f-b645-03a8831e61d6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_f9ba74a6-62f0-4f5f-a8a8-9753382b3484" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_d347b8d9-faa8-495f-b645-03a8831e61d6" xlink:to="loc_srt_ConsolidationItemsDomain_f9ba74a6-62f0-4f5f-a8a8-9753382b3484" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_5bb5ca0e-1ed5-4637-8daa-6c2ad71cfb41" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingSegmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_f9ba74a6-62f0-4f5f-a8a8-9753382b3484" xlink:to="loc_us-gaap_OperatingSegmentsMember_5bb5ca0e-1ed5-4637-8daa-6c2ad71cfb41" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_3dde3dfb-8aae-490c-90a9-7e3e2c2947ed" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_3420ea52-4aed-4912-ae9c-53a5ef1c3a33" xlink:to="loc_srt_StatementGeographicalAxis_3dde3dfb-8aae-490c-90a9-7e3e2c2947ed" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_3dde3dfb-8aae-490c-90a9-7e3e2c2947ed_default" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_3dde3dfb-8aae-490c-90a9-7e3e2c2947ed" xlink:to="loc_srt_SegmentGeographicalDomain_3dde3dfb-8aae-490c-90a9-7e3e2c2947ed_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_071b5280-309c-4eae-9e89-b3394d6ed3be" xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_3dde3dfb-8aae-490c-90a9-7e3e2c2947ed" xlink:to="loc_srt_SegmentGeographicalDomain_071b5280-309c-4eae-9e89-b3394d6ed3be" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_MO_67a0cf76-7b1e-4893-bbb0-0a2b13b0a934" xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_MO"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_071b5280-309c-4eae-9e89-b3394d6ed3be" xlink:to="loc_country_MO_67a0cf76-7b1e-4893-bbb0-0a2b13b0a934" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_d0adfe0f-e9a2-4348-99c5-aa48d6ede816" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_3420ea52-4aed-4912-ae9c-53a5ef1c3a33" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_d0adfe0f-e9a2-4348-99c5-aa48d6ede816" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_d0adfe0f-e9a2-4348-99c5-aa48d6ede816_default" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_d0adfe0f-e9a2-4348-99c5-aa48d6ede816" xlink:to="loc_us-gaap_SegmentDomain_d0adfe0f-e9a2-4348-99c5-aa48d6ede816_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_6f10c5a7-85ba-4ac1-aa63-9dda51921f88" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_d0adfe0f-e9a2-4348-99c5-aa48d6ede816" xlink:to="loc_us-gaap_SegmentDomain_6f10c5a7-85ba-4ac1-aa63-9dda51921f88" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauMember_4ee966df-256e-4a1e-9dea-a83f6a5c8efd" xlink:href="wynn-20200930.xsd#wynn_WynnMacauMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_6f10c5a7-85ba-4ac1-aa63-9dda51921f88" xlink:to="loc_wynn_WynnMacauMember_4ee966df-256e-4a1e-9dea-a83f6a5c8efd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnPalaceMember_dc97a072-8d98-413e-bdaa-51f3af825d3f" xlink:href="wynn-20200930.xsd#wynn_WynnPalaceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_6f10c5a7-85ba-4ac1-aa63-9dda51921f88" xlink:to="loc_wynn_WynnPalaceMember_dc97a072-8d98-413e-bdaa-51f3af825d3f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OtherMacauMember_4825c936-c08d-4f6d-86b3-85d96ceb50fc" xlink:href="wynn-20200930.xsd#wynn_OtherMacauMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_6f10c5a7-85ba-4ac1-aa63-9dda51921f88" xlink:to="loc_wynn_OtherMacauMember_4825c936-c08d-4f6d-86b3-85d96ceb50fc" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnLasVegasMember_c20f3edf-23c8-4de3-9d0a-cb4de9977b39" xlink:href="wynn-20200930.xsd#wynn_WynnLasVegasMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_6f10c5a7-85ba-4ac1-aa63-9dda51921f88" xlink:to="loc_wynn_WynnLasVegasMember_c20f3edf-23c8-4de3-9d0a-cb4de9977b39" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EncoreBostonHarborMember_5db50963-3f08-4440-8bf5-17278517eb47" xlink:href="wynn-20200930.xsd#wynn_EncoreBostonHarborMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_6f10c5a7-85ba-4ac1-aa63-9dda51921f88" xlink:to="loc_wynn_EncoreBostonHarborMember_5db50963-3f08-4440-8bf5-17278517eb47" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateAndOtherMember_278886a5-7350-4248-9800-77f9713de6a1" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CorporateAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_6f10c5a7-85ba-4ac1-aa63-9dda51921f88" xlink:to="loc_us-gaap_CorporateAndOtherMember_278886a5-7350-4248-9800-77f9713de6a1" xlink:type="arc" order="5"/>
  </link:definitionLink>
</link:linkbase>
