<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2021 Workiva-->
<!--r:150c7465-dece-4f6a-904a-d0569cfe69e0,g:69a8038a-42a4-4a35-8175-cfaac361cf31-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.wynnresorts.com/role/DocumentandEntityInformation" xlink:type="simple" xlink:href="wynn-20210510.xsd#DocumentandEntityInformation"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/DocumentandEntityInformation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_6aba94cb-1c08-41b8-afb4-4672834a4fdc" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_Security12bTitle_6aba94cb-1c08-41b8-afb4-4672834a4fdc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_e402817a-844d-4622-b280-15b7f51bbdf1" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_EntityIncorporationStateCountryCode_e402817a-844d-4622-b280-15b7f51bbdf1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_793c083c-0893-4737-86c6-425ccf5af98e" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_EntityFileNumber_793c083c-0893-4737-86c6-425ccf5af98e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_51032b25-9237-4c2f-a118-964cbfd7d631" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_EntityTaxIdentificationNumber_51032b25-9237-4c2f-a118-964cbfd7d631" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_dcd4e39c-2ad8-4660-9d65-8ce08b0cfdf4" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_EntityAddressAddressLine1_dcd4e39c-2ad8-4660-9d65-8ce08b0cfdf4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_59992272-9d6c-4ba8-89c4-a910569df9ce" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_EntityAddressCityOrTown_59992272-9d6c-4ba8-89c4-a910569df9ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_c339dab6-6290-463f-8c06-06200eb6a9f2" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_EntityAddressStateOrProvince_c339dab6-6290-463f-8c06-06200eb6a9f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_d3500afa-1387-48e5-99f0-df62ee9f9d68" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentType"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_DocumentType_d3500afa-1387-48e5-99f0-df62ee9f9d68" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_5240041f-0c28-46af-b794-220e047a0ccb" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_EntityRegistrantName_5240041f-0c28-46af-b794-220e047a0ccb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_8d0a1f75-5429-493e-ae90-8ecddbef7e59" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_EntityCentralIndexKey_8d0a1f75-5429-493e-ae90-8ecddbef7e59" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_569263c1-be20-40a2-9829-384436e1b0e2" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_DocumentPeriodEndDate_569263c1-be20-40a2-9829-384436e1b0e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_5a51cba3-b1ce-4acd-ae8d-d69efa74e30f" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_EntityAddressPostalZipCode_5a51cba3-b1ce-4acd-ae8d-d69efa74e30f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_8b754dd2-8169-47c0-85c5-92261684600f" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_CityAreaCode_8b754dd2-8169-47c0-85c5-92261684600f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_c1c14b2b-fc22-4352-b57f-e5def5403729" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_LocalPhoneNumber_c1c14b2b-fc22-4352-b57f-e5def5403729" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_eae1e7b1-63d7-4432-8b4c-5561123d5b29" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_WrittenCommunications_eae1e7b1-63d7-4432-8b4c-5561123d5b29" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_b735b026-db17-46ff-91b0-b96db7d95d74" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_TradingSymbol_b735b026-db17-46ff-91b0-b96db7d95d74" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_d10b215a-3c52-452a-9865-c6a63d8df564" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_SecurityExchangeName_d10b215a-3c52-452a-9865-c6a63d8df564" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_c6af6c8e-320d-479f-acce-ee8b96782c56" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_SolicitingMaterial_c6af6c8e-320d-479f-acce-ee8b96782c56" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_9751bd6e-fb56-4537-a816-bd663cd0a961" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_PreCommencementTenderOffer_9751bd6e-fb56-4537-a816-bd663cd0a961" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_91786713-d5de-4c64-a1b8-8b285c0517eb" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_91786713-d5de-4c64-a1b8-8b285c0517eb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_55448714-7b88-4de4-ac6c-6060b16c7611" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_EntityEmergingGrowthCompany_55448714-7b88-4de4-ac6c-6060b16c7611" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_7ef64647-1ac1-4531-9d60-adac84a7040e" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b3831e72-5b20-4971-a295-633b2ef6f855" xlink:to="loc_dei_AmendmentFlag_7ef64647-1ac1-4531-9d60-adac84a7040e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
