<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:1eaa4fd3-a952-4871-a6da-da81bced03e7,g:9fba031c-d4e7-4508-ab5f-741c083bf28e-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.wynnresorts.com/role/DocumentandEntityInformation" xlink:type="simple" xlink:href="wynn-20220505.xsd#DocumentandEntityInformation"/>
  <link:presentationLink xlink:role="http://www.wynnresorts.com/role/DocumentandEntityInformation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:href="wynn-20220505.xsd#wynn_DEIAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_d1044f01-a9f1-4abc-8e3f-82486e910249" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_Security12bTitle_d1044f01-a9f1-4abc-8e3f-82486e910249" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_1aad406d-1d44-4ce1-9d75-584f6d993857" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_EntityIncorporationStateCountryCode_1aad406d-1d44-4ce1-9d75-584f6d993857" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_40129dcd-f4f6-46a0-b412-8c89723aa700" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_EntityFileNumber_40129dcd-f4f6-46a0-b412-8c89723aa700" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_f61f73b6-2f25-40ea-be90-5e08f23b6dea" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_EntityTaxIdentificationNumber_f61f73b6-2f25-40ea-be90-5e08f23b6dea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_8a9b0257-1735-43df-be82-1028aaec7f67" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_EntityAddressAddressLine1_8a9b0257-1735-43df-be82-1028aaec7f67" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_1fbe9136-de16-4afa-8f96-e5b9d49cc4c7" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_EntityAddressCityOrTown_1fbe9136-de16-4afa-8f96-e5b9d49cc4c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_0ccf64ca-8dc8-4797-a8ca-d4c3e09aa1e1" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_EntityAddressStateOrProvince_0ccf64ca-8dc8-4797-a8ca-d4c3e09aa1e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_035575d6-74fb-43f6-9fca-b1ebc63f3c6d" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentType"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_DocumentType_035575d6-74fb-43f6-9fca-b1ebc63f3c6d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_cdd08a56-3cde-4f52-8a75-09aefdda962e" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_EntityRegistrantName_cdd08a56-3cde-4f52-8a75-09aefdda962e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_aac3a4cd-8d77-4aaa-b8ec-82a2ac9d026b" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_EntityCentralIndexKey_aac3a4cd-8d77-4aaa-b8ec-82a2ac9d026b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_0edefc4c-3606-47aa-8eac-6820b3740f66" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_DocumentPeriodEndDate_0edefc4c-3606-47aa-8eac-6820b3740f66" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_8af02914-efef-4269-818b-4057e29634be" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_EntityAddressPostalZipCode_8af02914-efef-4269-818b-4057e29634be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_ab60e8d0-c5c8-4e44-b457-49cf29e9e5bc" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_CityAreaCode_ab60e8d0-c5c8-4e44-b457-49cf29e9e5bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_dc7eb242-9fb9-450b-9562-ee726ee8bc52" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_LocalPhoneNumber_dc7eb242-9fb9-450b-9562-ee726ee8bc52" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_c7d912d6-eb95-42c1-8a81-0c9b4c0731a1" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_WrittenCommunications_c7d912d6-eb95-42c1-8a81-0c9b4c0731a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_cbf071fa-27c2-4684-9145-0920dce390b6" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_TradingSymbol_cbf071fa-27c2-4684-9145-0920dce390b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_3e9dfa1c-f003-497f-b0a2-194ac3653a3a" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_SecurityExchangeName_3e9dfa1c-f003-497f-b0a2-194ac3653a3a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_fbb33c31-d8db-4304-a3c3-98b01a9eac55" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_SolicitingMaterial_fbb33c31-d8db-4304-a3c3-98b01a9eac55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_21b6d55c-3eee-4d18-a194-f2d2d99f7f65" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_PreCommencementTenderOffer_21b6d55c-3eee-4d18-a194-f2d2d99f7f65" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_ec1048d0-a9c2-44ce-95f5-aef4cf98a63f" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_ec1048d0-a9c2-44ce-95f5-aef4cf98a63f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_abdf497d-2a7d-4e79-b25f-ea65056ed1c9" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_EntityEmergingGrowthCompany_abdf497d-2a7d-4e79-b25f-ea65056ed1c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_bbaf4a52-a226-4435-ba6c-73098866b730" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_wynn_DEIAbstract_cc7f07ad-9977-4a17-9417-5e2748ccb578" xlink:to="loc_dei_AmendmentFlag_bbaf4a52-a226-4435-ba6c-73098866b730" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
