<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:94f90933-ae7d-4e1e-8cf4-8131b5a86175,g:5b53bb13-d6dd-4bdf-a1c3-d9af3342f30d-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsofIncomeunaudited" xlink:type="simple" xlink:href="wynn-20240930.xsd#CondensedConsolidatedStatementsofIncomeunaudited"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsofIncomeunaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_b02bf6ea-f3cb-4235-8b6e-b606af1182e7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_eaf32af5-81c5-487a-ae97-bcc6ca6758db" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_b02bf6ea-f3cb-4235-8b6e-b606af1182e7" xlink:to="loc_us-gaap_StatementTable_eaf32af5-81c5-487a-ae97-bcc6ca6758db" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_bf90ab04-2eb6-4f0f-a03a-2c8077d6d8f2" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_eaf32af5-81c5-487a-ae97-bcc6ca6758db" xlink:to="loc_srt_ProductOrServiceAxis_bf90ab04-2eb6-4f0f-a03a-2c8077d6d8f2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_bf90ab04-2eb6-4f0f-a03a-2c8077d6d8f2_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_bf90ab04-2eb6-4f0f-a03a-2c8077d6d8f2" xlink:to="loc_srt_ProductsAndServicesDomain_bf90ab04-2eb6-4f0f-a03a-2c8077d6d8f2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_02cda974-1248-4415-b955-d44af58d8978" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_bf90ab04-2eb6-4f0f-a03a-2c8077d6d8f2" xlink:to="loc_srt_ProductsAndServicesDomain_02cda974-1248-4415-b955-d44af58d8978" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CasinoMember_d208a037-74b5-4ff3-a7cc-6ed197ee2746" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CasinoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_02cda974-1248-4415-b955-d44af58d8978" xlink:to="loc_us-gaap_CasinoMember_d208a037-74b5-4ff3-a7cc-6ed197ee2746" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OccupancyMember_f0d43b2d-3f9c-4fb8-8e2f-9fc3076a5140" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OccupancyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_02cda974-1248-4415-b955-d44af58d8978" xlink:to="loc_us-gaap_OccupancyMember_f0d43b2d-3f9c-4fb8-8e2f-9fc3076a5140" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FoodAndBeverageMember_9643754e-e4d3-41c3-941a-6ba6a653199d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FoodAndBeverageMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_02cda974-1248-4415-b955-d44af58d8978" xlink:to="loc_us-gaap_FoodAndBeverageMember_9643754e-e4d3-41c3-941a-6ba6a653199d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EntertainmentRetailAndOtherMember_55c440f3-6e08-413c-aeac-cea39f5505d3" xlink:href="wynn-20240930.xsd#wynn_EntertainmentRetailAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_02cda974-1248-4415-b955-d44af58d8978" xlink:to="loc_wynn_EntertainmentRetailAndOtherMember_55c440f3-6e08-413c-aeac-cea39f5505d3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_412390c4-a380-4178-bfeb-d912a5960ad3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b02bf6ea-f3cb-4235-8b6e-b606af1182e7" xlink:to="loc_us-gaap_RevenuesAbstract_412390c4-a380-4178-bfeb-d912a5960ad3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_a784c9f7-b926-4476-8593-4101504eddca" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_412390c4-a380-4178-bfeb-d912a5960ad3" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_a784c9f7-b926-4476-8593-4101504eddca" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpensesAbstract_6e9585ca-7e9e-4071-a759-eb2de695822b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostsAndExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b02bf6ea-f3cb-4235-8b6e-b606af1182e7" xlink:to="loc_us-gaap_CostsAndExpensesAbstract_6e9585ca-7e9e-4071-a759-eb2de695822b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_05643e62-1434-4982-8c13-971f9cf123b5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_6e9585ca-7e9e-4071-a759-eb2de695822b" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_05643e62-1434-4982-8c13-971f9cf123b5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_4a6b4341-8774-44bb-a610-fe13f88b1edb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_6e9585ca-7e9e-4071-a759-eb2de695822b" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_4a6b4341-8774-44bb-a610-fe13f88b1edb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_9e83564a-3b94-40fb-ac9b-088a608dcb8d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProvisionForDoubtfulAccounts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_6e9585ca-7e9e-4071-a759-eb2de695822b" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_9e83564a-3b94-40fb-ac9b-088a608dcb8d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreOpeningCosts_ca7505db-6064-42bf-ac8d-3ea77453e778" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreOpeningCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_6e9585ca-7e9e-4071-a759-eb2de695822b" xlink:to="loc_us-gaap_PreOpeningCosts_ca7505db-6064-42bf-ac8d-3ea77453e778" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAndAmortization_a9ad6c76-12db-4487-af29-821e64ecdd58" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_6e9585ca-7e9e-4071-a759-eb2de695822b" xlink:to="loc_us-gaap_DepreciationAndAmortization_a9ad6c76-12db-4487-af29-821e64ecdd58" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetImpairment_0759ff93-73ab-43db-8c9a-7e82c3e80e77" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GoodwillAndIntangibleAssetImpairment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_6e9585ca-7e9e-4071-a759-eb2de695822b" xlink:to="loc_us-gaap_GoodwillAndIntangibleAssetImpairment_0759ff93-73ab-43db-8c9a-7e82c3e80e77" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_PropertyChargesandOther_95f698fd-63b9-4094-82bb-61289025f3fd" xlink:href="wynn-20240930.xsd#wynn_PropertyChargesandOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_6e9585ca-7e9e-4071-a759-eb2de695822b" xlink:to="loc_wynn_PropertyChargesandOther_95f698fd-63b9-4094-82bb-61289025f3fd" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_577d7411-59fb-48e8-8904-877bcf2269b6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostsAndExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_6e9585ca-7e9e-4071-a759-eb2de695822b" xlink:to="loc_us-gaap_CostsAndExpenses_577d7411-59fb-48e8-8904-877bcf2269b6" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_329c28c4-8c69-4fcf-8b9d-994c63bb8dfe" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b02bf6ea-f3cb-4235-8b6e-b606af1182e7" xlink:to="loc_us-gaap_OperatingIncomeLoss_329c28c4-8c69-4fcf-8b9d-994c63bb8dfe" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_192d4195-2ca4-4f1a-ad81-bf296d137055" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NonoperatingIncomeExpenseAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b02bf6ea-f3cb-4235-8b6e-b606af1182e7" xlink:to="loc_us-gaap_NonoperatingIncomeExpenseAbstract_192d4195-2ca4-4f1a-ad81-bf296d137055" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_68267e49-3c07-47f6-8490-f6566b4f82b4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_192d4195-2ca4-4f1a-ad81-bf296d137055" xlink:to="loc_us-gaap_InvestmentIncomeInterest_68267e49-3c07-47f6-8490-f6566b4f82b4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_e91f32e2-5fad-45d6-90d4-d4012a000dda" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_192d4195-2ca4-4f1a-ad81-bf296d137055" xlink:to="loc_us-gaap_InterestExpense_e91f32e2-5fad-45d6-90d4-d4012a000dda" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_7a9f3894-5305-4803-a4ee-b7e894275b97" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_192d4195-2ca4-4f1a-ad81-bf296d137055" xlink:to="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_7a9f3894-5305-4803-a4ee-b7e894275b97" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_bcdebbc8-b2e8-4818-9b18-e27d9aabe3d2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_192d4195-2ca4-4f1a-ad81-bf296d137055" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_bcdebbc8-b2e8-4818-9b18-e27d9aabe3d2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_f6c1a516-e050-42e3-a4a9-3eb45a4220d2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_192d4195-2ca4-4f1a-ad81-bf296d137055" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_f6c1a516-e050-42e3-a4a9-3eb45a4220d2" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_7aa14df4-7d0e-4007-b3b5-7b445b1593d8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_192d4195-2ca4-4f1a-ad81-bf296d137055" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_7aa14df4-7d0e-4007-b3b5-7b445b1593d8" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_bf1ee491-6e04-46c1-b715-562e10df54c2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b02bf6ea-f3cb-4235-8b6e-b606af1182e7" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_bf1ee491-6e04-46c1-b715-562e10df54c2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_d67ea6ca-5ef4-4397-9103-c05f19409d67" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b02bf6ea-f3cb-4235-8b6e-b606af1182e7" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_d67ea6ca-5ef4-4397-9103-c05f19409d67" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_addf9b69-2a88-4b4a-a096-aaed0a81af4d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b02bf6ea-f3cb-4235-8b6e-b606af1182e7" xlink:to="loc_us-gaap_ProfitLoss_addf9b69-2a88-4b4a-a096-aaed0a81af4d" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_8e2674f3-4158-4c17-a87d-49cfad32eb5e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b02bf6ea-f3cb-4235-8b6e-b606af1182e7" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_8e2674f3-4158-4c17-a87d-49cfad32eb5e" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_90e881bb-98ca-4859-9984-b20016fc35c7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b02bf6ea-f3cb-4235-8b6e-b606af1182e7" xlink:to="loc_us-gaap_NetIncomeLoss_90e881bb-98ca-4859-9984-b20016fc35c7" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EarningsPerShareBasicAndDilutedEPSAbstract_c70bf20f-b7ee-4445-a881-978fb22cc786" xlink:href="wynn-20240930.xsd#wynn_EarningsPerShareBasicAndDilutedEPSAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b02bf6ea-f3cb-4235-8b6e-b606af1182e7" xlink:to="loc_wynn_EarningsPerShareBasicAndDilutedEPSAbstract_c70bf20f-b7ee-4445-a881-978fb22cc786" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_46658ed7-f39f-4ca7-bc10-b6168626edde" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_EarningsPerShareBasicAndDilutedEPSAbstract_c70bf20f-b7ee-4445-a881-978fb22cc786" xlink:to="loc_us-gaap_EarningsPerShareAbstract_46658ed7-f39f-4ca7-bc10-b6168626edde" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_71d65899-1ecf-4116-819a-a916a506d48e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_46658ed7-f39f-4ca7-bc10-b6168626edde" xlink:to="loc_us-gaap_EarningsPerShareBasic_71d65899-1ecf-4116-819a-a916a506d48e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_5d18e4ac-9433-4b0a-9dc5-f9d4f65574da" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_46658ed7-f39f-4ca7-bc10-b6168626edde" xlink:to="loc_us-gaap_EarningsPerShareDiluted_5d18e4ac-9433-4b0a-9dc5-f9d4f65574da" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_8b79bc5e-4606-4887-8ea8-3fcbecae230b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b02bf6ea-f3cb-4235-8b6e-b606af1182e7" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_8b79bc5e-4606-4887-8ea8-3fcbecae230b" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_074e496c-c9d5-4d23-8759-ab4a29a39fbb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_8b79bc5e-4606-4887-8ea8-3fcbecae230b" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_074e496c-c9d5-4d23-8759-ab4a29a39fbb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_76d2c5d2-07fb-43a8-96b4-76387b3dbe68" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_8b79bc5e-4606-4887-8ea8-3fcbecae230b" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_76d2c5d2-07fb-43a8-96b4-76387b3dbe68" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementofStockholdersDeficitunaudited" xlink:type="simple" xlink:href="wynn-20240930.xsd#CondensedConsolidatedStatementofStockholdersDeficitunaudited"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/CondensedConsolidatedStatementofStockholdersDeficitunaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_0a81df6c-7de4-4e1b-8209-13a04eed7211" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_73ce72df-4070-427f-94de-42296caf5e5c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_0a81df6c-7de4-4e1b-8209-13a04eed7211" xlink:to="loc_us-gaap_StatementTable_73ce72df-4070-427f-94de-42296caf5e5c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_f89dfe88-7dd5-41ca-9dab-ecac67bd5ac3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_73ce72df-4070-427f-94de-42296caf5e5c" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_f89dfe88-7dd5-41ca-9dab-ecac67bd5ac3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_f89dfe88-7dd5-41ca-9dab-ecac67bd5ac3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_f89dfe88-7dd5-41ca-9dab-ecac67bd5ac3" xlink:to="loc_us-gaap_EquityComponentDomain_f89dfe88-7dd5-41ca-9dab-ecac67bd5ac3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_7ebb4f5d-020b-49ff-83c2-b69b72b5311b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_f89dfe88-7dd5-41ca-9dab-ecac67bd5ac3" xlink:to="loc_us-gaap_EquityComponentDomain_7ebb4f5d-020b-49ff-83c2-b69b72b5311b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ParentMember_2dc1ba79-689d-426d-879a-e6bc2246e29a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_7ebb4f5d-020b-49ff-83c2-b69b72b5311b" xlink:to="loc_us-gaap_ParentMember_2dc1ba79-689d-426d-879a-e6bc2246e29a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_401ad838-3746-4e3b-b136-8f4f5652c723" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_2dc1ba79-689d-426d-879a-e6bc2246e29a" xlink:to="loc_us-gaap_CommonStockMember_401ad838-3746-4e3b-b136-8f4f5652c723" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonMember_25736723-7542-4b86-b731-a9af802cda7f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockCommonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_2dc1ba79-689d-426d-879a-e6bc2246e29a" xlink:to="loc_us-gaap_TreasuryStockCommonMember_25736723-7542-4b86-b731-a9af802cda7f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_2efa71b2-c1aa-4c80-9f6f-1ade41afcc15" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_2dc1ba79-689d-426d-879a-e6bc2246e29a" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_2efa71b2-c1aa-4c80-9f6f-1ade41afcc15" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_eee17350-1505-4ccf-ac3d-dfdb87c1d08d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_2dc1ba79-689d-426d-879a-e6bc2246e29a" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_eee17350-1505-4ccf-ac3d-dfdb87c1d08d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_099cd19c-ba91-4951-a43c-38780f5225fe" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_2dc1ba79-689d-426d-879a-e6bc2246e29a" xlink:to="loc_us-gaap_RetainedEarningsMember_099cd19c-ba91-4951-a43c-38780f5225fe" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestMember_203a1d5a-0a4f-4148-b824-8d8b7150fa5f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_7ebb4f5d-020b-49ff-83c2-b69b72b5311b" xlink:to="loc_us-gaap_NoncontrollingInterestMember_203a1d5a-0a4f-4148-b824-8d8b7150fa5f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_de04983e-f0c6-4e2d-b935-7edeca044aae" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0a81df6c-7de4-4e1b-8209-13a04eed7211" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_de04983e-f0c6-4e2d-b935-7edeca044aae" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_34c583f7-594c-4e71-aa94-a4d76d4985ae" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_de04983e-f0c6-4e2d-b935-7edeca044aae" xlink:to="loc_us-gaap_SharesOutstanding_34c583f7-594c-4e71-aa94-a4d76d4985ae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_ca361b6a-3186-4b4c-bc20-9f30ebd6c2cb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_de04983e-f0c6-4e2d-b935-7edeca044aae" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_ca361b6a-3186-4b4c-bc20-9f30ebd6c2cb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_7b787826-2e62-4c6f-8496-343043ca9baf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_de04983e-f0c6-4e2d-b935-7edeca044aae" xlink:to="loc_us-gaap_ProfitLoss_7b787826-2e62-4c6f-8496-343043ca9baf" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_af086ffb-e6d3-468b-b7d9-07da02240b91" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_de04983e-f0c6-4e2d-b935-7edeca044aae" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_af086ffb-e6d3-468b-b7d9-07da02240b91" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_19b6213c-2d90-41cf-9c4e-838b4078f613" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_de04983e-f0c6-4e2d-b935-7edeca044aae" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_19b6213c-2d90-41cf-9c4e-838b4078f613" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_d13578cd-91f7-47e8-a460-778e8c16db12" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_de04983e-f0c6-4e2d-b935-7edeca044aae" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_d13578cd-91f7-47e8-a460-778e8c16db12" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_4ba52958-8232-4686-9ae0-345bbf45f29b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_de04983e-f0c6-4e2d-b935-7edeca044aae" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_4ba52958-8232-4686-9ae0-345bbf45f29b" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures_e5480671-e676-41aa-b706-9ce0ee2e5de2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_de04983e-f0c6-4e2d-b935-7edeca044aae" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures_e5480671-e676-41aa-b706-9ce0ee2e5de2" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited_503b7d95-e5d6-415e-8e6f-c47919ca702a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_de04983e-f0c6-4e2d-b935-7edeca044aae" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited_503b7d95-e5d6-415e-8e6f-c47919ca702a" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_462c4916-7d1d-4b68-9645-51e36d0a2af1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockSharesAcquired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_de04983e-f0c6-4e2d-b935-7edeca044aae" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_462c4916-7d1d-4b68-9645-51e36d0a2af1" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_d9cbddbb-5d8e-4503-99f6-2d34c155ca0c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_de04983e-f0c6-4e2d-b935-7edeca044aae" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_d9cbddbb-5d8e-4503-99f6-2d34c155ca0c" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCommonStockCash_084c0390-3d5b-46d6-a542-bf012ac3b84a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DividendsCommonStockCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_de04983e-f0c6-4e2d-b935-7edeca044aae" xlink:to="loc_us-gaap_DividendsCommonStockCash_084c0390-3d5b-46d6-a542-bf012ac3b84a" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_04cf168e-1181-4b33-85d4-a9c784c73b72" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_de04983e-f0c6-4e2d-b935-7edeca044aae" xlink:to="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_04cf168e-1181-4b33-85d4-a9c784c73b72" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_NoncontrollingInterestTransactionsWithSubsidiaryMinorityShareholdersShares_48f0d602-bc15-45f3-aa02-a6f889b74ba0" xlink:href="wynn-20240930.xsd#wynn_NoncontrollingInterestTransactionsWithSubsidiaryMinorityShareholdersShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_de04983e-f0c6-4e2d-b935-7edeca044aae" xlink:to="loc_wynn_NoncontrollingInterestTransactionsWithSubsidiaryMinorityShareholdersShares_48f0d602-bc15-45f3-aa02-a6f889b74ba0" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_NoncontrollingInterestTransactionsWithSubsidiaryMinorityShareholdersValue_3c06e4cc-48b5-4802-ad27-1d89ed63dfd2" xlink:href="wynn-20240930.xsd#wynn_NoncontrollingInterestTransactionsWithSubsidiaryMinorityShareholdersValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_de04983e-f0c6-4e2d-b935-7edeca044aae" xlink:to="loc_wynn_NoncontrollingInterestTransactionsWithSubsidiaryMinorityShareholdersValue_3c06e4cc-48b5-4802-ad27-1d89ed63dfd2" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_6e15bcc6-9faa-48e5-991d-5e00f9adeddb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_de04983e-f0c6-4e2d-b935-7edeca044aae" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_6e15bcc6-9faa-48e5-991d-5e00f9adeddb" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_62d9265d-2134-45ef-8028-feadd56b306c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_d40d7d88-a5bf-44d5-8c5e-7e0fa323c190" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/OrganizationDetails" xlink:type="simple" xlink:href="wynn-20240930.xsd#OrganizationDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/OrganizationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_5bc102ae-f174-46ab-91ac-80807c39d43c" xlink:href="wynn-20240930.xsd#wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_e13f0659-9e82-4205-b75b-f5893c19dbcc" xlink:href="wynn-20240930.xsd#wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_5bc102ae-f174-46ab-91ac-80807c39d43c" xlink:to="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_e13f0659-9e82-4205-b75b-f5893c19dbcc" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipAxis_d04c6a06-66fe-439a-8bc4-8ca00c3b12e0" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_OwnershipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_e13f0659-9e82-4205-b75b-f5893c19dbcc" xlink:to="loc_srt_OwnershipAxis_d04c6a06-66fe-439a-8bc4-8ca00c3b12e0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_d04c6a06-66fe-439a-8bc4-8ca00c3b12e0_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_OwnershipAxis_d04c6a06-66fe-439a-8bc4-8ca00c3b12e0" xlink:to="loc_srt_OwnershipDomain_d04c6a06-66fe-439a-8bc4-8ca00c3b12e0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_77ce334e-9167-44b7-88b7-90c462906f31" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_OwnershipAxis_d04c6a06-66fe-439a-8bc4-8ca00c3b12e0" xlink:to="loc_srt_OwnershipDomain_77ce334e-9167-44b7-88b7-90c462906f31" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnPalaceandWynnMacauMember_99e058ea-e678-4f10-b4c4-7a33be900d0f" xlink:href="wynn-20240930.xsd#wynn_WynnPalaceandWynnMacauMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_77ce334e-9167-44b7-88b7-90c462906f31" xlink:to="loc_wynn_WynnPalaceandWynnMacauMember_99e058ea-e678-4f10-b4c4-7a33be900d0f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnLasVegasMember_7e3b0396-7ab4-4b5a-b705-b476f172b652" xlink:href="wynn-20240930.xsd#wynn_WynnLasVegasMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_77ce334e-9167-44b7-88b7-90c462906f31" xlink:to="loc_wynn_WynnLasVegasMember_7e3b0396-7ab4-4b5a-b705-b476f172b652" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailJointVentureMember_7e1b1d8b-0193-47c7-87c0-6fa3c676116e" xlink:href="wynn-20240930.xsd#wynn_RetailJointVentureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_77ce334e-9167-44b7-88b7-90c462906f31" xlink:to="loc_wynn_RetailJointVentureMember_7e1b1d8b-0193-47c7-87c0-6fa3c676116e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_87263f6e-c118-4354-a4f5-6e0bb4d20cb9" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable_e13f0659-9e82-4205-b75b-f5893c19dbcc" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_87263f6e-c118-4354-a4f5-6e0bb4d20cb9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_87263f6e-c118-4354-a4f5-6e0bb4d20cb9_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_87263f6e-c118-4354-a4f5-6e0bb4d20cb9" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_87263f6e-c118-4354-a4f5-6e0bb4d20cb9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_dd73f7b5-78b4-4f0b-8dbd-4709d4957522" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_87263f6e-c118-4354-a4f5-6e0bb4d20cb9" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_dd73f7b5-78b4-4f0b-8dbd-4709d4957522" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_Island3AMIFZLLCMember_c9924767-5131-4a75-b49e-b097f288128a" xlink:href="wynn-20240930.xsd#wynn_Island3AMIFZLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_dd73f7b5-78b4-4f0b-8dbd-4709d4957522" xlink:to="loc_wynn_Island3AMIFZLLCMember_c9924767-5131-4a75-b49e-b097f288128a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_52ef3f93-f778-4f03-96f0-4bdabd3ca058" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MinorityInterestOwnershipPercentageByParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_5bc102ae-f174-46ab-91ac-80807c39d43c" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_52ef3f93-f778-4f03-96f0-4bdabd3ca058" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_11e4e409-80f4-46d6-a154-97e63c36edea" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems_5bc102ae-f174-46ab-91ac-80807c39d43c" xlink:to="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_11e4e409-80f4-46d6-a154-97e63c36edea" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CashCashEquivalentsandRestrictedCashScheduleofCashCashEquivalentsandRestrictedCashDetails" xlink:type="simple" xlink:href="wynn-20240930.xsd#CashCashEquivalentsandRestrictedCashScheduleofCashCashEquivalentsandRestrictedCashDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/CashCashEquivalentsandRestrictedCashScheduleofCashCashEquivalentsandRestrictedCashDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsItemsLineItems_0051aca0-cf0d-468c-8ab2-b34a35b05bc6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedCashAndCashEquivalentsItemsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTable_f89ef7d8-f84f-4068-9c91-617dbcaaaa50" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsItemsLineItems_0051aca0-cf0d-468c-8ab2-b34a35b05bc6" xlink:to="loc_us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTable_f89ef7d8-f84f-4068-9c91-617dbcaaaa50" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_7c2bdb2f-6e1a-4212-912a-4f24e644a595" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTable_f89ef7d8-f84f-4068-9c91-617dbcaaaa50" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_7c2bdb2f-6e1a-4212-912a-4f24e644a595" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_7c2bdb2f-6e1a-4212-912a-4f24e644a595_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_7c2bdb2f-6e1a-4212-912a-4f24e644a595" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_7c2bdb2f-6e1a-4212-912a-4f24e644a595_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_5d7dd8e3-ebb5-449a-980a-b967e455a472" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_7c2bdb2f-6e1a-4212-912a-4f24e644a595" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_5d7dd8e3-ebb5-449a-980a-b967e455a472" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_CashHeldInTrustAccountsForDebtExtinguishmentMember_db9bdf72-1593-411f-af45-5c589020d6b7" xlink:href="wynn-20240930.xsd#wynn_CashHeldInTrustAccountsForDebtExtinguishmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_5d7dd8e3-ebb5-449a-980a-b967e455a472" xlink:to="loc_wynn_CashHeldInTrustAccountsForDebtExtinguishmentMember_db9bdf72-1593-411f-af45-5c589020d6b7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_5631dd96-5146-4213-a73d-1a844bb4a6fb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTable_f89ef7d8-f84f-4068-9c91-617dbcaaaa50" xlink:to="loc_us-gaap_DebtInstrumentAxis_5631dd96-5146-4213-a73d-1a844bb4a6fb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_5631dd96-5146-4213-a73d-1a844bb4a6fb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_5631dd96-5146-4213-a73d-1a844bb4a6fb" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_5631dd96-5146-4213-a73d-1a844bb4a6fb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_78b1890d-6415-4bf0-96af-75914ec2d981" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_5631dd96-5146-4213-a73d-1a844bb4a6fb" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_78b1890d-6415-4bf0-96af-75914ec2d981" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FourandSevenOverEightPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentyFourMember_0c2ad9c9-2021-428f-bd69-8ee246a20e24" xlink:href="wynn-20240930.xsd#wynn_FourandSevenOverEightPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentyFourMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_78b1890d-6415-4bf0-96af-75914ec2d981" xlink:to="loc_wynn_FourandSevenOverEightPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentyFourMember_0c2ad9c9-2021-428f-bd69-8ee246a20e24" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember_9eeb0916-b688-4ff2-bd05-80077fafcbc6" xlink:href="wynn-20240930.xsd#wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_78b1890d-6415-4bf0-96af-75914ec2d981" xlink:to="loc_wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember_9eeb0916-b688-4ff2-bd05-80077fafcbc6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCash_73bb8740-6b05-482b-8ce9-f5b72636077d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsItemsLineItems_0051aca0-cf0d-468c-8ab2-b34a35b05bc6" xlink:to="loc_us-gaap_RestrictedCash_73bb8740-6b05-482b-8ce9-f5b72636077d" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/ReceivablesnetDetails" xlink:type="simple" xlink:href="wynn-20240930.xsd#ReceivablesnetDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/ReceivablesnetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_d797e4cc-c1c3-4c9d-9d82-8bfccb12837c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_916ff340-0e6b-4a09-9107-ea137250102e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_d797e4cc-c1c3-4c9d-9d82-8bfccb12837c" xlink:to="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_916ff340-0e6b-4a09-9107-ea137250102e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_1cc11c30-73f4-4f01-9e88-d458fb69f40b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_916ff340-0e6b-4a09-9107-ea137250102e" xlink:to="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_1cc11c30-73f4-4f01-9e88-d458fb69f40b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_1cc11c30-73f4-4f01-9e88-d458fb69f40b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LegalEntityTypeOfCounterpartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_1cc11c30-73f4-4f01-9e88-d458fb69f40b" xlink:to="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_1cc11c30-73f4-4f01-9e88-d458fb69f40b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_bd53075b-0629-4266-b302-ef4bf37a2ebb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LegalEntityTypeOfCounterpartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_1cc11c30-73f4-4f01-9e88-d458fb69f40b" xlink:to="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_bd53075b-0629-4266-b302-ef4bf37a2ebb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CasinoMember_2c3840e5-30df-4da8-9ed2-50fd31be92f2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CasinoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_bd53075b-0629-4266-b302-ef4bf37a2ebb" xlink:to="loc_us-gaap_CasinoMember_2c3840e5-30df-4da8-9ed2-50fd31be92f2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_HotelMember_9f8f7c1b-c756-49e8-9a03-302210a8e616" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_HotelMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_bd53075b-0629-4266-b302-ef4bf37a2ebb" xlink:to="loc_srt_HotelMember_9f8f7c1b-c756-49e8-9a03-302210a8e616" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailLeasesAndOtherMember_04e183bf-47c9-4fed-b080-869d76cd4a1c" xlink:href="wynn-20240930.xsd#wynn_RetailLeasesAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_bd53075b-0629-4266-b302-ef4bf37a2ebb" xlink:to="loc_wynn_RetailLeasesAndOtherMember_04e183bf-47c9-4fed-b080-869d76cd4a1c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_5f06dcae-d211-4960-b2b8-8a6c644e819e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_916ff340-0e6b-4a09-9107-ea137250102e" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_5f06dcae-d211-4960-b2b8-8a6c644e819e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_5f06dcae-d211-4960-b2b8-8a6c644e819e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_5f06dcae-d211-4960-b2b8-8a6c644e819e" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_5f06dcae-d211-4960-b2b8-8a6c644e819e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_454250e7-f226-4a75-ba21-0addb6af58d4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_5f06dcae-d211-4960-b2b8-8a6c644e819e" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_454250e7-f226-4a75-ba21-0addb6af58d4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeographicConcentrationRiskMember_7bef7b91-735b-4f95-8811-9ea333c16945" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GeographicConcentrationRiskMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_454250e7-f226-4a75-ba21-0addb6af58d4" xlink:to="loc_us-gaap_GeographicConcentrationRiskMember_7bef7b91-735b-4f95-8811-9ea333c16945" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_8c5a4c75-622a-4b1b-9a36-836f05520481" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_916ff340-0e6b-4a09-9107-ea137250102e" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_8c5a4c75-622a-4b1b-9a36-836f05520481" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_8c5a4c75-622a-4b1b-9a36-836f05520481_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_8c5a4c75-622a-4b1b-9a36-836f05520481" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_8c5a4c75-622a-4b1b-9a36-836f05520481_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_f635b43b-76f2-40be-984c-56e2fb271169" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_8c5a4c75-622a-4b1b-9a36-836f05520481" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_f635b43b-76f2-40be-984c-56e2fb271169" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableMember_df7ecbb7-e967-401d-a6f3-05d44192ec9e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsReceivableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_f635b43b-76f2-40be-984c-56e2fb271169" xlink:to="loc_us-gaap_AccountsReceivableMember_df7ecbb7-e967-401d-a6f3-05d44192ec9e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_c370f2a5-8dd1-43d6-a912-8f48f3a6b716" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_916ff340-0e6b-4a09-9107-ea137250102e" xlink:to="loc_srt_StatementGeographicalAxis_c370f2a5-8dd1-43d6-a912-8f48f3a6b716" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_c370f2a5-8dd1-43d6-a912-8f48f3a6b716_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_c370f2a5-8dd1-43d6-a912-8f48f3a6b716" xlink:to="loc_srt_SegmentGeographicalDomain_c370f2a5-8dd1-43d6-a912-8f48f3a6b716_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_9ce00131-acb5-4774-b3d6-86b404dd1ca0" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_c370f2a5-8dd1-43d6-a912-8f48f3a6b716" xlink:to="loc_srt_SegmentGeographicalDomain_9ce00131-acb5-4774-b3d6-86b404dd1ca0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_AsiaMember_d2e2ec66-cbf7-4b22-9d90-58edd4febe9d" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_AsiaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_9ce00131-acb5-4774-b3d6-86b404dd1ca0" xlink:to="loc_srt_AsiaMember_d2e2ec66-cbf7-4b22-9d90-58edd4febe9d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableGrossCurrent_c3a0b8fa-692a-4f5e-a191-69c890de8f09" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsReceivableGrossCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_d797e4cc-c1c3-4c9d-9d82-8bfccb12837c" xlink:to="loc_us-gaap_AccountsReceivableGrossCurrent_c3a0b8fa-692a-4f5e-a191-69c890de8f09" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_8c64cdfc-ecec-4e32-8f1c-ff79dbd078fd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_d797e4cc-c1c3-4c9d-9d82-8bfccb12837c" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_8c64cdfc-ecec-4e32-8f1c-ff79dbd078fd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_c55d89d8-8ce4-44cb-ba8b-65facbe67818" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_d797e4cc-c1c3-4c9d-9d82-8bfccb12837c" xlink:to="loc_us-gaap_ReceivablesNetCurrent_c55d89d8-8ce4-44cb-ba8b-65facbe67818" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_4b05327d-9aa7-42b2-8465-f4a0e0d53f83" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_d797e4cc-c1c3-4c9d-9d82-8bfccb12837c" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_4b05327d-9aa7-42b2-8465-f4a0e0d53f83" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_AccountsReceivableAllowanceForCreditLossPercentOfGrossCasinoReceivables_ac2112f4-b5af-4116-9c8d-db264904fce8" xlink:href="wynn-20240930.xsd#wynn_AccountsReceivableAllowanceForCreditLossPercentOfGrossCasinoReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_d797e4cc-c1c3-4c9d-9d82-8bfccb12837c" xlink:to="loc_wynn_AccountsReceivableAllowanceForCreditLossPercentOfGrossCasinoReceivables_ac2112f4-b5af-4116-9c8d-db264904fce8" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/PropertyandEquipmentnetNarrativeDetails" xlink:type="simple" xlink:href="wynn-20240930.xsd#PropertyandEquipmentnetNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/PropertyandEquipmentnetNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_d67ac6b1-15b4-411f-87f9-03a71be906ca" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_ab3fd929-bd01-4c2d-b0ba-262e024698c5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_d67ac6b1-15b4-411f-87f9-03a71be906ca" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_ab3fd929-bd01-4c2d-b0ba-262e024698c5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_417614a8-1266-4d1b-99d0-cb3a64c0a220" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_ab3fd929-bd01-4c2d-b0ba-262e024698c5" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_417614a8-1266-4d1b-99d0-cb3a64c0a220" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_417614a8-1266-4d1b-99d0-cb3a64c0a220_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_417614a8-1266-4d1b-99d0-cb3a64c0a220" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_417614a8-1266-4d1b-99d0-cb3a64c0a220_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_40addcb8-0de3-4f25-87f5-338a48ac2a94" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_417614a8-1266-4d1b-99d0-cb3a64c0a220" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_40addcb8-0de3-4f25-87f5-338a48ac2a94" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressMember_8e0ea7c8-1cc2-4367-b0da-3f253e96ba75" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConstructionInProgressMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_40addcb8-0de3-4f25-87f5-338a48ac2a94" xlink:to="loc_us-gaap_ConstructionInProgressMember_8e0ea7c8-1cc2-4367-b0da-3f253e96ba75" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_CapitalizedProjectCostsExpense_93257dd8-020c-4811-9f39-233fd1d3df72" xlink:href="wynn-20240930.xsd#wynn_CapitalizedProjectCostsExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_d67ac6b1-15b4-411f-87f9-03a71be906ca" xlink:to="loc_wynn_CapitalizedProjectCostsExpense_93257dd8-020c-4811-9f39-233fd1d3df72" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_CapitalizedProjectCostsExpenseOverhead_44994b5b-1333-44dd-9f55-72d21aa6f5ea" xlink:href="wynn-20240930.xsd#wynn_CapitalizedProjectCostsExpenseOverhead"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_d67ac6b1-15b4-411f-87f9-03a71be906ca" xlink:to="loc_wynn_CapitalizedProjectCostsExpenseOverhead_44994b5b-1333-44dd-9f55-72d21aa6f5ea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_04ad6174-5700-4c37-bf67-e0a2f29f62b8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Depreciation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_d67ac6b1-15b4-411f-87f9-03a71be906ca" xlink:to="loc_us-gaap_Depreciation_04ad6174-5700-4c37-bf67-e0a2f29f62b8" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebtSummaryofLongTermDebtDetails" xlink:type="simple" xlink:href="wynn-20240930.xsd#LongTermDebtSummaryofLongTermDebtDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/LongTermDebtSummaryofLongTermDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_54be6710-6788-40e0-9b74-3a4f46299972" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_93c63c94-03ae-4800-93b4-68839988d10e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_54be6710-6788-40e0-9b74-3a4f46299972" xlink:to="loc_us-gaap_DebtInstrumentTable_93c63c94-03ae-4800-93b4-68839988d10e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_3cf5f41c-22e3-4ce7-9f39-a4fa563bfabb" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_93c63c94-03ae-4800-93b4-68839988d10e" xlink:to="loc_dei_LegalEntityAxis_3cf5f41c-22e3-4ce7-9f39-a4fa563bfabb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_3cf5f41c-22e3-4ce7-9f39-a4fa563bfabb_default" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_3cf5f41c-22e3-4ce7-9f39-a4fa563bfabb" xlink:to="loc_dei_EntityDomain_3cf5f41c-22e3-4ce7-9f39-a4fa563bfabb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_15c6fec6-cc46-45ca-9db1-7ae7b586b1cf" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_3cf5f41c-22e3-4ce7-9f39-a4fa563bfabb" xlink:to="loc_dei_EntityDomain_15c6fec6-cc46-45ca-9db1-7ae7b586b1cf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMCaymanHoldingsLimitedIIMember_81e45207-be59-48ab-8551-198b242c1509" xlink:href="wynn-20240930.xsd#wynn_WMCaymanHoldingsLimitedIIMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_15c6fec6-cc46-45ca-9db1-7ae7b586b1cf" xlink:to="loc_wynn_WMCaymanHoldingsLimitedIIMember_81e45207-be59-48ab-8551-198b242c1509" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauLimitedMember_e4ddbd81-4a4c-42b2-9b9c-c3fc62d99726" xlink:href="wynn-20240930.xsd#wynn_WynnMacauLimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_15c6fec6-cc46-45ca-9db1-7ae7b586b1cf" xlink:to="loc_wynn_WynnMacauLimitedMember_e4ddbd81-4a4c-42b2-9b9c-c3fc62d99726" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnResortsFinanceLLCMember_0c6a30af-9add-44af-b243-1203a9b9150e" xlink:href="wynn-20240930.xsd#wynn_WynnResortsFinanceLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_15c6fec6-cc46-45ca-9db1-7ae7b586b1cf" xlink:to="loc_wynn_WynnResortsFinanceLLCMember_0c6a30af-9add-44af-b243-1203a9b9150e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember_6d195f11-1b7c-4b86-87ba-7502a5bf8200" xlink:href="wynn-20240930.xsd#wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_15c6fec6-cc46-45ca-9db1-7ae7b586b1cf" xlink:to="loc_wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember_6d195f11-1b7c-4b86-87ba-7502a5bf8200" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember_18c3c230-e011-4223-9d06-ae6016a424e5" xlink:href="wynn-20240930.xsd#wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_15c6fec6-cc46-45ca-9db1-7ae7b586b1cf" xlink:to="loc_wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember_18c3c230-e011-4223-9d06-ae6016a424e5" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_a92b2dc2-33db-42c4-bb64-afb5c2e8fe6d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_93c63c94-03ae-4800-93b4-68839988d10e" xlink:to="loc_us-gaap_DebtInstrumentAxis_a92b2dc2-33db-42c4-bb64-afb5c2e8fe6d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_a92b2dc2-33db-42c4-bb64-afb5c2e8fe6d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_a92b2dc2-33db-42c4-bb64-afb5c2e8fe6d" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_a92b2dc2-33db-42c4-bb64-afb5c2e8fe6d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_ae368cce-702b-4aac-8d77-34e63bf44713" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_a92b2dc2-33db-42c4-bb64-afb5c2e8fe6d" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_ae368cce-702b-4aac-8d77-34e63bf44713" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMCaymanIIRevolverDue2025Member_cd7cc67d-1acb-494b-a3be-156a70ede126" xlink:href="wynn-20240930.xsd#wynn_WMCaymanIIRevolverDue2025Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_ae368cce-702b-4aac-8d77-34e63bf44713" xlink:to="loc_wynn_WMCaymanIIRevolverDue2025Member_cd7cc67d-1acb-494b-a3be-156a70ede126" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FourandSevenOverEightPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentyFourMember_cfcccebe-db38-4a31-823c-ed6e70b6df68" xlink:href="wynn-20240930.xsd#wynn_FourandSevenOverEightPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentyFourMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_ae368cce-702b-4aac-8d77-34e63bf44713" xlink:to="loc_wynn_FourandSevenOverEightPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentyFourMember_cfcccebe-db38-4a31-823c-ed6e70b6df68" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentySixMember_1ec45f46-0048-4b70-9714-fa3b813ddba4" xlink:href="wynn-20240930.xsd#wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentySixMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_ae368cce-702b-4aac-8d77-34e63bf44713" xlink:to="loc_wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentySixMember_1ec45f46-0048-4b70-9714-fa3b813ddba4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentySevenMember_f145da66-ff6e-4b80-ba41-7ce1b4ffe916" xlink:href="wynn-20240930.xsd#wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentySevenMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_ae368cce-702b-4aac-8d77-34e63bf44713" xlink:to="loc_wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentySevenMember_f145da66-ff6e-4b80-ba41-7ce1b4ffe916" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyNineMember_7347de9d-e557-4631-abdd-10a759cb3f00" xlink:href="wynn-20240930.xsd#wynn_FiveAndOneOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyNineMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_ae368cce-702b-4aac-8d77-34e63bf44713" xlink:to="loc_wynn_FiveAndOneOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyNineMember_7347de9d-e557-4631-abdd-10a759cb3f00" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndFiveOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyEightMember_f67acea0-77d3-4032-9d83-5cc81be4d7c2" xlink:href="wynn-20240930.xsd#wynn_FiveAndFiveOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyEightMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_ae368cce-702b-4aac-8d77-34e63bf44713" xlink:to="loc_wynn_FiveAndFiveOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyEightMember_f67acea0-77d3-4032-9d83-5cc81be4d7c2" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FourAndOneOverTwoPercentageWynnMacauLimitedConvertibleBondsDueTwoThousandTwentyNineMember_706f1975-e91e-450b-b7e0-f7bed3c653b7" xlink:href="wynn-20240930.xsd#wynn_FourAndOneOverTwoPercentageWynnMacauLimitedConvertibleBondsDueTwoThousandTwentyNineMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_ae368cce-702b-4aac-8d77-34e63bf44713" xlink:to="loc_wynn_FourAndOneOverTwoPercentageWynnMacauLimitedConvertibleBondsDueTwoThousandTwentyNineMember_706f1975-e91e-450b-b7e0-f7bed3c653b7" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_1d88712a-66db-4bab-8de5-fb82aab2e6c2" xlink:href="wynn-20240930.xsd#wynn_WRFSeniorSecuredCreditFacilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_ae368cce-702b-4aac-8d77-34e63bf44713" xlink:to="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_1d88712a-66db-4bab-8de5-fb82aab2e6c2" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorTermLoanFacilityDue2024Member_be56a8dd-7bb2-49e8-8e9e-69c81554a32c" xlink:href="wynn-20240930.xsd#wynn_SeniorTermLoanFacilityDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_1d88712a-66db-4bab-8de5-fb82aab2e6c2" xlink:to="loc_wynn_SeniorTermLoanFacilityDue2024Member_be56a8dd-7bb2-49e8-8e9e-69c81554a32c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorTermLoanFacilityDue2027Member_78fdd898-adb6-4642-ac96-3e7c5083e6a1" xlink:href="wynn-20240930.xsd#wynn_SeniorTermLoanFacilityDue2027Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_1d88712a-66db-4bab-8de5-fb82aab2e6c2" xlink:to="loc_wynn_SeniorTermLoanFacilityDue2027Member_78fdd898-adb6-4642-ac96-3e7c5083e6a1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_9e278c36-62a4-4f11-a7aa-bc980f837b03" xlink:href="wynn-20240930.xsd#wynn_SeniorRevolvingCreditFacilityDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_1d88712a-66db-4bab-8de5-fb82aab2e6c2" xlink:to="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_9e278c36-62a4-4f11-a7aa-bc980f837b03" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember_51ffb906-653f-4f22-b61d-f0ba63e1c375" xlink:href="wynn-20240930.xsd#wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_ae368cce-702b-4aac-8d77-34e63bf44713" xlink:to="loc_wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember_51ffb906-653f-4f22-b61d-f0ba63e1c375" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverFourPercentageSeniorNotesDueMay152027Member_d67e27bc-080b-4286-9f3f-8804cda86ea2" xlink:href="wynn-20240930.xsd#wynn_FiveAndOneOverFourPercentageSeniorNotesDueMay152027Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_ae368cce-702b-4aac-8d77-34e63bf44713" xlink:to="loc_wynn_FiveAndOneOverFourPercentageSeniorNotesDueMay152027Member_d67e27bc-080b-4286-9f3f-8804cda86ea2" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveAndOneOverEightPercentageSeniorNotesDue2029Member_38dc04bf-155d-4277-a05b-1bfad8429c94" xlink:href="wynn-20240930.xsd#wynn_FiveAndOneOverEightPercentageSeniorNotesDue2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_ae368cce-702b-4aac-8d77-34e63bf44713" xlink:to="loc_wynn_FiveAndOneOverEightPercentageSeniorNotesDue2029Member_38dc04bf-155d-4277-a05b-1bfad8429c94" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SevenAndOneOverEightPercentageSeniorNotesDue2031Member_1f4e2eae-008b-4e24-982c-a8cb78454823" xlink:href="wynn-20240930.xsd#wynn_SevenAndOneOverEightPercentageSeniorNotesDue2031Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_ae368cce-702b-4aac-8d77-34e63bf44713" xlink:to="loc_wynn_SevenAndOneOverEightPercentageSeniorNotesDue2031Member_1f4e2eae-008b-4e24-982c-a8cb78454823" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_A614SeniorNotesDue2033Member_7257f2c4-3467-4259-afd1-cb33679c1501" xlink:href="wynn-20240930.xsd#wynn_A614SeniorNotesDue2033Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_ae368cce-702b-4aac-8d77-34e63bf44713" xlink:to="loc_wynn_A614SeniorNotesDue2033Member_7257f2c4-3467-4259-afd1-cb33679c1501" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailTermLoanAgreementMember_08eaee5e-edb5-4806-9ead-9fdecca90a49" xlink:href="wynn-20240930.xsd#wynn_RetailTermLoanAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_ae368cce-702b-4aac-8d77-34e63bf44713" xlink:to="loc_wynn_RetailTermLoanAgreementMember_08eaee5e-edb5-4806-9ead-9fdecca90a49" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_3729bf02-eb19-4a4f-9586-8de0f11beb39" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_93c63c94-03ae-4800-93b4-68839988d10e" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_3729bf02-eb19-4a4f-9586-8de0f11beb39" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_3729bf02-eb19-4a4f-9586-8de0f11beb39_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_3729bf02-eb19-4a4f-9586-8de0f11beb39" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_3729bf02-eb19-4a4f-9586-8de0f11beb39_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_cffb379e-d119-4f35-8bde-2321e0155a07" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_3729bf02-eb19-4a4f-9586-8de0f11beb39" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_cffb379e-d119-4f35-8bde-2321e0155a07" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_e07702e4-5cc3-4727-afbb-a2a7ef4d6027" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_cffb379e-d119-4f35-8bde-2321e0155a07" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_e07702e4-5cc3-4727-afbb-a2a7ef4d6027" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_ba2740d3-be6c-4597-a8a9-3af75d074425" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_cffb379e-d119-4f35-8bde-2321e0155a07" xlink:to="loc_us-gaap_SeniorNotesMember_ba2740d3-be6c-4597-a8a9-3af75d074425" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_08053f2b-a30f-4b8f-8d9a-aded5d1165b4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_cffb379e-d119-4f35-8bde-2321e0155a07" xlink:to="loc_us-gaap_ConvertibleDebtMember_08053f2b-a30f-4b8f-8d9a-aded5d1165b4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredDebtMember_a17c497b-4bda-4c10-82dd-9856d6aaf87f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SecuredDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_cffb379e-d119-4f35-8bde-2321e0155a07" xlink:to="loc_us-gaap_SecuredDebtMember_a17c497b-4bda-4c10-82dd-9856d6aaf87f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MediumTermNotesMember_9e88701e-27cb-4f03-aefb-777e5ebd211f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MediumTermNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_cffb379e-d119-4f35-8bde-2321e0155a07" xlink:to="loc_us-gaap_MediumTermNotesMember_9e88701e-27cb-4f03-aefb-777e5ebd211f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_a1e3816f-939d-4359-897e-6e1bb1848e37" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_54be6710-6788-40e0-9b74-3a4f46299972" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_a1e3816f-939d-4359-897e-6e1bb1848e37" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_755a37c6-edfb-4fa4-a825-bb346dae815b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_54be6710-6788-40e0-9b74-3a4f46299972" xlink:to="loc_us-gaap_DerivativeLiabilities_755a37c6-edfb-4fa4-a825-bb346dae815b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_2568cdc7-34f0-4eaa-be0b-f3ee11a92079" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_54be6710-6788-40e0-9b74-3a4f46299972" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_2568cdc7-34f0-4eaa-be0b-f3ee11a92079" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_68491ca3-38c1-483a-ab65-7904976c1435" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_54be6710-6788-40e0-9b74-3a4f46299972" xlink:to="loc_us-gaap_LongTermDebt_68491ca3-38c1-483a-ab65-7904976c1435" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_87a8af6b-9eba-43cd-b35d-1e218e6352d9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_54be6710-6788-40e0-9b74-3a4f46299972" xlink:to="loc_us-gaap_LongTermDebtCurrent_87a8af6b-9eba-43cd-b35d-1e218e6352d9" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_043283ad-884b-493d-a65b-ab7a35d2c87c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_54be6710-6788-40e0-9b74-3a4f46299972" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_043283ad-884b-493d-a65b-ab7a35d2c87c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_cde12698-58cf-4232-a024-a36337b78d40" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_54be6710-6788-40e0-9b74-3a4f46299972" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_cde12698-58cf-4232-a024-a36337b78d40" xlink:type="arc" order="6"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebtSummaryofLongTermDebtAdditionalInformationDetails" xlink:type="simple" xlink:href="wynn-20240930.xsd#LongTermDebtSummaryofLongTermDebtAdditionalInformationDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/LongTermDebtSummaryofLongTermDebtAdditionalInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_7b8d6734-24d1-4567-8fcc-c234e655a3e0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_de580c84-d7eb-423c-931b-037f84fdfbdd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7b8d6734-24d1-4567-8fcc-c234e655a3e0" xlink:to="loc_us-gaap_DebtInstrumentTable_de580c84-d7eb-423c-931b-037f84fdfbdd" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_154148b9-8ffa-4d8b-b71c-12c33c78163f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_VariableRateAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_de580c84-d7eb-423c-931b-037f84fdfbdd" xlink:to="loc_us-gaap_VariableRateAxis_154148b9-8ffa-4d8b-b71c-12c33c78163f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_154148b9-8ffa-4d8b-b71c-12c33c78163f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableRateAxis_154148b9-8ffa-4d8b-b71c-12c33c78163f" xlink:to="loc_us-gaap_VariableRateDomain_154148b9-8ffa-4d8b-b71c-12c33c78163f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_24542ec5-d606-40e4-bd38-55ace53c2c55" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableRateAxis_154148b9-8ffa-4d8b-b71c-12c33c78163f" xlink:to="loc_us-gaap_VariableRateDomain_24542ec5-d606-40e4-bd38-55ace53c2c55" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SecuredOvernightFinancingRateSOFRMember_125434ea-eec4-4ffb-8a88-e7281c54bddc" xlink:href="wynn-20240930.xsd#wynn_SecuredOvernightFinancingRateSOFRMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_24542ec5-d606-40e4-bd38-55ace53c2c55" xlink:to="loc_wynn_SecuredOvernightFinancingRateSOFRMember_125434ea-eec4-4ffb-8a88-e7281c54bddc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_HIBOROrLIBORMember_3b8231bc-a647-4803-9bd5-563615026ba2" xlink:href="wynn-20240930.xsd#wynn_HIBOROrLIBORMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_24542ec5-d606-40e4-bd38-55ace53c2c55" xlink:to="loc_wynn_HIBOROrLIBORMember_3b8231bc-a647-4803-9bd5-563615026ba2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_LondonInterbankOfferedRateLIBOR1Member_651e88f0-901d-4244-9d2c-448d297c955c" xlink:href="wynn-20240930.xsd#wynn_LondonInterbankOfferedRateLIBOR1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_24542ec5-d606-40e4-bd38-55ace53c2c55" xlink:to="loc_wynn_LondonInterbankOfferedRateLIBOR1Member_651e88f0-901d-4244-9d2c-448d297c955c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_HIBORMember_4a3db611-f6aa-436c-9d81-ac9acf3a26a9" xlink:href="wynn-20240930.xsd#wynn_HIBORMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_24542ec5-d606-40e4-bd38-55ace53c2c55" xlink:to="loc_wynn_HIBORMember_4a3db611-f6aa-436c-9d81-ac9acf3a26a9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_13f13815-5510-4d67-98f1-089cef6e9cdf" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_de580c84-d7eb-423c-931b-037f84fdfbdd" xlink:to="loc_dei_LegalEntityAxis_13f13815-5510-4d67-98f1-089cef6e9cdf" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_13f13815-5510-4d67-98f1-089cef6e9cdf_default" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_13f13815-5510-4d67-98f1-089cef6e9cdf" xlink:to="loc_dei_EntityDomain_13f13815-5510-4d67-98f1-089cef6e9cdf_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_8ef5851b-2bf9-43ba-836a-161f00ded596" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_13f13815-5510-4d67-98f1-089cef6e9cdf" xlink:to="loc_dei_EntityDomain_8ef5851b-2bf9-43ba-836a-161f00ded596" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMCaymanHoldingsLimitedIIMember_6d69bd3c-fef3-4105-8e67-ed0da0fa57e0" xlink:href="wynn-20240930.xsd#wynn_WMCaymanHoldingsLimitedIIMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_8ef5851b-2bf9-43ba-836a-161f00ded596" xlink:to="loc_wynn_WMCaymanHoldingsLimitedIIMember_6d69bd3c-fef3-4105-8e67-ed0da0fa57e0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauLimitedMember_f8b798fe-6553-4a51-9f89-9f95073ce31e" xlink:href="wynn-20240930.xsd#wynn_WynnMacauLimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_8ef5851b-2bf9-43ba-836a-161f00ded596" xlink:to="loc_wynn_WynnMacauLimitedMember_f8b798fe-6553-4a51-9f89-9f95073ce31e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnResortsFinanceLLCMember_16bee5f0-8b00-4532-aa0f-ff36f6137329" xlink:href="wynn-20240930.xsd#wynn_WynnResortsFinanceLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_8ef5851b-2bf9-43ba-836a-161f00ded596" xlink:to="loc_wynn_WynnResortsFinanceLLCMember_16bee5f0-8b00-4532-aa0f-ff36f6137329" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember_1c5e2a50-88ea-48da-beb7-90b7aaa96e93" xlink:href="wynn-20240930.xsd#wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_8ef5851b-2bf9-43ba-836a-161f00ded596" xlink:to="loc_wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember_1c5e2a50-88ea-48da-beb7-90b7aaa96e93" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_3f1ea1f2-2caf-4d9d-9e17-9ee68343b0dd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_de580c84-d7eb-423c-931b-037f84fdfbdd" xlink:to="loc_us-gaap_DebtInstrumentAxis_3f1ea1f2-2caf-4d9d-9e17-9ee68343b0dd" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_3f1ea1f2-2caf-4d9d-9e17-9ee68343b0dd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_3f1ea1f2-2caf-4d9d-9e17-9ee68343b0dd" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_3f1ea1f2-2caf-4d9d-9e17-9ee68343b0dd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_d844ab43-d688-4b40-a12d-82cb4e01157b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_3f1ea1f2-2caf-4d9d-9e17-9ee68343b0dd" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_d844ab43-d688-4b40-a12d-82cb4e01157b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMCaymanIIRevolverDue2025Member_aa5ed259-2a89-4049-880c-949889f87bed" xlink:href="wynn-20240930.xsd#wynn_WMCaymanIIRevolverDue2025Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_d844ab43-d688-4b40-a12d-82cb4e01157b" xlink:to="loc_wynn_WMCaymanIIRevolverDue2025Member_aa5ed259-2a89-4049-880c-949889f87bed" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FourAndOneOverTwoPercentageWynnMacauLimitedConvertibleBondsDueTwoThousandTwentyNineMember_55246c85-1cf5-42af-8107-90d6fa5c38b7" xlink:href="wynn-20240930.xsd#wynn_FourAndOneOverTwoPercentageWynnMacauLimitedConvertibleBondsDueTwoThousandTwentyNineMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_d844ab43-d688-4b40-a12d-82cb4e01157b" xlink:to="loc_wynn_FourAndOneOverTwoPercentageWynnMacauLimitedConvertibleBondsDueTwoThousandTwentyNineMember_55246c85-1cf5-42af-8107-90d6fa5c38b7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_6bae9332-2c49-4544-ad3c-48be5a125fed" xlink:href="wynn-20240930.xsd#wynn_WRFSeniorSecuredCreditFacilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_d844ab43-d688-4b40-a12d-82cb4e01157b" xlink:to="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_6bae9332-2c49-4544-ad3c-48be5a125fed" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_924fb198-c435-4533-b5e3-68702f94e8a0" xlink:href="wynn-20240930.xsd#wynn_SeniorRevolvingCreditFacilityDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_WRFSeniorSecuredCreditFacilitiesMember_6bae9332-2c49-4544-ad3c-48be5a125fed" xlink:to="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_924fb198-c435-4533-b5e3-68702f94e8a0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailTermLoanAgreementMember_b72cb67b-056e-463a-838b-5d5d601ce0ff" xlink:href="wynn-20240930.xsd#wynn_RetailTermLoanAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_d844ab43-d688-4b40-a12d-82cb4e01157b" xlink:to="loc_wynn_RetailTermLoanAgreementMember_b72cb67b-056e-463a-838b-5d5d601ce0ff" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_d78f5feb-d886-41e7-8ce6-834da2a64c04" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_de580c84-d7eb-423c-931b-037f84fdfbdd" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_d78f5feb-d886-41e7-8ce6-834da2a64c04" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_d78f5feb-d886-41e7-8ce6-834da2a64c04_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_d78f5feb-d886-41e7-8ce6-834da2a64c04" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_d78f5feb-d886-41e7-8ce6-834da2a64c04_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_239a82cf-dc82-45b2-b766-dd0bb6558236" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_d78f5feb-d886-41e7-8ce6-834da2a64c04" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_239a82cf-dc82-45b2-b766-dd0bb6558236" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_53238b8e-3079-43c1-985b-ed0d78803960" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_239a82cf-dc82-45b2-b766-dd0bb6558236" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_53238b8e-3079-43c1-985b-ed0d78803960" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_9db7c5e4-8d8b-4334-96c4-595fb94671f4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_239a82cf-dc82-45b2-b766-dd0bb6558236" xlink:to="loc_us-gaap_ConvertibleDebtMember_9db7c5e4-8d8b-4334-96c4-595fb94671f4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredDebtMember_b471d3ed-508e-4178-9b44-b12bf795d56d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SecuredDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_239a82cf-dc82-45b2-b766-dd0bb6558236" xlink:to="loc_us-gaap_SecuredDebtMember_b471d3ed-508e-4178-9b44-b12bf795d56d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MediumTermNotesMember_373cdc1f-8490-408a-abc5-7b733f86aaf0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MediumTermNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_239a82cf-dc82-45b2-b766-dd0bb6558236" xlink:to="loc_us-gaap_MediumTermNotesMember_373cdc1f-8490-408a-abc5-7b733f86aaf0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_7d0c50f1-6e32-431b-a14c-7e9b866bcb90" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_de580c84-d7eb-423c-931b-037f84fdfbdd" xlink:to="loc_srt_RangeAxis_7d0c50f1-6e32-431b-a14c-7e9b866bcb90" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_7d0c50f1-6e32-431b-a14c-7e9b866bcb90_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_7d0c50f1-6e32-431b-a14c-7e9b866bcb90" xlink:to="loc_srt_RangeMember_7d0c50f1-6e32-431b-a14c-7e9b866bcb90_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_3d34df64-29e0-4366-b7be-06ed58cbbccd" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_7d0c50f1-6e32-431b-a14c-7e9b866bcb90" xlink:to="loc_srt_RangeMember_3d34df64-29e0-4366-b7be-06ed58cbbccd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_2fe4a002-ccea-4c4c-ae91-9cd5ca25fe1e" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_3d34df64-29e0-4366-b7be-06ed58cbbccd" xlink:to="loc_srt_MinimumMember_2fe4a002-ccea-4c4c-ae91-9cd5ca25fe1e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_48c272ec-6f8b-4801-97f2-1f5526bd1cc2" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_3d34df64-29e0-4366-b7be-06ed58cbbccd" xlink:to="loc_srt_MaximumMember_48c272ec-6f8b-4801-97f2-1f5526bd1cc2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_7863191e-842b-4509-b085-38ea7ac28f01" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_de580c84-d7eb-423c-931b-037f84fdfbdd" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_7863191e-842b-4509-b085-38ea7ac28f01" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_7863191e-842b-4509-b085-38ea7ac28f01_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_7863191e-842b-4509-b085-38ea7ac28f01" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_7863191e-842b-4509-b085-38ea7ac28f01_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_843a0832-b46a-4051-97b5-2687350014dd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_7863191e-842b-4509-b085-38ea7ac28f01" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_843a0832-b46a-4051-97b5-2687350014dd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_0fceae0a-b806-428c-bf24-08f1912f3dac" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_843a0832-b46a-4051-97b5-2687350014dd" xlink:to="loc_us-gaap_SubsequentEventMember_0fceae0a-b806-428c-bf24-08f1912f3dac" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_6974ad0b-88c3-4187-9153-44479c0f866c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7b8d6734-24d1-4567-8fcc-c234e655a3e0" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_6974ad0b-88c3-4187-9153-44479c0f866c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_85f56914-db69-402b-92cb-a5a3799a5ed5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7b8d6734-24d1-4567-8fcc-c234e655a3e0" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_85f56914-db69-402b-92cb-a5a3799a5ed5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtWeightedAverageInterestRate_fe1f1b19-23bb-4e54-aafe-4194ad6aa935" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtWeightedAverageInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7b8d6734-24d1-4567-8fcc-c234e655a3e0" xlink:to="loc_us-gaap_DebtWeightedAverageInterestRate_fe1f1b19-23bb-4e54-aafe-4194ad6aa935" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_62b15c73-feee-4ba1-b6f8-968d7b6f620e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7b8d6734-24d1-4567-8fcc-c234e655a3e0" xlink:to="loc_us-gaap_LongTermDebt_62b15c73-feee-4ba1-b6f8-968d7b6f620e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_3799693e-a51a-433f-9aa0-832b4ab70fb6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7b8d6734-24d1-4567-8fcc-c234e655a3e0" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_3799693e-a51a-433f-9aa0-832b4ab70fb6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebt_c89c867c-6530-42c7-bb9f-122bafba1d14" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestExpenseDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7b8d6734-24d1-4567-8fcc-c234e655a3e0" xlink:to="loc_us-gaap_InterestExpenseDebt_c89c867c-6530-42c7-bb9f-122bafba1d14" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_1c0ea548-5809-4ae5-a730-b1622f3d787f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7b8d6734-24d1-4567-8fcc-c234e655a3e0" xlink:to="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_1c0ea548-5809-4ae5-a730-b1622f3d787f" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_c4432295-23a4-46b1-85d7-9af38ed23731" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7b8d6734-24d1-4567-8fcc-c234e655a3e0" xlink:to="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_c4432295-23a4-46b1-85d7-9af38ed23731" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LettersOfCreditOutstandingAmount_3eedaa6c-44e3-40d0-b052-417eddf28d49" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LettersOfCreditOutstandingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7b8d6734-24d1-4567-8fcc-c234e655a3e0" xlink:to="loc_us-gaap_LettersOfCreditOutstandingAmount_3eedaa6c-44e3-40d0-b052-417eddf28d49" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_448148a2-a4a0-4774-9c09-c3cfc5b5fb49" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentInterestRateDuringPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_7b8d6734-24d1-4567-8fcc-c234e655a3e0" xlink:to="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_448148a2-a4a0-4774-9c09-c3cfc5b5fb49" xlink:type="arc" order="9"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/LongTermDebtAdditionalInformationDetails" xlink:type="simple" xlink:href="wynn-20240930.xsd#LongTermDebtAdditionalInformationDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/LongTermDebtAdditionalInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_3da087d6-a30c-4426-926e-84b6f8ac6a95" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_d7e29059-69ec-4521-b9ca-474e894d4dff" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3da087d6-a30c-4426-926e-84b6f8ac6a95" xlink:to="loc_us-gaap_DebtInstrumentTable_d7e29059-69ec-4521-b9ca-474e894d4dff" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_9e29a16b-effd-454f-8190-d538d74f6c2a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_d7e29059-69ec-4521-b9ca-474e894d4dff" xlink:to="loc_us-gaap_DebtInstrumentAxis_9e29a16b-effd-454f-8190-d538d74f6c2a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_9e29a16b-effd-454f-8190-d538d74f6c2a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_9e29a16b-effd-454f-8190-d538d74f6c2a" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_9e29a16b-effd-454f-8190-d538d74f6c2a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_304df073-c16d-4f88-a3dc-1962884192d0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_9e29a16b-effd-454f-8190-d538d74f6c2a" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_304df073-c16d-4f88-a3dc-1962884192d0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WRF2031SeniorNotesAndWLV2025SeniorNotesMember_7a5b92af-58c1-4c60-885b-1b015f5deac8" xlink:href="wynn-20240930.xsd#wynn_WRF2031SeniorNotesAndWLV2025SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_304df073-c16d-4f88-a3dc-1962884192d0" xlink:to="loc_wynn_WRF2031SeniorNotesAndWLV2025SeniorNotesMember_7a5b92af-58c1-4c60-885b-1b015f5deac8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SevenAndOneOverEightPercentageSeniorNotesDue2031Member_7e9744ef-04fa-4767-a22e-819a90328756" xlink:href="wynn-20240930.xsd#wynn_SevenAndOneOverEightPercentageSeniorNotesDue2031Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_WRF2031SeniorNotesAndWLV2025SeniorNotesMember_7a5b92af-58c1-4c60-885b-1b015f5deac8" xlink:to="loc_wynn_SevenAndOneOverEightPercentageSeniorNotesDue2031Member_7e9744ef-04fa-4767-a22e-819a90328756" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember_aeb5ea16-0f7a-418c-8a8a-f45f13dd33a2" xlink:href="wynn-20240930.xsd#wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_WRF2031SeniorNotesAndWLV2025SeniorNotesMember_7a5b92af-58c1-4c60-885b-1b015f5deac8" xlink:to="loc_wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember_aeb5ea16-0f7a-418c-8a8a-f45f13dd33a2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WRFCreditFacilityAgreementAmendmentMember_304e09d2-2981-4f55-9d33-df72469b5db5" xlink:href="wynn-20240930.xsd#wynn_WRFCreditFacilityAgreementAmendmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_304df073-c16d-4f88-a3dc-1962884192d0" xlink:to="loc_wynn_WRFCreditFacilityAgreementAmendmentMember_304e09d2-2981-4f55-9d33-df72469b5db5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_A614SeniorNotesDue2033Member_bb9feac0-1a9a-4afa-ace9-81eb7b1b788b" xlink:href="wynn-20240930.xsd#wynn_A614SeniorNotesDue2033Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_304df073-c16d-4f88-a3dc-1962884192d0" xlink:to="loc_wynn_A614SeniorNotesDue2033Member_bb9feac0-1a9a-4afa-ace9-81eb7b1b788b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailTermLoanAgreementMember_156c6961-0380-4f32-80df-0794c2ae478b" xlink:href="wynn-20240930.xsd#wynn_RetailTermLoanAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_304df073-c16d-4f88-a3dc-1962884192d0" xlink:to="loc_wynn_RetailTermLoanAgreementMember_156c6961-0380-4f32-80df-0794c2ae478b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMCaymanIIRevolverDue2025Member_ac28bbd3-f049-4654-b835-5bc6950ccdd6" xlink:href="wynn-20240930.xsd#wynn_WMCaymanIIRevolverDue2025Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_304df073-c16d-4f88-a3dc-1962884192d0" xlink:to="loc_wynn_WMCaymanIIRevolverDue2025Member_ac28bbd3-f049-4654-b835-5bc6950ccdd6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FourandSevenOverEightPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentyFourMember_15aff08b-d8d4-412c-80c3-dea04365a2aa" xlink:href="wynn-20240930.xsd#wynn_FourandSevenOverEightPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentyFourMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_304df073-c16d-4f88-a3dc-1962884192d0" xlink:to="loc_wynn_FourandSevenOverEightPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentyFourMember_15aff08b-d8d4-412c-80c3-dea04365a2aa" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_1e66ced5-b369-462a-a1b5-f223508bd46c" xlink:href="wynn-20240930.xsd#wynn_SeniorRevolvingCreditFacilityDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_304df073-c16d-4f88-a3dc-1962884192d0" xlink:to="loc_wynn_SeniorRevolvingCreditFacilityDue2024Member_1e66ced5-b369-462a-a1b5-f223508bd46c" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_1007ddfa-a145-4816-9225-733ccf9c739e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_d7e29059-69ec-4521-b9ca-474e894d4dff" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_1007ddfa-a145-4816-9225-733ccf9c739e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_1007ddfa-a145-4816-9225-733ccf9c739e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_1007ddfa-a145-4816-9225-733ccf9c739e" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_1007ddfa-a145-4816-9225-733ccf9c739e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_1286776b-6a9d-4c94-ad37-0f686e2b860e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_1007ddfa-a145-4816-9225-733ccf9c739e" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_1286776b-6a9d-4c94-ad37-0f686e2b860e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_85ec73e7-a504-4348-8632-aa29f44ae0b5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1286776b-6a9d-4c94-ad37-0f686e2b860e" xlink:to="loc_us-gaap_SeniorNotesMember_85ec73e7-a504-4348-8632-aa29f44ae0b5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MediumTermNotesMember_c749a46e-bb7b-4ec0-99f4-7da185a9b990" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MediumTermNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1286776b-6a9d-4c94-ad37-0f686e2b860e" xlink:to="loc_us-gaap_MediumTermNotesMember_c749a46e-bb7b-4ec0-99f4-7da185a9b990" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredDebtMember_2cf1cf9b-65d7-4f5e-9c2b-6290631d173a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SecuredDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1286776b-6a9d-4c94-ad37-0f686e2b860e" xlink:to="loc_us-gaap_SecuredDebtMember_2cf1cf9b-65d7-4f5e-9c2b-6290631d173a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_0005441d-9f02-4d41-8ce0-9291b2c04927" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1286776b-6a9d-4c94-ad37-0f686e2b860e" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_0005441d-9f02-4d41-8ce0-9291b2c04927" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_98eb9ca4-823a-406b-b4a1-1f6639b9c3d7" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_d7e29059-69ec-4521-b9ca-474e894d4dff" xlink:to="loc_dei_LegalEntityAxis_98eb9ca4-823a-406b-b4a1-1f6639b9c3d7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_98eb9ca4-823a-406b-b4a1-1f6639b9c3d7_default" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_98eb9ca4-823a-406b-b4a1-1f6639b9c3d7" xlink:to="loc_dei_EntityDomain_98eb9ca4-823a-406b-b4a1-1f6639b9c3d7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_f1fc7a7f-1bb3-49c5-a635-819145020fb9" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_98eb9ca4-823a-406b-b4a1-1f6639b9c3d7" xlink:to="loc_dei_EntityDomain_f1fc7a7f-1bb3-49c5-a635-819145020fb9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnResortsFinanceLLCMember_b814a4a0-1b26-4c17-8a79-dc1c41b745df" xlink:href="wynn-20240930.xsd#wynn_WynnResortsFinanceLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_f1fc7a7f-1bb3-49c5-a635-819145020fb9" xlink:to="loc_wynn_WynnResortsFinanceLLCMember_b814a4a0-1b26-4c17-8a79-dc1c41b745df" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember_14bf7db7-0bd6-4cde-892d-cd76cb83aadd" xlink:href="wynn-20240930.xsd#wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_f1fc7a7f-1bb3-49c5-a635-819145020fb9" xlink:to="loc_wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember_14bf7db7-0bd6-4cde-892d-cd76cb83aadd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember_e6d76c73-2a31-48c2-a379-f624e526b661" xlink:href="wynn-20240930.xsd#wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_f1fc7a7f-1bb3-49c5-a635-819145020fb9" xlink:to="loc_wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember_e6d76c73-2a31-48c2-a379-f624e526b661" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMCaymanHoldingsLimitedIIMember_ae48dd75-4be7-4c95-b9cd-db965b8c1667" xlink:href="wynn-20240930.xsd#wynn_WMCaymanHoldingsLimitedIIMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_f1fc7a7f-1bb3-49c5-a635-819145020fb9" xlink:to="loc_wynn_WMCaymanHoldingsLimitedIIMember_ae48dd75-4be7-4c95-b9cd-db965b8c1667" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauLimitedMember_f2e401f9-0890-403e-b8da-43ebc89b5d43" xlink:href="wynn-20240930.xsd#wynn_WynnMacauLimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_f1fc7a7f-1bb3-49c5-a635-819145020fb9" xlink:to="loc_wynn_WynnMacauLimitedMember_f2e401f9-0890-403e-b8da-43ebc89b5d43" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_4002303e-013f-4083-89bf-943d479628ad" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_d7e29059-69ec-4521-b9ca-474e894d4dff" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_4002303e-013f-4083-89bf-943d479628ad" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_4002303e-013f-4083-89bf-943d479628ad_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_4002303e-013f-4083-89bf-943d479628ad" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_4002303e-013f-4083-89bf-943d479628ad_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_5ad3fa2c-5260-426d-b6c0-2da12d1243c9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_4002303e-013f-4083-89bf-943d479628ad" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_5ad3fa2c-5260-426d-b6c0-2da12d1243c9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_c31982c4-ed81-4818-941a-f27498e08867" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentRedemptionPeriodOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_5ad3fa2c-5260-426d-b6c0-2da12d1243c9" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_c31982c4-ed81-4818-941a-f27498e08867" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_15955036-9407-49cc-ba91-8ec39d9a6735" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentRedemptionPeriodTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_5ad3fa2c-5260-426d-b6c0-2da12d1243c9" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_15955036-9407-49cc-ba91-8ec39d9a6735" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_ce437fa4-b125-4309-87d5-09bf2e957ee7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_d7e29059-69ec-4521-b9ca-474e894d4dff" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_ce437fa4-b125-4309-87d5-09bf2e957ee7" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_ce437fa4-b125-4309-87d5-09bf2e957ee7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_ce437fa4-b125-4309-87d5-09bf2e957ee7" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_ce437fa4-b125-4309-87d5-09bf2e957ee7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_5ca79e98-08b6-4342-9c69-a0866e1ec0f9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_ce437fa4-b125-4309-87d5-09bf2e957ee7" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_5ca79e98-08b6-4342-9c69-a0866e1ec0f9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_cd7a054e-801a-4d4f-9669-b60d2ef76b36" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_5ca79e98-08b6-4342-9c69-a0866e1ec0f9" xlink:to="loc_us-gaap_SubsequentEventMember_cd7a054e-801a-4d4f-9669-b60d2ef76b36" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_a450fbf7-a3cd-4b98-bd37-87cb2a4f80a6" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_d7e29059-69ec-4521-b9ca-474e894d4dff" xlink:to="loc_srt_RangeAxis_a450fbf7-a3cd-4b98-bd37-87cb2a4f80a6" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_a450fbf7-a3cd-4b98-bd37-87cb2a4f80a6_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_a450fbf7-a3cd-4b98-bd37-87cb2a4f80a6" xlink:to="loc_srt_RangeMember_a450fbf7-a3cd-4b98-bd37-87cb2a4f80a6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_dde117d7-c95c-4e14-9523-f8e1e9103e1e" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_a450fbf7-a3cd-4b98-bd37-87cb2a4f80a6" xlink:to="loc_srt_RangeMember_dde117d7-c95c-4e14-9523-f8e1e9103e1e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_487615e1-9f5a-4cc2-a11d-7a6e7f39ea2e" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_dde117d7-c95c-4e14-9523-f8e1e9103e1e" xlink:to="loc_srt_MaximumMember_487615e1-9f5a-4cc2-a11d-7a6e7f39ea2e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_630084e0-a283-4ce3-8d95-d03ae2e0ea89" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_VariableRateAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_d7e29059-69ec-4521-b9ca-474e894d4dff" xlink:to="loc_us-gaap_VariableRateAxis_630084e0-a283-4ce3-8d95-d03ae2e0ea89" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_630084e0-a283-4ce3-8d95-d03ae2e0ea89_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableRateAxis_630084e0-a283-4ce3-8d95-d03ae2e0ea89" xlink:to="loc_us-gaap_VariableRateDomain_630084e0-a283-4ce3-8d95-d03ae2e0ea89_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_60017692-5f61-4485-91d7-87e59b73d1ec" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableRateAxis_630084e0-a283-4ce3-8d95-d03ae2e0ea89" xlink:to="loc_us-gaap_VariableRateDomain_60017692-5f61-4485-91d7-87e59b73d1ec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SecuredOvernightFinancingRateSOFRMember_0456834b-25ee-4244-800e-fa6b699aa210" xlink:href="wynn-20240930.xsd#wynn_SecuredOvernightFinancingRateSOFRMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_60017692-5f61-4485-91d7-87e59b73d1ec" xlink:to="loc_wynn_SecuredOvernightFinancingRateSOFRMember_0456834b-25ee-4244-800e-fa6b699aa210" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_76df35de-ed56-44f7-9725-80ab3948b2b1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3da087d6-a30c-4426-926e-84b6f8ac6a95" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_76df35de-ed56-44f7-9725-80ab3948b2b1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_c2cdc9a2-02c6-4c12-b70a-d0620d58a757" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentRedemptionPricePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3da087d6-a30c-4426-926e-84b6f8ac6a95" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_c2cdc9a2-02c6-4c12-b70a-d0620d58a757" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_b1148baa-b385-43b3-bedc-b9e42baeba5f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3da087d6-a30c-4426-926e-84b6f8ac6a95" xlink:to="loc_us-gaap_LongTermDebt_b1148baa-b385-43b3-bedc-b9e42baeba5f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfDebt_98e2009c-9a48-4333-8df5-88a22fb758b3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RepaymentsOfDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3da087d6-a30c-4426-926e-84b6f8ac6a95" xlink:to="loc_us-gaap_RepaymentsOfDebt_98e2009c-9a48-4333-8df5-88a22fb758b3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnRestructuringOfDebt_f155a408-cdc1-4a30-97c8-b997fccac231" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainsLossesOnRestructuringOfDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3da087d6-a30c-4426-926e-84b6f8ac6a95" xlink:to="loc_us-gaap_GainsLossesOnRestructuringOfDebt_f155a408-cdc1-4a30-97c8-b997fccac231" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_3661baca-12e7-4b2f-a837-2461b6007004" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3da087d6-a30c-4426-926e-84b6f8ac6a95" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_3661baca-12e7-4b2f-a837-2461b6007004" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRepurchasedFaceAmount_2ea9bb68-a672-4fd4-8af5-8474efaa0dc0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentRepurchasedFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3da087d6-a30c-4426-926e-84b6f8ac6a95" xlink:to="loc_us-gaap_DebtInstrumentRepurchasedFaceAmount_2ea9bb68-a672-4fd4-8af5-8474efaa0dc0" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_DebtInstrumentEarlyTenderPremium_9f726e24-4cb0-48cf-b459-d9b057942aca" xlink:href="wynn-20240930.xsd#wynn_DebtInstrumentEarlyTenderPremium"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3da087d6-a30c-4426-926e-84b6f8ac6a95" xlink:to="loc_wynn_DebtInstrumentEarlyTenderPremium_9f726e24-4cb0-48cf-b459-d9b057942aca" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFairValue_07539aca-7ee4-4297-b876-b33882537916" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3da087d6-a30c-4426-926e-84b6f8ac6a95" xlink:to="loc_us-gaap_DebtInstrumentFairValue_07539aca-7ee4-4297-b876-b33882537916" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_1e750a22-47e1-4c62-9c0c-e2902fc047b1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3da087d6-a30c-4426-926e-84b6f8ac6a95" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_1e750a22-47e1-4c62-9c0c-e2902fc047b1" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ExtinguishmentOfDebtAmount_4da434b5-cd33-4284-a845-a51c4b00f013" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ExtinguishmentOfDebtAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3da087d6-a30c-4426-926e-84b6f8ac6a95" xlink:to="loc_us-gaap_ExtinguishmentOfDebtAmount_4da434b5-cd33-4284-a845-a51c4b00f013" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_LineOfCreditFacilityBorrowingCapacityExtended_cb8f8fe7-f1c4-4a72-944d-ee30625bd360" xlink:href="wynn-20240930.xsd#wynn_LineOfCreditFacilityBorrowingCapacityExtended"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3da087d6-a30c-4426-926e-84b6f8ac6a95" xlink:to="loc_wynn_LineOfCreditFacilityBorrowingCapacityExtended_cb8f8fe7-f1c4-4a72-944d-ee30625bd360" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSeniorLongTermDebt_81cf3d7a-0c09-4f64-b7b0-77597f35f38b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromIssuanceOfSeniorLongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3da087d6-a30c-4426-926e-84b6f8ac6a95" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSeniorLongTermDebt_81cf3d7a-0c09-4f64-b7b0-77597f35f38b" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfFinancingCosts_b82530fd-8759-4d83-92f9-5140e6c69a80" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsOfFinancingCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3da087d6-a30c-4426-926e-84b6f8ac6a95" xlink:to="loc_us-gaap_PaymentsOfFinancingCosts_b82530fd-8759-4d83-92f9-5140e6c69a80" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentPeriodicPaymentPrincipal_8d7b013f-62b9-4b1d-b009-b6e36609eac8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentPeriodicPaymentPrincipal"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3da087d6-a30c-4426-926e-84b6f8ac6a95" xlink:to="loc_us-gaap_DebtInstrumentPeriodicPaymentPrincipal_8d7b013f-62b9-4b1d-b009-b6e36609eac8" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_af06955b-5268-44a0-8807-35d738e56d5a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3da087d6-a30c-4426-926e-84b6f8ac6a95" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_af06955b-5268-44a0-8807-35d738e56d5a" xlink:type="arc" order="15"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/WMLConvertibleBondConversionOptionDerivativeValuationTechniquesforEmbeddedDerivativeDetails" xlink:type="simple" xlink:href="wynn-20240930.xsd#WMLConvertibleBondConversionOptionDerivativeValuationTechniquesforEmbeddedDerivativeDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/WMLConvertibleBondConversionOptionDerivativeValuationTechniquesforEmbeddedDerivativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_777fd58d-2cef-4408-8676-bc2366fc8384" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_f520b1c5-23a3-4932-8f1a-c61854fc44dd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_777fd58d-2cef-4408-8676-bc2366fc8384" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_f520b1c5-23a3-4932-8f1a-c61854fc44dd" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_21f27774-f4a3-40b3-9e00-08303f28e7a8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MeasurementInputTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_f520b1c5-23a3-4932-8f1a-c61854fc44dd" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_21f27774-f4a3-40b3-9e00-08303f28e7a8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_21f27774-f4a3-40b3-9e00-08303f28e7a8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_21f27774-f4a3-40b3-9e00-08303f28e7a8" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_21f27774-f4a3-40b3-9e00-08303f28e7a8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_d4e7137a-112c-4992-a0d6-79b1a3f4193b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_21f27774-f4a3-40b3-9e00-08303f28e7a8" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_d4e7137a-112c-4992-a0d6-79b1a3f4193b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputSharePriceMember_648c8ac7-7b02-4ff8-8f80-88e1233b3d43" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MeasurementInputSharePriceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_d4e7137a-112c-4992-a0d6-79b1a3f4193b" xlink:to="loc_us-gaap_MeasurementInputSharePriceMember_648c8ac7-7b02-4ff8-8f80-88e1233b3d43" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputPriceVolatilityMember_dac947c9-33e1-4f08-b7d0-1cf6b510a88e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MeasurementInputPriceVolatilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_d4e7137a-112c-4992-a0d6-79b1a3f4193b" xlink:to="loc_us-gaap_MeasurementInputPriceVolatilityMember_dac947c9-33e1-4f08-b7d0-1cf6b510a88e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember_9128b48b-def3-414e-9a88-4911b3ed799c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MeasurementInputRiskFreeInterestRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_d4e7137a-112c-4992-a0d6-79b1a3f4193b" xlink:to="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember_9128b48b-def3-414e-9a88-4911b3ed799c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputExpectedTermMember_83c95fcc-9208-47de-b204-31f590fd0543" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MeasurementInputExpectedTermMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_d4e7137a-112c-4992-a0d6-79b1a3f4193b" xlink:to="loc_us-gaap_MeasurementInputExpectedTermMember_83c95fcc-9208-47de-b204-31f590fd0543" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputExpectedDividendRateMember_ddcb7924-a63f-4d9e-9061-5ce382b28884" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MeasurementInputExpectedDividendRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_d4e7137a-112c-4992-a0d6-79b1a3f4193b" xlink:to="loc_us-gaap_MeasurementInputExpectedDividendRateMember_ddcb7924-a63f-4d9e-9061-5ce382b28884" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmbeddedDerivativeLiabilityMeasurementInput_69ddec85-08e9-44cd-8288-b90837511276" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmbeddedDerivativeLiabilityMeasurementInput"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_777fd58d-2cef-4408-8676-bc2366fc8384" xlink:to="loc_us-gaap_EmbeddedDerivativeLiabilityMeasurementInput_69ddec85-08e9-44cd-8288-b90837511276" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/WMLConvertibleBondConversionOptionDerivativeNarrativeDetails" xlink:type="simple" xlink:href="wynn-20240930.xsd#WMLConvertibleBondConversionOptionDerivativeNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/WMLConvertibleBondConversionOptionDerivativeNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_2719abb4-8506-46e8-844e-f00f8fc63fb8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_20b9af37-c4fb-46e7-97ab-9ce64602fce4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_2719abb4-8506-46e8-844e-f00f8fc63fb8" xlink:to="loc_us-gaap_DerivativeTable_20b9af37-c4fb-46e7-97ab-9ce64602fce4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_7628b075-996f-4e19-9535-5dd81fda754a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_20b9af37-c4fb-46e7-97ab-9ce64602fce4" xlink:to="loc_us-gaap_DebtInstrumentAxis_7628b075-996f-4e19-9535-5dd81fda754a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_7628b075-996f-4e19-9535-5dd81fda754a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_7628b075-996f-4e19-9535-5dd81fda754a" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_7628b075-996f-4e19-9535-5dd81fda754a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_fd726eea-aa6c-4f20-a9c6-7466ea680ec4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_7628b075-996f-4e19-9535-5dd81fda754a" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_fd726eea-aa6c-4f20-a9c6-7466ea680ec4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMLConvertibleBondsMember_b97d77fb-94dc-4a9f-b067-459e9ce3e770" xlink:href="wynn-20240930.xsd#wynn_WMLConvertibleBondsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_fd726eea-aa6c-4f20-a9c6-7466ea680ec4" xlink:to="loc_wynn_WMLConvertibleBondsMember_b97d77fb-94dc-4a9f-b067-459e9ce3e770" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_af3909f0-bc21-42a6-9e05-81666a3e465d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_20b9af37-c4fb-46e7-97ab-9ce64602fce4" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_af3909f0-bc21-42a6-9e05-81666a3e465d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_af3909f0-bc21-42a6-9e05-81666a3e465d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_af3909f0-bc21-42a6-9e05-81666a3e465d" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_af3909f0-bc21-42a6-9e05-81666a3e465d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_b74a78ae-121d-4a27-92ba-d0769f7a629d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_af3909f0-bc21-42a6-9e05-81666a3e465d" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_b74a78ae-121d-4a27-92ba-d0769f7a629d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_650ac1c0-deb3-44fa-9b6b-844e8ef2c390" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_b74a78ae-121d-4a27-92ba-d0769f7a629d" xlink:to="loc_us-gaap_ConvertibleDebtMember_650ac1c0-deb3-44fa-9b6b-844e8ef2c390" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_26727797-5b7a-4a2b-8da1-ce3c6700455d" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_20b9af37-c4fb-46e7-97ab-9ce64602fce4" xlink:to="loc_dei_LegalEntityAxis_26727797-5b7a-4a2b-8da1-ce3c6700455d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_26727797-5b7a-4a2b-8da1-ce3c6700455d_default" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_26727797-5b7a-4a2b-8da1-ce3c6700455d" xlink:to="loc_dei_EntityDomain_26727797-5b7a-4a2b-8da1-ce3c6700455d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_79796fc8-ebca-4616-a8eb-bb1c05d4b35d" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_26727797-5b7a-4a2b-8da1-ce3c6700455d" xlink:to="loc_dei_EntityDomain_79796fc8-ebca-4616-a8eb-bb1c05d4b35d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauLimitedMember_43ca6c34-a5e1-458d-9d50-7d23284c701d" xlink:href="wynn-20240930.xsd#wynn_WynnMacauLimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_79796fc8-ebca-4616-a8eb-bb1c05d4b35d" xlink:to="loc_wynn_WynnMacauLimitedMember_43ca6c34-a5e1-458d-9d50-7d23284c701d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_4d33d835-f718-481d-a6ed-062a709c60eb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_2719abb4-8506-46e8-844e-f00f8fc63fb8" xlink:to="loc_us-gaap_DerivativeLiabilities_4d33d835-f718-481d-a6ed-062a709c60eb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_bacb1df7-b27b-4629-8b03-ef5b0c036cd5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_2719abb4-8506-46e8-844e-f00f8fc63fb8" xlink:to="loc_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_bacb1df7-b27b-4629-8b03-ef5b0c036cd5" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/StockholdersDeficitDetails" xlink:type="simple" xlink:href="wynn-20240930.xsd#StockholdersDeficitDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/StockholdersDeficitDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockLineItems_58978860-c23b-464a-85dd-25989c009e78" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsidiarySaleOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_3f2bc54f-a2e3-4fbc-9f34-bd8321bcec71" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_58978860-c23b-464a-85dd-25989c009e78" xlink:to="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_3f2bc54f-a2e3-4fbc-9f34-bd8321bcec71" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_5082ffcb-3318-4051-a08b-1cae0e37c908" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_3f2bc54f-a2e3-4fbc-9f34-bd8321bcec71" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_5082ffcb-3318-4051-a08b-1cae0e37c908" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_5082ffcb-3318-4051-a08b-1cae0e37c908_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_5082ffcb-3318-4051-a08b-1cae0e37c908" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_5082ffcb-3318-4051-a08b-1cae0e37c908_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_6d961bb0-1c59-46a8-8130-b5381a68b26a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_5082ffcb-3318-4051-a08b-1cae0e37c908" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_6d961bb0-1c59-46a8-8130-b5381a68b26a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_05edd6e6-9dd0-4ce0-a7b6-caa4439f7f86" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_6d961bb0-1c59-46a8-8130-b5381a68b26a" xlink:to="loc_us-gaap_SubsequentEventMember_05edd6e6-9dd0-4ce0-a7b6-caa4439f7f86" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipAxis_92e07c0a-45f6-4982-acd2-a71df77754e9" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_OwnershipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_3f2bc54f-a2e3-4fbc-9f34-bd8321bcec71" xlink:to="loc_srt_OwnershipAxis_92e07c0a-45f6-4982-acd2-a71df77754e9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_92e07c0a-45f6-4982-acd2-a71df77754e9_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_OwnershipAxis_92e07c0a-45f6-4982-acd2-a71df77754e9" xlink:to="loc_srt_OwnershipDomain_92e07c0a-45f6-4982-acd2-a71df77754e9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_884861f1-9daa-4dc8-ab58-4f8210571505" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_OwnershipAxis_92e07c0a-45f6-4982-acd2-a71df77754e9" xlink:to="loc_srt_OwnershipDomain_884861f1-9daa-4dc8-ab58-4f8210571505" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnPalaceandWynnMacauMember_b5481dea-20cf-4632-a528-7c9671b9169c" xlink:href="wynn-20240930.xsd#wynn_WynnPalaceandWynnMacauMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_884861f1-9daa-4dc8-ab58-4f8210571505" xlink:to="loc_wynn_WynnPalaceandWynnMacauMember_b5481dea-20cf-4632-a528-7c9671b9169c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_74fbefcd-367c-49e7-a251-febc085d3379" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_3f2bc54f-a2e3-4fbc-9f34-bd8321bcec71" xlink:to="loc_srt_CounterpartyNameAxis_74fbefcd-367c-49e7-a251-febc085d3379" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_74fbefcd-367c-49e7-a251-febc085d3379_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_74fbefcd-367c-49e7-a251-febc085d3379" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_74fbefcd-367c-49e7-a251-febc085d3379_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_5816d289-1925-48ae-8cac-6f4cb05e1842" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_74fbefcd-367c-49e7-a251-febc085d3379" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_5816d289-1925-48ae-8cac-6f4cb05e1842" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_GoldmanSachsInternationalMember_5711d422-35f3-4dfc-b10f-262d2a85c131" xlink:href="wynn-20240930.xsd#wynn_GoldmanSachsInternationalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_5816d289-1925-48ae-8cac-6f4cb05e1842" xlink:to="loc_wynn_GoldmanSachsInternationalMember_5711d422-35f3-4dfc-b10f-262d2a85c131" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauLimitedMember_76ba28d6-9c37-4fcb-bf1b-8ec66d4b5eed" xlink:href="wynn-20240930.xsd#wynn_WynnMacauLimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_5816d289-1925-48ae-8cac-6f4cb05e1842" xlink:to="loc_wynn_WynnMacauLimitedMember_76ba28d6-9c37-4fcb-bf1b-8ec66d4b5eed" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseAxis_191e855a-6ed6-459a-9fac-5770ecc92882" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_3f2bc54f-a2e3-4fbc-9f34-bd8321bcec71" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseAxis_191e855a-6ed6-459a-9fac-5770ecc92882" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_191e855a-6ed6-459a-9fac-5770ecc92882_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseAxis_191e855a-6ed6-459a-9fac-5770ecc92882" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_191e855a-6ed6-459a-9fac-5770ecc92882_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_2a0a822b-897d-402f-8498-7b475295da08" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseAxis_191e855a-6ed6-459a-9fac-5770ecc92882" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_2a0a822b-897d-402f-8498-7b475295da08" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SecuritiesLendingAgreementMember_d1bdff0e-cec0-4123-a9c3-265a3e404040" xlink:href="wynn-20240930.xsd#wynn_SecuritiesLendingAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseTypeDomain_2a0a822b-897d-402f-8498-7b475295da08" xlink:to="loc_wynn_SecuritiesLendingAgreementMember_d1bdff0e-cec0-4123-a9c3-265a3e404040" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_823642bb-e33f-484e-b0fe-1207e3fed391" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_3f2bc54f-a2e3-4fbc-9f34-bd8321bcec71" xlink:to="loc_dei_LegalEntityAxis_823642bb-e33f-484e-b0fe-1207e3fed391" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_823642bb-e33f-484e-b0fe-1207e3fed391_default" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_823642bb-e33f-484e-b0fe-1207e3fed391" xlink:to="loc_dei_EntityDomain_823642bb-e33f-484e-b0fe-1207e3fed391_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_eb49855c-bd52-4f0d-a148-179d2cd42a8f" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_823642bb-e33f-484e-b0fe-1207e3fed391" xlink:to="loc_dei_EntityDomain_eb49855c-bd52-4f0d-a148-179d2cd42a8f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WMCaymanIMember_45a015b9-5c36-4a46-8574-f01e1434e503" xlink:href="wynn-20240930.xsd#wynn_WMCaymanIMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_eb49855c-bd52-4f0d-a148-179d2cd42a8f" xlink:to="loc_wynn_WMCaymanIMember_45a015b9-5c36-4a46-8574-f01e1434e503" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauLimitedMember_a98b34a1-c59f-470e-ac82-9c049607337b" xlink:href="wynn-20240930.xsd#wynn_WynnMacauLimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_eb49855c-bd52-4f0d-a148-179d2cd42a8f" xlink:to="loc_wynn_WynnMacauLimitedMember_a98b34a1-c59f-470e-ac82-9c049607337b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramAxis_b9eb2165-9429-403f-86dc-94657093001f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareRepurchaseProgramAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_3f2bc54f-a2e3-4fbc-9f34-bd8321bcec71" xlink:to="loc_us-gaap_ShareRepurchaseProgramAxis_b9eb2165-9429-403f-86dc-94657093001f" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_b9eb2165-9429-403f-86dc-94657093001f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareRepurchaseProgramDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_b9eb2165-9429-403f-86dc-94657093001f" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_b9eb2165-9429-403f-86dc-94657093001f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_0c280142-fbf9-4e67-af30-567fe6b98e97" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareRepurchaseProgramDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_b9eb2165-9429-403f-86dc-94657093001f" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_0c280142-fbf9-4e67-af30-567fe6b98e97" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_April2016EquityRepurchaseProgramMember_78ea0ea1-fb3f-4104-b866-bb8493f26e61" xlink:href="wynn-20240930.xsd#wynn_April2016EquityRepurchaseProgramMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareRepurchaseProgramDomain_0c280142-fbf9-4e67-af30-567fe6b98e97" xlink:to="loc_wynn_April2016EquityRepurchaseProgramMember_78ea0ea1-fb3f-4104-b866-bb8493f26e61" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesAxis_df9e91a7-30ca-4505-b15a-e258251f9137" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ConsolidatedEntitiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_3f2bc54f-a2e3-4fbc-9f34-bd8321bcec71" xlink:to="loc_srt_ConsolidatedEntitiesAxis_df9e91a7-30ca-4505-b15a-e258251f9137" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesDomain_df9e91a7-30ca-4505-b15a-e258251f9137_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ConsolidatedEntitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidatedEntitiesAxis_df9e91a7-30ca-4505-b15a-e258251f9137" xlink:to="loc_srt_ConsolidatedEntitiesDomain_df9e91a7-30ca-4505-b15a-e258251f9137_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesDomain_c9ae47f4-ee9a-4bee-8df7-26db10a0f882" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ConsolidatedEntitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidatedEntitiesAxis_df9e91a7-30ca-4505-b15a-e258251f9137" xlink:to="loc_srt_ConsolidatedEntitiesDomain_c9ae47f4-ee9a-4bee-8df7-26db10a0f882" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SubsidiariesMember_d7bdf0b1-8e80-4dab-97e0-885b484f6232" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_SubsidiariesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidatedEntitiesDomain_c9ae47f4-ee9a-4bee-8df7-26db10a0f882" xlink:to="loc_srt_SubsidiariesMember_d7bdf0b1-8e80-4dab-97e0-885b484f6232" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsAxis_2adf86d3-8e1d-4436-90c5-852cbe0002b8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DividendsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_3f2bc54f-a2e3-4fbc-9f34-bd8321bcec71" xlink:to="loc_us-gaap_DividendsAxis_2adf86d3-8e1d-4436-90c5-852cbe0002b8" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsDomain_2adf86d3-8e1d-4436-90c5-852cbe0002b8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DividendsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DividendsAxis_2adf86d3-8e1d-4436-90c5-852cbe0002b8" xlink:to="loc_us-gaap_DividendsDomain_2adf86d3-8e1d-4436-90c5-852cbe0002b8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsDomain_6313cb52-698d-424b-8b2c-32b6e1efa6e4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DividendsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DividendsAxis_2adf86d3-8e1d-4436-90c5-852cbe0002b8" xlink:to="loc_us-gaap_DividendsDomain_6313cb52-698d-424b-8b2c-32b6e1efa6e4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_O2024Q1DividendsMember_c943336a-e0f4-4116-852b-3258060ba6bd" xlink:href="wynn-20240930.xsd#wynn_O2024Q1DividendsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsDomain_6313cb52-698d-424b-8b2c-32b6e1efa6e4" xlink:to="loc_wynn_O2024Q1DividendsMember_c943336a-e0f4-4116-852b-3258060ba6bd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_O2024Q2DividendsMember_7438c19d-955a-4cae-99f0-d55537544927" xlink:href="wynn-20240930.xsd#wynn_O2024Q2DividendsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsDomain_6313cb52-698d-424b-8b2c-32b6e1efa6e4" xlink:to="loc_wynn_O2024Q2DividendsMember_7438c19d-955a-4cae-99f0-d55537544927" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_O2024Q3DividendsMember_73085041-f6dd-43bc-ae74-69ab0ea7e457" xlink:href="wynn-20240930.xsd#wynn_O2024Q3DividendsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsDomain_6313cb52-698d-424b-8b2c-32b6e1efa6e4" xlink:to="loc_wynn_O2024Q3DividendsMember_73085041-f6dd-43bc-ae74-69ab0ea7e457" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_149ad53d-0377-4701-ada4-2d36c09411d3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_3f2bc54f-a2e3-4fbc-9f34-bd8321bcec71" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_149ad53d-0377-4701-ada4-2d36c09411d3" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_149ad53d-0377-4701-ada4-2d36c09411d3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_149ad53d-0377-4701-ada4-2d36c09411d3" xlink:to="loc_us-gaap_EquityComponentDomain_149ad53d-0377-4701-ada4-2d36c09411d3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_29f68016-f0c0-4737-a06b-71c37bf82641" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_149ad53d-0377-4701-ada4-2d36c09411d3" xlink:to="loc_us-gaap_EquityComponentDomain_29f68016-f0c0-4737-a06b-71c37bf82641" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_ef0e008f-c4bc-4c73-9c95-81e23e565ee4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_29f68016-f0c0-4737-a06b-71c37bf82641" xlink:to="loc_us-gaap_RetainedEarningsMember_ef0e008f-c4bc-4c73-9c95-81e23e565ee4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_fb7515cb-82af-42da-8a31-dd405d04a5dd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_58978860-c23b-464a-85dd-25989c009e78" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_fb7515cb-82af-42da-8a31-dd405d04a5dd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_ca7f62d8-773f-4bca-95b5-d7b58b5ee85e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockSharesAcquired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_58978860-c23b-464a-85dd-25989c009e78" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_ca7f62d8-773f-4bca-95b5-d7b58b5ee85e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockAcquiredAverageCostPerShare_b9df6376-c284-4696-bdb8-494911ba0bf7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockAcquiredAverageCostPerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_58978860-c23b-464a-85dd-25989c009e78" xlink:to="loc_us-gaap_TreasuryStockAcquiredAverageCostPerShare_b9df6376-c284-4696-bdb8-494911ba0bf7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_76ba659e-4704-412e-99b2-15855828557a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_58978860-c23b-464a-85dd-25989c009e78" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_76ba659e-4704-412e-99b2-15855828557a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_61db7410-732b-4f35-b47a-6704be370982" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_58978860-c23b-464a-85dd-25989c009e78" xlink:to="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_61db7410-732b-4f35-b47a-6704be370982" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_StockRepurchaseProgramAdditionalAuthorizedAmount_4ebea0d2-3fb9-4ca2-90bd-37b8423fffd3" xlink:href="wynn-20240930.xsd#wynn_StockRepurchaseProgramAdditionalAuthorizedAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_58978860-c23b-464a-85dd-25989c009e78" xlink:to="loc_wynn_StockRepurchaseProgramAdditionalAuthorizedAmount_4ebea0d2-3fb9-4ca2-90bd-37b8423fffd3" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareCashPaid_6a1206f1-fe13-4321-858e-3c096bbb7064" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockDividendsPerShareCashPaid"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_58978860-c23b-464a-85dd-25989c009e78" xlink:to="loc_us-gaap_CommonStockDividendsPerShareCashPaid_6a1206f1-fe13-4321-858e-3c096bbb7064" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCommonStockCash_7739bd29-2e38-49a0-bab3-1d204678fa47" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DividendsCommonStockCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_58978860-c23b-464a-85dd-25989c009e78" xlink:to="loc_us-gaap_DividendsCommonStockCash_7739bd29-2e38-49a0-bab3-1d204678fa47" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPayableAmountPerShare_c3684414-45e8-4db6-933e-21dc5ff387d6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DividendsPayableAmountPerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_58978860-c23b-464a-85dd-25989c009e78" xlink:to="loc_us-gaap_DividendsPayableAmountPerShare_c3684414-45e8-4db6-933e-21dc5ff387d6" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_e74e201b-baeb-4ca4-9661-ba83c6394b6a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MinorityInterestOwnershipPercentageByParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_58978860-c23b-464a-85dd-25989c009e78" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_e74e201b-baeb-4ca4-9661-ba83c6394b6a" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_081fa67c-2c39-4ed8-824e-a115dc8b77ef" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_58978860-c23b-464a-85dd-25989c009e78" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_081fa67c-2c39-4ed8-824e-a115dc8b77ef" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_afbf01be-9bc6-4130-9549-abdd7ede044d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_58978860-c23b-464a-85dd-25989c009e78" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_afbf01be-9bc6-4130-9549-abdd7ede044d" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDistributionsToAffiliates_7a99778b-7b63-4b64-9100-9e6e1f291a06" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsOfDistributionsToAffiliates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_58978860-c23b-464a-85dd-25989c009e78" xlink:to="loc_us-gaap_PaymentsOfDistributionsToAffiliates_7a99778b-7b63-4b64-9100-9e6e1f291a06" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCash_380314cd-ba35-446c-b6ce-4d259384c8be" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DividendsCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_58978860-c23b-464a-85dd-25989c009e78" xlink:to="loc_us-gaap_DividendsCash_380314cd-ba35-446c-b6ce-4d259384c8be" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromDividendsReceived_dbf66c5d-b4e2-45e2-874a-87395041e4ff" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromDividendsReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_58978860-c23b-464a-85dd-25989c009e78" xlink:to="loc_us-gaap_ProceedsFromDividendsReceived_dbf66c5d-b4e2-45e2-874a-87395041e4ff" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_d0900220-e588-4bd4-befc-64dd92c41719" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_58978860-c23b-464a-85dd-25989c009e78" xlink:to="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_d0900220-e588-4bd4-befc-64dd92c41719" xlink:type="arc" order="15"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/FairValueMeasurementsDetails" xlink:type="simple" xlink:href="wynn-20240930.xsd#FairValueMeasurementsDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/FairValueMeasurementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_83f6fca8-3673-4e59-a668-da2795e3f1ff" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_990ef2fb-4a70-43ec-9f26-3646ee90d975" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_83f6fca8-3673-4e59-a668-da2795e3f1ff" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_990ef2fb-4a70-43ec-9f26-3646ee90d975" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_878605c0-45b2-4f2b-87e8-649296a1bb43" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_990ef2fb-4a70-43ec-9f26-3646ee90d975" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_878605c0-45b2-4f2b-87e8-649296a1bb43" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_878605c0-45b2-4f2b-87e8-649296a1bb43_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_878605c0-45b2-4f2b-87e8-649296a1bb43" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_878605c0-45b2-4f2b-87e8-649296a1bb43_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_72f6e0d1-05e8-4883-9183-34e7ad0209a6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_878605c0-45b2-4f2b-87e8-649296a1bb43" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_72f6e0d1-05e8-4883-9183-34e7ad0209a6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_9507b5c9-8833-4af7-b706-0d8046f30497" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_72f6e0d1-05e8-4883-9183-34e7ad0209a6" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_9507b5c9-8833-4af7-b706-0d8046f30497" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_f9d86cdb-784a-4190-a251-4ab012052c4f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_990ef2fb-4a70-43ec-9f26-3646ee90d975" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_f9d86cdb-784a-4190-a251-4ab012052c4f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_f9d86cdb-784a-4190-a251-4ab012052c4f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_f9d86cdb-784a-4190-a251-4ab012052c4f" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_f9d86cdb-784a-4190-a251-4ab012052c4f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2cd76cfe-1442-4c89-96c4-114c8ad82060" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_f9d86cdb-784a-4190-a251-4ab012052c4f" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2cd76cfe-1442-4c89-96c4-114c8ad82060" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_7db81f55-569b-4bbb-828a-3a0b0d4a8fff" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2cd76cfe-1442-4c89-96c4-114c8ad82060" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_7db81f55-569b-4bbb-828a-3a0b0d4a8fff" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_c5f679ed-0806-4292-b307-f511d54a9172" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2cd76cfe-1442-4c89-96c4-114c8ad82060" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_c5f679ed-0806-4292-b307-f511d54a9172" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_b9149722-fc91-46ad-a064-2e58dce283cd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2cd76cfe-1442-4c89-96c4-114c8ad82060" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_b9149722-fc91-46ad-a064-2e58dce283cd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosureAbstract_33dbb564-83e3-4bb5-b069-9fc2e69f69f9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsFairValueDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_83f6fca8-3673-4e59-a668-da2795e3f1ff" xlink:to="loc_us-gaap_AssetsFairValueDisclosureAbstract_33dbb564-83e3-4bb5-b069-9fc2e69f69f9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValue_804a9673-633e-4e76-89fc-d2bf0441c315" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_33dbb564-83e3-4bb5-b069-9fc2e69f69f9" xlink:to="loc_us-gaap_CashEquivalentsAtCarryingValue_804a9673-633e-4e76-89fc-d2bf0441c315" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_20a5f850-7821-4824-bb20-e62f7418a465" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedCashAndCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_33dbb564-83e3-4bb5-b069-9fc2e69f69f9" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_20a5f850-7821-4824-bb20-e62f7418a465" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashEquivalentsCurrent_c37214b3-1801-4027-b8e3-6fb1c9497764" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedCashEquivalentsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_33dbb564-83e3-4bb5-b069-9fc2e69f69f9" xlink:to="loc_us-gaap_RestrictedCashEquivalentsCurrent_c37214b3-1801-4027-b8e3-6fb1c9497764" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_2c112d3e-55a9-4942-97ca-bdc319a3bb4c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_33dbb564-83e3-4bb5-b069-9fc2e69f69f9" xlink:to="loc_us-gaap_DerivativeAssets_2c112d3e-55a9-4942-97ca-bdc319a3bb4c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_69ce911a-8c5a-4364-8a34-8c9cec4d19f2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesFairValueDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_83f6fca8-3673-4e59-a668-da2795e3f1ff" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_69ce911a-8c5a-4364-8a34-8c9cec4d19f2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_f154403c-3c5e-4f9e-ae33-f3ad76a3cf39" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_69ce911a-8c5a-4364-8a34-8c9cec4d19f2" xlink:to="loc_us-gaap_DerivativeLiabilities_f154403c-3c5e-4f9e-ae33-f3ad76a3cf39" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/StockBasedCompensationShareBasedCompensationAllocatedCostsDetail" xlink:type="simple" xlink:href="wynn-20240930.xsd#StockBasedCompensationShareBasedCompensationAllocatedCostsDetail"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/StockBasedCompensationShareBasedCompensationAllocatedCostsDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_16bc6358-74c7-42b5-96aa-87480b8b3a18" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_f33860d9-dfce-4288-aa33-f32c2125c365" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_16bc6358-74c7-42b5-96aa-87480b8b3a18" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_f33860d9-dfce-4288-aa33-f32c2125c365" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_70c32e95-a39d-4ada-98b1-87ee82b8ce3b" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_f33860d9-dfce-4288-aa33-f32c2125c365" xlink:to="loc_srt_ProductOrServiceAxis_70c32e95-a39d-4ada-98b1-87ee82b8ce3b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_70c32e95-a39d-4ada-98b1-87ee82b8ce3b_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_70c32e95-a39d-4ada-98b1-87ee82b8ce3b" xlink:to="loc_srt_ProductsAndServicesDomain_70c32e95-a39d-4ada-98b1-87ee82b8ce3b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_4a1c1ff8-ca71-4d76-a777-576d438e3cb5" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_70c32e95-a39d-4ada-98b1-87ee82b8ce3b" xlink:to="loc_srt_ProductsAndServicesDomain_4a1c1ff8-ca71-4d76-a777-576d438e3cb5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CasinoMember_caca156a-fab1-4768-b6fc-0163efea166c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CasinoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_4a1c1ff8-ca71-4d76-a777-576d438e3cb5" xlink:to="loc_us-gaap_CasinoMember_caca156a-fab1-4768-b6fc-0163efea166c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RoomsMember_0688c9bc-8547-4e54-bf08-6c7287a3433c" xlink:href="wynn-20240930.xsd#wynn_RoomsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_4a1c1ff8-ca71-4d76-a777-576d438e3cb5" xlink:to="loc_wynn_RoomsMember_0688c9bc-8547-4e54-bf08-6c7287a3433c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FoodAndBeverageMember_4e9139dc-0cd0-41c8-b417-2c884e0334d3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FoodAndBeverageMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_4a1c1ff8-ca71-4d76-a777-576d438e3cb5" xlink:to="loc_us-gaap_FoodAndBeverageMember_4e9139dc-0cd0-41c8-b417-2c884e0334d3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EntertainmentRetailAndOtherMember_5fef9312-6f04-422a-bf51-744595d50ac7" xlink:href="wynn-20240930.xsd#wynn_EntertainmentRetailAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_4a1c1ff8-ca71-4d76-a777-576d438e3cb5" xlink:to="loc_wynn_EntertainmentRetailAndOtherMember_5fef9312-6f04-422a-bf51-744595d50ac7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_GeneralAndAdministrativeMember_9829bc65-20e2-40b5-b60b-3f0ba1518878" xlink:href="wynn-20240930.xsd#wynn_GeneralAndAdministrativeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_4a1c1ff8-ca71-4d76-a777-576d438e3cb5" xlink:to="loc_wynn_GeneralAndAdministrativeMember_9829bc65-20e2-40b5-b60b-3f0ba1518878" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_f2ac14c6-6abb-4273-b463-9ea9b2db6690" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_16bc6358-74c7-42b5-96aa-87480b8b3a18" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_f2ac14c6-6abb-4273-b463-9ea9b2db6690" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount_8fe796e6-eeca-4b73-81e0-d01c6996a354" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_16bc6358-74c7-42b5-96aa-87480b8b3a18" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount_8fe796e6-eeca-4b73-81e0-d01c6996a354" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_9ed4c991-d516-4992-82ac-a6d3394552f7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_16bc6358-74c7-42b5-96aa-87480b8b3a18" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_9ed4c991-d516-4992-82ac-a6d3394552f7" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/CommitmentsandContingenciesDetails" xlink:type="simple" xlink:href="wynn-20240930.xsd#CommitmentsandContingenciesDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/CommitmentsandContingenciesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_31f7ede0-d551-47bd-9674-f912be7908cb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_e7349c18-e184-4a7c-89e4-334dda621abb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_31f7ede0-d551-47bd-9674-f912be7908cb" xlink:to="loc_us-gaap_LossContingenciesTable_e7349c18-e184-4a7c-89e4-334dda621abb" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_dbaa35e1-d48e-4569-92fb-7f2aa4d82f21" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_LitigationCaseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_e7349c18-e184-4a7c-89e4-334dda621abb" xlink:to="loc_srt_LitigationCaseAxis_dbaa35e1-d48e-4569-92fb-7f2aa4d82f21" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_dbaa35e1-d48e-4569-92fb-7f2aa4d82f21_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_LitigationCaseAxis_dbaa35e1-d48e-4569-92fb-7f2aa4d82f21" xlink:to="loc_srt_LitigationCaseTypeDomain_dbaa35e1-d48e-4569-92fb-7f2aa4d82f21_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_e2792a15-e3a5-4d7e-a5b3-c57f021e1121" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_LitigationCaseAxis_dbaa35e1-d48e-4569-92fb-7f2aa4d82f21" xlink:to="loc_srt_LitigationCaseTypeDomain_e2792a15-e3a5-4d7e-a5b3-c57f021e1121" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SecuritiesClassActionMember_66f57065-097b-4801-917d-69bb548e9f1d" xlink:href="wynn-20240930.xsd#wynn_SecuritiesClassActionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_e2792a15-e3a5-4d7e-a5b3-c57f021e1121" xlink:to="loc_wynn_SecuritiesClassActionMember_66f57065-097b-4801-917d-69bb548e9f1d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FederalInvestigationMember_ed08e5e7-f03c-4d97-ac45-04c10d0d4ca8" xlink:href="wynn-20240930.xsd#wynn_FederalInvestigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_e2792a15-e3a5-4d7e-a5b3-c57f021e1121" xlink:to="loc_wynn_FederalInvestigationMember_ed08e5e7-f03c-4d97-ac45-04c10d0d4ca8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationSettlementAmountAwardedToOtherParty_f3eecad8-67d5-40bf-96c7-c70a3e42e560" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LitigationSettlementAmountAwardedToOtherParty"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_31f7ede0-d551-47bd-9674-f912be7908cb" xlink:to="loc_us-gaap_LitigationSettlementAmountAwardedToOtherParty_f3eecad8-67d5-40bf-96c7-c70a3e42e560" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationSettlementExpense_b53c0c8f-8e4b-4bb6-bcc4-90d609a2d620" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LitigationSettlementExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_31f7ede0-d551-47bd-9674-f912be7908cb" xlink:to="loc_us-gaap_LitigationSettlementExpense_b53c0c8f-8e4b-4bb6-bcc4-90d609a2d620" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/RetailJointVentureAdditionalinformationDetails" xlink:type="simple" xlink:href="wynn-20240930.xsd#RetailJointVentureAdditionalinformationDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/RetailJointVentureAdditionalinformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_335fc36f-1854-4a1b-af74-ac92441ab514" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_0c320b6b-1a21-4469-adf1-3db271c0a7d8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_335fc36f-1854-4a1b-af74-ac92441ab514" xlink:to="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_0c320b6b-1a21-4469-adf1-3db271c0a7d8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_b578559e-7e2f-4977-b88c-1625a8b2e5bf" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_0c320b6b-1a21-4469-adf1-3db271c0a7d8" xlink:to="loc_dei_LegalEntityAxis_b578559e-7e2f-4977-b88c-1625a8b2e5bf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_b578559e-7e2f-4977-b88c-1625a8b2e5bf_default" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_b578559e-7e2f-4977-b88c-1625a8b2e5bf" xlink:to="loc_dei_EntityDomain_b578559e-7e2f-4977-b88c-1625a8b2e5bf_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_a5d634e4-d552-46e2-baff-7c5ea7a4e9d8" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_b578559e-7e2f-4977-b88c-1625a8b2e5bf" xlink:to="loc_dei_EntityDomain_a5d634e4-d552-46e2-baff-7c5ea7a4e9d8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_RetailJointVentureMember_1c271e14-dad8-4850-a04e-af0535fe557c" xlink:href="wynn-20240930.xsd#wynn_RetailJointVentureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_a5d634e4-d552-46e2-baff-7c5ea7a4e9d8" xlink:to="loc_wynn_RetailJointVentureMember_1c271e14-dad8-4850-a04e-af0535fe557c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_e5cdf605-e45f-4237-9a9b-e1faaa9fd73b" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_0c320b6b-1a21-4469-adf1-3db271c0a7d8" xlink:to="loc_srt_ProductOrServiceAxis_e5cdf605-e45f-4237-9a9b-e1faaa9fd73b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_e5cdf605-e45f-4237-9a9b-e1faaa9fd73b_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_e5cdf605-e45f-4237-9a9b-e1faaa9fd73b" xlink:to="loc_srt_ProductsAndServicesDomain_e5cdf605-e45f-4237-9a9b-e1faaa9fd73b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_b2eee076-aa08-4304-bb27-e013e0833185" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_e5cdf605-e45f-4237-9a9b-e1faaa9fd73b" xlink:to="loc_srt_ProductsAndServicesDomain_b2eee076-aa08-4304-bb27-e013e0833185" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetailMember_13c611fd-af33-4c28-bdab-4edab6490f6e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetailMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_b2eee076-aa08-4304-bb27-e013e0833185" xlink:to="loc_us-gaap_RetailMember_13c611fd-af33-4c28-bdab-4edab6490f6e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_b1ef0c98-9e85-4b5b-ae8b-83261c743910" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Assets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_335fc36f-1854-4a1b-af74-ac92441ab514" xlink:to="loc_us-gaap_Assets_b1ef0c98-9e85-4b5b-ae8b-83261c743910" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_1d7d2971-0aba-440f-8212-0217ceb436b4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Liabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_335fc36f-1854-4a1b-af74-ac92441ab514" xlink:to="loc_us-gaap_Liabilities_1d7d2971-0aba-440f-8212-0217ceb436b4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_f4f23273-00f0-46e5-8b73-ef5f77bdac52" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_335fc36f-1854-4a1b-af74-ac92441ab514" xlink:to="loc_us-gaap_LongTermDebt_f4f23273-00f0-46e5-8b73-ef5f77bdac52" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/SegmentInformationSummaryofResultsofOperationsbySegmentDetails" xlink:type="simple" xlink:href="wynn-20240930.xsd#SegmentInformationSummaryofResultsofOperationsbySegmentDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/SegmentInformationSummaryofResultsofOperationsbySegmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_8a372fd9-74fa-433b-9599-8feb9992769b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_24ce228f-495c-486a-96bf-0d03abfecedb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_8a372fd9-74fa-433b-9599-8feb9992769b" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_24ce228f-495c-486a-96bf-0d03abfecedb" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_eec1403f-92f9-4ab4-b269-ffe0c59b44c3" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_24ce228f-495c-486a-96bf-0d03abfecedb" xlink:to="loc_srt_ProductOrServiceAxis_eec1403f-92f9-4ab4-b269-ffe0c59b44c3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_eec1403f-92f9-4ab4-b269-ffe0c59b44c3_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_eec1403f-92f9-4ab4-b269-ffe0c59b44c3" xlink:to="loc_srt_ProductsAndServicesDomain_eec1403f-92f9-4ab4-b269-ffe0c59b44c3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_03c05496-86d4-46a6-9473-53c3fc128fce" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_eec1403f-92f9-4ab4-b269-ffe0c59b44c3" xlink:to="loc_srt_ProductsAndServicesDomain_03c05496-86d4-46a6-9473-53c3fc128fce" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CasinoMember_14cd51a6-7dae-4e38-9288-66017c3ad784" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CasinoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_03c05496-86d4-46a6-9473-53c3fc128fce" xlink:to="loc_us-gaap_CasinoMember_14cd51a6-7dae-4e38-9288-66017c3ad784" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OccupancyMember_4749dddd-891d-4692-8961-eca45444fe96" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OccupancyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_03c05496-86d4-46a6-9473-53c3fc128fce" xlink:to="loc_us-gaap_OccupancyMember_4749dddd-891d-4692-8961-eca45444fe96" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FoodAndBeverageMember_f79393f7-9fc5-47c2-958a-0857689a2f39" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FoodAndBeverageMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_03c05496-86d4-46a6-9473-53c3fc128fce" xlink:to="loc_us-gaap_FoodAndBeverageMember_f79393f7-9fc5-47c2-958a-0857689a2f39" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EntertainmentRetailAndOtherMember_36cbc7a7-6afb-4b51-92ed-0b36c670775d" xlink:href="wynn-20240930.xsd#wynn_EntertainmentRetailAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_03c05496-86d4-46a6-9473-53c3fc128fce" xlink:to="loc_wynn_EntertainmentRetailAndOtherMember_36cbc7a7-6afb-4b51-92ed-0b36c670775d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_62a325ea-8245-4e58-be2e-7a7b1b60bc36" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_24ce228f-495c-486a-96bf-0d03abfecedb" xlink:to="loc_srt_ConsolidationItemsAxis_62a325ea-8245-4e58-be2e-7a7b1b60bc36" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_62a325ea-8245-4e58-be2e-7a7b1b60bc36_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_62a325ea-8245-4e58-be2e-7a7b1b60bc36" xlink:to="loc_srt_ConsolidationItemsDomain_62a325ea-8245-4e58-be2e-7a7b1b60bc36_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_787ccc9b-c64f-4bfd-af36-a68a7d65581f" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_62a325ea-8245-4e58-be2e-7a7b1b60bc36" xlink:to="loc_srt_ConsolidationItemsDomain_787ccc9b-c64f-4bfd-af36-a68a7d65581f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_b777910c-6e01-4439-822b-5a1bf1d46320" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingSegmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_787ccc9b-c64f-4bfd-af36-a68a7d65581f" xlink:to="loc_us-gaap_OperatingSegmentsMember_b777910c-6e01-4439-822b-5a1bf1d46320" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateNonSegmentMember_89e486bb-fafb-4291-983c-1a279d310e09" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CorporateNonSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_787ccc9b-c64f-4bfd-af36-a68a7d65581f" xlink:to="loc_us-gaap_CorporateNonSegmentMember_89e486bb-fafb-4291-983c-1a279d310e09" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_f1e329ab-9dfc-4b35-a5fc-43d7ea1bd87f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_24ce228f-495c-486a-96bf-0d03abfecedb" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_f1e329ab-9dfc-4b35-a5fc-43d7ea1bd87f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_f1e329ab-9dfc-4b35-a5fc-43d7ea1bd87f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_f1e329ab-9dfc-4b35-a5fc-43d7ea1bd87f" xlink:to="loc_us-gaap_SegmentDomain_f1e329ab-9dfc-4b35-a5fc-43d7ea1bd87f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_d8819e01-ece5-49bd-a83e-ed95150cf82d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_f1e329ab-9dfc-4b35-a5fc-43d7ea1bd87f" xlink:to="loc_us-gaap_SegmentDomain_d8819e01-ece5-49bd-a83e-ed95150cf82d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_MacauOperationsMember_c696ef1a-bbdd-457e-a2cf-c9789649fa47" xlink:href="wynn-20240930.xsd#wynn_MacauOperationsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_d8819e01-ece5-49bd-a83e-ed95150cf82d" xlink:to="loc_wynn_MacauOperationsMember_c696ef1a-bbdd-457e-a2cf-c9789649fa47" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnLasVegasMember_3c257431-f69a-4d2e-b8fa-503aff9b0563" xlink:href="wynn-20240930.xsd#wynn_WynnLasVegasMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_d8819e01-ece5-49bd-a83e-ed95150cf82d" xlink:to="loc_wynn_WynnLasVegasMember_3c257431-f69a-4d2e-b8fa-503aff9b0563" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EncoreBostonHarborMember_4b227e7a-c768-4250-bdd7-6bf2b57afd45" xlink:href="wynn-20240930.xsd#wynn_EncoreBostonHarborMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_d8819e01-ece5-49bd-a83e-ed95150cf82d" xlink:to="loc_wynn_EncoreBostonHarborMember_4b227e7a-c768-4250-bdd7-6bf2b57afd45" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_cfab3a1d-b986-4077-a024-54482163a606" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_24ce228f-495c-486a-96bf-0d03abfecedb" xlink:to="loc_dei_LegalEntityAxis_cfab3a1d-b986-4077-a024-54482163a606" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_cfab3a1d-b986-4077-a024-54482163a606_default" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_cfab3a1d-b986-4077-a024-54482163a606" xlink:to="loc_dei_EntityDomain_cfab3a1d-b986-4077-a024-54482163a606_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_081665e7-3da8-453a-9b48-f82602dc505c" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_cfab3a1d-b986-4077-a024-54482163a606" xlink:to="loc_dei_EntityDomain_081665e7-3da8-453a-9b48-f82602dc505c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnPalaceMember_2d1bcdac-b1df-44bc-a3a5-bf3cb37e5017" xlink:href="wynn-20240930.xsd#wynn_WynnPalaceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_081665e7-3da8-453a-9b48-f82602dc505c" xlink:to="loc_wynn_WynnPalaceMember_2d1bcdac-b1df-44bc-a3a5-bf3cb37e5017" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauMember_ad73dcc6-977c-47fc-a6c1-0ac7a0ef1895" xlink:href="wynn-20240930.xsd#wynn_WynnMacauMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_081665e7-3da8-453a-9b48-f82602dc505c" xlink:to="loc_wynn_WynnMacauMember_ad73dcc6-977c-47fc-a6c1-0ac7a0ef1895" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_11884293-f60c-4c85-aedf-dd72a255f39d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_24ce228f-495c-486a-96bf-0d03abfecedb" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_11884293-f60c-4c85-aedf-dd72a255f39d" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_11884293-f60c-4c85-aedf-dd72a255f39d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_11884293-f60c-4c85-aedf-dd72a255f39d" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_11884293-f60c-4c85-aedf-dd72a255f39d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_917dfdb9-e8a2-4a75-b764-d5f3c4b8df07" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_11884293-f60c-4c85-aedf-dd72a255f39d" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_917dfdb9-e8a2-4a75-b764-d5f3c4b8df07" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressMember_e53046ee-957f-4ef6-ae40-bdb39506e08f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConstructionInProgressMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_917dfdb9-e8a2-4a75-b764-d5f3c4b8df07" xlink:to="loc_us-gaap_ConstructionInProgressMember_e53046ee-957f-4ef6-ae40-bdb39506e08f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_99e4e766-39d8-489b-ab45-9c98b46eae2d" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_LitigationCaseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_24ce228f-495c-486a-96bf-0d03abfecedb" xlink:to="loc_srt_LitigationCaseAxis_99e4e766-39d8-489b-ab45-9c98b46eae2d" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_99e4e766-39d8-489b-ab45-9c98b46eae2d_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_LitigationCaseAxis_99e4e766-39d8-489b-ab45-9c98b46eae2d" xlink:to="loc_srt_LitigationCaseTypeDomain_99e4e766-39d8-489b-ab45-9c98b46eae2d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_05235620-114c-453a-b854-8ed43cd8c614" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_LitigationCaseAxis_99e4e766-39d8-489b-ab45-9c98b46eae2d" xlink:to="loc_srt_LitigationCaseTypeDomain_05235620-114c-453a-b854-8ed43cd8c614" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_FederalInvestigationMember_3994902c-66cf-405f-ac21-bffdc0418315" xlink:href="wynn-20240930.xsd#wynn_FederalInvestigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_05235620-114c-453a-b854-8ed43cd8c614" xlink:to="loc_wynn_FederalInvestigationMember_3994902c-66cf-405f-ac21-bffdc0418315" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_SecuritiesClassActionMember_48d27e71-ecac-4b7c-b294-05a52117b516" xlink:href="wynn-20240930.xsd#wynn_SecuritiesClassActionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_05235620-114c-453a-b854-8ed43cd8c614" xlink:to="loc_wynn_SecuritiesClassActionMember_48d27e71-ecac-4b7c-b294-05a52117b516" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_cb3609b3-0911-4caa-a909-51ea188254ef" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_24ce228f-495c-486a-96bf-0d03abfecedb" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_cb3609b3-0911-4caa-a909-51ea188254ef" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_cb3609b3-0911-4caa-a909-51ea188254ef_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_cb3609b3-0911-4caa-a909-51ea188254ef" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_cb3609b3-0911-4caa-a909-51ea188254ef_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_f3173dd8-44e7-4d45-a512-a6a178dbb060" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_cb3609b3-0911-4caa-a909-51ea188254ef" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_f3173dd8-44e7-4d45-a512-a6a178dbb060" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnInteractivesDigitalSportsBettingAndCasinoGamingBusinessMember_93eed0b1-886b-440d-af09-aeffbb8aaaba" xlink:href="wynn-20240930.xsd#wynn_WynnInteractivesDigitalSportsBettingAndCasinoGamingBusinessMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_f3173dd8-44e7-4d45-a512-a6a178dbb060" xlink:to="loc_wynn_WynnInteractivesDigitalSportsBettingAndCasinoGamingBusinessMember_93eed0b1-886b-440d-af09-aeffbb8aaaba" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_836fa723-3994-4226-9712-4ade9349365f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_8a372fd9-74fa-433b-9599-8feb9992769b" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_836fa723-3994-4226-9712-4ade9349365f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_AdjustedPropertyEbitda_24652969-4f0b-4db2-8e86-23bf9dfcfcb3" xlink:href="wynn-20240930.xsd#wynn_AdjustedPropertyEbitda"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_8a372fd9-74fa-433b-9599-8feb9992769b" xlink:to="loc_wynn_AdjustedPropertyEbitda_24652969-4f0b-4db2-8e86-23bf9dfcfcb3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OtherOperatingCostsAndExpensesAbstract_e0471ff4-d603-4ba6-8581-76a58f21f3b5" xlink:href="wynn-20240930.xsd#wynn_OtherOperatingCostsAndExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_8a372fd9-74fa-433b-9599-8feb9992769b" xlink:to="loc_wynn_OtherOperatingCostsAndExpensesAbstract_e0471ff4-d603-4ba6-8581-76a58f21f3b5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreOpeningCosts_57491243-f508-4be0-82c0-155bde143c47" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreOpeningCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_e0471ff4-d603-4ba6-8581-76a58f21f3b5" xlink:to="loc_us-gaap_PreOpeningCosts_57491243-f508-4be0-82c0-155bde143c47" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAndAmortization_5458387f-e644-48e9-b99b-29f70b69dab7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_e0471ff4-d603-4ba6-8581-76a58f21f3b5" xlink:to="loc_us-gaap_DepreciationAndAmortization_5458387f-e644-48e9-b99b-29f70b69dab7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetImpairment_fe2657ee-bcfc-44a1-a618-79c5deb6ac21" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GoodwillAndIntangibleAssetImpairment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_e0471ff4-d603-4ba6-8581-76a58f21f3b5" xlink:to="loc_us-gaap_GoodwillAndIntangibleAssetImpairment_fe2657ee-bcfc-44a1-a618-79c5deb6ac21" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_ProjectAbandonmentCosts_ee13a3ff-950a-467b-8d40-6aafcf3aa677" xlink:href="wynn-20240930.xsd#wynn_ProjectAbandonmentCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_e0471ff4-d603-4ba6-8581-76a58f21f3b5" xlink:to="loc_wynn_ProjectAbandonmentCosts_ee13a3ff-950a-467b-8d40-6aafcf3aa677" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_CorporateExpensesAndOther_a54c17c4-1bd4-429d-baab-79095b716416" xlink:href="wynn-20240930.xsd#wynn_CorporateExpensesAndOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_e0471ff4-d603-4ba6-8581-76a58f21f3b5" xlink:to="loc_wynn_CorporateExpensesAndOther_a54c17c4-1bd4-429d-baab-79095b716416" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_e2daa18b-5972-4b2a-bc38-888a8d463802" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_e0471ff4-d603-4ba6-8581-76a58f21f3b5" xlink:to="loc_us-gaap_ShareBasedCompensation_e2daa18b-5972-4b2a-bc38-888a8d463802" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OperatingLeaseTripleNetCost_a953a496-db09-4680-b31a-f5e65b883598" xlink:href="wynn-20240930.xsd#wynn_OperatingLeaseTripleNetCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_e0471ff4-d603-4ba6-8581-76a58f21f3b5" xlink:to="loc_wynn_OperatingLeaseTripleNetCost_a953a496-db09-4680-b31a-f5e65b883598" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCostAndExpenseOperating_07c482fb-a003-4bf0-8880-6d1eb0a8f9c9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherCostAndExpenseOperating"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_wynn_OtherOperatingCostsAndExpensesAbstract_e0471ff4-d603-4ba6-8581-76a58f21f3b5" xlink:to="loc_us-gaap_OtherCostAndExpenseOperating_07c482fb-a003-4bf0-8880-6d1eb0a8f9c9" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_30037dd0-28a6-44be-880d-a2f57b941674" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_8a372fd9-74fa-433b-9599-8feb9992769b" xlink:to="loc_us-gaap_OperatingIncomeLoss_30037dd0-28a6-44be-880d-a2f57b941674" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_aa358f09-9ff4-4841-9cc9-baa2a3d9ba28" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NonoperatingIncomeExpenseAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_8a372fd9-74fa-433b-9599-8feb9992769b" xlink:to="loc_us-gaap_NonoperatingIncomeExpenseAbstract_aa358f09-9ff4-4841-9cc9-baa2a3d9ba28" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_1c512db5-31a5-4bbe-99a9-dca88486f7a9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_aa358f09-9ff4-4841-9cc9-baa2a3d9ba28" xlink:to="loc_us-gaap_InvestmentIncomeInterest_1c512db5-31a5-4bbe-99a9-dca88486f7a9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_7ccf2956-eb88-4df7-8010-82b5255a4f29" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_aa358f09-9ff4-4841-9cc9-baa2a3d9ba28" xlink:to="loc_us-gaap_InterestExpense_7ccf2956-eb88-4df7-8010-82b5255a4f29" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_9b9d521d-a5bd-4165-ad88-88ffa8d1ae8f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_aa358f09-9ff4-4841-9cc9-baa2a3d9ba28" xlink:to="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_9b9d521d-a5bd-4165-ad88-88ffa8d1ae8f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_7802f250-f9a7-4f37-ab2a-b46d8464bab4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_aa358f09-9ff4-4841-9cc9-baa2a3d9ba28" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_7802f250-f9a7-4f37-ab2a-b46d8464bab4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_1f3115ec-c282-41ad-a232-0e706c9bc6cf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_aa358f09-9ff4-4841-9cc9-baa2a3d9ba28" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_1f3115ec-c282-41ad-a232-0e706c9bc6cf" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_22a0e9aa-a8af-401b-aa95-f9a8ac73cab2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_aa358f09-9ff4-4841-9cc9-baa2a3d9ba28" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_22a0e9aa-a8af-401b-aa95-f9a8ac73cab2" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_0cf02029-80c4-4d0c-8755-cef353546f42" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_8a372fd9-74fa-433b-9599-8feb9992769b" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_0cf02029-80c4-4d0c-8755-cef353546f42" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_439c8efa-5704-4bf6-aa23-d8aee45929e3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_8a372fd9-74fa-433b-9599-8feb9992769b" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_439c8efa-5704-4bf6-aa23-d8aee45929e3" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_5f2d69c3-d46c-4502-868f-747866f5213a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_8a372fd9-74fa-433b-9599-8feb9992769b" xlink:to="loc_us-gaap_ProfitLoss_5f2d69c3-d46c-4502-868f-747866f5213a" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_161be426-4570-461d-b7e2-836dcdafc0bc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_8a372fd9-74fa-433b-9599-8feb9992769b" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_161be426-4570-461d-b7e2-836dcdafc0bc" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_3ed33b15-10fc-48ec-8a52-5e071510e311" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_8a372fd9-74fa-433b-9599-8feb9992769b" xlink:to="loc_us-gaap_NetIncomeLoss_3ed33b15-10fc-48ec-8a52-5e071510e311" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_CapitalizedProjectCostsExpense_84c40656-2625-47e9-823f-e3b2b6311585" xlink:href="wynn-20240930.xsd#wynn_CapitalizedProjectCostsExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_8a372fd9-74fa-433b-9599-8feb9992769b" xlink:to="loc_wynn_CapitalizedProjectCostsExpense_84c40656-2625-47e9-823f-e3b2b6311585" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationSettlementExpense_e9d494ee-4c31-471f-864c-da63ff7bec30" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LitigationSettlementExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_8a372fd9-74fa-433b-9599-8feb9992769b" xlink:to="loc_us-gaap_LitigationSettlementExpense_e9d494ee-4c31-471f-864c-da63ff7bec30" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDispositionOfAssets1_f7eb6178-e2e8-4e39-907c-86534ed8f447" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainLossOnDispositionOfAssets1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_8a372fd9-74fa-433b-9599-8feb9992769b" xlink:to="loc_us-gaap_GainLossOnDispositionOfAssets1_f7eb6178-e2e8-4e39-907c-86534ed8f447" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessExitCosts1_f3b3bde5-f486-44ac-810a-f4e1faa6a992" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessExitCosts1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_8a372fd9-74fa-433b-9599-8feb9992769b" xlink:to="loc_us-gaap_BusinessExitCosts1_f3b3bde5-f486-44ac-810a-f4e1faa6a992" xlink:type="arc" order="13"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.wynnresorts.com/role/SegmentInformationSummaryofAssetsbySegmentDetails" xlink:type="simple" xlink:href="wynn-20240930.xsd#SegmentInformationSummaryofAssetsbySegmentDetails"/>
  <link:definitionLink xlink:role="http://www.wynnresorts.com/role/SegmentInformationSummaryofAssetsbySegmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_8511b895-a317-462a-ace3-fd9c3a21f75c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d65b41ee-bb7b-4c64-94c1-e84349c76fd6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_8511b895-a317-462a-ace3-fd9c3a21f75c" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d65b41ee-bb7b-4c64-94c1-e84349c76fd6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_3f17896c-b2bf-4c26-9d52-ab63e57bc113" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d65b41ee-bb7b-4c64-94c1-e84349c76fd6" xlink:to="loc_srt_ConsolidationItemsAxis_3f17896c-b2bf-4c26-9d52-ab63e57bc113" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_3f17896c-b2bf-4c26-9d52-ab63e57bc113_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_3f17896c-b2bf-4c26-9d52-ab63e57bc113" xlink:to="loc_srt_ConsolidationItemsDomain_3f17896c-b2bf-4c26-9d52-ab63e57bc113_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_74d81d63-466a-47d1-b4de-6cda430252dc" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_3f17896c-b2bf-4c26-9d52-ab63e57bc113" xlink:to="loc_srt_ConsolidationItemsDomain_74d81d63-466a-47d1-b4de-6cda430252dc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_87e82cdf-ba52-4761-949b-6a41d124e9b1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingSegmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_74d81d63-466a-47d1-b4de-6cda430252dc" xlink:to="loc_us-gaap_OperatingSegmentsMember_87e82cdf-ba52-4761-949b-6a41d124e9b1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_2be7fdae-909d-4027-a116-ac618c9a043c" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d65b41ee-bb7b-4c64-94c1-e84349c76fd6" xlink:to="loc_srt_StatementGeographicalAxis_2be7fdae-909d-4027-a116-ac618c9a043c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_2be7fdae-909d-4027-a116-ac618c9a043c_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_2be7fdae-909d-4027-a116-ac618c9a043c" xlink:to="loc_srt_SegmentGeographicalDomain_2be7fdae-909d-4027-a116-ac618c9a043c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_e10f9f58-d28c-4fd7-ac21-1808c1d5281b" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_2be7fdae-909d-4027-a116-ac618c9a043c" xlink:to="loc_srt_SegmentGeographicalDomain_e10f9f58-d28c-4fd7-ac21-1808c1d5281b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_MO_0535a083-c39d-436d-8ec8-994f786eae18" xlink:href="https://xbrl.sec.gov/country/2023/country-2023.xsd#country_MO"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_e10f9f58-d28c-4fd7-ac21-1808c1d5281b" xlink:to="loc_country_MO_0535a083-c39d-436d-8ec8-994f786eae18" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_f430e1e6-d1bc-47f0-beee-00ba6fd98c11" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d65b41ee-bb7b-4c64-94c1-e84349c76fd6" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_f430e1e6-d1bc-47f0-beee-00ba6fd98c11" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_f430e1e6-d1bc-47f0-beee-00ba6fd98c11_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_f430e1e6-d1bc-47f0-beee-00ba6fd98c11" xlink:to="loc_us-gaap_SegmentDomain_f430e1e6-d1bc-47f0-beee-00ba6fd98c11_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_65a65152-5997-4d76-a2f2-929d2449efe7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_f430e1e6-d1bc-47f0-beee-00ba6fd98c11" xlink:to="loc_us-gaap_SegmentDomain_65a65152-5997-4d76-a2f2-929d2449efe7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnPalaceMember_176b6125-8a36-4d9e-a34a-64254bbe7fbb" xlink:href="wynn-20240930.xsd#wynn_WynnPalaceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_65a65152-5997-4d76-a2f2-929d2449efe7" xlink:to="loc_wynn_WynnPalaceMember_176b6125-8a36-4d9e-a34a-64254bbe7fbb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnMacauMember_beb10d57-9f61-41f2-89d8-78c4a9f399ae" xlink:href="wynn-20240930.xsd#wynn_WynnMacauMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_65a65152-5997-4d76-a2f2-929d2449efe7" xlink:to="loc_wynn_WynnMacauMember_beb10d57-9f61-41f2-89d8-78c4a9f399ae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_OtherMacauMember_0e1619c6-1046-4b31-8ec7-8bc65b61c995" xlink:href="wynn-20240930.xsd#wynn_OtherMacauMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_65a65152-5997-4d76-a2f2-929d2449efe7" xlink:to="loc_wynn_OtherMacauMember_0e1619c6-1046-4b31-8ec7-8bc65b61c995" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_MacauOperationsMember_0d6272ff-d9e1-45c8-9cc8-310a58b4afb8" xlink:href="wynn-20240930.xsd#wynn_MacauOperationsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_65a65152-5997-4d76-a2f2-929d2449efe7" xlink:to="loc_wynn_MacauOperationsMember_0d6272ff-d9e1-45c8-9cc8-310a58b4afb8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_WynnLasVegasMember_135607f4-ebce-4f0c-a777-40bc045c69b5" xlink:href="wynn-20240930.xsd#wynn_WynnLasVegasMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_65a65152-5997-4d76-a2f2-929d2449efe7" xlink:to="loc_wynn_WynnLasVegasMember_135607f4-ebce-4f0c-a777-40bc045c69b5" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_wynn_EncoreBostonHarborMember_29c0ec92-1f69-454d-b377-3723ce2463f9" xlink:href="wynn-20240930.xsd#wynn_EncoreBostonHarborMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_65a65152-5997-4d76-a2f2-929d2449efe7" xlink:to="loc_wynn_EncoreBostonHarborMember_29c0ec92-1f69-454d-b377-3723ce2463f9" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateAndOtherMember_1a7cedf9-e95e-4c7b-b4ce-282558a87ccd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CorporateAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_65a65152-5997-4d76-a2f2-929d2449efe7" xlink:to="loc_us-gaap_CorporateAndOtherMember_1a7cedf9-e95e-4c7b-b4ce-282558a87ccd" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_fab9d3f0-9461-4a4f-a5d5-fe990a25c314" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Assets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_8511b895-a317-462a-ace3-fd9c3a21f75c" xlink:to="loc_us-gaap_Assets_fab9d3f0-9461-4a4f-a5d5-fe990a25c314" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://fasb.org/us-gaap/role/eedm/ExtensibleEnumerationLists" xlink:type="simple" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-roles-2023.xsd#eedm"/>
  <link:definitionLink xlink:role="http://fasb.org/us-gaap/role/eedm/ExtensibleEnumerationLists" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Investments" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Investments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract" xlink:to="loc_us-gaap_Investments" xlink:type="arc" order="1"/>
  </link:definitionLink>
</link:linkbase>
